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      • SCOPUSKCI등재

        Myeloid Sarcoma and Acute Myelomonocytic Leukemia in an Adolescent with Tetrasomy 8: Staging with $^{18}F$-FDG PET/CT

        Makis, William,Rakheja, Rajan,Lavoie, Josee,Hickeson, Marc The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.2

        Tetrasomy 8 is a relatively rare chromosomal abnormality that has been reported in only 33 cases in hematologic disorders. It is known for its association with aggressive acute myeloid leukemia (AML) and myeloid sarcoma and is considered a very poor prognostic factor. Myeloid sarcoma is a rare hematologic malignancy characterized by tumor masses consisting of immature myeloid cells, presenting at an extramedullary site. We present a case of a 17-year-old boy referred for an $^{18}F$-FDG PET/CT for the evaluation of pleural masses and spinal bone lesions seen on CT, after presenting with a 4 month history of chest pain. The PET/CT revealed extensive FDG-avid extramedullary disease in the soft tissues of the chest, abdomen, and pelvis, which were biopsy-proven to be myeloid sarcoma, as well as extensive intramedullary disease biopsy proven to be AML. This is the first report of the use of $^{18}F$-FDG PET/CT to stage a subset of aggressive AML and myeloid sarcoma in a patient with an associated chromosomal abnormality (tetrasomy 8).

      • The role of autonomous demand growth in a neo-Kaleckian conflicting-claims framework

        Won Jun Nah,Marc Lavoie 한국사회경제학회 2017 한국사회경제학회 학술대회 자료집 Vol.2017 No.여름

        This paper incorporates the role of an independently growing autonomous demand component into a neo-Kaleckian model of growth and distribution where the distribution of income is fully endogenized. The model presents the combined dynamic effects of the conflicting-claims, the Sraffian supermultiplier, the Harrodian instability mechanism and the reserve army of labor forces. The key features of the model include the convergence towards the steady state in the long run where it achieves the normal rate of utilization of capacity and the stable rates of employment and inflation. Even with this classical convergence, the model vindicates that some of the main Keynesian tenets still hold even in the long run in the sense that both the average rates of accumulation and utilization decrease during the whole traverse after either an increase in the marginal propensity to save out of profits, or an upward adjustment in the claims on profits, or an enhancement of the bargaining power of capitalists relative to workers.

      • KCI등재

        GLUT2 proteins and PPARγ transcripts levels are increased in liver of ovariectomized rats: reversal effects of resistance training

        Luciane M. Tomaz,Jean-Marc Lavoie,Marina R. Barbosa,Zahra Farahnak,Cristiani G. Lagoeiro,Natalia S.S Magosso,Sérgio E. A. Perez 한국운동영양학회 2016 Physical Activity and Nutrition (Phys Act Nutr) Vol.20 No.2

        Purpose: This study investigated the effects of ovariectomy (Ovx) and 12 weeks of resistance training (RT) on gene expression of GLUT2, the main glucose transporter in the liver, and on PPARγ, a transcription factor known to target GLUT2 expression. Methods: Forty Holtzman rats were divided into 5 groups: Sham-sedentary (Sed), Sham-RT, Ovx-Sed, Ovx-RT, and Ovx-Sed with hormone replacement (E2). The RT protocol consisted of sessions held every 72 h for 12 weeks, during which the animals performed 4 to 9 vertical climbs (1.1 m) at 2 min intervals with progressively heavier weights (30 g after the fourth climb) tied to the tail. The E2 silastic capsule was inserted into the rats’ backs 48 hours before the first RT session. Results: In addition to liver fat, GLUT2 protein levels and PPARγ transcripts were increased (P < 0.05) in Ovx compared to Sham-Sed animals, suggesting increased hepatic glucose uptake under estrogen deficient conditions. RT and E2 in Ovx rats decreased liver fat accumulation as well as GLUT2 and PPARγ gene expression to the level of Sham-Sed animals. Conclusion: The results of this study suggest that liver GLUT2 as well as PPARγ expression in Ovx rats are accompanied by increased fat accumulation and glucose uptake, thus providing a substrate for increased de novo lipogenesis. RT appears to be an appropriate exercise model to circumvent these effects.

      • SSCISCOPUSKCI등재

        Demand-led Growth and Long-run Convergence in a Neo-Kaleckian Two-sector Model

        ( Jung Hoon Kim ),( Marc Lavoie ) 한국경제학회 2017 The Korean Economic Review Vol.33 No.1

        This paper analyzes a two-sector model, with consumption and investment sectors, which incorporates both Kaleckian and Classical views. Starting from a model where investment depends on actual profit rates and rates of capacity utilization, we characterize three regimes with different investment functions and specific adjustment mechanisms to bring about a uniform rate of profit and convergence between the actual and the normal rates of capacity utilization. We find that the paradox of thrift holds in the long run for all regimes. With regards to income distribution, results concerning wage-led growth and the paradox of costs are more ambiguous. The reproportioning of the capital stock between the two sectors is also discussed. We conclude that our analysis provides some justification for using simple one-sector Kaleckian models, since the results achieved with the two-sector model are roughly in conformity with those of the one-sector model, depending on the closure being used.

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