건강한 청년의 단시간 공해노출과 일회성 운동이 폐기능과 생리반응에 미치는 영향

김민주(Min-Joo Kim),이대택(Dae-Taek Lee),송국섭(Gook-Sup Song),방승기(Seung-Ki Pang) 한국생활환경학회 2015 한국생활환경학회지 Vol.22 No.1

This study examined whether an acute exercise during a short-term exposure to a polluted environment affected pulmonary function and physiological responses in healthy young adults. Thirteen men (mean = 22.4 yrs) were randomly exposed to a polluted air (PA) or to clean air (CA) in a chamber. During the exposure, they rested for 30 min followed by a bench stepping exercise (40 cm height, 120 bpm) for 10 min. And they recovered from the exercise for 15 min in the chamber. The pulmonary function, heart rate, blood lactate, and blood pressure were measured during the exposure. At the end of 30 min resting, peak expiratory flow rate (PEFR) was higher in PA than CA. Immediately after the exercise, forced expiratory volume at 1 sec (FEV1) was higher in PA than CA. At 15th min of recovery, forced vital capacity, FEV1, and PEFR were significantly higher in PA than CA. No differences in cardiovascular and blood lactate responses were noticed. The results suggest that an acute intensive physical work out with breathing of volatile organic compounds induced changes of pulmonary function but not physiological adjustments.

심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

Simulated Moving Bed를 이용한 Bupivacaine 키랄분리 : (1) Preparative Chromatography를 이용한 기본조건 결정 (1) Optical Separation Conditions for Preparative Chromatography

윤지연,이중기,서성섭,최민호,박태진 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.6

Racemate Bupivacaine의 키랄분리를 위한 크로마토그래피의 최적분리조건을 조사하였다. Kromasii^(�) 키랄고정상에서 최적이동상조성 성분은 n-hexane/2-propanol/acetic acid/triethylamine, 99/1/0.3/0.05(vol.%)이였다. 이동상 조성성분인 2-propanol의 부피비가 증가할수록 체류시간과 분리도가 동시에 감소되었다. 이동상 성분 중에서 미량으로 존재하는 triethylamine이 증가할수록 피크의 sharpness가 증가하고 체류시간 역시 감소하였다. 또한, acetic acid가 없으면, 크로마토그래피 광학분할이 불가능하였으며 부피 0.3%에서 분리도가 가장 높음을 확인할 수 있었다. 한편, 키랄의약품의 대량분리방법중의 하나인 SMB(simulated moving bed)크로마토그래피 시스템(직경 1.0cm×10cm×8개 칼럼으로 구성)의 최적분리조건을 전산모사에 의해 구하였으며, 이를 실험으로 확인하였다. 그 결과 switching time 15분, feed의 유량 0.1 ml/min, desorbent 0.86 ml/min, raffinate 0.3 ml/min, extract 0.66 ml/min, recycle 1.0 ml/min일 때 100% 순도의 R-form과 S-form을 얻을 수 있었으며, 실험치와 전산모사치간의 오차는 ??2%이내였다. The chiral separation of racemate Bupivacaine was carried out to find the optimum condition for chromatographic system. The optimum species and composition for mobile phase were n-hexane/2-propanol/acetic acid/triethylamine, 99/1/0.3/0.05(vol.%) in case Kromasil� chiral stationary phase was employed. The retention time and resolution decreased with the increase in the ratio of 2-propanol in the mobile phase. The sharpness of peak and retention time decreased, as the content of triethylamine increased. Without the existence of acetic acid, the chromatographic separation didn't occur, and the resolution was the highest at the acetic acid volume ratio of 0.3%. The optimum condition of SMB (simulated moving bed) was determined by simulation and its results was compared with exprimental data from lab-scale SMB (10 mm 1D×8 ea). Rased on the SMB simulation and experimental results, 100% purity of R and S Bupivacaine were obtained and the error between the calculated and experimental value was within ±2%.

아동기 경계선 장애 : 8 CASES 8증례

신민섭,이정섭,홍강의 대한소아·청소년정신의학회 1995 소아청소년정신의학 Vol.6 No.1

요 약 아동에서의 경계선 장애는 현실감각의 불안정, 대인관계의 장애, 충동조절의 장애, 심 한 기능의 변동, 발달상의 불균형, 불안등을 보이며 현재의 진단 체계로는 진단하기 어려운 환아를 의미한다. 본 논문에서는 Bemporad등과 Vera등이 제안한 '경계선 아동'에 부 합하는 7세에서 11 세사이의 8명의 소아정신과를 내원한 아동들을 대상으로 37개의 병인들을 비교하여 다음 과 같은 결과를 얻었다. 1) 임상적인 특징으로는 모든 환아들이 다 남아였으며, 현재의 진단체계에서는 진단을 내리기가 어려웠고, 공존정신과적인 진단이 많았다. 주소는 산만하고 또래와 어울리지 못한다는 것 이 많았다. 현실과 환상사이의 경계가 불명확한 것과 사고의 장애가 특징적인 증상이었다. 2) 심리학적 및 신경생리학 검사상 지능은 보통수준이었으며, 동작성 지능이 언어성 지능보다 우수한 경향이 있었다. 투사법 검사에서는 사고 장애의 지표를 보였으며, 정서적으로 불안 정하고 공격성이 심하였다. 반수에서 주의력 검사상 주의력결핍을 시사하였다. 기질적인 요인은 뚜렷하지 않았다. 3) 발달력 및 가족력상 원하지 않았던 아이가 많았고, 주 양육자는 어머니였으나, 양육 방식에 중등도의 문제가 있었다. 부모간에 불화가 많았고, 사회 경제적으로는 중하가 많았다. 언 어발달은 대부분에서 지연이 되었거나, 성장하면서 점차로 정상이 되었다. 공격적이어서 또래들로 부터 따 돌림을 많이 받았다. 4) 치료 및 경과상 6세경에 처음 병원에 방문하였으며,평균 치료 기간은 2년이었고,주 로 외래에서 치료를 받았다. 약물치료에 대한 반응은 뚜렷하지 않았으며, 장기 놀이치료의 필요성이 암 시되었 다. 본 연구 방법에 여러가지 제한점이 있으나, 앞으로 이 장애의 명확한 진단 기준을 확 립하고 역학 및 치료에 대한 연구들이 이루어져야 할 것이다. ABSTRACT The so-called borderline children are characterised by disturbances in the sense of reality and interpersonal relationships, lack of control, fluctuation of functioning, uneven development and excessive anxiety. But the concept of borderline disorder of childhood is very difficult to define and diagnose in current classification system. The present study adapted the consensus symptoms in borderline children by Bemporad and Vera. Eight cases aged 7-11 were examined in 37 variables. Results are as follows. 1) All subjects are boys and can hardly be diagnosed in current diagnostic system and have many concurrent diagnoses. Common chief complaints are hyperactivity and poor peer relation. The most prominent clinical feature is disturbances in the sense of reality. 2) In KEDI-WISC test, the borderline children showed average intelligence, but performance IQ tends to be higher than verbal IQ. In Rorschach test. they showed high thought disorder index, emotional instabilities and aggressive impulses. The results of TOVA suggested attentional deficit in half of the subjects. The organicity is not prominent. 3) Many of the borderline children were unwanted baby. Although primary care takers of all the subjects were their mothers, there were moderate problems in caring attitude of their children and marital relationship with their husbands. Socioeconomic status was generally below middle class. Most of all subjects have delayed language development, but have overcome subsequently. Many subjects were rejected by peers because of their aggression. 4) The first visit of the subjects was about 6 years of age. Average duration of treatment was 2 years. All of them were treated in the outpatient basis except one. The effect of pharmaco- therapy was doubtful and the necessity of long term play therapy was suggested. Although there were many limitations of method in present study, it was suggested that further research is needed for diagnostic criteria, epidemiology and treatment.

관상동맥색전증에 의한 급성심근경색증 4예

김민근,주혜원,강경필,최병돈,박민석,변영섭,고충원,이건주,김병옥 인제대학교 2006 仁濟醫學 Vol.27 No.-

Acute myocardial infarction(AMI) due to coronary embolism can occur in patients with normal coronary artery. Coronary embolism is believed to be a cause of acute myocardial infarction when emergent coronary angiography shows perfectly normal coronary trees, except for the finding of coronary artery occlusion. In this report, we describe four patients with AMI due to coronary embolism who were successfully treated using a thrombus aspiration device and anticoagulation, and those patients had intracardial thrombus arising from the left atrium due to chronic atrial fibrillation and valvular heart disease. Patients with chronic or paroxysmal atrial fibrillation can present with AMI due to coronary embolism, and thrombus aspiration with percutaneous aspiration device is a feasible treatment option for these patients along with anticoagulation the rapy.

Rotor 증후군

심찬섭(Chan Sup Sim),이성원(Sung Won Lee),손무영(Moo Young Sohn),김진숙(Jean Sook Kim),한명동(Myung Dong Han),백정민(Cheong Min Paik) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.2

Rotor syndrame is a familial disorder characterized by chronic, nonhemolytic, and predominantly conjugated hyperbilirubinemia with normal liver tissue without any pigment deposit in the liver cells. A 36-year-old Korean female was admitted due to intermittent jaundice, indigestion and general malaise. Physical examination revealed icteric sclera, but no hepatomegaly. Laboratory findings showed increased serum bilirubin with direct reacting bilirubin predominating and prolonged BSP retention (32% in 45 min.) Oral cholecystography revealed well-visualization but intravenous cholangiography did not reveal the gall bladder and the duct, Percutaneous needle biopsy specimen of liver showed no special abnormalities. Urinary total coproporphyrin excreation was increased. A brief review of the pertinent literature was made.

建築法에서의 地表面算定基準에 관한 硏究

김수영,이민섭 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

The building act controls the form and size of buildings under development with the provisions of building coverage, floor area ratio, height of building, number of floors. building area etc. The height and area of a building should be measured at the ground level. Therefore, the ground level of a building should be clearly defined. In practice, however, it is hard to define the ground level under the current building act, especially at a sloping site. This study put together the practical problems of defining the ground level by investigating the relevant articles of the building act, official records of questions and answers on the issue between practitioners and the code officials, and practical guidelines set out by the code administration. In summary, this paper proposes certain changes to the currently ambiguous definition of the ground level.

오차드그래스(Dactylis glomerata L.)의 품종에 따른 종자유래의 캘러스 형성률과, 캘러스 크기 및 식물체 재분화 효율의 비교

배은경,이인애,김기용,이병현,손대영,이효신,정민섭,조진기 Plant molecular biology and biotechnology research 2002 Plant molecular biology and biotechnology research Vol.2002 No.-

Comparison results of callus formation ratio from seed explants, callus sizes, regeneration ratios from callus and regeneration efficiency [calculated by following formular; callus formation ratio(%) × regeneration ratio(%)/100]for 27 ochardgrass (Dactylis glomerata L.)varieties imported and Hapsung 2 developed in Korea are as follows; 1. Among ochardgrass varieties showing more than 50% callus formation ratios, the descending order of callus formation ratio after bedding the seed explants for 4 weeks was 93>Sparta>Pizza>Condor>Lidaglo>Glorus>Hapsung2>Frode. 2. The callus sizes after bedding for 4 weeks were in the range of φ 0.43cm~4.2cm in which there was 10 times size difference between the largest one and the smallest one but most of them were between φ2.5cm~4cm. 3. The regeneration ratio from callus among varieties were in the range of 0~36% and descending order of the upper 6 varieties was Plano>Akimidori>Justus>Lidacta>Currie>Hall mark. 4. The regeneration efficiency which is calculated by the ratios of regeneration from seed explant numbers was between 0 to 17.4% among which Justus showed the highest value in the 4-week treatment. 5. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration efficiency were r=0.5765, r=0.6365 and r=0.6246, respectively in 4-week callus and all the correlations were significant on the 1% level. 6. In 6-week callus, the descending order callus formation ratios from seed sxplants for the best 6 varieties was Condor>Sparta>93M>Justus>Potomac>Lidaglo>Frode. 7. The callus sizes formed were between φ1.5~5.7cm in which Sparta, the largest one of φ5.7cm was five times larger than the smallest one. The callus size of the control variety. Hapsung 2 was φ3.8cm, which belonged to larger size. 8. Regeneration ratio showed a great deviation among varieties from 6-week old calli by showing from 0% to 100% in which all the calli were regenerated in Plano while no callus was regenerated in Juno, 9. The range of regeneration effciency was between 0~28% among varieties in which the values from 6-week callus treatment were larger than those from 4-week callus treatment. Especially, the value of Potomac in 6-week was 3 times larger than that in 4-week. 10. The correlation between callus formation ratios and the callus sizes, callus formation ratios and regeneration efficiency, and callus sizes and regeneration effciency were r=0.8369, r=0.6683 and r=0.5937, respectively in 6-week callus, and all the correlations were significant on the 1% level.

Dopant-Activation and Damage-Recovery of Ion-Shower-Doped Poly-Si through $PH_3/H_2$ after Furnace Annealing

Kim, Dong-Min,Kim, Dae-Sup,Ro, Jae-Sang,Choi, Kyu-Hwan,Lee, Ki-Yong The Korean Infomation Display Society 2004 Journal of information display Vol.5 No.1

Ion shower doping with a main ion source of $P_2H_x$ using a source gas mixture of $PH_3/H_2$ was conducted on excimer-laser- annealed (ELA) poly-Si. The crystallinity of the as-implanted samples was measured using a UV-transmittance. The measured value of as-implanted damage was found to correlate well with the one calculated through/obtained from TRIM-code simulation. The sheet resistance was found to decrease as the acceleration voltage increased from 1 kV to 15 kV at a doping time of 1 min. However, it increases as the acceleration voltage increases under severe doping conditions. Uncured damage after furnace annealing is responsible for the rise in sheet resistance.

최대근력부하와 폭발적 근력부하에 의한 신경-근피로와 그 회복과정 비교 분석

유관호,이무연,이승훈,김민섭,육조영,임정일,임완기,김대경 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

The result which was gained from this study is as follows. From the conclusion of this study it was confirmed that resistant motion at high level strength brings about rise in density of lactate in blood at the same time decline of muscular power and generates acute fatigue of nerve-muscle accompanied by decline in electrical activity of muscle. On the other hand explosive loading produced fatigue at body center and decline in nervine-muscular activity particularly for men, In case of women explosive load did not produce fatigue in the same level as men and they were also quicker in recovery after exercise. Based on 2 types of loading method used in this study there was clearly difference in the process of restoration from resistant motion. For greater decline in muscular power and electromyogram activity more longer period of recovery was require.