쿠싱증후군 환자에서 당 대사 이상 정도에 따른 인슐린 감수성과 인슐린 저항성의 변화

정인경,김성훈,정재훈,민용기,이명식,이문규,유형준,안규정,노정현,김동준,김광원 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.4

연구배경 당질 코르티코이드는 당 대사에 매우 중요한 호르몬으로 내인성 당질 코르티코이드 과다상태인 쿠싱증후군에서는 말초조직에서 인슐린 저항이 증가하고 이를 보상하고자 인슐린 분비의 증가로 고인슐린혈증이 동반된다고 보고되고 있다. 하지만 생체 내에서와 달리 시험관내에서는 췌도세포에 당질 코르티코이드를 장시간 처리하면, 인슐린 분비 및 생합성이직접적으로 억제됨이 확인된 바 있어 쿠싱증후군 환자에서 당뇨병의 원인으로는 아마도 말초조직에서 증가된 인슐린 저항성 뿐 아니라 이를 충분히 보상하지 못하는 췌장에서의 인슐린 분비 저하가 같이 동반되어있지 않을까 하는 가설을 세우게 되었고, 아직까지 당질코르티코이드가 당대사 이상을 일으키는 기전에 대해 쿠싱증후군을 당대사 정도에 따라 인슐린 감수성과 분비능을 분석한 연구는 없었기에 이를 알아보고자 하였다. 방법: 삼성서울병원에서 쿠싱증후군으로 진단 받은 환자 15명을 대상으로 하였다. 이에 대한 대조군으로는 쿠싱증후군 환자와 같은 성별 그리고 체질량지수를 갖은 15명의 건강한 성인을 대상으로 비교 하였다 쿠싱증후군 환자를 대상으로 경구당부하 검사를 통해 당대사 정도를 정상군, 내당능장애군, 그리고 당뇨병군으로 나눈 후 정맥 당부하 검사를 시행하여 각군의 인슐린 저항성과 인슐린 분비능의 지표를 비교하고, 수술 후 쿠싱증후군이 완치된 상태에서 수술 전후의 당대사 지표의 변화를 조사하였다. 결과: 1) 쿠싱증후군 환자 중 정상인은 20%, 내당능 장애는 27%, 그리고 당뇨병은 53%였다. 체질량지수, 나이, 그리고 발병 기간은 세 군간에 의미 있는 차이가 없었으나, 24시간 소변검사의 코르티솔 농도는 당뇨병군에서 의미있게 높았다. 2) 정맥당부하 검사 결과, 인슐린 감수성 지표인 Sl는쿠싱증추린」서 1.58±0.10[×10^(-4)(min^(-1)(μU/mL)^(-1)]로 정상 대조군의 3.37±0.49[×10^(-4)(min^(-1)(μU/mL)^(-1)]에 비해 의미있게 낮았으나(P=0.024), 쿠싱증후군 환자 중 NGT, IGT, DM 군간에 서로 통계적인 차이는 없었다. 3) SG는 정상 대조군과 쿠싱증후군 환자간에는 의미있는 차이가 없었고, 쿠싱 증후군에 있어서 당대사가 악화될수록 감소하는 경향을 보였으나 의미있는 차이는 없었다. 4) 인슐린 분비능의 지표인 AIRg는 정상인에 비해 전체 쿠싱증후군 환자의 경우 증가하는 경향을 보였으나 의미있는 차이는 없었다. 하지만 쿠싱증후군 환자중에서 당대사 상태에 따라 NGT군은 1299 (1297∼1310)(mu/g/min ×10^(-2))로 정상 대조군(368.9±98.6[mu/g/min ×10^(-2)]) 보다도 의미있게 높았고, DM군{202.2 (91.1~371.4) [mu/g/min ×10^(-2)}은 NGT군에 비해 의미있게 낮았다(P=0.0031). 5) 15명중 현재 완치 상태에 있는 6명에 대해 수술전과 후로 비교하였다. 수술 전 당대사 상태가 1명은정상, 1명은 내당능 장애, 그리고 4명은 당뇨병이었으나 수술 후 시행한 경구 당부하 검사상 모두 정상 당대사 상태를 보였다. 6) 수술 후 완치된 환자 6명에 있어 인슐린 감수성지표인 Sl는 수술전에 중앙값이 1.22[×10^(-4)(min^(-1)(μU/mL)^(-1)]로 대조군에 비해 의미있게 감고』어 있었으나(p.0.05), 수술후 10.95 [×10^(-4)(min^(-1)(μU/mL)^(-1)]로 정상 수준으로 회복되었고(P=0.0022), 인슐린 분비능을 나타내는 AIRg [mu/g/min ×10^(-2)] 값도 정상수준으로 회복되었다. 특히 인슐린 분비능의 회복양상은 혈당농도에 따라 판이하게 나타나서, 정상과 내당능장애 상태에 있던 2명은 수술전에 1201 [mu/g/min ×10^(-2)]로 증가되어 있던 AIRg 값이 수술 후 정상 수준으로 감소하였고, 수술 전에 당뇨병 상태에 있던 4명의 경우 245.9 [mu/g/min ×10^(-2)]로 인슐린 분비능이 감고il어 있었는데 이들은 수술 후 모두 정상 수준으로 증가되었다 (P=0.0286). 결론: 쿠싱증후군 환자에서 당대사 이상은 80%로 높은 유병률을 보였다. 모든 쿠싱증후군환자에서 인슐린 감수성은 정상인에 비해 저하되어 있어 말초조직의 인슐린 저항이 선행됨을 시사하며, 인슐린 분비능은 당대사의 정도에 따라 다르게 나타났는데, 정상 당대사군에서는 인슐린의 저항성을 극복할 만큼 정상 대조군보다 더 많은 양의 인슐린 분비를 하다가 고코르티솔혈증이 심할수록 인슐린 분비능의 감소로 당뇨병으로 진행됨을 확인할 수 있었고, 이런 인슐린 저항성과 인슐린 분비장애는 수술 후 다시 회복되는 가역적인변화를 보였다. Background: Glucocorticoid plays an important role in the control of carbohydrate metabolism. Patients with Cushing's syndrome have been reported to have an increased incidence of carbohydrate intolerance due to peripheral insulin resistance and hyperinsulinemia, although the exact incidence and nature of this disorder have remained unclear. Few results have been published about insulin resistance and insulin secretion according to the level of glucose concentration, or about the reversibility of such defects in patients with Cushing's syndrome. Methods: To assess the effect of glucocorticoid on the insulin sensitivity and insulin secretion in Cushing's syndrome, 15 patients with Cushing's syndrome were classified into 3 groups (normal glucose tolerance: NGT, impaired glucose tolerance: IGT, diabetes: DM) according to the degree of glucose tolerance based on the oral glucose tolerance test (OGTT). Insulin modified, frequently sampled, intravenous glucose tolerance test (FSIGT) was performed before and after curative surgery on these patients and on 15 healthy control subjects. Data were evaluated by non-parametric statistical analysis. Results: 1) Among the 15 patients with Cushing's syndrome, 3 (20%) were NGT, 4 (27%) IGT, and 8 (53%) DM, based on OGTT. Twenty-four hour urinary free cortisol (UFC) was significantly higher in the DM group. 2) Insulin sensitivity index (SI) of Cushing's syndrome was significantly lower than that of the control group p=0.0024), but was not significantly different among the three Cushing's syndrome groups of NGT, IGT and DM. 3) Glucose mediated glucose disposal (SG) (Ed- confirm this abbreviation; it does not seem to match the definition) of Cushing's syndrome was not significantly different from that of the control group. 4) Insulin secretion (AIRg) of Cushing's syndrome tended to be high, but it was not significantly different from that of control. However, according to the level of glucose concentration there was significant difference in AlRg among the three Cushing's syndrome groups p=0.0031); AIRg of DM was significantly lower than that of NGT. 5) After surgical treatment, parameters of insulin sensitivity and insulin secretion were normalized in 6 cured patients; 1 with NGT, 1 with IGT, and 4 with DM, preoperatively. Median SI of all 6 patients was significantly improved up to the normal range postoperatively p=0.0022). Median AIRg of these 6 patients was balanced around that of normal control postoperatively p=0.0286). Conclusion: Eighty percent of patients with Cushing's syndrome had abnormality of carbohydrate metabolism. Insulin sensitivity was significantly decreased in Cushing's syndrome. Insulin secretion was significantly higher only in the NGT and IGT groups of Cushing's syndrome. As the hypercortisolemia is exacerbated, insulin secretion is significantly decreased and causes DM, suggesting that glucocorticoid has a direct or indirect toxic effect on the pancreatic beta cell (J Kor SOC Endocrinol 18:392-403, 2003).

서울시 근대문화유산의 스토리텔링을 통한 관광활성화 방안

반정화 ( Jeong Hwa Pan ),민현석 ( Hyun Suk Min ),노민택 ( Min Taek Noh ) 서울시정개발연구원 2009 연구보고서 Vol.2009 No.28

Ⅰ. Introduction The area inside the original city walls of Seoul contains the history of Seoul`s modern culture and played an important part in establishing Seoul`s unique authenticity and identity. However, the level of awareness and utilization of Seoul`s modern cultural heritage is very low. To resolve this situation, this study 1) accumulated references by making a database of Seoul`s modern cultural heritage, 2) researched literature and case studies on storytelling for tourism revitalization, and 3) concluded as to how storytelling techniques could be used to revitalize awareness and utilization of modern cultural heritage inside Seoul`s original four city walls. The modern cultural heritage studied was defined as that within current Jung-gu and Jongro-gu (the area inside the original city walls). Based on material from the Cultural Heritage Administration of Korea and the city of Seoul, a total of 74 modern cultural heritage (45 in Jongro-gu, 29 in Jung-gu) were found for research. Ⅱ. The Current State of Modern Cultural Heritage inside Seoul`s City Walls Modern cultural heritage includes all aspects of the era between the beginning of Korea`s modernization (roughly 1876) to 50 years before today, including among others the spheres of humanities, society, geography, and environment. Most modern cultural heritage cannot be internally changed and have limited utilization in other ways than originally intended. 63.5% of Seoul`s modern cultural heritage is privately owned, and 41.9% (31 items) are non-public, making it difficult to make them into proper tourist capital. Most tourism resources are distributed following the pattern of capital, being focused in the Bukchon and Insadong area, the Jeong-dong area, and the Bukchang/Namdaemun/Myeongdong area. Tourist attractions inside the original Seoul city walls are rarely utilized, being only partially introduced as part of Seoul`s city tour program. Ⅲ. Storytelling of Tourism Destinations ``Storytelling``is a combination of "story" and "telling." Here, "story" means a plot, and "telling" refers to the method of communication appropriate for a particular medium. Storytelling techniques are used in a variety of fields, and is being recognized not only as a way to maximize consumers` experience but also as an effective method of behavioral change. Storytelling in tourism must be understood as a meaning system created in concert between the story surrounding a particular tourist attraction, and the tourist. It is important to use ``interaction`` between the tourist and a particular attraction to bring to the surface an aspect valued by both sides. This study proposes that tourism storytelling be developed through the next five steps: 1) finding stories about tourist attractions, 2) selecting the main goal of storytelling, 3) developing a main theme, 4) selecting media, and 5) realizing the plan. Ⅳ. Revitalizing Tourism of Seoul`s Modern Cultural Heritage Through Storytelling 1. Step-by-Step Strategy for Storytelling of Seoul`s Modern Cultural Heritage Step 1: Discovery of stories surrounding cultural heritage inside the Seoul city walls: after making a database of the modern cultural heritage inside the Seoul city walls and categorizing them, use the information to find stories and themes that could be used to improve tourism in the area. -Facilities related to modern technology and industry, -Changes in modern architecture -Education facilities and changes in education -Portraits of modern personalities(political, cultural, artistic) -History of the Korean interim government and modern Korean history, -Religious facilities, -Socio-cultural facilities Step 2: selection of a goal for storytelling of modern cultural heritage: studying the goals of modern cultural heritage storytelling from the perspective of maximization of tourists` experience, heritage protection, expansion of advertisement, and safe tourism. Step 3: development of a theme for modern cultural heritage storytelling: division of stories found in step 1 between three districts (Bukchon, Jeong-dong, Namchon). Step 4: Planning the media for delivering stories about modern cultural heritage inside city walls: proposal of possible media outlets for storytelling. 2. Expanding Storytelling about Modern Cultural Heritage Inside Seoul City Walls Changing perceptions about modern cultural heritage: the following was proposed as solutions to bring new meaning to the Bukchon, Jeong-dong, and Namchon areas. Expansion and development of tour routes focusing on the Jeong-dong, Bukchon and Insadong, and Namchon areas. Increased utilization of modern cultural heritage through virtual reality and video: creation of virtual tours and documentaries Building of museums on modern culture and history of modern life Changing perceptions about modern culture and creation of educational materials Reenactment of Wongudan and 3/1 protests Ⅴ. Conclusion and Policy Suggestions In order to change perceptions of modern cultural heritage, it is necessary to give new meaning to the Bukchon, Jeong-dong, and Namchon areas, making them an opportunity to introduce "Seoul culture" through modern cultural heritage. The utilization of these heritage must be increased using stories and storytelling media with the help of specialists. The possibilities of the heritage must be carefully studied to develop diverse tourism routes and to select appropriate storytelling media.

동종골 이식을 이용한 경골 근위부 절골술

노정호,민병현 대한슬관절학회 2002 대한슬관절학회지 Vol.14 No.2

목적: 내반슬을 동반한 골관절염의 치료방법 중 개방형 경골 근위부 절골술에서 동종골이식의 유용성을 알아보고자 하였다. 대상 및 방법: 1999년 4월부터 2001년 1월까지 내반슬을 동반한 골관절염 환자중 1년 이상 추시가 가능하였던 총 8명(8례)을 대상으로 개방형 경골 근위부 절골술과 함께 동종골로 골이식한후 L-형태의 금속판으로 내고정을 실시하였다. 수술전후 체중부하 전후면 방사선 사진을 통해 내반슬 교정의 정도를 측정하였고 추시관찰중 내고정물 제거술시 골조직을 채취하여 표본을 image analyzer로 분석하여 골유합의 정도를 파악하였다. Lysholm's knee score와 Hopital for Special Surgery(HSS) knee score를 이용하여 환자이 기능적 상태를 평가하였다. 결과: 측정된 수술전 체중부하 전후면 방사선 사진 상 내반각의 평균값은 5.3±4.3˚이었고 수술후 체중부하 전후면 방사선사진상 교정각의 평균값은 16.1±4.1˚ 이었으며 외반각 평균값은 10.7±4.3˚이었다. 추시 관찰에서 시행한 체중부하 전후면 및 측면 방사선사진상 골유합은 모두 이루어 졌으며 교정 손실각온 평균 1.5±1.0˚이었으며 내고정물 제거시 시행한 골조직표본을 image analyzer(ProPlus® system)로 분석한 결과 검체는 모두 골조직으로 이루어져 있으며 이중 생골과 사골의 비율은 3.3:1로 생골의 비율이 전체의 76.7±8.0%로 나타내었다. 최종 추시시인 수술 15.3개월 후의 Lysholm's knee score와 HSS knee score의 평균 값은 각각 66.2±8.3에서 75.7±9.1로, 55.2±9.0에서 79.0±7.5로 증가하였다. 결론: 동종골을 이식한 개방형 경골 근위부 절골술에서 절골부위는 이식된 동종골에 의하여 골유합이 잘 이루어 졌고 만족할 만한 교정각을 얻을 수 있었으며 교정각 소실이 적었고 향상된 슬관절 기능을 나타내었다. Purpose: The purpose was trying to clarify utility of allogenous bone graft on open type high tibial osteotomy, among the method of treatment of osteoarthritis with genu varum deformity. Materials and Methods: Working with eight patients who have osteoarthritis with genu varum deformity, performed the open type high tibial osteotomy, and after transplanting allogenous bone graft, fixed using L-shaped plate. Before and after the operation, measured the degree of correction of genu varum through radiography of anterior and posterior of weigh load, understudied degree of union by testing bone histology during removal of implant, and evaluated functional factor as well as improvement of patients using Lysholm's knee score and HSS knee score. Results: According to radiography of anterior and posterior of weigh load, the average of varus angle was 5.3±3.2˚ before operation, the average of correction angle was 16.1±4.1˚ after operation and the average of valgus angle was 10.7±4.3˚. By radiography of anterior and posterior of weigh load and lateral taken during the continual observation, complete bone union was seen. It got result that bone histology of transplanted part was composed of osteologic tissue and ration of live bone and dead bone was 3.3:1, which live bone was 76.7±8% by image analyzer(Pro Plus® system) during the implant removal. The average of correction loss angle was 1.5±1.0˚ After 15. months, average period of observation, average of Lysholm's score and HSS knee score were increased from 66.2±8.3 to 75.7±9.1 and from 55.2±9.0 to 79.0±7.5 respectively. Conclusion: The method that using a transplantation of allogenous bone graft on open type high tibial osteotomy, can be a fine surgical technique because it gains a perfect union, has an inconsiderable loss of correction angle and precision of correction angle, and can be contributed to the improvement of functional knee joint.

와전류와 히스테레시스가 자체 측정 자기베어링의 성능에 미치는 영향

노명규,정민경 충남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.16 No.1

A preliminary analysis of the effects of eddy currents and magnetic hysteresis on the performance of self-sensing magnetic bearings is presented. A self-sensing magnetic bearing employs an estimator of rotor position utilizing the information available in the electromagnets, instead of using separate position sensors as in typical magnetic hearings. An estimator which embeds a model of the bearing is designed using parameter estimation technique. The performance of the estimator is briefly presented. The model of the bearing on which the estimator is based assumes that the magnetic material is perfectly linear without eddy currents and hysteresis. A simple analysis is carried out to see how the performance of the estimator is affected by eddy currents and hysteresis which can be substantial in high-performance magnetic bearings.

cDNA array 방법을 이용한 망간에 노출된 흰쥐 뇌기저핵의 유전자발현 분석

이채관,노성민,문덕환,,김정호,손병철,김대환,이창희,김휘동,김정원,김종은,안진홍,이채언 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study investigated the gene expression profile in basal ganglia of manganese-exposed rats based on cDNA array analysis. Methods: For cDNA array, 25 male Sprague-Dawley rats (250±25 g) were intraperitoneally injected with 25 ㎎/㎏ B. W./day of MnCl2 (0.3 ㎖) for 10 days. For dose-related gene expression analysis, rats were intraperitoneally injected with 0.2, 1.0, and 5.0 ㎎/㎏ B. W/day of MnCl2 for 10 days. Control rats were injected with an equal volume of saline. RNA samples were extracted from brain tissue and reverse-transcribed in the presence of [α^(32)P]-dATP. Membrane sets of the Atlas Rat 1.2 array Ⅱ and Toxicology array 1.2 kit (Clontech, Palo Alto, CA) were hybridized with cDNA probe sets. Northern blot hybridization method was employed to assess the dose-related gene expression. Results: Fifty-two genes showed significant changes in expression of more than two-fold. Twenty-eight were up-regulated and 24 were down-regulated in the manganese-exposed group compared to the control. Among the 52 genes, 28 genes including nuclear factor I-X1 (NF1-X1), neuroligin 2 and 3, mitochondrial stress-70 protein (MTHSP70), neurodegeneration-associated protein 1 (Neurodap 1), multidrug resistance protein (MDR), and endoplasmic reticulum stress protein 72 (ERP72), were reported for the first time related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia. According to the dose-related gene expression analyses, MTHSP70, Neurodap 1 and ERP72 genes were up-regulated compared to the control even in the group exposed to low manganese dose ( 0.2 ㎎/㎏ B.W./day). Conclusions: Twenty-eight genes detected for the first time in this study were closely related to the manganese-induced neurotoxic-metabolism in the rat basal ganglia and further study of these genes can give some more useful information about the manganese metabolism.

유전알고리즘을 이용한 수직벽면 이동 로봇의 정·동적 최적설계

김재덕,노민석,정성현,홍대선 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

Most shipbuilding works are manually carried out by workers, and safety consideration is an important issue especially in elevated-spot works such as painting and cleaning of outer wall of a ship. To cope with the circumstance, shipbuilding makers start to introduce wall-climbing robots for carrying out such tasks. In designing such a wall-climbing robot, it is essential to minimize its own weight to improve the performance such as moving speed and power saving. For such purpose, this paper proposes a method of optimal design for a wall-climbing robot body using genetic algorithm through static and dynamic analysis. Specifically, the thickness of the robot base is minimized to reduce the weight while maintaining the allowable strength and avoiding resonance frequencies. The proposed method is applied to the design of a wall-climbing robot, and the simulation results show that the method can be successfully adopted to the early stage of design.

쌍태아에서 제 1태아의 분만 후 제 2태아의 지연분만 : 중례보고

김주환,서민정,유희정,노권일,조대현,박정규,이정헌,조성남,손영수 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

With the widespread use of fertility medications and techniques of in vitro fertilization, multiple gestation has become epidemic in modern obstetric practice. Delivery of the initial fetus in a multiple gestation usually is followed by delivery of the subsequent fetus or fetuses shortly thereafter. However in rare circumstances, the delivery is delayed for days due to disappearance of uterine contraction after delivery of the first fetus. When uterine activity ceases after the delivery of the first neonate, a policy of nonintervention may be considered in case of an immature or very premature delivery, in order to achieve a gestational age for the remaining fetus(es) more compatible with neonatal survival. We report a case of twin gestation with prolongation of the delivery interval between the twins for 46 days.

Articles : Supercritical Fluid Extraction and Bioassay Identification of Prodrug Substances from Natural Resources

( Min Jeong Noh ),( Eun Sun Choi ),( Seon Hee Kim ),( Ki Pung Yoo ),( Young Hae Choi ),( Young Won Chin ),( Jin Woong Kim ) 한국화학공학회 1997 Korean Journal of Chemical Engineering Vol.14 No.2

For arbitrarily chosen thirty types of natural resources which have heen widely used in oriental traiditional herb medicine, supercritical CO₂, extraction (SFE) and organic liquid solvent extraction (LSE) with n-hexane, chloroform and methanol were carried out to extract pharmaceutical substances. To evaluate relative advantages and shortcomings between the SFE and LSE, five types of bioactivity assays as well as gas- and thin layer-chromatographic analysis were performed for all the extracts obtained by the two extraction methods. Types of bioassays performed included cytotoxicity, bleb forming, DNA binding, oxygen free radical scavenger and Xanthine oxidase inhibitor tests. To evaluate economic viability of the SFE over the traditional LSE, extractability of prodrug substances was evaluated as the functions of extraction temperature and pressure SFE was proven to be a feasible alternative over LSE. Also, the optimum SFE conditions which provided maximum extraction and cytotoxicity for each selected sample were presented.

Preclinical dose escalation study of adult human multipotent neural cells (ahMNCs) for spinal cord injury

Jeong-Seob Won,Kyoung Min Lee,Kyeung Min Joo,Yu-Jeong Noh,Hee-Jang Pyeon,Chung Kwon Kim 한국실험동물학회 2019 한국실험동물학회 학술발표대회 논문집 Vol.2019 No.7

MEASUREMENTS AND CORRELATION OF EFFECT OF COSOLVENTS ON THE SOLUBILITIES OF COMPLEX MOLECULES IN SUPERCRITICAL CARBON DIOXIDE

Noh, Min Jeong,Kim, Tae Gyun,Hong, In Kwon,Yoo, Ki Pung 한국화학공학회 1995 Korean Journal of Chemical Engineering Vol.12 No.1

A new transparent microscale circulation-type high pressure equilibrium cell with on-line sampling was devised. With this apparatus, experimental solubility of molecularly complex species such as steroids (cholesterol, stigmasterol and ergosterol) and fatty acids (palmitic acid and stearic acid) in supercritical carbon dioxide(sc-CO₂) were measured. Also, to find an appropriate substance for enhancing both the polarity and the solubility power of the sc-CO₂ solvent, we arbitrarily selected three polar substances such as acetone, methanol and water and the effect of these cosolvents on the solubility of solutes in sc-CO₂ are examined. The supercritical phase equilibrium data of solute-cosolvent-sc-CO₂ systems were quantitatively correlated using a new equation of state based on the lattice fluid theory incorporated with the concept of multibody interaction. We found that the addition of tracer amount of acetone or methanol to sc-CO₂ enhances the solubility of alt solutes about thirty to sixty times when compared with the case of pure sc-CO₂. However, for the case of cosolvent water, no further enhancement of the solubility of solutes was realized. Also, the versatile fittability of the equation of state proposed in this work was demonstrated with the newly measured ternary supercritical equilibrium data.