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RISS 인기검색어
- 검색키워드
- 저자 : ( Madan Mohan Pandey ) (검색결과 4 건)
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Madan Mohan Pandey,Raghavan Govindarajan,Ajay Kumar Singh Rawat,Yashpal Singh Pangtey,Shanta Mehrotra 한국생약학회 2004 Natural Product Sciences Vol.10 No.1
A simple quantitative HPLC method has been developed for differentiating two plants of Asteraceae family viz. S. costus and A. lappa by using a pharmacologically active constituent chlorogenic acid and symmetry C18 column clubbed with a binary gradient using acetonitrile: 0.1% phosphoric acid and detected using a PDA at 327nm. Quantitatively chlorogenic acid was found to be more in A. lappa (0.140%) than in S. costus (0.087%).
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Pharmacognostical Evaluation of Roots of Pygmaeopremna herbacea (Roxb.) Mold.
Subha Rastogi,Madan Mohan Pandey,Kaushal Kumar,Ajay Kumar Singh Rawat,Palpu Pushpangadan 한국생약학회 2005 Natural Product Sciences Vol.11 No.2
Pygmaeopremna herbacea (Roxb.) Mold. (Verbenaceae) is a small herb or sometimes an undershrub arising from a perennial rootstock. The dry roots are dark muddy brown in colour having root nodules. Itsextensively developed roots are widely used in tribal medicine. They are used as an aphrodisiac and for thetreatment of gout, rheumatism and ulcers. This study deals with the detailed pharmacognostical evaluation of thedried roots and root nodules of P. herbacea which includes macro and microscopic studies, determination ofphysicochemical parameters and chemoprofiling of the extract using HPTLC fingerprint profiles. It was observedthat the roots consist of a well developed cortical region consisting of tangentially elongated thin walledparenchymatous. The HPTLC fingerprint profile of the methanolic extract showed the presence of seven majorbands. Such an analysis may thus be utilized in identifying P. herbacea and in differenciating it from other specieswhich are similar to it or are used as its adultrants/substitutes under the same vernacular name of Bharangi.
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Impact of Treatment Time on Chemoradiotherapy in Locally Advanced Cervical Carcinoma
Pathy, Sushmita,Kumar, Lalit,Pandey, Ravindra Mohan,Upadhyay, Ashish,Roy, Soumyajit,Dadhwal, Vatsla,Madan, Renu,Chander, Subhash Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
Background: Adverse effects of treatment prolongation beyond 8 weeks with radiotherapy for cervical cancer have been established. Clinical data also show that cisplatin increases the biologically effective dose of radiotherapy. However, there are no data on the effect of overall treatment time in patients with locally advanced cervical cancer treated with concomitant chemo-radiotherapy (CCRT) in an Indian population. The present study concerned the feasibility of concurrent chemotherapy and interspacing brachytherapy during the course of external radiotherapy to reduce the overall treatment time and compare the normal tissue toxicity and loco-regional control with a conventional schedule. Materials and Methods: Between January 2009 and March 2012 fifty patients registered in the Gynaecologic Oncology Clinic of Institute Rotary Cancer Hospital with locally advanced cervical cancer (FIGO stage IIB-IIIB) were enrolled. The patients were randomly allocated to treatment arms based on a computer generated random number. Arm I (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions, and weekly cisplatin $40mg/m^2$. High dose rate intra-cavitary brachytherapy (HDR-ICBT) was performed after one week of completion of external beam radiotherapy (EBRT). The prescribed dose for each session was 7Gy to point A for three insertions at one week intervals. Arm II (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions. Mention HDR-ICBT ICRT was performed after 40Gy and 7Gy was delivered to point A for three insertions (days 23, 30, 37) at one week intervals. Cisplatin $20mg/m^2/day$ was administered from D1-5 and D24-28. Overall treatment time was taken from first day of EBRT to last day of HDR brachytherapy. The overall loco-regional response rate (ORR) was determined at 3 and 6 months. Results: A total of 46 patients completed the planned treatment. The overall treatment times in arm I and arm II were $65{\pm}12$ and $48{\pm}4$ days, respectively (p=0.001). At three and six months of follow-up the ORR for arm I was 96% while that for arm II was 88%. No statistically significant difference was apparent between the two arms. The overall rate of grade ${\geq}3$ toxicity was numerically higher in arm I (n=7) than in arm II (n=4) though statistical significance was not reached. None of the predefined prognostic factors like age, performance status, baseline haemoglobin level, tumour size, lymph node involvement, stage or histopathological subtype showed any impact on outcome. Conclusions: In the setting of concurrent chemoradiotherapy a shorter treatment schedule of 48 days may be feasible by interspacing brachytherapy during external irradiation. The response rates and toxicities were comparable.
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Ajay Kumar Singh Rawat,Madan Mohan Pandey,Subha Rastogi 한국생약학회 2007 Natural Product Sciences Vol.13 No.4
costus (Falc.) Lipchitz syn S. lappato the family Asteraceae is a well known medicinal plant which finds wide usage in different indigenous systemsof medicine of India, China, Korea & Tibet. In different folk medicines the rots of S. costus are used to treatvarious disorders like ulcer, stomachache, malaria, leprosy, dysentery and toothache. However due to overexploitation, it has become endangered and has become the concern of different governmental bodies in India.The increasing demand of this endangered Himalayan species has resulted in a situation where it is oftensubstituted, knowingly or unknowingly, by other morphologically similar species. Arctium lappa, belonging to thesame family, is one such plant that has often been found to be present in the market samples of ‘Kuth’. Thepresent study was thus carried out and morphoanatomical characters, physicochemical as well as chemicalparameters were developed for proper identification of roots of S. costus and its differenciation from A. lappa aswell as authentication of the commercial market samples. The detailed morphoanatomical studies revealed thatroots of S. costus can be distinguished from A. lappa on the basis of some important microscopial characters eg.S. costus, were absent in A. lappa.. Besides, the HPTLCfingerprint profile showed a distinct band at Rf. 0.72 in S. costus, which was totally absent in A. lappa and a bandat Rf 0.64 in A. lappa which was absent in S. costus Chlorogenic acid, used as a chemical marker for HPTLCanalysis, was estimated to be 0.077% in S. costus as compared to 0.107% in A. lappa. Thus these detailedpharmacognostical parameters can be successfully used to distinguish between roots of S. costus and A. lappa.KeywordsSaussurea costus, Arctium lappa, ‘Kuth’, ‘Jangali Kuth’, Pharmacognosy, Chlorogenic acid
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