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Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression
Yoo, Jung-Yoon,Choi, Kyung-Chul,Kang, HeeBum,Kim, Young Jun,Lee, Jeongmin,Jun, Woo Jin,Kim, Mi-Jeong,Lee, Yoo-Hyun,Lee, Ok-Hee,Yoon, Ho-Geun Elsevier 2010 FEBS letters Vol.584 No.11
<P><B>Abstract</B></P><P>This is the first report that L(3)mbt-like 2 (L3MBTL2) specifically interacts with the histone deacetylase domain of histone deacetylase 3 (HDAC3) via its MBT domain. Here, we show that L3MBTL2 selectively interacts with HDAC3, but not other class I HDACs. An in vitro peptide-binding assay demonstrated the specific association of HDAC3 with methylated histone-K20 tail and L3MBTL2. Furthermore, depletion of HDAC3 resulted in a decrease of methylated K20-H4, as well as an increase in acetylated histone H3. Consequently, HDAC3 knock-down selectively suppressed L3MBTL2-mediated transcriptional repression. Taken together, our results reveal the concerted action of both HDAC3 and L3MBTL2 in histone deacetylation and methylation-dependent transcriptional repression.</P><P><B>Structured summary</B></P><P>MINT-7719975: <I>L3MBTL2</I> (uniprotkb:Q969R5) and <I>HDAC3</I> (uniprotkb:O15379) <I>colocalize</I> (MI:0403) by <I>fluorescence microscopy</I> (MI:0416)</P><P>MINT-7719941, MINT-7719921: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>binds</I> (MI:0407) to <I>HDAC3</I> (uniprotkb:O15379) by <I>pull down</I> (MI:0096)</P><P>MINT-7719991: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-7719958: <I>L3MBTL2</I> (uniprotkb:Q969R5) <I>physically interacts</I> (MI:0915) with <I>HDAC3</I> (uniprotkb:O15379) by <I>anti tag coimmunoprecipitation</I> (MI:0007)</P><P>MINT-7719897: <I>HDAC3</I> (uniprotkb:O15379) <I>physically interacts</I> (MI:0915) with <I>L3MBTL2</I> (uniprotkb:Q969R5) by <I>two hybrid</I> (MI:0018)</P>
최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1
This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.
이민숙,김미연,김형옥,박영민 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.12
A 63-year-old-man presented with an asymptomatic, solitary, yellowish papule on the scalp for one year. There was no family history of similar lesions. A punch biopsy taken from the papule Showed an oily yellowish discharge. Histopathological findings showed a thin-walled cyst lined by a stratified squamous epithelium with hyaline cuticle and no granular layer. Based on this histologic finding, we diagnosed this case as a steatocystoma simplex occurring on the scalp, an unusual site. (Korean J Dermatol 2003;41(12):1657-1658)
뇌졸중 후 치매환자에서 도네피질(아리셉트^(?))이 인지기능 및 일상생활 수행능력, 삶의 질에 미치는 효과
이상열,장혁,송재은,조성옥,류정미,이미경,조진호,신용일 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.1
Background: This study evaluated the efficacy of administering Donepezil(Aricept^(?)) for improving cognitive function, activities of daily living, and quality of life in patients with post-stroke dementia. Methods: Patients(n=99; mean age, 69.89 years; 48.5% men) with post-stroke dementia, according to criteria of the DSM-IV and MRI, were treated with donepezil 5mg/day or 10mg/day during 24 weeks. They were examined using Mini-mental Status Examination(MMSE), Chinical Dementia Rating(CDR), Barthel Activities of daily living(B-ADL), Instrumental Activities of daily living(I-ADL), Short Form 36 Health Survey-Korean(SF-36-K), and Geriatric Depression Scale(GDS) at before treatment and 24 weeks after treatment. Results: The 97 patients completed the trial. At 24 weeks, they showed significant improvement in MMSE(p<0.001), CDR(p<0.001), B-ADL(p=0.002), I-ADL(p<0.001), and SF-36-K(p=0.003) except GDS(p=0.288). Donepezil was well tolerated. There was no withdrawal due to adverse events. Conclusion: This results demonstrate that donepezil was beneficial in improving the cognitive function, activities of daily living, and quality of life in patients with post-stroke dementia and was well toleraetd.
이연희;박재옥;서미아;안민영 한양대학교 2004 韓國 生活 科學 硏究 Vol.- No.24
The purpose of this project was to design a patient's uniform which gives functional and psychological satisfaction to the patients. The project was developed to follow the design process. That is, the project was based on the survey which is on dissatisfaction of exiting patient's uniform, evaluation criteria and design preference for patient's uniform. The result of the survey was reflected to the design of new patient's uniform for Hanyang University Hospital. The uniform consists of a shirt and a pair of pants. The style of the garment is comfortable box-silhouette for ease and action. The shirt has a compromised neckline of U-neckline and round-neckline. It has buttons on front for closure, a patch pocketon left side of the garment. It also has three-quarter sleeves to complement dissatisfactions on the length and the distinction of seasons. The button extension was deeply given to avoid becoming open. To give decorative accents, piping was added. The ankle-length pants aredesigned to satisfy the need for shortening the length of existing uniform pants. The waistband of the pants has both closures, a drawstring and an elastic band, to make up for the dissatisfactions on durability and slip-off problems. The colors, white, light blue, pink, and yellow, are used to give a psychological sense of security to the patients. The flower symbol of Hanyang University was used for the textile surface design. Therefore, this project is worthwhile to present more systematic and scientific approach for patient's uniform design which gives functional and psychological satisfaction to the patients.
직장여성의 쇼핑성향에 따른 의복구매동기와 제품평가기준에 관한 연구
이영미,이옥희 服飾文化學會 2003 服飾文化硏究 Vol.11 No.2
The purpose of this study was to investigate the demographics and general clothing buying behavior according to clothing shopping orientation of female workers. A questionnaire was developed to measure clothing shopping orientation , fashion information sources, stores selection criteria, clothing purchasing frequency of a year, purchasing expenditure of clothing, the demographics. The questionnaire was administered to 775 female teacher in Chonnam. The data was analyzed using percentage, frequency, mean, factor analysis, Cluster Analysis, x^2-test and ANOVA, Duncan test. The results of the study were as follow: 1. The female teachers were classified into four groups by the cluster analysis; indifferent shopping group, rational shopping group, conspocuous shopping group, recreational shopping group. 2. In the case of purchasing motives, significant differences were found according to shopping orientation subdivision in four factors. 3. The evaluation criteria of product were significantly different depending on shopping orientation subdivision in practical attribute, socio-psychological attribute, and aesthetic attribute. 4. The significant difference were found according to shopping orientation subdivision in general clothing purchasing behavior(purchasing price range of clothing, clothing purchasing frequency of a year, method of payment, number, of stores visited, experience of buying in the import brand)
이미옥,류소연,변익건,박정희 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2
Objective : This study was performed to identify the relationship between job stress and depression of nurses who work at hospitals in Gwangju city. Methods : The data were collected from October 2 to 22, 2003 using the self-administered questionnaire which was composed demographic characteristics, job-related factors, health-related factors, family-related factors, job stress, self-esteem and Korean Beck's depression inventory. The statistic methods were t-test, analysis of variance (ANOVA), Pearson's correlation analysis and multiple regression analysis. Results : 1. The score of job stress of clinical nurses was 169.23 (24.44) , and depression point was 11.37 (7.71). By the depression criteria, the prevalence of depression were 11.2% in pre-depression, 5.7% in moderate and 4.6% in severe depression. 2. It was found that the characteristics that had a statistically significant relation with depression scores were age, marital status, educational background, career, income, drinking status, satisfaction in living and self-esteem. And job stress was statistically significant positive correlation with depression scores. 3. As a result of multiple regression analysis, the job stress had not a statistically significant relation with depression with controlled other related factors. Conclusion : It is necessary to prepare the program about the control and prevention of depression In clinical nurses. Further study need to identify the relationship between depression and job-related factors in nurses working at the hospitals.
유근피가 고콜레스테롤식이를 급여한 흰쥐의 지질대사에 미치는 영향
이미정,하진옥,이재준,이명렬 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1
연구배경: 유근피는 기능성식품의 신소재로 개발하기 위해서 체계적인 식품학적 연구 및 생리활성효능의 검증이 요구된다. 본 연구에서는 유근피 에탄올 추출물(UDEE)이 고콜레스테롤식이를 급여한 흰쥐의 지방대사 개선효과에 미치는 영향을 구명하고자 혈청 및 간 중의 지질 조성 변화를 검토하였다. 방법: 5주령의 Sprague Dawley계 웅성 흰쥐에게 1% 콜레스테롤과 0.25% sodium cholate를 함유한 고콜레스테롤식이를 조제하여 6주간 급여하였다. 실험군은 정상식이군(NOR), 고콜레스테롤식이군(대조군, CON), 정상식이와 유근피 에탄올 추출물 저용량 투여군(UD1), 정상식이와 유근피 에탄올 추출물 고용량 투여군(UD2), 고콜레스테롤식이와 유근피 에탄올 추출물 저용량 병합 투여군(UDC1) 및 고콜레스테롤식이와 유근피 에탄올 추출물 고용량 병합 투여군(UDC2)의 6군으로 나누어 실시하였다. 유근피 에탄올 추출물은 매일 같은 시각에 경구 투여한 후 흰쥐의 혈액과 간장 내의 지질 조성을 관찰하였다. 결과: 체중증가율과 간 무게는 CON군이 NOR군에 비하여 높게 나타났으나, 고콜레스테롤식이와 유근피 추출물을 병합 투여한 UDC1군과 UDC2군에서 점차 감소하는 경향을 보였다. 혈청 중 ALT, AST 및 ALP 활성은 CON군에서 유의적으로 증가하였고, UDEE 투여로 농도 의존적으로 감소하였다. UDEE 투여군에서는 CON군에 비하여 HDL-콜레스테롤/총콜레스테롤, HDL-콜레스테롤 및 인지질 함량은 증가하였으나 중성지질, 총콜레스테롤, 유리콜레스테롤 및 LDL-콜레스테롤 함량은 감소하였다. 중성지질, 인지질, LDL-콜레스테롤, HDL-콜레스테롤 및 유리콜레스테롤 함량은 정상식이를 급여한 군들 간에는 유의차가 없었다. 또한, 간 중 중성지질과 총콜레스테롤 함량도 UDEE 투여군이 CON군에 비하여 낮았다. 결론: 유근피 에탄올 추출물은 혈청 및 간의 콜레스테롤 함량을 저하시켜 고콜레스테롤혈증 예방과 치료에 효과적일 것으로 판단되어진다. Background and Objectives: This study was performed to investigate the effect of ethanol extract of Ulmus davidiana var. japonica Nakai(UDEE) on serum and liver lipid metabolism in rats fed high cholesterol diet. Methods and Materials: Male Sprague-Dawley rats were administered 1% cholesterol and 0.25% sodium cholate to induce hypercholesterolemia. We divided into six groups; normal diet group(NOR), high cholesterol diet group(CON), normal diet and UDEE 200 mg/kg administered group(UD1), normal diet and UDEE 400 mg/kg administered group(UD2), high cholesterol diet and UDEE 200 mg/kg administered group(UDC1), and high cholesterol diet and UDEE 400 mg/kg administered group(UDC2). Results: The growth rate and liver weight of the CON group was higher than the NOR, whereas the administered UDEE groups were gradually decreased. There was a significant increase in the activities of serum ALT, AST and ALP in CON group. The administration of UDEE decreased serum ALT, AST and ALP activities in dose dependently manners. UDEE administered groups were increased HDL-C/T-C, HDL-cholesterol and phospholipid levels, and decreased serum triglyceride, total cholesterol, free cholesterol, and LDL-cholesterol levels as compared with CON group. There were no differences in the levels of serum triglyceride, phospholipid, LDL-cholesterol, HDL-cholesterol and free cholesterol between normal diet groups. The hepatic levels of total cholesterol and triglyceride were also lower in UDEE administered groups than in CON group. Conclusion: These results suggest that UDEE exerts hypocholesterolemic effect by reducing serum and liver cholesterol contents.
이숙영,이현옥,노숙령,김기숙,이복희,박미정 중앙대학교 생활과학연구소 2002 생활과학논집 Vol.15 No.-
The study was to investigate the functional properties of soy protein isolate hydrolyzed by immobilized α-chymotrypsin and the quality characteristics of soy ice cream made by the soy protein isolate treated with immobilized α-chymotrypsin. Up to the hydrolysis rate of 22.9%, treatement by immobilized α-chymotrypsin costed more time than that of α-chymotrypsin. Foam and emulsion capacity were decreased by the number of repetitive usage. Apparent viscosity and overrun of soy ice cream treated with immobilized α-chymotrypsin and α-chymotrypsin were shown similar tendency. In the sensory characteristics, soy ice cream by enzyme treatment was evaluated as much acceptable than untreacted soy ice cream in the item of beany flavor, icy feel and overall quality. For efficient use of immobilized α-chymotrypsin industrially, α-chymotrypsin immobilized on glass beads can be reused for about 11 times more than α-chymotrypsin.
이옥희,김경희,최미현 服飾文化學會 2002 服飾文化硏究 Vol.10 No.4
The Main objective of this study was to investigate the relationship between shopping orientations and Knit wear Buying Behavior of college female students. A questionnaire was developed to measure knit wear purchasing motives, fashion information sources of knit wear, evaluation criteria of knit wear product, and general clothing buying behavior. The questionnaire was administered to 505 college female students in Chonbuk and Connnam. the data was analyzed using percentage, frequency, mean, factor analysis, Cluster Analysis and ANOVA, Duncan Multiple Range test. The results of the study were as follows: 1. The college female students were classified into fifth subdivisions by the cluster analysis; convenient shopping group, recreational shopping group, self-confident shopping group, those of Fashion-pursuit group, economic shopping group. 2. The knit wear purchasing motives of consumers were significantly different according to shopping orientation subdivision in social, personal, rational. 3. In the case of fashion information sources of knit wear, significant differences were found according to shopping orientation subdivision in mass media information, information by marketer, mail order advertisements, information by consumer. 4. The evaluation criteria of knit wear product of consumers were significantly different depending on shopping orientation subdivision in esthetic, practicality, individual expression, external criterion. 5. In the case of dissatisfactory factors for wearing knit wear product, significant differences were found according to shopping orientation subdivision. 6. In the case of asking factors to the manufactures of knit wear product, significant differences were found according to shopping orientation subdivision.