Gastric Calcifying Fibrous Tumor : A Rare Cause of Gastric Subepithelial Lesion

박상훈;오태훈;김병규;강미선;허란;김정연 인제대학교 2011 仁濟醫學 Vol.32 No.-

석회화 섬유종양은 원인 미상의 흔하지 않은 양성 중앙이다. 이 종양은 복강이나 복막에서 기원하는 경우가 많으나 위에서 기원한 석회화 섬유종양은 매우 드물 다. 건강검진시 위내시경에서 우연히 발견된 위 점막하 종양 평가를 위해 28세 여성이 본원으로 전원되었다. 본원에서 시행한 위 내시경에서 위 중간체부에 1.2cm의 평탄한 표면의 위 점막하 종양이 관찰되었다. 초음파 내시경을 시행하였고 점막하층에 위치한 불균질한 저에코성의 병변과 함께 종양 내부에는 음향 음영을 동반한 다수의 고 에코성의 부위가 관찰되었다. 위 점막하 중앙은 악성종양을 완전히 배제할 수 없기 때문에 내시경적 점막하 절제술을 시행하였다. 조직 검사결과 종양은 석회화률 동반하는 호산구성 콜라겐 섬유가 풍부한 위 석회화 섬유 종양으로 진단되었다. 이에 위 점막하 중앙에 관한 다른 문헌을 고찰하면서 본 증례를 보고하는 바이다.

생물학적 처리공정을 거친 돈사폐수의 영양염류 제거를 위한 Duckweed(Lemna Species)의 이용 및 생장특성(Ⅰ)

박미란,김병욱,임재명 江原大學校 附設 環境硏究所 2000 環境硏究 Vol.17 No.-

This study was performed to investigate nutrient removal characteristics of swine wastewater using duckweed as floating aquatic plant, and growth characteristics of duckweed with retention time. As the result of experiments, nutrient removal efficiency was very high in a retention time of 3 days, and was more than 90 % on the all operation conditions in a retention time of 10 days. Growth rate was most effected by the change of retention time. Growth rate was very high as 0.280 day^(-1) in a retention time of 3 days. Growth rate decreased gradually as retention time increased, so it was very low as 0.084 day^(-1) when a retention time was 10 days. Crude protein content was very high with ranges of from 23.9 % to 37.6 % as dry content during operating periods. Consequently, duckweed can be used to treat the swine wastewater and its biomass can be used for the alternative protein source as animal food, very effectively.

콤포머의 NaOH용액내에서의 화학적 분해

박미란,양규호 전남대학교 치의학연구소 2001 구강과학 Vol.13 No.3

Ideal restorative materials should have not only physical and chemical properties covering the chewing function and esthetics but also biological adaptability and durability to oral environmental changes. However when the restoration was exposed to oral environment for a long time, surface degradation of restoration, discoloration and destruction of restoration itself could be occurred. One of the major deficiencies of compomers using in pediatric dentistry in recent years is insufficient resistance to wear. Of the multitude of factors that have been associated with wear, subsurface degradation within the restoration is considered to be one. The aim of this study was to evaluate the resistance to degradation of three commercial compomers in an alkaline solution. Dyract(Dentsply), Elan(Kerr) and F-2000(3M) polyacid-modified resin composites(compomers) were used in this study. Preweighed discs of each material were exposed to 0.1N NaOH solution at 60℃ for 2 weeks. The resistance to degradation was evaluated on the basis of mass loss(%), degradation depth(㎛) and Si, Al, Ba loss(ppm). The results were as follows: 1. The mass loss of each brand was 1.42%∼2.14% and there was no statistically significant difference of mass loss among Dyract, F2000 and Elan. 2. The degradation layer depth of each brand was 182.92㎛∼227.7㎛ and there was no statistically significant difference of degradation layer depth among Dyarct, F2000 and Elan. 3. There were statistically significant difference of Si-loss and Al-loss among three compomers (p<0.05). Si loss was the highest value in Dyract and Al loss was the highest value in F2000. 4. There was statistically significant correlation between mass loss and degradation layer depth(r=0.60, p<0.05). 5. In SEM finding, there was destruction of compomer matrix-filter interface in post-exposure specimen to NaOH solution. As the matrix decreased, the filler particles distinguished and the periphery of the filler particles were appeared whitish color due to degradation.

콤포머의 NaOH 용액 내에서의 화학적 분해

박미란,양규호,최남기,이영준,김선미 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.2

이상적인 수복재료는 치아의 저작기능과 심미성을 회복할 수 있어야 하며 동시에 생체 적합성과 구강 내 환경변화에 대한 내구성을 가지고 있어야 한다. 그러나 수복물이 장기간 구강 내 환경에 노출되면 수복물 표면의 마모와 변색 및 수복물 자체의 파괴가 발생될 수 있다. 콤포머도 복합 레진처럼 낮은 마모 저항성을 주요한 단점으로 지적할 수 있다. 본 연구에서는 현재 유치 수복에 많이 사용되고 있는 Dyract (Dentsply, USA), Elan(Kerr, USA), F-2000(3M, USA)의 3종의 콤포머(polyacid modified resin composites)를 알칼리성 용액(0.1N NaOH)에 보관하였을 때 각 제품의 무게손실, 분해층 깊이 및 시편내에서 용출된 Si, Al과 Ba의 농도를 평가하여 제품간의 분해저항성을 평가하고 비교를 하고자 하였다. 각 제품 당 6개의 시편을 제작하여 무게 측정을 한 후, 0.1N NaOH용액, 3㎖에 저장하여 60℃에서 보관하였다. 2주후 제거하여 1.23% HCI로 2시간동안 중화하고 증류수로 세척한 60℃에서 건조하였다. 분해저항성은 무게손실, 분해층 깊이 및 시편내의 Si, Al과 Ba의 농도 변화를 근거로 평가하여 다음과 같은 결과를 얻었다. 1. 각 제품의 무게 손실량은 1.43%~2.14%까지 다양하였으며 제품 간에 유의한 차이는 없었다. 2. 각 제품의 표면하 분해층 깊이는 182.92㎛~227.70㎛였으며 제품 간에 유의한 차이는 없었다. 3. 각 제품으로부터 용출된 Si, Al양은 각 제품마다 유의한 차이가 있었으며(p<0.05), Si는 Dyract에서 Al은 F-2000에서 가장 많은 양이 방출되었다. 용출된 Ba양은 각 제품마다 유의한 차이가 없었다. 4. 무게 손실량과 표면하 분해층 깊이 사이의 상관 관계에서 비교적 높은 상관관계를 보였다(r=0.64, p<0.05). 5. 주사전자현미경 관찰시 0.1N NaOH용액에 보관한 후 콤포머기질과 필러사이의 결합의 파괴를 관찰할 수 있었으며, 기질이 소실되어 필러입자가 두드러진 양상을 보였다. 또한 필러입자의 표면은 분해에 의해 탈회된 모습을 보였다. 이상의 결과에서 현재 유치 수복에 사용되고 있는 3종의 콤포머는 분해저항성에 있어 유의한 차이를 보이지 않았다. The aim of this study was to evaluate the resistance to degradation of three commercial compomers in an alkaline solution. Dyract(Dentsply). Elan(Kerr) and F-2000(3M) polyacid modified resin composites(compomers) were used in this study. The resistance to degradation was evaluated on the basis of mass loss(%), degradation depth(μm) and Si, Al, Ba loss(ppm). The results were as follows : 1. The mass loss of each brand was 1.42%-2.14% and there was no statistically significant difference of mass loss among Dyract, F2000 and Elan. 2. The degradation layer depth of each brand was 182.92-227.7μm and there was no statistically significant difference of degradation layer depth among Dyract, F2000 and Elan. 3. There was statistically significant differences in Si-loss and Al-loss among three compomers (p〈0.05). Si loss was the highest value in Dyract and Al loss was the highest value in F2000. 4. There was statistically significant correlation between mass loss and degradation layer depth (r=0.60, p〈0.05). 5. In SEM finding, there was some destruction of compomer matrix-filler interface in post-exposure specimen to NaOH solution. As the matrix decreased, the filler particles distinguished and the periphery of the filler particles appeared whitish color due to degradation.

인터넷 활용 수업지도안

박미란 忠北大學校 敎育. 生活硏究所 1999 한국교육논총 Vol.- No.2

고객충성도의 측정방법에 대한 이론적 고찰

박진영 ; 석미란 김천대학교 2004 김천대학교 논문집 Vol.25 No.-

The purpose of this study is to abstract problems and suggestions from a theoretical research and an analysis of the recent studies in rela-tion to loyalty. The study shows problems and situations of the loyalty measurement based on the various sides of loyalty as follows: 1. There is a typical difference according to the purpose of research, products and service to the type of loyalty. In various researches, how-ever, measuring tools of loyalty are used as they are depending on the result of former researches. 2. The measurement of loyalty can be measured on various point of view: behavior, attitude, cognition and complexity, as per the prior research. 3. Most frequently used questions on the measuring items of loyalty in domestic research were the intention of repurchase and recommendation to friends and relatives. 4. Methodology that can verify the superiority should be considered through the practical analysis of various measuring tools of loyalty. 5. For further research in the future, it will be needed re-verification of model on the loyalty including the analysis of influential factors that shows the causal relation on the loyalty as well as the measuring method of loyalty.

진흙버섯으로부터 Tyrosinase 저해활성물질의 탐색연구

박영현,김미란 순천향대학교 기초과학연구소 1995 순천향자연과학연구 논문집 Vol.1 No.2

자외선으로 인한 피부노화 및 melanin색소 생성과 식품의 갈변화 현상 등을 저해하는 활성물질을 탐색하고자 최근 기호성, 기능성, 및 의약품 소재로서 주목받는 버섯류중 진흙버섯(Phellinus ribis)을 선택하여 tyrosinase활성 저해효과를 검색하였다. 진흙버섯 methanol추출물을 용매극성에 따라 순차적으로 분획하였다. 각 분획에 대한 tyrosinase저해활성을 측정하고 기질로는 L-3,4-dihydroxy-phenylalanine(L-DOPA)을 사용하였으며 phenol성 화합물인 arbutin, resorcinol, salicylic acid 등의 저해효과와 비교 검색하였다. Phenol성 화합물을 1mg/ml의 농도로 첨가했을 때 arbutin 37.1%, resorcinol 73.9% 그리고 salicylic acid 74.3%로 나타났다. 진흙버섯의 hexane, CHCI₃, EtOAc, n-BuOH 및 H₂O 추출물에 대한 저해작용은 각각 29.8%, 100% 95.6%, 19.6%, 13.7%를 나타내었다. Hexane 추출물중 0.1mg/ml의 농도에서 37.8% 저해활성을 갖는 분획으로부터 dehydroergosterol peroxide(Ⅰ)와 ergosterol peroxide(Ⅱ)를 분리하였다. 이들을 ¹H, 13C NMR, ¹H-¹H NMR COSY, ¹H,13C NMR COSY 및 Electron Impact Mass Spectroscopy(EI mass)에 의해 그 화학구조를 규명하였다. Phellinus ribis was investigated for the inhibitory activity on mushroom-tyrosinase. Several phenolic compounds were used as positive standards. The inhibitory activity on the phenolic compounds was observed arbutin(37.1%), resorcinol(73.9%) and salicylic acid(74.3%) at the concentration of lmg/ml. The inhibitory activity of Phellinus ribis was observed in hexane soluble fraction(29.8%), in CHCI₃soluble fraction(100%), in EtOAc soluble fraction(95.6%), in n-BuOH soluble fraction(19.6%) and in H₂O soluble fraction(13.7%). Dehydroergosterol peroxide(Ⅰ), ergosterol peroxide(Ⅱ) were isolated from hexane extract of Phellinus ribis. Their structure were elucidated by ¹H, 13C NMR, ¹H-¹H NMR COSY, ¹H, 13C NMR COSY and Electron Impact Mass Spectroscopy(EI mass).

일부 부인과 양성 질환자의 지방조직 및 혈청의 PCBs와 DDE 농도

박성균,이강숙,노영만,구정완,민선영,한진구,고원경,김미란,정재근,이종승,김진홍 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 연구는 지방조직과 혈청의 PCBs와 DDE 농도를 측정하고, 이에 영향을 미치는 것으로 알려진 요인들과의 관련성을 평가하고자 하였다. 방법 : 유방암, 자궁내막증 등 유기염소계 화합물의 영향이 있는 것으로 알려진 호르몬 관련 질병을 제외한 부인과 환자 52명을 대상으로 지방조직과 혈청을 분석하였으며, 설문조사를 통하여 연령, 교육수준, 직업, 비만도, 흡연과 음주, 출산력, 수유력등을 조사하였다. 지방조직과 혈청의 PCBs와 DDE 농도는 가스크로마토그래피를 사용하여 측정하였다. 결과 : 지방조직의 경우, 13개 PCBs congeners 농도의 합은 중앙값이 48.29 ng/g, 기하평균값이 56.78 ng/g이었고, DDE 농도는 중앙값이 142.89ng/g, 기하평균값이 117.06 ng/g이었으며, 혈청의 경우는 PCBs congeners 농도의 합은 중앙값이 4.67 ㎍/L, 기하평균값이 4.85 ㎍/L이었고, DDE 농도는 중앙값이 1.75 ㎍/L, 기하평균값이 2.09 ㎍/L로 나타났다. 지방조직과 혈청의 DDE 농도 사이는 높은 상관성을 보였으나(r²=0.310, p=0,0002), PCBs는 상관성이 약한 것으로 나타났다(r²=0.029, p=0.2582). 영향요인을 범주화한 후 로그변환 시킨 지방조직과 혈청의 PCBs, DDE 평균의 차이를 분석한 결과, 지방조직의 DDE만이 출산자녀수(p=0.015), 초산연령 (p=0.014), 비만지수(p=0.035)와 연관성이 발견되었다 다중회귀분석의 결과 지방조직의 DDE는 출산자녀수가 적을수록, 초산연령이 늦을수록 증가하는 경향을 보였다. 결론 : 출산자녀수와 초산연령, 비만도가 지방조직의 DDE와 관련성을 보였으며, 또한 유기염소계 화합물의 장기간의 노출에 의한 영향을 평가하는데 있어서 혈청보다 지방조직이 더 유용한 생물지표임을 알 수 있었다. Objectives : This study was purposed to determine the levels of PCBs and DDE in adipose tissue and serum and to evaluate the relations with factors affecting these levels. Methods : We analyzed adipose tissues and sera from 52 gynecologic benign disease patients aged 27-78 years, except hormonal diseases such as breast cancer and endometriosis. We also surveyed age, education, occupation, body mass index (BMI), smoking, drinking, number of children, and duration of breastfeeding by questionnaires. Tissue and serum levels of PCBs and DDE were measured using gas chromatography. Results : The median and geometric mean levels of PCBs were 48.29 ng/g, 56.78 ng/g for adipose tissue and 4.67 ㎍/L, 4.85 ㎍/L for serum, and those of DDE were 142.89 ng/g, 117.06 ng/g for adipose tissue and 1.75 ㎍/L, 2.09 ㎍/L for serum, respectively. Adipose tissue and serum levels for DDE showed high correlation (r²=0.310, p=0.0002), but those of PCBs didn't (r²=0.029, p=0.2582). In analyses of the differences of the means of log transformed adipose tissue and serum PCBs and DDE levels for groups of potential covariates, only adipose tissue DDE levels were significantly associated with number of children (p=0.015), age at first birth (p=0.074) and BMI (p=0.035). In multiple regression analysis, adipose tissue DDE levels were significantly increased with decreasing number of children and increasing age at first birth. Conclusions : This study suggested that parity and adiposity were associated with levels of DDE in adipose tissue, and adipose tissue is a better biomarker than serum for evaluating the long-term exposure of organochlorines.

마약길항제의 방출 제어형 제제 (제2보) : 나록손 이식제제의 생체적합성 및 약물속도론적 평가 Biocompatibility and Pharmacokinetics of Naloxone Implant

문미란,박주애,이승진,김형국,김길수 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

For the effective administration of narcotic antagonist, the application of sustained release implantable systems with biodegradable polyphosphazene was examined. Using poly[(diethyl glutamate)-co-(ethyl glycinate) phosphazene]. the implantable devices containing naloxone hydrochloride were prepared and in vivo implantation studies were carried out subcutaneously in rat and rabbit with this preparation for the biocompatibility and pharmacokinetics. The histological finding in rats at initial time period was the inflammation that occurred focally around the implants, but they were showed subsequent mild and limited chronic inflammations and the irreversible changes such as necrosis and degeneration of the muscle or connective tissues were not observed. Therefore the placebo and naloxone implants are considered to be biocompatible formulations histologically. In pharmacokinetic studies, the release of naloxone from the naloxone implants into blood plasma was maintained in 192 hours, but the initial burst effect was observed. If this problem was solved, the application for the narcotic antagonist sustained release systems can be expected.

급성 췌장염을 동반한 임신성 급성 지방간 1 예

강미선;박상훈;박지영 서희영;허란;김상현 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-

Acute fatty liver of pregnancy (AFLP) was first described as a specific clinical entity in 1940 and thought to be universally fatal. Maternal mortality in the past approached 75 percent. However early diagnosis and prompt delivery have dramatically improved the prognosis, and maternal mortality rate is now less than 18 percent. A early diagnosis, a prompt delivery, and a intensive supportive care have improved maternal and perinatal outcome. We report a 30—year—old woman at 37 weeks gestation who have multiple complications including acute pancreatitis in AFLP. She was complicated with acute renal failure, disseminated intravascular coagulation, duodenal ulcer bleeding, spontaneous bacterial peritonitis, pulmonary edema and acute pancreatitis.