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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
SPME와 GC/MS를 이용한 녹나무 향기성분 특성분석
원미미,차은주,윤옥경,김남선,김건,이동선 서울여자대학교 자연과학연구소 2007 자연과학연구논문집 Vol.19 No.-
Recently, land managers have come to realize that, outside Asia, camphor trees grow like street-tree or weeds, infesting forests and displacing native trees. This is because camphor trees are prolific seed producers that do not have serious predators or diseases outside their native range. The camphor tree (Cinnamomum camphora), belongs to lauraceae, is the aromatic evergreen tree from which camphor was derived. Headspace solid-phase microextraction (HS-SPME) and GC-MS were applied for the analysis of volatile fragrances emanated from camphor tree. Divinylbenzene / Carboxen / PDMS fiber was used for HS-SPME adsorption materials. (+)-Camphor (31.00%) and cineol (21.89%) were found as the major volatile aroma components from Chinese camphor tree, whereas (+)-camphor (62.06%) and β-caryophyllene (10.01%) from Japanese camphor tree. Camphor tree is a promising garden tree for well-being.
개에서 발생한 양파 섭취에 의한 하인즈 소체 용혈성 빈혈 증례
이미선,윤기영,서경원,최호정,정성목,송근호,조종기,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1
A 10 month-old Yorkshire Terrier was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of lethargy, bile pigment in urine and anorexia. Blood smear showed Heinz body, polychromatocytosis, schistocytosis, anisocytosis, which were the results from the oxidative injury. Hematology demonstrated a moderate anemia(PCV 22.4%, reference rage 35-55%), which was regeneration based on the degree of RPI (4.03, reference rage > 1). Serum biochemistry demonstrated mild elevation in total bilrubin, and mild decrease in total protein and albumin concentration. A diagnosis of Heinz body hemolytic anemia secondary to onion ingestion was made and treated with fluid therapy, oxygen and antioxidant drugs. The dog recovered without any complication.
한지 쌈지 극미량 고체상 추출법을 이용한 레몬과 오렌지 향유 성분 분석
원미미,이동선 서울여자대학교 2010 자연과학연구논문집 Vol.22 No.-
In this study, headspace mulberry paper bag micro solid phase extraction (HS-MPB-μ-SPE) combined to gas chromatography/mass spectrometry has been applied for the analysis of volatile aromas of liquid essential oils from lemon and orange. The technique uses an adsorbent of Tenax TA contained in a mulberry paper bag, minimal amount of organic solvent and very small amount (10 μL) of sample size. Linearity for the calibration curve was excellent, the LOD value was 10.3 ng/mL. Precision and recovery were generally good. In addition, this method allowed combining extraction, enrichment, and clean-up in a single step. Analysis of aroma components in lemon and orange essential oils were performed successfully using this method.
윤미향,정미선,박원혁 부산대학교 사범대학 과학교육연구소 2007 科學敎育硏究報 Vol.34 No.-
The purpose of this study was to find out the difference of decision-making process based on the nature of science. The contemporary and traditional point of view group regarding the nature of science were composed and provided socio-scientific issues. Also, the decision-making process questionaries and interview about socio-scientific issues were conducted to groups. The decision-making process questionary was consisted of five steps : identification of problem, searching alternatives, generation of alternatives, analysing alternatives, and selecting alternative. The results of this study showed at the both groups' decision-making process was difference in the first four steps: the one who has contemporary point of view recognized the various conflict situation, searched the objective informations, applied a diverse of standards, and found the concert solution but the other recognized conflict situation fragmentarily, searched the subjective informations, applied limited standards, and found the realizable solution. The result to the final step, selecting alternatives, were similar in both groups because they didn't suggest the rational reason for selecting alternatives. so, it request the long terms of decision-making experience to make rational decision regardless of the nature of science.
박미향,정미선,박원혁 부산대학교 과학교육연구소 2007 교사교육연구 Vol.46 No.2
본 연구는 환경문제의 심각성을 학습자에게 알리고, 환경에 대한 인식 및 태도를 변화시키는 교육적 방안으로서 자기평가의 효과를 알아보고자 한다. 이를 위해 자기평가지를 개발하여 학습자에게 투입한 결과 자기평가 활동에 참여한 학습자들은 첫째 환경에 대해 의지, 실천, 정서적 측면에서 긍정적으로 변화하였으며, 둘째 환경일반, 환경오염, 재활용, 동물보호, 물 절약 등 주제별 환경 문제에 대해서도 그 심각성을 깊이 인식하며 이를 해결하기 위한 대안 구성에 적극적인 태도를 가지는 것으로 조사되었다. 셋째, 이러한 자기평가 활동은 환경에 대한 태도변화에 있어 남학생보다 여학생의 태도변화에 더 의미 있는 것으로 나타났다. 그러므로 환경문제에 대한 학습자의 자기평가 활동은 학습자의 환경에 대한 인식 및 태도변화에 긍정적인 효과를 나타내므로 환경교육에 있어 현장체험 중심의 프로그램이 가지는 활동적·단기적·장소 제한적 이라는 단점을 보완할 수 있을 것으로 기대된다 The purpose of this study is to find out the effectiveness of self-assessment on the elementary school students' attitude toward environment dealing with environmental issue. For this study, 63 participants in the 3rd grade were chosen and divided into two groups. The self-assessment was applied to the experimental group and the control group were taught by the traditional teaching method focused on the teacher's lecture for 10 lessons. To analyze the effectiveness of the self-assessment, the pre- and post-test for the attitude toward environment was applied to both the groups. As a result, the attitude toward environment including the awareness on environment and environmental issues was not significantly different(p>.05) between the experimental and control group in terms of the pre-test score. However, the post-test score of the experimental group turned out higher than that of the control group(p<.05). Especially the post-test score of the female experimental group was more significant than that of the male experimental group(p<.05). Therefore the self-assessment could make a positive effect on the elementary school students' environment attitude.
악성흑색점흑색종 19예에 대한 임상 및 병리 조직학적 연구
홍원진 ( Won Jin Hong ),장홍선 ( Hong Sun Jang ),이상희 ( Sang Hee Lee ),이상은 ( Sang Eun Lee ),정기양 ( Kee Yang Chung ),노미령 ( Mi Ryung Roh ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.10
Background: Lentigo maligna melanoma (LMM) is a subtype of melanoma that typically develops on sun-damaged skin. LMM is estimated to comprise 4∼15% of melanomas, but the prevalence is known to be relatively lower in the Korean population than in the Caucasian population. Objective: To review the clinico-pathologic features and treatment outcomes of Korean patients with LMM. Methods: Nineteen patients diagnosed with LMM during 2003∼2015, in the Yonsei University Health System, were included in this study. The age and sex of the patients, lesion location, thickness (Breslow), stage, treatment methods, BRAF, NRAS, and KIT mutation status, and survival rates were analyzed. Results: Among the 19 Korean patients, 11 were male and 8 were female. The median age was 59.2 years. The most common site was the cheek (47.4%), followed by the scalp, eyelid, nose, forehead, lip, and neck. At the time of diagnosis, 13 patients were in localized stages (5 patients, stage 0; 3 patients, stage I; and 5 patients, stage II) and 6 patients were in advanced stages (3 patients, stage III; and 3 patients, stage IV). Patients in the localized stages showed better overall survival (OS) than those in the advanced stages (p=0.012). Nine patients were treated with a wide excision, and 6 using Mohs micrographic surgery. Three patients received high-dose interferon-α therapy; 6, chemotherapy; and 4, radiotherapy. Two patients in stage 0 were treated with topical ingenol mebutate. Two patients had BRAF V600E mutation; 1, NRAS G12R mutation; and 1, KIT mutation. Median OS of the patients was 40.8 months. Conclusion: Our analysis provides additional information about clinical characteristics, treatment, and prognosis of LMM in Korean patients. (Korean J Dermatol 2016;54(10):769∼775)
최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1
This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.