P211 : Red blood cell distribution width is increased in patients with psoriasis vulgaris: a retrospective study on 261 patients

( Dae Suk Kim ),( Dongyun Shin ),( Minseok Lee ),( Hyunjoong Jee ),( Tae Gyun Kim ),( Sung Hee Kim ),( Do Young Kim ),( Soo Min Kim ),( Min Geol Lee1 ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Circulating inflammatory cytokines and markers are increased in patients with psoriasis. Recent studies have shown that a higher red blood cell distribution width (RDW) is associated with disease activity in various disorders. Objectives: Our objective was to investigate whether RDW is increased in psoriasis patients, and to evaluate its association with disease severity. Methods: We conducted a retrospective study of psoriasis patients seen in single hospital in Korea. Demographic data, hematologic parameters and disease severity were collected. Results: A total of 261 psoriasis patients and 102 healthy controls were included in our study. The RDW value was significantly increased in psoriasis patients compared to healthy control (p=0.037). Compared to mild psoriasispatients (PASI<7), moderate to severe patients (PASI≥7) showed significantly higher RDW values (p=0.044). RDW did not show significant correlation with PASI (p=0.358). When patients were divided into two groups according to their RDW value (<14.6% and ≥14.6%), the mean value of PASI was not significantly different (p=0.219). Conclusion: Patients with psoriasis showed increased RDW values compared to healthy controls. It was also higher in moderate and severe disease group than mild group. RDW values were increased in psoriasis patients and it is possible that RDW value reflects the inflammatory status of psoriasis, but this needs to be evaluated in near future.

Prediction of Travel Time of Fire Service using Kriging and Weighted-sum Technique

Yoonha Lee(Yoonha Lee),Minseok Kim(Minseok Kim),Jisoo Lee(Jisoo Lee) 한국화재소방학회 2022 International Journal of Fire Science and Engineer Vol.36 No.2

The accessibility of city fire services is an important indicator for evaluating fire services and optimizing fire resource allocation. For firefighting, rescue, and first-aid activities, it is recommended that the time from fire vehicles leaving the garage to arrive at the scene is less than 5 minutes. Therefore, the travel time of fire services is one of the main concerns for many researchers. This study assumes that changing the urban environment affects the travel time of fire services. Therefore, in this study, weights were applied over the years to predict the travel time of fire service by using the kriging technique. As a result of the case study, temporal factors (elapsed year, term of travel time, and time spent) did not significantly affect travel time prediction accuracy using the kriging technique. As observed in previous studies, it is confirmed that the prediction accuracy is high because it is less affected by traffic-related factors at short travel distances. The results of this study contribute to the development of spatial analysis techniques to improve the accuracy of travel-time prediction.

A new classification rule of hydrological soil groups of Jeju Island: Application to representative basins and evaluation of previous studies

Kang Minseok,Lee Youngju,Park Changyeol,Yoo Chulsang 한국수자원학회 2018 한국수자원학회논문집 Vol.51 No.12

본 연구에서는 Lee et al.(2018)의 연구에서 제시한 새로운 수문학적 토양군 분류 방법을 제주도의 3개의 하천유역(중문천, 천미천, 한천)에 적용하고 그 적용성을 평가하였다. 적용의 결과로서 이들 세 유역의 CN 값이 산정되었으며, 이 값은 기존의 세 가지 방법론을 적용한 결과와 비교하였다. 또한 제주도에서의 침투, 강우-유출 해석 등에 사용되는 수문학적 토양군 분류와 관련된 선행 연구들을 검토하여 선택된 방법론에 따라 수문학적 토양 군 분류 결과가 어떻게 다른지를 평가하였다. 그 결과를 정리하면 다음과 같다. (1) 수문학적 토양군 분류 방법에 따른 제주도 대표 유역의 수문학적 토양군 분류 결과를 비교한 결과, Lee et al.(2018)의 토양군 분류 방법을 적용하는 경우에는 B군이 크게 나타났다. 이는 Hu and Jung(1987)의 분 류 방법을 적용하는 경우에서는 C군과 D군이, Jung et al.(1995)의 분류 방법을 적용하는 경우에서 A군과 C군, 마지막으로 RDA(2007)의 분류 방 법을 적용하는 경우에서는 D군이 상대적으로 크게 나타나는 결과와 비교된다. (2) Lee et al.(2018)의 수문학적 토양군 분류 방법을 제주도의 3개 대표 유역에 적용한 결과, 3개 유역 모두 기존 방법에 비해 가장 작은 CN 값이 추정되었다. 마지막으로 (3) 제주도에서의 강우-유출과 관련된 연구를 검토한 결과, 제주도 유역의 CN 값은 기존 방법에 의해 추정된 것에 비해 작을 가능성이 크고, 또한 초기 손실은 0.2S 이상의 큰 값을 가질 것으로 판단되었다. This study evaluates the applicability of the classification rule of hydrological soil group proposed by Lee et al. (2018) with its application to three river basins (Jungmuncheon, Cheonmicheon, and Hancheon) in Jeju Island. The CN values are estimated as results of this application to these three basins, which is then compared with those estimated by applying the conventional three methods. Additionally, previous studies related with the classification of soil groups of Jesu Island, such as the infiltration and rainfall-runoff analysis, are reviewed to evaluate how the resulting hydrological soil groups vary depending on the adopted classification method.. Summarizing the results is as follows. (1) Comparison result of the hydrological soil groups of Jeju Island with respect to the classification method shows that the soil group B is dominant in the application of Lee et al. (2018). However, it is hydrological soil groups C and D in the application of Hu and Jung (1987), hydrological soil groups A and C in the application of Jung et al. (1995), and hydrological soil group D in the application of RDA (2007). (2) In all the applications of Lee et al. (2018) to three selected river basins in Jeju Island, the CN valuse are found to be smaller than those by other conventional three methods.. Lastly, (3) The evaluation results of previous studies related with the classification of hydrological soil groups analysis in Jeju Island shows that the CN value in the Jeju Island may be smaller than those estimated by conventional three methods, also the initial loss higher than 0.2S.

Embedded earring in a 19-year-old female

( Minseok Lee ),( Young In Lee ),( Dongyun Shin ),( Hee Joo Kim ),( Min Geol Lee ),( Dae Suk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Ear piercing is a common practice among children and adolescents especially in females. There are various complications with ear piercing, including local infection, bleeding, allergic reaction, keloid scar, sarcoid granulomas, lipomas, cyst formation, ear lobe deformity, organizing hematoma and systemic problems (hepatitis, staphylococcal sepsis). Among them, embedded earring is a complication with relatively low incidence. We report a case of embedded earring completely embedded in the earlobe of a young female. A 19-year-old female visited our dermatology clinic with a 1-month history of discomfort in her left earlobe. On physical examination, a pea-sized nodule was palpated. The patient did not have any pains, and strongly insisted that the earring was completely removed. Skin biopsy was done under the clinical impressions of foreign body, epidermal cyst and keloid. During the procedure, the back portion of the earring wasfound embedded within her left earlobe. Punch excision was performed and the embedded earring was totally removed. Embedded earrings usually occur in young female with reported mean age of 8 years. The patient in this case is quite older than average and there has been no reported cases with embedding earrings in Korea. This case highlights that earrings can be embedded even without pain or signs of inflammation and can occur in older ages.

Clinical features and treatment patterns in Korean patients with psoriatic arthritis: a restrospective single center study

( Minseok Lee ),( Jaewon Lee ),( Tae-gyun Kim ),( Min-geol Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Psoriatic arthritis (PsA) is a seronegative inflammatory arthritis associated with psoriasis. The prevalence of PsA varies in different countries and there are about 9-14% of prevalence of PsA among psoriatic patients in Korea. There are limited data of clinical features and treatment patterns of Korean patients with PsA. Objectives: To evaluate the clinical features of Korean PsA patients and treatment modalities used in the real-world setting. Methods: 104 Korean patients who were diagnosed with PsA under CASPAR criteria were analyzed. Each patient’s medical records, PASI score, BSA, manifestation pattern of PsA, and treatment course were reviewed. Results: Total of 104 patients were enrolled (male:female=1:1.08). The mean age was 50.7 years. The average PASI score was 8.6 and BSA was 11.5%. Spondylitis was the most common subtype of PsA (39.4%). NSAIDs were the most commonly utilized treatment modality (79.8%, n=83), followed by methotrexate (69.2%) and sulfasalazine (37.5%). The order of treatment options maintained at the time of enrollment was NSAIDs (67.3%), methotrexate (48.1%) and sulfasalazine (23.1%). 33 patients were treated with biologics and ustekinumab (n=10) was the most common regimen. Conclusion: Our results suggest that spondylitis was the most common type of arthritis in our cohorts consistent with the previous reports in Korea. NSAIDs, methotrexate and sulfasalazine were commonly utilized in the treatment of PsA patients in Korea.

Lichen planus developed in partial unilateral lentiginosis

( Minseok Lee ),( Young In Lee ),( Dongyun Shin ),( Hee Joo Kim ),( Min Geol Lee ),( Dae Suk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Lichen planus (LP) is a chronic inflammatory disease that most often affects middle-aged adults. The skin manifestations of LP are papulosquamous lesions presenting with violaceous, polygonal, flat-topped papules and plaques that show a chronic course. The pathophysiology of LP is not fully understood, yet an immune-mediate pathogenesis is recognized. In this case, we introduce an interesting case of LP that developed on partial unilateral lentiginosis A 69-year old female visited our clinic with a 1 year history of itchy violaceous papules within multiple brownish pigmentations on her left thigh. The patient had lentiginosis by birth, and until 1year before, it was non-symptomatic. Skin biopsy was done under the clinical impression of linear LP and lichen striatus. According to the pathologic report, melanin incontinence suggesting interface dermatitis was observed and was diagnosed with LP. LP arising from lentiginosis is a rare and interesting condition. Since LP lesions were only limited within lentiginosis, we think there should be a pathological relationship between two diseases. However, further investigations are needed in near future to reveal such associations.

Resident and monocyte-derived Langerhans cells are required for imiquimod-induced psoriasis-like dermatitis model

Lee, Minseok,Kim, Sung Hee,Kim, Tae-Gyun,Park, Jeyun,Lee, Jae Won,Lee, Min-Geol Elsevier 2018 Journal of dermatological science Vol.91 No.1

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Langerhans cells (LCs) are dendritic cells that reside in the epidermis and local inflammation results in an increased differentiation of monocyte-derived LCs. Only few studies have investigated on the role of LCs in psoriasis-like dermatitis model, but the results are variable and the exact role of LCs in psoriasis model remains to be elucidated.</P> <P><B>Objective</B></P> <P>To explore the functional role of resident (rLCs) and monocyte-derived LCs (mLCs) in imiquimod (IMQ)-induced psoriasis-like inflammation using human Langerin-diphtheria toxin subunit A (huLang-DTA) mice.</P> <P><B>Methods</B></P> <P>5% IMQ cream was topically applied on the skins. Clinical and histopathological features were evaluated. Psoriasis-related gene expression was analyzed by quantitative polymerase chain reaction. The production of psoriasis-related cytokines including IL-17A and IL-22 by T cells were assessed by flow cytometry from the lesional skins.</P> <P><B>Results</B></P> <P>huLang-DTA mice showed a common depletion of both rLCs and mLCs in the IMQ-treated skins. huLang-DTA mice had a reduced IMQ-induced psoriasis-like inflammation featuring erythema, scale, and thickness compared with wild-type mice. Psoriatic lesions from huLang-DTA mice had a decreased level of <I>Il23a</I> and accordingly demonstrated an attenuated cytokine production of IL-17A and IL-22 from γδ<SUP>low</SUP> T cells. mLCs revealed a significantly greater level of IL-23 expression compared to rLCs in response to topical IMQ treatment.</P> <P><B>Conclusion</B></P> <P>Although both rLCs and mLCs are involved in the development of IMQ-induced psoriasis-like dermatitis, inflammation-induced mLCs present a superior capacity for producing IL-23 in this murine experimental model of psoriasis.</P>

한국인 건선관절염 환자의 임상적 특징과 치료양상에 대한 후향적 단일기관 연구

이민석 ( Minseok Lee ),이재원 ( Jae Won Lee ),김태균 ( Tae-gyun Kim ),이민걸 ( Min-geol Lee ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.5

Background: Psoriatic arthritis (PsA) is a seronegative inflammatory arthritis associated with psoriasis. The prevalence of PsA varies across different countries, and a few previous studies have reported that 9∼17% of Korean patients with psoriasis present with PsA. However, limited data are available regarding the clinical features and treatment of Korean patients with PsA. Objective: To evaluate the clinical features of Korean patients with PsA and the treatment modalities used in the real-world setting. Methods: This study was a retrospective single-center study. We analyzed 101 Korean patients who had been diagnosed with PsA based on the Classification Criteria for Psoriatic Arthritis (CASPAR). We reviewed the patients’ medical records, Psoriasis Area and Severity Index (PASI) score, body surface area (BSA), manifestation pattern of PsA, and treatment course. Results: Our study included 101 patients. The mean age was 50.7 years. The mean PASI score was 8.6, and the mean BSA was 11.5%. Spondylitis was the most common manifestation (40.6%). In most patients, psoriatic lesions preceded the onset of PsA (57.4%). Psoriasis and PsA occurred simultaneously in 32.7%, and PsA developed prior to psoriasis in 9.9% of patients. The administration of nonsteroidal anti-inflammatory drugs (NSAIDs) was the most commonly utilized treatment strategy (82.2%), followed by the use of methotrexate and sulfasalazine. Twenty-two patients were treated with biologics with favorable efficacy. Conclusion: Spondylitis was the most common manifestation in patients. NSAIDs, methotrexate and sulfasalazine were the drugs most commonly used to treat Korean patients with PsA. Dermatologists should be mindful of this entity, and during history taking at the patient’s initial visit, those with psoriasis should be asked, “Do you have any pain or swelling of joints?” to ensure early diagnosis of PsA. (Korean J Dermatol 2018;56(5):308∼313)

데스크탑 규모의 간결한 롤투롤 나노임프린팅 기반 나노패턴 연속가공 시스템 개발

이정수(Jeongsoo Lee),이지훈(Jihun Lee),남승범(Seungbum Nam),조성일(Sungil Cho),조용수(Yongsu Jo),고민석(Minseok Go),이승조(Seungjo Lee),오동교(Dong Kyo Oh),김정대(Jeong Dae Kim),이재혁(Jae Hyuk Lee),옥종걸(Jong G. Ok) 한국기계가공학회 2017 한국기계가공학회지 Vol.16 No.1

We have developed a compact desktop-sized nanopatterning system driven by the Roll-to-Roll (R2R) nanoimprinting (NIL) principle. The system realizes the continuous and high-speed stamping of various nanoscale patterns on a large-area flexible substrate without resorting to ponderous and complicated instruments. We first lay out the process principle based on continuous NIL on a UV-curable resin layer using a flexible nanopatterned mold. We then create conceptual and specific designs for the system by focusing on two key processes, imprinting and UV curing, which are performed in a continuous R2R fashion. We build a system with essential components and optimized modules for imprinting, UV curing, and R2R conveying to enable simple but effective nanopatterning within the desktop volume. Finally, we demonstrate several nanopatterning results such as nanolines and nanodots, which are obtained by operating the built desktop R2R NIL system on transparent and flexible substrates. Our system may be further utilized in the scalable fabrication of diverse flexible nanopatterns for many functional applications in optics, photonics, sensors, and energy harvesters.

Effectiveness of nivolumab versus regorafenib in hepatocellular carcinoma patients who failed sorafenib treatment

Cheol-Hyung Lee,Yun Bin Lee,Minseok Albert Kim,Heejoon Jang,Hyunwoo Oh,Sun Woong Kim,Eun Ju Cho,Kyung-Hun Lee,Jeong-Hoon Lee,Su Jong Yu,Jung-Hwan Yoon,Tae-You Kim,Yoon Jun Kim 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.3

Background/Aims: Several treatment options are currently available for patients with hepatocellular carcinoma (HCC) failing previous sorafenib treatment. We aimed to compare the effectiveness of regorafenib and nivolumab in these patients. Methods: Consecutive HCC patients who received regorafenib or nivolumab after failure of sorafenib treatment were included. Primary endpoint was overall survival (OS) and secondary endpoints were time to progression, tumor response rate, and adverse events. Inverse probability of treatment weighting (IPTW) using the propensity score was conducted to reduce treatment selection bias. Results: Among 150 study patients, 102 patients received regorafenib and 48 patients received nivolumab. Median OS was 6.9 (95% confidence interval [CI], 3.0–10.8) months for regorafenib and 5.9 (95% CI, 3.7–8.1) months for nivolumab (P=0.77 by log-rank test). In multivariable analysis, nivolumab was associated with prolonged OS (vs. regorafenib: adjusted hazard ratio [aHR], 0.54; 95% CI, 0.30–0.96; P=0.04). Time to progression was not significantly different between groups (nivolumab vs. regorafenib: aHR, 0.82; 95% CI, 0.51–1.30; P=0.48). HRs were maintained after IPTW. Objective response rates were 5.9% and 16.7% in patients treated with regorafenib and nivolumab, respectively (P=0.04). Conclusions: After sorafenib failure, the use of nivolumab may be associated with improved OS and better objective response rate as compared to using regorafenib.