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Rui-Le Pan,Di-Hua Chen,Jian-Yong Si,Xiao-Hong Zhao,Zhan Li,Li Cao 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Two new cyclolanostane diglycosides, cimifoetiside A (1) and cimifoetiside B (2), were isolated from an 80% ethanolic extract of the aerial part of Cimicifuga foetida L. (Ranuculaceae). Using spectral data and chemical analysis, the structures of 1 and 2 were identified as (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→3')-β-D-xylopyranoside and (23R, 24S) cimicigenol 3-O-β-D-glucopyranosyl-(1"→2')-β-D-xylopyranoside, respectively. The in vitro immunosuppressive effects of the two new compounds 1 and 2, as well as four other known cyclolanostane saponins 3-6 on T cells were evaluated. All the agents tested effectively inhibited the proliferation of murine splenocytes induced by Concanavalin A (ConA), with IC50 values ranging from 12.7 nM to 33.3 nM.
Deterministic Construction of Compressed Sensing Matrix Based on Q-Matrix
Yang Nie,Xin-Le Yu,Zhan-Xin Yang 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.10
Compressed sensing is an innovative technology, which provides a new sampling mode. The key problem in compressed sensing is the construction of sensing matrix, which has an important influence on the signal sampling and reconstruction algorithm. At present, in most cases the sensing matrix is a random structure, and is difficult to realize due to its huge storage in practical applications. In this paper, we introduce a novel deterministic construction of sensing matrix via Q-matrix, which is calculated by solving the N-queens problem. The proposed sensing matrix has good orthogonality and circularity. Using the circularity of Q-matrix, we can construct sensing matrix for compressed sensing. A large number of simulation results show that the proposed sensing matrix in this paper can obtain a better quality of the reconstructed image, and it is easily realized owing to its cyclic characteristic.
Yuze Xue,Mingwei Zhang,Le Xin,Luchao Ren,Panpan Lv,Hang Zhan,Jing He,Jiwei Zhai 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.2
0.2ZnAl2O4/0.8Ba0.5Sr0.5TiO3 ceramics with good dielectric temperature stability were synthesized by controlling sinteringbehavior. The relationship between sintering conditions, microstructure, and dielectric properties of ceramics was studied. Cubic structures were confirmed in all ceramics. Double sintering (DS) behavior can effectively improve the density, and thegrain size has no obvious change compared with non-repeated sintering. The maximum dielectric permittivity (220 at 10 kHz)and minimum leakage current (3.98×10-6 A/cm2 at 0.25 kV/cm) are obtained in the DS ceramics, which is superior to thoseof the single sintering ceramics. This can be ascribed to the higher relative density of the DS ceramics in contrast to the singlesintering ceramics. More importantly, the temperature stability of the DS sample in all samples is optimal due to the highsurface energy at grain boundaries and improved density. This work demonstrates a route to produce ceramics with weaktemperature sensitivity for microwave applications.
S100A14 Promotes the Growth and Metastasis of Hepatocellular Carcinoma
Zhao, Fu-Tao,Jia, Zhan-Sheng,Yang, Qun,Song, Le,Jiang, Xiao-Jing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Background: S100A14 has recently been implicated in the progress of several types of cancers. This study aimed to investigate the clinical significance and possible mechanisms of action of S100A14 in the invasion and metastasis of hepatocellular carcinoma (HCC). Methods: S100A14 expression in HCC was detected at mRNA and protein levels and its prognostic significance was assessed. Functional roles of S100A14 in HCC were investigated using MTT, BrdU, wound healing, transwell invasion assay and HCC metastatic mouse model. Results: S100A14 was significantly elevated in HCC tissues, correlated with multiple tumor nodes, high Edmondson-Steiner grade and vascular invasion. Multivariate Cox analysis showed that the S100A14 expression level was a significant and independent prognostic factor for overall survival (OS) of HCC patients (hazard ratio=1.98, 95% confidence interval=1.14-3.46, P=0.013). S100A14 promoted cell proliferation, invasion and metastasis of HCC in vitro and in vivo. Conclusion: These results suggest S100A14 is a novel prognostic marker and therapeutic target for HCC.
A Interlaced Filling Algorithm in Deterministic Constructing Compressed Sensing Matrix
Yang Nie,Xin-Le Yu,Zhan-Xin Yang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.10
The sensing matrix has an important influence on the original signal sampling and reconstruction algorithm in the compressed sensing theory. A complete random sensing matrix has the drawbacks of large storage and high complexity in its implementation. In this paper, we propose an interlaced filling algorithm to construct the sensing matrix, which has a quasi-cyclic structure for efficient hardware implementation. The new sensing matrix has small coherence, which provides assurance for the recovery of sparse signal. Meanwhile, some experimental comparison with the other sensing matrix is accomplished. The simulation results demonstrate that the proposed sensing matrix not only obtains better performance but also owns easy hardware implementation.
Effects of Temperature and Additives on the Thermal Stability of Glucoamylase from Aspergillus niger
( Yang Liu ),( Zhaoli Meng ),( Ruilin Shi ),( Le Zhan ),( Wei Hu ),( Hongyu Xiang ),( Qiuhong Xie ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.1
GAM-1 and GAM-2, two themostable glucoamylases from Aspergillus niger B-30, possess different molecular masses, glycosylation, and thermal stability. In the present study, the effects of additives on the thermal inactivation of GAM-1 and GAM-2 were investigated. The half-lives of GAM-1 and GAM-2 at 70ºC were 45 and 216 min, respectively. Data obtained from fluorescence spectroscopy, circular dichroism spectroscopy, UV absorption spectroscopy, and dynamic light scattering demonstrated that during the thermal inactivation progress, combined with the loss of the helical structure and a majority of the tertiary structure, tryptophan residues were partially exposed and further led to glucoamylases aggregating. The thermal stability of GAM-1 and GAM-2 was largely improved in the presence of sorbitol and trehalose. Results from spectroscopy and Native-PAGE confirmed that sorbitol and trehalose maintained the native state of glucoamylases and prevented their thermal aggregation. The loss of hydrophobic bonding and helical structure was responsible for the decrease of glucoamylase activity. Additionally, sorbitol and trehalose significantly increased the substrate affinity and catalytic efficiency of the two glucoamylases. Our results display an insight into the thermal inactivation of glucoamylases and provide an important base for industrial applications of the thermally stable glucoamylases.