백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

고콜레스테롤 혈증 환자에서 Cerivastatin(LIPOBAY, 의과학연구소)의 임상효과 및 안전성에 관한 연구

박성훈,김미연,정수진,이영숙,박창한,변은경,전성희 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.3

목적 : Cerivastatin(LIPOBAY)은 최근에 개발되어 사용되기 시작한 HMG-CoA 환원효소 억제제로서 저용량으로 탁월한 콜레스테롤 강하효과를 보이는 약물이다. 저자들은 Cerivatatin(LIPOBAY)의 혈중 콜레스테롤 강하효과를 평가하고 약물의 안전성을 평가하기 위하여 본 연구를 시행하였다. 방법 : 고콜레스테롤혈증 환자 37명(남자 13명, 여자 24명)을 대상으로 하였다. 대상환자는 2주간의 저콜레스테롤 식이 후에도 혈청 콜레스테롤이 240㎎/㎗이상이거나, 관상동맥질환이 있는 환자는 혈청콜레스테롤이 220㎎/㎗이상인 경우 cerivastatin 0.4㎎을 8주간 복용하도록 하였다. 임상적 관찰과 검사실 검사(간기능검사, 일반혈액검사, 혈청지질검사)는 투약개시 후 4주 및 8주 후에 시행하였다. 결과 : Cerivastatin 0.4㎎을 4주간 투여한 후 측정한 LDL 콜레스테롤, 총콜레스테롤, triglyceride, 및 HDL 콜레스테롤은 각각 38%, 28.8%, 11.6% 및 7.8% 감소하였다. 총콜레스테롤/HDL 콜레스테롤 비 및 LDL/HDL비는 각각 20.8% 및 31.1% 감소하였다. 투약 8주후에 측정한 검사소견은 4주후에 비해 유의한 변화를 보이지 않았다. 한명의 환자(2.7%)에서 간기능 검사상 AST, 및 ALT의 지속적인 상승으로 투약을 중지하였다. 결론 : Cerivastatin 0.4㎎/day는 혈청콜레스테롤을 효과적으로 감소시켰으며 심각한 부작용은 볼 수 없었다. 따라서 적극적으로 LDL콜레스테롤을 낮출 필요가 있는 고콜레스테롤혈증 환자에서 cerivastatin은 효과적이고 안전한 약물이라고 생각된다. Objectives : Cerivastain(LIPOBAY) is recently developed HMG-CoA reductase inhibitor which is effective in lowering serum cholesterol levels at microgram does. We evaluated the clinical efficacy and safety of cerivastatin(LIPOBAY) in patients with hypercholesterolemia. Method : Thirty-seven patients(male : 13, female : 24) with hypercholesteolemia defined as baseline serum total cholesterol ≥240㎎/㎗, or ≥220㎎/㎗ in patients with known coronary artery disease were included for this study. After 2 weeks of low cholesterol diet, if the serum total choesterol level meet the criteria, cerivastain 0.4㎎/day was prescribed for 8 weeks. Clinical follow-up and laboratory tests were performed 4 weeks and 8 weeks after medication. Results : After 4 weeks of cerivastain 0.4㎎/day treatment, low density lipoprotein(LDL) cholesterol decreased 38% and total cholesterol decreased 28.8% from baseline. Triglyceride decreased 11.6%, and high density lipoprotein(HDL) cholesterol decreased 7.8% from baseline. Total cholesterol/HDL ratio decreased 20.8% and LDL/HDL ratio decreased 31.1% from baseline. After 8 weeks of treatment, no further significant changes were noted compared with the values at 4 weeks. Cervastatin was discontinued in one patient(2.7%) due to continuous liver enzyme elevation. Conclusion : Cerivastatin 0.4㎎/day is effective in lowering serum cholesterol levels without significant adverse reactions. Cerivastatin is effective and safe for patients with hypercholesterolemia who needs aggressive LDL cholesterol lowering.

주사전자현미경을 이용한 토마토에 발생하는 아메리카잎굴파리(Liriomyza trifolii)의 외부형태적 특징

윤영남,김기덕,박수진,김남성,서미자,채순용 충남대학교 농업과학연구소 2000 농업과학연구 Vol.27 No.1

SEM을 이용하여 아메리카잎굴파리(Liriomyza trifolii)의 암 ·수컷 성충의 외부형태적 특징을 살펴보았다. 더듬이에 있어 감각모의 3가지 형태는 더듬이가는마디(funicle)에서 관찰되었으며, 모상감각기(trlchold sensillum)는 말단 부위가 뽀족한 특징적인 형태를 하고 있고 감각기들 중에서 가장 많이 분포하고 있다. 원추상 감각기(basiconic sensillum)는 길이가 13㎛, 지름이 1.4㎛에서 1.2㎛인 원형곡선형이다. 홈형 감각기(grooved sensillum)는 간상(peg) 끝에서 나온 손 모양을 하고 있으며, 이 모든 감각기들은 후각과 연관되어져 있는것으로 추정된다. 구기는 홉즙형으로 작고 펼쳐진 윗입술(labrum)과 합쳐져서 하나의 연결된 주둥이(rostrum)을 형성하고 있다. 가느다란 한 쌍의 작은턱수염(maxillary palp)은 긴 관 모양으로 각각의 세로로 이어져 있다. 발마디는 5마디로 이루어져 있으며 그 한가운데에는 패드모양의 흡착반(pulvillus)과 가시모양의 발톱사이돌기(empodium)가 있다. 아메리카잎굴파리는 흡착반과 발톱사이돌기에서 미끄러운 표면에 부착할 수 있는 물질을 분비한다. 수컷의 생식기는 매우 복잡하며 삽입구(aedeagus)는 생식기관으로서 가장 일반적인모양이다. 반면에 암컷의 생식기는 상대적으로 간단한데 이 구조는 외부로 돌출된 관모양이었다. 또한 이러한 결과를 이미 발표된 다른 여러 종의파리와 비교하였다. The external morphology of male and female of Liriomyza trifolii (Burgess) was studied using the scanning electron microscopy (SEM). Three types of sensilla were identified on the funicle of antennae. The trichoid sensilla were most conspicious and distributed with a characteristic sharp structure at the apical end. Basiconic sensilla were showed distal curvature about 13㎛ long and 1.2㎛ to 1.4㎛ in diameter. Grooved sensilla were showed a finger-like projections at the peg apex. The function of these sensilla likely to be olfactory. The mouthparts were adapted for sucking food, and formed a elongate rostrum which was incorporated with labrum. The labrum was a small and flap-like shape. The slender and paired maxillary palp seemed to combine with each other lengthwise to long tube. The tarsus typically consisted of 5 segments, which might be variously modified, principally by thickening or flattening. The segment healed a pair of claws. Beneath the claws, there was a pair of pad-like pulvillia and a bristle-like median empodium. L. trifolii secreted on the pulvillus and empodium an adhesive substance that enable them to cling to smooth surfaces. Male terminalia was complicated. The name 'aedeagus' seemed the best available general term for the copulatory organ, otherwise, female terminalia was usually relatively simple. This structure was reduced and formed a telescopic, eversible, and tubular ovipositor.

주사전자현미경을 이용한 무당벌레에 기생하는 무당벌레기생파리(Degeeria separata)의 외부형태적 특징

윤영남,김남성,김기덕,박수진,서미자,채순용 충남대학교 농업과학연구소 2000 농업과학연구 Vol.27 No.1

External morphological characteristics of male and female of Degeeria separata, which was endoparasited in adult of the Asian ladybird, were studied by using the scanning electron microscopy(SEM). The antenna of Degeeria separata was consisted of three segment and arista. Anstae were about 750㎛ length and 30㎛ in diameter. The surface of antennae was covered with many sensilla. They were long or short, slender or thick, and straight or curved. Each three morphological types of sensilla were observed on the second and third segment of antennae. The mouthpart was sponging type. It was consisted with clypeus, labellum, labium, labrum, and maxillary palp. The labellum is 400㎛ width and double folded vertically. The leg consist of tarsus, tarsus claw, pulvilli, and empodium.

건강한 성인에서 발병한 칸디다와 연관된 위궤양 1례

박지훈,이상혁,김희,이재호,박성재,지삼룡,양성연,박은택,이연재,설상영,정정명,강미선 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Fungus such as Candida albicans is a normal flora that is frequently found in the oral cavity, gastrointestinal tract, genitourinary tract, vaginal mucosa in a normal person. However, candida can cause opportunistic infection in an immune compromised host. Candidiasis has broad spectrum of disease from mucocutaneous infection to invasive or disseminated infection. But, it is rarely reported that candida is associaed with gastrointestinal tract disease in a healthy adult. The case of gastric ulcer associated with candida particularly in a health adult is reported with relevant literature.

토양환경지도 자료를 이용한 콩밭 토양의 화학성 비교

박지숙,이민진,정재원,김미혜,이서연,지윤미,한준호,김유학,공명석,한광현,노희명 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

It is important to interpret the soil chemical properties in order to effectively manage the farmland. This study was conducted to investigate the soil chemical properties of upland soybean field according to the soil series at 32 upland fields located in the parts of Gangwon-do. Soil sampling sites were selected by using the National Statistics DB and KSIS DB that is a soil environment information system provided by the Rural Development Administration. Soil samples were collected from 0~15 cm of top soil before seeding or transplanting, air-dried, passed through a 2 mm sieve, and analyzed for soil pH, EC, organic matter, available phosphorus (P2O5), exchangeable potassium, exchangeable calcium and exchangeable magnesium. The average chemical properties have exceeded the each nutrient optimum range level of RDA, except the organic matter in experimental soil 2015. And despite application of conventional fertilization, each soil series nutrient contents were change respectively. The results of this study suggest that conventional fertilization should be applied based on the analysis about the amount of accumulated nutrient contents in the soil.

Q 열에 의한 감염성 심내막염 2예

문수연,최영실,박미연,이정아,정미경,정혜숙,정두련,송재훈,백경란 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Q fever is a zoonosis caused by Coxiella burnetii, Presenting as acute and chronic illness and it has been reported worldwide. Acute Q fever is usually asymptomatic or mild and self-limiting, but infective endocarditis is one of the most serious complications of chronic Q fever and can be fatal. Known risk factors for Q fever endocarditis are valvular heart disease, immunocompromised hosts, and pregnancy. There have been some reports on Q fever in Korea but there exists no report on Q fever endocarditis. We have experienced 2 cases of Q fever with underlying valvular heart disease; both Patients came to the hospital for evaluation of prolonged fever. Although Q fever and Q fever endocarditis are rare in Korea, Q fever endocarditis should be considered in the differential diagnosis of patient with infective endocarditis when causative microorganism cannot be identified.

감각조절장애 아동의 문제행동에 무게감 있는 조끼 착용이 미치는 영향

한미애,김지연,장기연,박미진 대한감각통합치료학회 2010 대한감각통합치료학회지 Vol.8 No.1

목적 : 본 연구는 주변 환경에 민감하고 감정기복이 심한 감각조절장애 아동에게 무게감 있는 조끼 착용을 통한 고유수용성 감각을 제공하여 아동의 문제행동에 미치는 영향을 알아보기 위하여 실시하였다. 연구 방법 : 연구 대상자는 일반초등학교 1학년에 재학 중인 만 7세 남아로 연구설계는 ABA’단일사례연구를 사용하였고, 14회기 실험을 실시하였다. 중재기간(B)동안 1.3kg의 무게를 첨부한 조끼를 착용하고 학습인지교육을 받았다. 결과 : 치료회기가 진행될수록 의자에서 엉덩이를 떼고 일어나거나 몸을 앞/뒤, 좌/우로 흔드는 경우 및 엄지손가락을 입에 넣기, 손등 입으로 가져가기, 손장난하기 등 행동적 측면에서의 문제행동은 점차 감소되는 경향을 보였다. 결론 : 연구결과 무게감 있는 조끼를 착용한 후 아동의 문제행동이 회기가 지날수록 감소되는 양상을 보였다. 무게감 있는 조끼가 감각조절장애 아동의 문제행동에 대한 감각통합치료의 효과 유지에 미치는 영향을 설명하는데 본 연구설계 및 중재기간상 제한점이 있어서, 무게감 있는 조끼가 감각조절장애 아동의 문제행동에 영향을 주었다기보다는 감각통합치료를 지속적으로 실시한 결과로 생각할 수 있다. 따라서 추후 연구에서는 연구설계의 변형이나 연구회기의 증가를 통해 무게감 있는 조끼가 감각통합치료의 효과를 지속하는지에 대해 명확히 알아보는 것이 필요하고, 감각조절장애 아동에게 무게감 있는 조끼를 착용시키는 것에 대한 적용방법, 무게, 적용시간에 대한 효율적인 프로토콜을 제시하는 연구가 필요할 것이다. Purpose : The purpose of the study is to find out the effect of wearing a weighted vest for sensory modulation disorder children. Methods : The participant of the study was an elementary school student, male, aged 7. The ABA single case study was used to design the study which was performed for 14 sessions. During the mediation period(B), the participant received the study cognitive education wearing weighted vest weighing 1.3kg. Results : Abnormal behaviors such as suddenly standing up from the chair, shaking body front and back, and left and right, sucking his thumb and putting the back of his hand to his mouth showed tendency to decrease gradually. Discussion : The participant's abnormal behaviors decreased as the sessions went by, which means the sensory integration therapy can improve the behavior of the child suffering the sensory modulation disorder. The design of the study had certain limitation to explain the influence a weighted vest to sustain the effect of the sensory integration therapy. New study design is needed for the extended studies to prove the lasting effect of a weighted vest for the sensory integration therapy and to suggest protocols incorporating wearing know-hows, proper wearing time, and the weight of a weighted vest.

디자인 프로세스를 적용한 환자복 개발 사례 연구

이연희;박재옥;서미아;안민영 한양대학교 2004 韓國 生活 科學 硏究 Vol.- No.24

The purpose of this project was to design a patient's uniform which gives functional and psychological satisfaction to the patients. The project was developed to follow the design process. That is, the project was based on the survey which is on dissatisfaction of exiting patient's uniform, evaluation criteria and design preference for patient's uniform. The result of the survey was reflected to the design of new patient's uniform for Hanyang University Hospital. The uniform consists of a shirt and a pair of pants. The style of the garment is comfortable box-silhouette for ease and action. The shirt has a compromised neckline of U-neckline and round-neckline. It has buttons on front for closure, a patch pocketon left side of the garment. It also has three-quarter sleeves to complement dissatisfactions on the length and the distinction of seasons. The button extension was deeply given to avoid becoming open. To give decorative accents, piping was added. The ankle-length pants aredesigned to satisfy the need for shortening the length of existing uniform pants. The waistband of the pants has both closures, a drawstring and an elastic band, to make up for the dissatisfactions on durability and slip-off problems. The colors, white, light blue, pink, and yellow, are used to give a psychological sense of security to the patients. The flower symbol of Hanyang University was used for the textile surface design. Therefore, this project is worthwhile to present more systematic and scientific approach for patient's uniform design which gives functional and psychological satisfaction to the patients.