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이용록,Xin Li,이승우,용철순,Ma-Ro Hwang,류원석 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.6
A new and efficient synthetic approach is reported for biologically interesting prenylated chalcones, 4'-Omethylxanthohumol (3), xanthohumol E (4), and sericone (5) from 2,4,6-trihydroxyacetophenone. The strategies involve the introduction of a prenyl group onto an aryl ring, benzopyran formation, and basecatalyzed aldol reactions.
박영준,최한곤,Ram Kwon,Qi Zhe Quan,Dong Hoon Oh,김종오,Ma Ro Hwang,Yoon Bon Koo,우종수,Chul Soon Yong 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.5
To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability, various ibuprofen-loaded solid dispersions were prepared with water, HPMC and poloxamer. The effect of HPMC and poloxamer on aqueous solubility of ibuprofen was investigated. The dissolution and bioavailability of solid dispersion in rats were then evaluated compared to ibuprofen powder. When the amount of carrier increased with a decreased in HPMC/poloxamer ratio, the aqueous solubility of ibuprofen was elevated. The solid dispersion composed of ibuprofen/ HPMC/poloxamer at the weight ratio of 10:3:2 improved the drug solubility approximately 4 fold. It gave significantly higher initial plasma concentration, AUC and Cmax of drug than did ibuprofen powder in rats. The solid dispersion improved the bioavailability of drug about 4- fold compared to ibuprofen powder. Thus, this ibuprofen-loaded solid dispersion with water, HPMC and poloxamer was a more effective oral dosage form for improving the bioavailability of poor water-soluble ibuprofen.
Lee, Yong-Rok,Li, Xin,Lee, Seung-Woo,Yong, Chul-Soon,Hwang, Ma-Ro,Lyoo, Won-Seok Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.6
A new and efficient synthetic approach is reported for biologically interesting prenylated chalcones, 4'-Omethylxanthohumol (3), xanthohumol E (4), and sericone (5) from 2,4,6-trihydroxyacetophenone. The strategies involve the introduction of a prenyl group onto an aryl ring, benzopyran formation, and basecatalyzed aldol reactions.
Development of Clindamycin-Loaded Wound Dressing with Polyvinyl Alcohol and Sodium Alginate
Kim, Jong Oh,Choi, Jun Young,Park, Jung Kil,Kim, Jeong Hoon,Jin, Sung Giu,Chang, Sun Woo,Li, Dong Xun,Hwang, Ma-Ro,Woo, Jong Soo,Kim, Jung-Ae,Lyoo, Won Seok,Yong, Chul Soon,Choi, Han-Gon Pharmaceutical Society of Japan 2008 Biological & pharmaceutical bulletin Vol.31 No.12
<P>To develop a clindamycin-loaded wound dressing, cross-linked hydrogel films were prepared using freeze–thawing method with various mixtures of polyvinyl alcohol (PVA) and sodium alginate (SA). The physicochemical properties such as swelling ratio, tensile strength and elongation of hydrogels were evaluated. The drug release from this clindamycin-loaded hydrogel, <I>in vitro</I> protein adsorption test and <I>in vivo</I> wound healing observations in rats were then performed. Increased SA concentration decreased the gelation %, maximum strength and break elongation, but it resulted into an increment in the swelling ability, elasticity and thermal stability of hydrogel film. However, SA had insignificant effect on the release of clindamycin. This hydrogel improved the healing rate of artificial wounds in rats. Thus, a clindamycin-loaded wound dressing with PVA and SA hydrogel should be a candidate for wound care.</P>