건설업 근로자의 유해 작업 환경 노출 실태에 관한 연구

최재욱,박희찬,김정아,원정일,문정수 한국산업위생학회 2000 한국산업보건학회지 Vol.10 No.1

This study was performed to evaluate the working conditions in construction workers through measurements of working environments and to improve the working conditions and to design the appropriate environmental and health management system. The results of measurement for working environments in construction work are as following: 1. The excess rate of noise and dust concentration in express highway construction, road construction, building construction and interior painting was 28.6% and 24.5% respectively. 2. The excess rate of mixed organic solvents concentration in interior painting was 39.3%. 3. The chain type bulldozer has the highest level of vibration; the excess rate was 85.7%, and among the vibration instruments, the level of left hand's vibration of all vibrators exceeded the criterion and in the case of drilling all the level of vibration exceeded the criterion in both hands. On the basis of the results in this research the environmental and health management system for construction workers must be considered. Therefore, it is necessary to be introduced the special medical examination and measurement of working environments in construction industry. In defining $quot;the working place$quot; of Article 39 of Enforcement regulations of industrial safety and health act, the word $quot;indoors$quot; should be deleted. Then the eligible industry for measurement of working environment must be extended. And it is also necessary for construction industry to be performed group health management service by agencies such as other manufacturing industry.

Chemokines Gene Expression of RAW 264.7 Cells by Actinobacillus actinomycetemcomitans Lipopolysaccharide Using Microarray and RT-PCR Analysis

정진,Mun Jeoung Choi,So Yeon Jeong,Jong Suk Oh,Hyung Keun Kim 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.2

Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) is an important pathogen casuing aggressive periodontitis. The present study was designed to investigate the chemokines expression regulated by A. actinomycetemcomitans lipopolysaccharide (LPS). Chemokines genes expression profiling was performed in Raw 264.7 cells by analyses of microarray and reverse transcription-polymerase chain reaction (RT-PCR). Microarray results showed that the induction of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1α (MIP-1α), MIP-1β, MIP-1γ, regulated upon activation, normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein-2 (MIP-2), and interferon-γ inducible protein 10 (IP 10) by A. actinomycetemcomitans LPS was increased to 12.5, 1.53, 9.09, 17.3, 2.82, 16.1, and 18.1 folds at 18 h, respectively. To check these chemo- kines expression by A. actinomycetemcomitans LPS, we examined gene expressions by RT-PCR, and found that the expression of MIP-1β, MIP-1γ, RANTES, MIP-2, and IP 10 was increased 107.1, 93.6, 106.8, 86.5, and 162.0 folds at 18 h, respectively. These results indicate that A. actinomycetemcomitans LPS stimulates the several chemokines expressions (MIP-1α, MIP-1β, MIP-1γ, RANTES, MIP-2, and IP 10) in Raw 264.7 cells.

Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta

Sung, Hui-Jin,Choi, Mun-Jeoung,Ok, Seong-Ho,Lee, Soo Hee,Hwang, Il Jeong,Kim, Hee Sook,Chang, Ki Churl,Shin, Il-Woo,Lee, Heon-Keun,Park, Kyeong-Eon,Chung, Young-Kyun,Sohn, Ju-Tae Canadian Science Publishing 2012 Canadian journal of physiology and pharmacology Vol.90 No.7

<P> Mepivacaine is an aminoamide-linked local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. The aims of this in-vitro study were to examine the direct effect of mepivacaine in isolated rat aortic rings and to determine the associated cellular mechanism with a particular focus on endothelium-derived vasodilators, which modulate vascular tone. In the aortic rings with or without endothelium, cumulative mepivacaine concentration-response curves were generated in the presence or absence of the following antagonists: N<SUP>ω</SUP>-nitro-l-arginine methyl ester [l-NAME], indomethacin, fluconazole, methylene blue, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one [ODQ], verapamil, and calcium-free Krebs solution. Mepivacaine produced vasoconstriction at low concentrations (1 × 10<SUP>−3</SUP> and 3 × 10<SUP>−3</SUP> mol/L) followed by vasodilation at a high concentration (1 × 10<SUP>−2</SUP> mol/L). The mepivacaine-induced contraction was higher in endothelium-denuded aortae than in endothelium-intact aortae. Pretreatment with l-NAME, ODQ, and methylene blue enhanced mepivacaine-induced contraction in the endothelium-intact rings, whereas fluconazole had no effect. Indomethacin slightly attenuated mepivacaine-induced contraction, whereas verapamil and calcium-free Krebs solution more strongly attenuated this contraction. The vasoconstriction induced by mepivacaine is attenuated mainly by the endothelial nitric oxide - cyclic guanosine monophosphate pathway. In addition, mepivacaine-induced contraction involves cyclooxygenase pathway activation and extracellular calcium influx via voltage-operated calcium channels. </P>

Growth of Ti on Si(111)-7×7 Surface and the Formation of Epitaxial C54 TiSi_2 on Si(111) Substrate

Kim, Kun Ho,Kim, In Ho,Lee, Jeoung Ju,Seo, Dong Ju,Choi, Chi Kyu,Hong, Sung Rak,Yang, Soo Jeong,Park, Hyung Ho,Lee, Joong Hwan,Paek, Mun Cheol,Kwon, Oh Joon,Park, Tong Soo,Lee, Jeong Yong 慶尙大學校 기초과학연구소 1992 基礎科學硏究所報 Vol.8 No.-

고에너지 반사 전자회절기 (RHEED) 및 투과전자현미경(HRTEM)을 이용하여 Si(111)-7×7 면에서의 Ti박막의 성장 mode와 Si(111) 면에서의 C54 TiSi_2의 정합성장을 조사하였다. 초고진공에서 Si(111)-7×7 표면에 상온에서 Ti를 증착하면 Ti/Si 계면에서 비정질의 Ti-Si 중간막이 먼저 형성되고 그 위에 Ti 박막은 다결정으로 성장하였다. 160ML의 Ti 증착한 시료를 초고진공 내에서 750℃로 10분 열처리하면 C54 TiSi_2가 정합성장하였으며 이는HRTEM격자상 및 TED pattern으로 확인할 수 있었다. TiSi_2/(111) 시료를 다시 900℃로 가열하면 TiSi_2 위의 단결정 Si층이 [111] 방향으로 성장하였다. The growth of Ti on Si(111)-7×7 and the formation of epitaxial C54 TiSi_2 were investigated by using relfection high energy electron diffraction(RHEED) and high resolution transmission electron microscopy(HRTEM). Polycrystalline Ti layer is grown on the amorphous Ti-Si interlayer which is formed at the Ti/Si interface by Ti deposition on Si(111)-7×7 at room temperature (RT). HRTEM lattice image and transmission electron diffraction (TED) showed that epitaxial C54 TiSi_2 grown on Si substrate with 160 ML of Ti on Si(111)-7×7 surface at RT, followed by annealing at 750℃ for 10min in UHV. Thin single crystal Si overlayer with [111] direction is grown on TiSi_2 surface when TiSi_2/Si(111) is annealed at ∼900℃ in UHV. which was confirmed by Si(111)-7×7 superstructure.

전자유도 탐사를 이용한 지하매설물 탐지 정확도 분석

권형석(Hyoung Seok Kwon),최준호(Joon ho Choi),황대진(Dae jin Hwang),김문재(Mun jae Kim),윤정섭(Jeoung seob Yoon) 한국방재안전학회 2008 한국방재안전학회 논문집 Vol.1 No.4

전자유도 탐사는 매설관로에서 발생되는 자기장을 측정하는 탐사방법으로 하나의 관로만 매설되어 있는 경우에는 20cm 이내의 높은 정확도를 보이지만, 탐지대상 관로 인근에 다른 관로가 매설되어 있으면 자기장의 교란으로 정확도가 감소한다. 본 연구에서는 지하매설물 탐지 정확도 향상을 위하여 대칭성을 이용하여 매설관로의 수평위치를 검증하는 방법과 에너지 크기 비교법과 삼각법을 이용하여 매설심도를 검증하는 방법에 대해 고찰하였다. 다음으로 현재 판매되는 전자유도 탐사장비가 별도의 저장장치를 가지고 있지 않아 측정자료의 분석이 불가능한 문제를 개선하기 위하여, Bluetooth 무선통신장치를 이용하여 측정자료를 저장하는 방법을 개발하였다. 마지막으로 두개의 인접관로를 하나로 오인하는 문제점을 개선하기 위하여 현장모형실험을 통해 인접관로의 거리에 따른 분해능을 고찰하였다. Electromagnetic induction surveys are one of the useful methods to detect the location and buried depth of underground utilities by measuring horizontal and vertical magnetic fields. It can effectively detects single buried utility with the accuracy of within 20 cm. However when another utility is buried near to target one, the accuracy of utility location considerably decreases due to the distortion of magnetic fields caused from adjacent utility. This study shows the ways to verify the location and buried depth of target utility when magnetic fields does not show symmetric distribution due to adjacent another utility. Using Bluetooth wireless communication tools, we developed the way to records measured magnetic fields to handheld PDA. We investigated the criteria for minimum distance of two adjacent utilities to separate the individual responses through field model test

Slimming of Lower Face by Contouring of the Mandibular Body in Orthognathic Surgery Patients

Park, Bong-Wook,Kang, Young-Hoon,Choi, Mun-Jeoung,Kim, Si-Yeob,Kang, Hea-Gea,Kim, Jong-Ryoul,Byun, June-Ho Korean Association of Maxillofacial Plastic and Re 2013 Maxillofacial Plastic Reconstructive Surgery Vol.35 No.5

The patient's appearance can be dramatically enhanced as a result of orthognathic surgery. However, esthetic contouring of the mandibular body portion is often overlooked in the surgery. Restoring a more beautiful jaw line is important and directly affects surgical results. From December 2010 to February 2012, we performed mandibular body contouring for the slimming of the third lower part of the face in 37 patients who had undergone either 1-jaw surgery or 2-jaw surgery. The third lower part of the facial contour was improved in all the patients after at least 3 months follow-up. Mandibular body contouring is a simple method that can be additionally used for the slimming of the third lower part of the face in patients who require orthognathic surgeries. It makes the lower face look more attractive from both the anterior and lateral perspectives.

골막기원세포의 조골세포로의 분화과정에서 염증성 사이토카인의 효과

박봉욱(Bong-Wook Park),최문정(Mun-Jeoung Choi),하영술(Young-Sool Hah),조희영(Hee-Young Cho),김덕룡(Deok Ryong Kim),김욱규(Uk-Kyu Kim),강희제(Hee-Jea Kang),김종렬(Jong-Ryoul Kim),변준호(June-Ho Byun) 대한구강악안면외과학회 2010 대한구강악안면외과학회지 Vol.36 No.5

Introduction: Skeletal homeostasis is normally maintained by the stability between bone formation by osteoblasts and bone resorption by osteoclasts. However, the correlation between the inflammatory reaction and osteoblastic differentiation of cultured osteoprogenitor cells has not been fully investigated. This study examined the effects of inflammatory cytokines on the osteoblastic differentiation of cultured human periosteal-derived cells. Materials and Methods: Periosteal-derived cells were obtained from the mandibular periosteum and introduced into the cell culture. After passage 3, the periosteal-derived cells were further cultured in an osteogenic induction Dulbecco’s modified Eagle’s medium (DMEM) medium containing dexamethasone, ascorbic acid, and β-glycerophosphate. In this culture medium, tumor necrosis factor (TNF)-αwith different concentrations (0.1, 1, and 10 ng/mL) or interleukin (IL)-1βwith different concentrations (0.01, 0.1, and 1 ng/mL) were added. Results: Both TNF-αand IL-1βstimulated alkaline phosphatase (ALP) expression in the periosteal-derived cells. TNF-αand IL-1βincreased the level of ALP expression in a dose-dependent manner. Both TNF-αand IL-1βalso increased the level of alizarin red S staining in a dose-dependent manner during osteoblastic differentiation of cultured human periosteal-derived cells. Conclusion: These results suggest that inflammatory cytokines TNF-αand IL-1βcan stimulate the osteoblastic activity of cultured human periosteal-derived cells.

Evaluation of Osteogenic Activity and Mineralization of Cultured Human Dental Papilla-Derived Cells

( Bong Wook Park ),( June Ho Byun ),( Mun Jeoung Choi ),( Young Sool Hah ),( Deok Ryong Kim ),( Yeong Cheol Cho ),( Lel Yong Sung ),( Jong Ryoul Kim ) 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.2S

HPLP와 사상체질설문(四象體質說問)을 이용(利用)한 근로자(勤勞者)들의 건강상태(健康狀態) 평가(評價)

최문일,이은경,권소희,고광재,서병윤,정재열,장두섭,송용선,이기남,Choi Mun-Il,Lee Eun-Kyoung,Kwon So-Hee,Ko Kwang-Jae,Seo Byeong-Yun,Jeoung Jae-Yeal,Jahng Doo-Sub,Song Yung-Sun,Lee Ki-Nam 대한예방한의학회 2001 대한예방한의학회지 Vol.5 No.1

개인의 건강증진사업을 진행하기 위해서는 건강에 긍정적인 영향을 미치는 생활양식과 생활양식에 영향을 미치는 요인에 대한 역학적 조사가 필요하며 이는 연령집단별로 건강위험인자나 생활양식 및 건강실천행위 등이 모두 다르게 나타나기 때문이다. 체질에 따른 생활양식 등의 차이를 규명하는 것은 체질의학이 예방서비스의 일환으로 적용될 수 있는 기초자료를 제공하는 데 큰 역할을 할 뿐 아니라 체질의학을 현대화하는 데에도 기여할 것으로 사고된다. 이에 본 연구에서는 각 체질을 분석하고 체질별 건강증진 생활양식 실천정도를 파악한 결과 몇 가지 결과를 얻었기에 보고하는 바이다. 1. 연구대상자 중 태음인(太陰人)은 43.7%였고 소음인(少陰人)은 33.6%였으며, 소양인(少陽人)은 22.7%로 나타났다. 2. 연구대상자의 자아실현, 건강책임, 운동, 영양, 대인관계, 스트레스 관리를 포함한 건강증진 생활양식의 총 평균은 138.9이고 총 평점은 2.62이었다. 각 영역별 평점은 대인관계 2.94, 자아실현 2.86, 스트레스관리 2.71, 영양상태 2.68, 건강책임 2.37, 운동영역 2.21의 순으로 대인관계가 가장 높고 운동영역이 가장 낮았다. 3. 건강증진 생활양식 전체영역과의 관계를 보면 여성의 경우와 연령이 높을수록 건강증진 생활양식 실천정도가 높게 나타났다. 건강증진 생활양식 각 영역과의 관계를 보면 성별에서 보면 건강책임영역과 영양영역, 스트레스관리 영역에서 여자가 더 높은 실행정도를 보였고 운동영역에서 남자가 더 높은 실행정도를 보였다(P<0.05). 연령에서는 건강책임영역에서는 30대가, 영양영역과 스트레스관리영역에서는 50대가 가장 높은 실행정도를 보였다(p<0.05). 결혼상태에 따라서는 영양의 영역에서만 기혼자가 유의하게 실행정도가 높게 나타났다(P<0.05). 4. 건강증진 생활양식 각 영역과 사회경제적 특성과의 차이를 보면 월수입에서는 대인관계영역에서만 월수입이 100만원 미만이 가장 높게 나타났고(P<0.05), 교육수준별로는 자아실현영역에서만 교육수준이 높을수록 이행정도가 높게 나타났으나(P<0.05) 나머지 영역에서는 유의한 차이가 나타나지 않았다. 5. 대인관계영역을 제외한 모든 영역에서 태음인(太陰人)의 건강증진 생활양식의 실천정도가 가장 높았으며 자아실현영역에서는 소양인(少陽人)과 거의 비슷했다. 소음인(少陰人)은 건강책임 영역을 제외하고는 모든 영역에서 실천정도가 가장 낮은 것으로 나타났고 건강책임은 태음인(太陰人), 소음인(少陰人), 소양인(少陽人)의 순서로, 대인관계 영역에서는 소음인(少陰人), 태음인(太陰人), 소양인(少陽人)의 순으로 실천정도가 높음을 알 수 있다. Overview: The purpose of this study was to evaluate the determinants on the correlation between constitution and health promoting lifestyle profile on the workers. Also, the questionnaire on the HPLP (health promoting lifestyle profile) of Walker(1987) and Sa-sang constitution of Lee(l894) were utilized Methods: Data from a representative sample of 652 workers were analyzed Pearson's chi-square test analysis was utilized to test the explanatory causal model and to determine the direct and indirect effects of independent variables on quality of life. Results: Constitutional distribution among exposed group, were Tae-eum In(43.7%), So-eum In(33.6%), and So-yang In(22.7%). The degree of the subjects practicing health promoting lifestyle, on a scale of 1 to 4, is an average of 2.62, personal relations 2.94, self-realization 2.86, stress management 2.71, nutrition 2.68, responsibility for health 2.37, and exercise 2.21, with personal relations earning the highest points and exercise the lowest As for factors influencing health promoting lifestyle, there is significant difference between sex and age. That is female and higher age. On the difference between constitution and health promoting lifestyle, Tae-eum In is the highest all area except personal relations. So-eum In is the lowest all area except responsibility for health. Conclusions: Tae-eum In totally do health promoting lifestyle well but So-eum In relatively not. On the Study we used the HPLP(health promoting lifestyle profile) on the premise that each person's daily life, the attitude and the practice level to the health have an influence on the health. So in the constitution there is a little differences in the consideration and the practice level and health condition will be different. On this study we finish up by knowing about the health promoting lifestyle. But on next time we will have to go on studying about the sign and the comparison with the result of western and oriental medical health examination to the each constitution on carrying out continuously oriental medical health examination.

Lipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta

옥성호,Jeong Yeol Han,Soo Hee Lee,신일우,이헌근,정영균,Mun-Jeoung Choi,손주태 대한마취통증의학회 2013 Korean Journal of Anesthesiology Vol.64 No.4

Background: Intravenous lipid emulsion has been used to treat systemic toxicity of local anesthetics. The goals of this in vitro study were to determine the ability of two lipid emulsions (IntralipidⓇ and LipofundinⓇ MCT/LCT) to reverse toxic dose local anesthetic-induced vasodilation in isolated rat aortas. Methods: Isolated endothelium-denuded aortas were suspended for isometric tension recording. Vasodilation was induced by bupivacaine (3 × 10-4 M), ropivacaine (10-3 M), lidocaine (3 × 10-3 M), or mepivacaine (7 × 10-3 M) after precontraction with 60 mM KCl. IntralipidⓇ and LipofundinⓇ MCT/LCT were then added to generate concentration-response curves. We also assessed vasoconstriction induced by 60 mM KCl, 60 mM KCl with 3 × 10-4 M bupivacaine, and 60 mM KCl with 3 × 10-4 M bupivacaine plus 1.39% lipid emulsion (IntralipidⓇ or LipofundinⓇ MCT/LCT). Results: The two lipid emulsions reversed vasodilation induced by bupivacaine, ropivacaine, and lidocaine but had no effect on vasodilation induced by mepivacaine. LipofundinⓇ MCT/LCT was more effective than IntralipidⓇ in reversing bupivacaine-induced vasodilation. The magnitude of lipid emulsion-mediated reversal of vasodilation induced by high-dose local anesthetics was as follows (from highest to lowest): 3 × 10-4 M bupivacaine-induced vasodilation, 10-3 M ropivacaine-induced vasodilation, and 3 × 10-3 M lidocaine-induced vasodilation. Conclusions: LipofundinⓇ MCT/LCT-mediated reversal of bupivacaine-induced vasodilation was greater than that of IntralipidⓇ; however, the two lipid emulsions equally reversed vasodilation induced by ropivacaine and lidocaine. The magnitude of lipid emulsion-mediated reversal of vasodilation appears to be correlated with the lipid solubility of the local anesthetic.