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퍼지 PID제어기를 이용한 전력계통의 안정화장치에 관한 연구
정형환,주석민,김상효 동아대학교 공과대학부설 생산기술연구소 1996 生産技術硏究所硏究論文集 Vol.1 No.2
This paper presents a design techique of the fuzzy PID controller for power system stabilization. PID parameters of the fuzzy PID controller were self-tuned by the fuzzy inference algorithm. The proposed controller compare with conventional power system stabilizer(PSS) under various of initial vlue of rotor angle deviation and load condition. The eslated simulation results show that the proposed controller was more excellent control characteristics than conventional PSS in transient-state and steady-state response.
전력계통의 부하주파수제어를 위한 신경망 PID제어기 설계
정형환,김상효,이정필,주석민 東亞大學校 大學院 1998 大學院論文集 Vol.23 No.-
This paper has presented a method for self-tuning the PID controller suing a BP method of multilayered NNs. The proposed controller employ input signal as a learning signal of PID control. The proposed controller is applied to load-frequency control of power system and it is investigated a dynamic characteristic. The simulation results shows that proposed NN STPID controller has the good dynamics responses against load disturbances.
Son, Jun-Hyeng,Jeong, Yoo-Seong,Lee, Jong-Hwa,Kim, Min-Soo,Lee, Kyeong-Ryoon,Shim, Chang-Koo,Kim, Young Ho,Chung, Suk-Jae Elsevier 2018 Journal of pharmaceutical and biomedical analysis Vol.151 No.-
<P><B>Abstract</B></P> <P>We previously reported that MDR-1339, an inhibitor of β-amyloid protein aggregation, was likely to be eliminated by biotransformation in rats. The objective of this study was to determine the chemical identity of metabolites derived from this aggregate inhibitor and to characterize the kinetics of formation of these metabolites in rats. Using high performance liquid chromatography coupled with mass spectrometry with a hybrid triple quadrupole-linear ion trap, 7 metabolites and 1 potential metabolic intermediate were identified in RLM incubations containing MDR-1339. In addition to these, 3 glucuronide metabolites were detected in urine samples from rats receiving a 10 mg/kg oral dose of MDR-1339. When the kinetics of the formation of two major metabolites, M1 and M2, were analyzed assuming simple Michaelis-Menten kinetics, the V<SUB>max</SUB> and K<SUB>m</SUB> values were found to be 0.459 ± 0.0196 nmol/min/mg protein and 28.3 ± 3.07 μM for M1, and 0.101 ± 0.00537 nmol/min/mg protein and 14.7 ± 2.37 μM for M2, respectively. When chemically synthesized M1 and M2 were individually administered to rats intravenously at the dose of 5 mg/kg respectively, the volume of distribution and elimination clearance were determined to be 4590 ± 709 mL/kg and 68.4 ± 5.60 mL/min/kg for M1 and 15300 ± 8110 mL/kg and 98.0 ± 19.5 mL/min/kg for M2, respectively. When MDR-1339 was intravenously administered to rats at a dose of 5 mg/kg, the parent drug and M1 were readily detected for periods of up to 6 h after the administration, but M2 was observed only from 2 to 4 h. A standard moment analysis indicates that the formation clearance of M1 is 6.01 mL/min/kg, suggesting that 19.7% of the MDR-1339 dose was eliminated in rats. These observations indicate that the hepatic biotransformation of MDR-1339 results in the formation of at least 10 metabolites and that M1 is the major metabolite derived from this aggregation inhibitor in rats.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Identification of ten metabolites (i.e., 7 Phase 1 + 3 Phase 2) of MDR-1339 in rats. </LI> <LI> Proposal for the major metabolic pathways to be CYP3A4, 2B6 and 2C9. </LI> <LI> Simultaneous quantification of MDR-1339 and its major metabolite M1 and M2. </LI> <LI> Formation of M1 accounted for ∼19.7% of the total MDR-1339 elimination in rats. </LI> </UL> </P>
Min Kyoung Kim(김민경),Hyeng Ju Kwak(곽형주),Jong Hun Kim(김종훈),최원호,Yun Kyung Ha(하연경),So Jung Lee(이소정),Dae Ho Kim(김대호),Yong-Gu Lee(이용구),Youngjin Lee(이영진) 대한전자공학회 2016 전자공학회논문지 Vol.53 No.9
최근 디지털 단층영상합성 시스템 (digital tomosynthesis system, DTS)은 일반 X-ray의 영상 중첩현상과 전산화단층촬영장치 (computed tomography, CT)의 높은 선량의 문제점을 해결하기 위하여 개발되었다. 본 연구의 목적은 흉부 촬영용 디지털단층영상합성 시스템 (chest digital tomosynthesis, CDT)의 재구성 알고리즘 개발 및 화질과 선량 평가를 수행하는 것이다. 영상의 재구성은 필터 후 역투영 (filtered back-projection, FBP)을 모델링하였고, 팬텀 영상을 획득하기 위한 X-선과 검출기 사이의 각도를 ±10°, ±15°, ±20°, 그리고 ±30°로 구성하였다. 영상의 화질 평가는 평균 제곱근 편차 (root mean square error, RMSE)와 신호대 잡음 변화율 (signal difference-to-noise ratio, SDNR)로 수행하였고, 선량 평가는 ±20°의 범위에서 유효선량으로 수행하였다. 결과적으로, 모든 각도에서 Slice thickness 필터를 적용한 팬텀영상이 가장 우수한 RMSE와 SDNR 결과를 나타내었고, 최종 유효 선량은 0.166 mSv로 측정되었다. 결론적으로, 개발한 CDT 재구성 알고리즘의 유용성을 증명하였고, 최종 유효 선량을 측정하여 CDT의 기초 실험 데이터를 구축할 수 있었다. Recently, digital tomosynthesis system (DTS) has been developed to reduce overlap using conventional X-ray and to overcome high patient dose problem using computed tomography (CT). The purpose of this study was to develop image reconstruction algorithm and to evaluate image characteristics and dose with chest digital tomosynthesis (CDT) system. Image reconstruction was used for filtered back-projection (FBP) methods and system geometry was constructed ±10°, ±15°, ±20°, and ±30° angular range for acquiring phantom images. Image characteristics carried out root mean square error (RMSE) and signal difference-to-noise ratio (SDNR), and dose is evaluated effective dose with ±20° angular range. According to the results, the phantom image with slice thickness filter has superb RMSE and SDNR, and effective dose was 0.166 mSv. In conclusion, we demonstrated usefulness of developed CDT image reconstruction algorithm and we constructed CDT basic output data with measuring effective dose.
Ju, Jung-Won,Joo, Hyun-Na,Lee, Myoung-Ro,Cho, Shin-Hyeong,Cheun, Hyeng-Il,Kim, Jung-Yeon,Lee, Young-Hee,Lee, Kwang-Jun,Sohn, Woon-Mok,Kim, Dong-Min,Kim, Il-Chul,Park, Byoung Chul,Kim, Tong-Soo WILEY-VCH Verlag 2009 Proteomics Vol.9 No.11
<P>Clonorchis sinensis, the Chinese liver fluke, is the causative agent of clonorchiasis as well as liver and biliary diseases. The excretory-secretory products (ESPs) of the parasites play important roles in host–parasite interactions. In this study, we have investigated the proteome of ESPs obtained from C. sinensis adult worms. Although the full genome database of C. sinensis is not yet available, we have successfully identified 62 protein spots using 2-DE-based mass analysis and EST database of C. sinensis. The proteins identified include detoxification enzymes, such as glutathione S-transferase and thioredoxin peroxidase, myoglobin and a number of cysteine proteases that are expressed abundantly. In order to identify potential targets for the diagnosis and therapy of clonorchiasis, we conducted immunoblot analysis of the ESPs proteome using the sera obtained from clonorchiasis patients and identified legumains and cysteine proteases as antigens present in the ESPs. Although the cysteine proteases were previously reported to elicit antigenicity, the legumains are found herein for the first time as a serological antigen of C. sinensis. To confirm these findings, we expressed recombinant legumain in Escherichia coli and verified that recombinant legumain also functions as a potent antigen against the sera of clonorchiasis patients. Our results illustrate the validity of immuno-proteomic approaches in the identification of serodiagnostic antigens in the parasites.</P>