실험적 급성 허혈성 신부전에서 Verapamil 이 혈중 Polyamine 동태에 미치는 영향

원동준(Dong Jun Won),권현민(Hyun Min Kwon),김용섭(Yong Seop Kim),구자룡(Ja Ryong Gu),권영주(Young Ju Kwon),조원용(Won Yong Cho),김형규(Hyung Kyu Kim) 대한내과학회 1991 대한내과학회지 Vol.40 No.6

N/A It has been proposd that calcium entry from an external medium increases intracellular free calcium to toxic levels during ischemic acute renal failure, and verapamil (ARF) has been suggested as the agentblocking calicium entry into renal cells and protecting renal function during ischemic injury. Polyamines, anorganic cations that play various roles in normal cellular proliferation and differentiation, accumulate in renal failare. Alsa it has been suggested tht the synthesis and metabolism of polyamine are influence by acute changes of the general condition, such as acute renal failure, and are mediated by a calcium influx into the cells. The study was designed to study the protective effects of systemic verapamil pretreatment on renal function and the influence on polyamine metabolism in experimental ischemic ARF in cats. For these purpose, the experimental animals were divided into 2 groups. While Group I (n=5) was an ischemic ARF model by renal artery clamping for 60 minutes, Group II (n=5) was ischemic ARF with systemic verapamil (5 ml/min/kg) pretreatment. The creatinine clearance and plasma and urinary polyamine were measured in each group before and after the renal artery clamp. The results were as follows: 1) Creatinine clearance before and after the renal artery clamp were 10.64±7.18 ml/min/kg and 2.09±1. 70 ml/min/kg in Group I, 4.47±3.38 ml min/kg and 0.60±0.79ml/min/kg in Group II, respectively, So creatinine clearance decreased more significantly in Group II campared with Group I. 2) Plasma polyamine increased after ischemia in Group I. In group I, plasma levels of putrescine, spermidine, and spermine before ischemia were 4.75±0.40 nmol/ml, 0.69±0.09 nmol/ml, and 0.83±0.63 nmol/ml, were elevated to 7.17±2.91 nmol/ml, 9.83±1.46 nmol/ ml, and 2.64±1.14nmol/ml after ischemia. But in Group II, the plasma level of polyamine was not changed, and especially, spermine decreased significantly from 0.83±0.27 before ischemia to 0.49±0.23 nmol/ml after ischenmine (p=0.033). 3) Urine polyamine excretion decreased after ischemia in Group I and Group II. In Group II, urinary excretion of spermidine and spermine before ischemia, 0.13±0.10 nmol/min and 0.17±0.13nmol/min, decreased after ischemia to 0.01±0.01nmol/min (p=0.019) and 0.032±0.26 nmol/min (p=0.0257). 4) In renal tissue, spermine content vas highest. In Group II, preischemic spermine were 397.20 nmol/g and increased to 646.66nmol/g after ischema, But there were no significant changes in the polyamine contents in Group II. From these data, it was suggested that systemic verapamil pretreatment exerts no protective effect on ischemic ARF. Plasma polyamines are elevated in ischemic ARF, and verapamil may protect these elevations.

경북 최초의 신장이식 1례

이중현,김용섭,이정호,이창우,김상욱,이문섭,오민구,하달봉,이경섭 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

신장이식은 환자의 삶의 질을 높이고 거의 정상적인 사회생활을 가능하게 함으로써 말기신부전 환자의 3가지 신대체 요법(혈액투석, 복막투석, 신장이식) 중에 가장 효과적이고 각광받는 치료법이라 할 수 있다. 최근 들어 의료기술과 의학의 발달로 신장이식의 성공률은 과거에 비해 비약적으로 높아지고 있으며 국내에서도 점차 신장이식수술을 받는 환자가 증가하고 있으나 서울이나 다른 대도시에 비해 의료환경이 열악한 중소도시나 지방의 병원에서는 아직도 시행하지 못하고 있는 형편이다. 이에 저자들은 경북 최초로 자체 의료진에 의해 고혈압과 말기 신부전으로 동국대 포항병원에서 혈액투석을 받고 있던 32세의 남자환자에게 부인으로부터 신장을 제공받아 신장이식을 성공적으로 시행하였기에 문헌고찰과 함께 보고하고자 한다. Kidney transplantation is the preferred treatment modality for many patients with end-stage renal disease (ESRD), because it offers improved quality of life over both hemodialysis and peritoneal dialysis. Patients who do well after transplantation generally report improvement in vitality and freedom to return to the style of life that they experienced before their progression to ESRD. Recently, the success rate of kidney transplantation is greatly being increased as the surgical technique and immunosuppressive drugs are developed. Kidney transplantation is also popular in Korea which has good result. But, until now the general hospitals which are located at small city can't try the kidney transplantation because they don't have proper facilities and experts. We firstly experienced a case of kidney transplantation in a 32 years old man with hypertension and chronic renal failure at KyoungBuk province. So we report this case with references.

축산분뇨 혐기소화 잔재물의 특성 및 초지 적용성 평가

김승민(Seung Min Kim),정웅기(Woong-gi Jung),성용주(Yong Joo Sung),안희권(Hee-Kwon Ahn),김동성(Dong Sung Kim),윤도현(Do-Hyun Yoon),김동섭(Dong-Seop Kim1),정광화(Hwa Gwang Jung) 한국펄프·종이공학회 2014 펄프.종이기술 Vol.46 No.3

디아조화합물의 광분해반응과 카르벤 중간체의 확인

김민식,엄태섭,성대동 東亞大學校 附設 基礎科學硏究所 1994 基礎科學硏究論文集 Vol.11 No.1

Diazotetracyanocyclopentadiene의 광화확적 분해반응 생성물을 저온 아르곤 및 크세논 매트릭스에서 적외선분광광도계법과 자외선-가시광선 분광광도계법으로 연구하였다. 저온 매트릭스에서 디아조화합물로부터 생성된 카르벤 중간체의 수득율은 낮았다. 디아조화합물을 광분해시켰을 때의 아레니우스 그림표는 온도변화에 직선적으로 변하지 않고 낮은 온도에서 tunneling효과를 보였다. Photolysis of diazotetracyanocyclopentadiene has been investigated by means of IR and UV-vis spectroscopy in Ar matrix. Parent carbene is produced in low yield and could be detected by UV-vis spectroscopy and IR spectroscopy. The carbene produced from the diazo compound is very photolabile and also decay thermally at temperature as low as 10K. When the diazo compound is photolyzed the Arrhenius plots show a tunneling effect that is not shown as non linearity.

금강 및 만경강 상류의 식물플랑크톤 군집구조와 동태

김백호,최민규,정연태,이종빈,위인선,길봉섭 원광대학교 환경과학연구소 1997 環境科學硏究誌 Vol.6 No.1

트레드밀 운동시 흡기근 테이핑이 폐활량에 미치는 영향

김민지,신수영,송월섭,조수진,최동락,황미진,황진규,박진현,김경,Dennis W. Fell 대구대학교 특수교육재활과학연구소 2011 再活科學硏究 Vol.29 No.1

이 연구는 트레드밀 운동과 키네시오 테이핑의 효과에 따른 폐활량의 변화를 알아보기 위해 26명의 비흡연자가 참가하였으며 키네시오 테이핑을 적용하지 않은 그룹과 키네시오 테이핑을 적용한 두 그룹으로 무작위로 배정하고 각 군들을 주 3회 6주간의 트레드밀 훈련을 실시하였다. 실험 전과 후, 스파이로미터를 사용하여 키네시오 테이핑의 적용 따른 폐활량 변화 효과를 측정하였다. 이 연구의 결과를 종합해보면 키네시오 테이핑을 적용 그룹에서 적용하지 않은 그룹에 비해 FVC, FEV1에서 유의한 증가를 보였다. 이러한 결과는 건강한 성인에서 키네시오 테이핑을 적용한 경우 키네시오 테이핑을 적용하지 않고 트레드밀 운동을 한 경우보다 폐활량의 향상에 효과적이라고 생각되어진다. The purpose of this study was to investigate the variation of vital capacity(VC) according to the effects of kinesio taping with treadmill exercise. Twenty-six non-smokers were participated in this research and these subjects were randomly assigned into two groups. To measure the VC variation effects of kinesio taping, spirometer was used. The collected data were analyzed statistically by using a paired Mauchly test and repeated measure ANOVA. The results of this study were as follows; A group: treadmill with kinesio taping B group: treadmill without kinesio taping. Between A and B, there were significant differences. In the case of A group, there was 11.66% increase of VC, during 3 weeks experiment(p<.01). In the case of B group, there were significant differences, 3.35% increase of VC, during 3 weeks taping intervention(p<.01). After 6 weeks experiment, the improvement of VC shown a significant difference with intergroup (p<.05). From this result, it was revealed that treadmill exercise with kinesio taping was effective to improve VC to healthy adult than treadmill exercise without kinesio taping.

중도장애인의 이전직장복귀 가능성에 관한 연구

김민섭,송치호 한국장애인고용촉진공단 고용개발원 2007 장애와 고용 Vol.17 No.2

본 연구는 중도장애인의 이전직장복귀 가능성에 영향을 미치는 요인을 인적자본이론과 차별이론을 중심으로 분석했다. 이를 위해 본 연구는 한국장애인고용촉진공단의‘2005년 장애인근로자 실태조사’데이터를 이용해 근로 중 장애가 발생한 중도장애인을 선별하고 이전직장복귀 여부에 대한 로지스틱 회귀분석을 실시했다. 분석 결과는 다음과 같다. 첫째, 인적자본이론은 중도장애인의 이전직장복귀 가능성을 설명하는 유효한 이론이라는 것이 확인되었다. 인적자본이론의 주요 변수인 교육정도의 경우, 교육기간이 1년 증가하면 이전직장복귀 확률은 평균적으로 0.7% 증가하고, 근속년수가 1년 증가하면 평균적으로 2.3%의 이전 직장복귀 확률이 높아지는 것으로 나타났다. 둘째, 여성장애인은 남성장애인에 비해 이전직장에 복귀할 확률이 평균적으로 6.5% 낮은 것으로 나타나, 중도장애인의 이전직장복귀에도 여성장애인에 대한 이중차별이 존재하는 것으로 분석됐다. 셋째, 장애유형 측면에서는 눈에 쉽게 보이는 신체외부장애인이 장애사실이 부각되지 않는 신체내부장애인보다 이전직장에 복귀할 확률이 낮은 것으로 분석되었다. 이는 장애 발생이후 복귀 여부 결정에 있어 장애에 대한 선입견과 낙인이 작용한다는 의미로서, 장애인의 이전직장복귀 여부를 설명하는 데 차별이론도 일정 정도의 설명력을 가지고 있음을 말해준다. This study analyzes factors determining job retention of the workers with acquired disabilities, focusing on human capital theory and discrimination theory. Using ‘2005 Survey of the Current Status of Workers with Disabilities’ collected by the Korea Employment Promotion Agency for the Disabled(KEPAD), we attempt logistic regression analysis. The model specification in this study has classified the factors that affect job retention probability into three categories; demographic, human capital, disability factor. Based on the pertinent results in the employment of the disabled workers, implications in theory and policy would be induced. The major findings are as follows. First, the human capital theory has been proved to be effective for explaining the job retention probability of the disabled workers. The educational factor, one of the factors based on that theory, has been influenced the job retention. Holding other things the same, as the educational year goes up by one unit, the job retention probability goes up by zero point seven percent on the average. Likewise, as the length of service increases by one unit, the probability increases by two point seven percent on the average, holding the other things constant. Second, holding the level of other things fixed, on average, women’s job retention probability is less than men’s by six point five percent. This result has been implied that the dual discrimination on the women disabled workers still exists in the job retention process of the disabled labor market. Third, one of the disability factors, the disabled type has effected on the job retention probability. Remaining other things the same, the externally corporeal handicapped workers’ job retention probability is lower than the internally corporeal handicapped’s, on the average. This result has suggested that the determinant of the job retention would be affected by the prejudice or stigmatization on the disabled. Consequently, the discrimination theory seems to be effective for elucidating the job retention probability of the disabled workers.

덕유산 국립공원의 담수조류상

김백호,최민규,정연태,이종빈,위인선,길봉섭 원광대학교 환경과학연구소 1996 環境科學硏究誌 Vol.5 No.1

柴胡桂枝湯의 臨床治驗에 關한 小考

이민섭,김동희,신순식 대전대학교 한의학연구소 2000 한의학연구소 논문집 Vol.9 No.1

Precise and detailed clinical research and evaluation based on objective standards are imperative factors in securing reliability of a clinical test. Built on this principle, this clinical test has been conducted during the period between March 1999 and March 2000 dealing with 31 outpatients treated with ShiHo-GuizhiTang or ShiHo-GuizhiTang modify and ShiHo-GuizhiTang mixed prescriptions at the Sung-bo ORIENTAL MEDICAL CLINIC. A variety of information relating to those patients has been collected and analyzed under such criteria as precise diagnoses and their clinical effectiveness. The analysis was duly based on "The theory of cold syndrome". Then, the 31 patients' individual clinical information was compared one another by breaking down the results into sub-categories including gender, age, disease, main symptom, blood pressure, pulse beats, syndrome of abdomen, treatment period, modify and mixed prescription, and evaluation. The result of this clinical test can be summarized as follows; First, ShiHo-GuizhiTang appears to be more frequently prescribed in the case of female patients than in the case of male patients despite the fact that it does not necessarily need to be applied only to female. In addition, the numbers of prescriptions of ShiHo-GuizhiTang in the two age groups consisting of elementary school children and economically active adults respectively were the highest among other age groups. Second, ShiHo--GuizhiTang proved to be most effective in treatment for respiratory ailments and arthritis. Third, ShiHo-GuizhiTang brought down blood pressure of hypertension patients and at the same time benefited patients with normal or lower-than-normal blood pressure who were vulnerable to diseases due to low disease-resistance. Fourth, ShiHo-GuizhiTang was effective in the case of frequent pulse(rapid pulse) and thereby indicating the fact it carries Taiyang superficies syndrome. 지맥 arises from suppressed immune responses owing to adrenocortical hormones. ShiHo-GuizhiTang controls and revitalizes those suppressed immune systems which stem from slow pulse and, as a consequence of that process, helps them return to normal condition of pulse. Fifth, from the standpoint of syndrome of abdomen, feeling of obstruction in the epigastrium serves as an important standard in the process of diagnosing diseases and evaluating effectiveness of treatments. Sixth, according to the results of the clinical test with the 31 patients, a total of 81 percent of test subjects benefited from the treatment. The figure is the sum of 52 percent of Ⅰ-class (both main symptom and accompanying symptoms had been eliminated) and 29 percent of Ⅱ-class (part of main symptom and accompanying symptoms had been eliminated) respectively. All told, it is safe to say that ShiHo-GuizhiTang can elect to be a viable clinical treatment. In conclusion, it is estimated that this clinical study has drawn up guidelines for objective diagnostic standards and evaluation on specific treatments' effectiveness. This will lead to more general application of ShiHo-GuizhiTang. On top of that, this study could also provide an opportunity to stress the significance of ShiHo-GuizhiTang and ShiHo-GuizhiTang modify and ShiHo-GuizhiTang mixed prescriptions as an alternative treatment for collagen disease which comes from environmental degradation and pollution.

레이저 웨이퍼 다이싱 장비의 가공 특성 평가

한민섭,김성수,민병권,이승우,이진하,이혜진 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

As the semiconductor wafer is required to be thinner for better compactness and higher integrity of the electronic products, mechanical dicing saw technique using the diamond blade is facing serious problems such as low cutting speed, tool wear, side wall crack and back side chipping. Recently, UV laser dicing process has emerged as an alternative methods to the blade dicing especially for the very thin wafers below 100㎛. In this study 355 nm UV laser dicing system has been developed in order to improve the productivity and reliability of ultra thin wafer dicing process. For the quality improvement of the developed dicing system various laser parameters are investigated such as power, speed and frequency of the laser beam. Moreover various measurement techniques are employed to evaluate the dicing quality using optical microscope, SEM and focused ion beam.