정상 한국인에서 연령증가에 따른 혈장 Dehydroepiandrosteronesulfate ( DHEA-S ) 농도 및 DHEA - S / cortisol 비의 변화

박성우,유형준,임성희,최문기,유재명,박민숙,이권엽,박철수,김철홍,김현규,김두만,박규용 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.2

Backgroud: DHEA-S is the most abundant steroid hormone in circulation, and primarily secreted from the adrenal cortex, but its physiological role is little known. One of the characteristic features of DHEA-S is progressive decrement of plasma DHEA-S level with advancing age, in contrast, plasma levels of other adrenal hormones are not chaging or littie decreasing. To grasp the trends of plasma DHEA-S level and DHEA-S/cortisol ratio by age in healthy Korean, we measured the plasma DHEA-S levels and DHEA-S/cortisol ratios in healthy Korean. Methods: Healthy Korean(men: 99, women: 102, age range: 15-97 year old)were studied. Subjects were not taking drugs(such as glucocorticoid or androgenic medication) or cigarettes known to modify the plasma level of DHEA-S and cortisol, and had no evidence of hepatic, renal disease or hyperlipidemia as determined by serum lipid, bilirubin, SGOT, SGPT, BUN, creatinine. Data were analyzed by 10-year age group for men and women: i.e, 10-19, 20-29, 30-39, 40- 49, 50-59, 60-69, 70-79, 80-89 and 90 year or more. Plasma DHEA-S levels were measured by using a commercially available RIA kit with 125I labeled-DHEA-SO4(Coat-A Count DHEA-SO4), and for the measurement of plasma cortisol levels, commercial Gamma Coat TM[125I] Cortisol Radioimmunassay Kit was used. Results:. 1) In both men and women, plasma DHEA-S level showed high interindividual variation within the same age group. 2) There were individual sex differences in plasma levels of DHEA-S, in all age groups, plasma DHEA-S levels were significantly higher values for men than for women. 3) Maximum plasma DHEA-S levels(men; 237+-3.35 ug/dL, women; 108+-17.5 ug/dL) were at third decade in both men and women. 4) Both men and women showed the continuous decline in plasma DHEA-S level with age. These age-related decline was more prominent in men than in women(men; y= -3.152 * +292.6, r2= 0.8459, P$lt;0.05, women; y= -1.417 * +143.3, r2 = 0.7278, P$lt; 0.05). 5) As an index of aging, there was no stastical difference between DHEA-S and DHEA- S/cortisol ratio. Conclusion: In healthy Korean, there were high interindividual variation of plasrna DHEA-S levels. In both men and women plasma DHEA-S level was peak at third decade, and from when it declined progressively with age. These results suggest that although the reliability of single plasma DHEA-S measurement are limited, the decline of DHEA-S with advancing age might be a specific marker of endocrinologic hormonal milieu(aging index). Also, concerning to individual adrenal secreting capacity, we measured DHEA-S/cortisol ratio. But we did not found that plasma DHEA-S/cortisol ratio is superior to the plasma DHEA-S level as an aging index. (J Kor Soc Endocrinol 12:245-254, 1997)

불국사 석탑의 물성 및 지반특성 조사

최희수,서만철,오진용 공주대학교 문화재보존과학연구소 2003 문화재과학기술 Vol.2 No.1

경주 불국사의 다보탑과 석가탑은 751년에 축조된 국보급 문화재이나 오늘날은 석재의 풍화 및 지대석의 어긋남 현상들이 관찰된다. 이에 대한 정확한 이해는 두 석탑의 안정성 진단에 필수적이며 따라서 석탑의 지반환경과 석재 물성에 관한 비파괴 정밀 조사가 필요로 한다. 이 연구에서는 석재의 역학적 성질을 위해 초음파 속도 측정을 실시하였고 천부지질구조를 위해 탄성파, 전기비저항, 지하레이더 등의 비파괴 복합 지구물리탐사를 석탑 주변에서 수행하였다. 초음파 속도범위는 석가탑에서는 1217~4403 m/s이며, 다보탑에서는 584~5845 m/s이며 이로부터 추정한 일축강도 평균치는 각각 463 kg/cm^(2), 409 kg/cm^(2)이다. 대체로 두 석탑 주변의 북서쪽 구역에서 낮은 탄성파 속도와 비저항 값이 나타나, 이 부분을 비교적 연약한 지반으로 해석한다. 그리고, 탄성파 속도분포에서는 다보탑 지반이 더 큰 속도를 보여 상대적으로 석가탑 지반보다 견고함을 보여준다. 대체로 석탑지반의 전기비저항은 최대 2200 Ωm이며 200 Ωm내외의 외부지반보다 더 높은 값을 보인다. 복합 지구물리탐사 결과를 종합하면 다보탑지반의 형태는 8각형(한 변은 6 m)으로 그 깊이는 약 4 m 이나, 석가탑지반은 약 8x10 m의 직사각형 형태로 깊이는 약 3 m 이다. Two three-story stone pagodas, Seokgatap and Dabotap, built in 791 at Bulkuksa temple, are well-known national treasures. However, they have experienced weathering process and an offset of the stone alignment is observed at the base part of Dabotap. Understanding of these phenomena is essential for the structural safety diagnosis for them, and therefore the nondestructive geophysical methods was applied. Direct measurements of ultrasonic velocities was introduced for the mechanical properties of the stone. Multidisciplinary geophysical prospectings including seismic, resistivity, ground-penetrating radar(GPR) methods were carried out around two pagodas for their site characteristics. The velocity ranges of ultrasonic waves for Dabotap and Seokgatap are 1217~4403m/s and 584~5845m/s, respectively, and the estimated averages of the uniaxial compressive strength are 463 kg/cm^(2) and 409 kg/cm^(2), respectively. At the northeast of each pagodas, the lower seismic velocities and resistivities are shown, which is interpreted to be weaker subsurface section. On the basis of the higher velocity structure, the site of Seokgatap appears to have solider stability than the Seokgatap site. Near the pagodas, higher(up to 2200 Ωm) resistivity is present whereas their outskirts have as low as 200 Ωm. By the combined results of each geophyscial methods, the subsurface boundaries of each stone pagodas are revealed. The Dabotap site is in the form of an octagon having 6-m-long side with the depth of ~4 m, whereas the Seokgatap site is the 8x10 m rectangle with the depth of 3 m.

회복실 환자의 현황 및 SaO_2의 변동

최세진,김만수,권성범 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

We have reviewed 2059 cases admitted at the recovery room of Chung Nam National University Hospital from Jan. 1, 1995 to April 30, 1995 to use of the results for better guidance and management. The cases were statistically analysed by various parameters, the number of patients of recovery room admission, department, anesthetic methods, recovery score, duration of stay and change of SaO_2. The results were as follows ; 1. Patients undertook anesthesia ; case of general or regional anesthesia were 2059 among the overall recovery room admission cases 2059. Admission rate of recovery room was 83.7% (2059/2630). 2. Among the 2059 cases in the recovery room, case of obstetric and gynecology were 464 (22.5%), followed by cases of orthopedic surgery (16.9%) and cases of general surgery (15.4%). 3. Operation were carried out in most case (84.7%) under general anesthesia, followed by case under regional anesthesia (15.3%). 4. The large part of the patients (79%) have postanesthetic recovery score 9-10 at the moment of admission in the recovery room and the most part of the patients (100%) have postanesthetic recovery score 9-10 at the moment of discharge in the recovery room. 5. Most of patients (92.6%) stayed less than 1 hour in the recovery room. 6. SaO_2 of patients were greater than 96% on arrival and discharged.

정전기적으로 분산된 콜로이드 실리카 입자의 코팅

沈秀萬,崔鎔成 홍익대학교 산업기술연구소 1996 産業技術 Vol.6 No.-

Spherical colloidal particles of silica in 0.1㎛ diameter were synthesized dispersed in water electrostatically by adjusting pH. The particles in suspensions were deposited using dip-coating on a soda-lime glass substrate. Total potential energy between the particles and the substrate was calculated and the result was discussed with the adhesion and arrangement of the deposited particles. Particles deposited from a suspension of pH=4 were removed after washing with deionlzed water due to the flocculation of the particles arising from an attraction force between the particles. Deposition of a suspension of pH=8 resulted in a dense coating that the particles were uniformly adhered. Whereas, the deposition with a suspension of pH=6 resulted in a realtively porous coating that the particles were less uniformly adhered. The dense and uniform packing of the particles was attributed to a repulsion force existing between the particles.

스포츠 몰입상태 척도(FSS)에 대한 통계적 타당성 검증 : The Korean Flow State Scale

손영수,최만식,문익수 한국스포츠심리학회 2002 한국스포츠심리학회지 Vol.13 No.2

본 연구의 목적은 한국설정에 맞는 스포츠 몰입상태 측정을 위한 도구의 타당도와 신뢰도를 검증하는데 있다. 연구대상자는 대학·고교 운동선수, 체육전공학생과 동호회 가입 학생들이었으며, 측정도구는 Jackson & Marsh(1996)가 개발한 몰입상태척도(Flow State Scal; FSS)를 사용하였다. FSS 설문지는 9개의 하위요인을 구성되었으며, 각 요인별 4문항씩 총 36문항으로 구성되었다. 이 FSS를 1, 2차에 걸쳐 조사를 실시하여 한국어판 FSS가 개발되었다. 한국어판 FSS의 신뢰도(Cronbach'α) 계수는 7개 하위요인에서 .61∼.81로 높게 나타났으며, 한국어판 FSS는 7개 요인구조를 보였으며, 설명변량으로 66.4%로 나타났다. 또한 확증적 요인분석을 통해 한국어판 FSS질문지로 측정한 몰입상태 측정모델이 적합함을 살펴보았다. 한국어판 FSS의 기초 적합도 지수(GFI)는 .89로서 일반적으로 수용되는 .90에 거의 근접한 것으로 측정모델에 적합한 것으로 나타났다. 조정 적합도 지수(AGFI)의 경우 .84로 적합한 것으로 나타났다. FSS는 이러한 타당성과 신뢰성 검증과정을 거쳐 한국어판 몰입상태 설문지로 완성되었다. The purpose of this study was the validity of Flow State Scale(FSS) when used with Korean athletes. The FSS was developed by Jackson and Marsh(1996) and translated into Korean by 3 Ph. D sport psychologist, 1 doctoral course student, and 1 master course student. In order to reflect culture difference, this study was focused on process of translation. Namely 3 time - translation course have enforced(first translation, reverse translation, commitment translation). After 2 times study, final translation version was used this study. Statistical procedures included descriptive statistic, factor analysis, internal consistency. Cronbach's Alpha was calculated to test the reliability of items and their internal consistency. Exploratory Factor Analysis(EFA) was conducted to test the structure of each factors with principal analysis and varimax rotation. Confirmatory Factor Analysis(CFA) was conducted to test the factor validity of this inventory with CALIS. Exploratory Factor Analysis(EFA) extracted a seven-factor solution and internal consistency estimates for the seven FSS scales were reasonable(alpha= 81). Confirmatory Factor Analysis(CFA) supported the seven scale. Suggestions for use of the scale and for further research are discussed.

Incisional Hernia in Adult Liver Transplant Recipients

( Ji Soo Lee ),( Kyeong Sik Kim ),( Chan Woo Cho ),( Kyo Won Lee ),( Gyu-seoung Choi ),( Jong Man Kim ),( Choon Hyuck David Kwon ),( Jae-won Joh ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Incisional hernia is one of the complication following abdominal operation. Patients undergoing liver transplantation have a high risk of developing an incisional hernia because of immunosuppression. The purpose of this study is to review incisional hernia cases after liver transplantation and to identify the risk factors for hernia formation. Methods: We retrospectively reviewed and analyzed the medical records of the ninety-four incisional hernia patients after liver transplant recipients from January 2000 to December 2015 in single center institution. Results: 1463 underwent adult liver transplantation during the study period. 94 Incisional hernia patients were found among them. The overall incisional hernia rate was 6.4 %. Mean age was 54 years old and 76.6 % were men. No significant difference was observed for sex, diagnosis, smoking, alcohol, albumin, Child-Pugh score, MELD score, intensive care unit stay, hepatorenal syndrome, ventilator, spontaneous bacterial peritonitis, diabetes, bile leakage, wound problems between patients with incisional hernia and patients without incisional hernia. The characteristics of patients with incisional hernia showed old recipient, more body weight, higher body mass index, living donor recipient compared with patients without incisional hernia. Hypertension, tuberculosis, rejection, postoperative complication event before hernia were significant risk factor (p<0.05). Conclusions: Present study identifies the risk factors for incisional hernia. Surgeons should strive to reduce the risk of incisional hernia after adult liver transplantation.

감잎(Diospyros kaki folium)의 Polyphenol 화합물군이 면역기능에 미치는 영향

배만종,성태수,최청,안봉전,박무희 경산대학교 생명자원개발연구소 1999 생명자원과 산업 Vol.3 No.-

한국산 감잎(Diospyros kaki folium)으로부터 polyphenol 화합물을 분리하여, 감잎의 기능성 식품으로서의 근거를 제시하고자, 면역기능의 활성화에 관한 실험을 행한 결과 다음과 같은 결과를 얻었다. 감잎의 폴리페놀 화합물이 면역기능에 미치는 영향에 관한 실험에서는 감잎으로부터 분리된 폴리페놀 화합물 Ⅰ, Ⅱ 및 Ⅲ에 비하여 시료를 투여한 군에서 항체생산이 증가되었으며, 특히 폴리페놀 화합물 Ⅱ와 Ⅲ에서 높은 유의성을 나타내었다. Rosette 형성의 결과에서도 감잎의 폴리페놀 화합물 Ⅱ와 Ⅲ을 투여한 군에서 분리된 비장과 복강 상재성 마크로파지에서 rosette 형성능이 높은 것으로 나타났다. Candida에 대한 시료의 탐식능을 관찰한 결과, 대조군에 비하여 fraction Ⅰ은 70%, Ⅱ는 76.8% 및 Ⅲ은 93%의 탐식능의 효과를 나타내었다. 또한, 면역기능을 담당하는 기관인 비장에 관한 세포증식능을 실험한 결과 대조군에 비하여 시료를 투여한 모든 군에서 비장세포가 증가하였으며, 시료의 농도가 증가할수록 세포증식도 증가되는 경향을 나타내었다. This study was conducted to investigate immuno functional activity of the ployphenol fractions isolated from persimmom leaves(Diospyros kaki folum). In the experiment of rosette forming cell, the results showed that all the polyphenol fractions enhanced the cell count compared with the control group. Especially polyphenol fraction Ⅱ and Ⅲ showed highly significant effect. The phagocytic activity of peritoneal macrophage on mice was significantly increased by the polyphenol fractions of the persimmon leaves compared with that of the control group. The gagocytic activity of polyphenol fraction Ⅰ, Ⅱ and Ⅲ oagainst the C. parapsilosis was 26.4%, 72% and 82.3% respectively. The pagocytic activity of the same fractions against the C. albicans was 70%, 76.8% and 93% respectively.

중학교 남자 테니스 선수의 운동기능수준별 시합 전 경쟁상태불안

남인수,최인태,전중기,윤재만,고성경,이종삼,임승현 대구대학교 인문과학연구소 2008 人文科學硏究 Vol.31 No.-

The purpose of this study was to investigate if there is any difference in the level of competitive state anxiety according to the level of motor skill before the game and to provide the players with basic data for the mental practice. The subjects of this study consist of 20 men's a middle school tennis players. The experimental group was divided into superior players group and inferior players group. And then by using a CSAI-2 questionnaire, three subfactors of competitive state anxiety, or cognitive state anxiety, somatic state anxiety and state self-confidence were measured. The method of measurement was carried out three times, or one week, one day and two hours before the game. The results of this study were as follows. First, About both cognitive state anxiety and somatic state anxiety, inferior players were significantly higher than superior players. Second, About state self-confidence, superior players were significantly higher than inferior players. Third, As the game was around, both cognitive state anxiety and somatic state anxiety which all the players including superior and inferior players had increased. But the state self-confidence of all players decreased.

승모판 혈류의 E파와 폐정맥혈류의 D파의 최대속도 간의 시간 간격과 승모판 도플러 지수들과의 관계

전두수,이만영,박지원,김용주,임효영,강동헌,이길환,김종진,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

자궁경부 세포진 검사에서 비정형 선세포의 임상병리학적 중요성

서동수,윤만수,최경운 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25