Correlation between skeletal and dental changes after mandibular setback surgery-first orthodontic treatment

Chang-Hoon Rhee,Youn-Kyung Choi,Yong-Il Kim,Seong-Sik Kim,Soo-Byung Park,Woo-Sung Son 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.2

Objective: To investigate skeletal and dental changes after application of a mandibular setback surgery-first orthodontic treatment approach in cases of skeletal Class III malocclusion. Methods: A retrospective study of 34 patients (23 men, 11 women; mean age, 26.2 ± 6.6 years) with skeletal Class III deformities, who underwent surgery-first orthodontic treatment, was conducted. Skeletal landmarks in the maxilla and mandible at three time points, pre-treatment (T0), immediate-postoperative (T1), and post-treatment (T2), were analyzed using cone-beam computed tomography (CBCT)-generated half-cephalograms. Results: The significant T0 to T1 mandibular changes occurred ?9.24 ± 3.97 mm horizontally. From T1 to T2, the mandible tended to move forward 1.22 ± 2.02 mm, while the condylar position (Cd to Po-perpendicular plane) shifted backward, and the coronoid process (Cp to FH plane) moved vertically. Between T1 and T2, the vertical dimension changed significantly (p < 0.05). Changes in the vertical dimension were significantly correlated to T1 to T2 changes in the Cd to Po-perpendicular plane (r = ?0.671, p = 0.034), and in the Cp to FH plane (r = 0.733, p = 0.016), as well as to T0 to T1 changes in the Cp to Poperpendicular plane (r = 0.758, p = 0.011). Conclusions: Greater alterations in the vertical dimension caused larger post-treatment (T2) stage skeletal changes. Studying the mandibular position in relation to the post-surgical vertical dimension emphasized the integral importance of vertical dimension control and proximal segment management to the success of surgery-first orthodontic treatment.

Brain SPECT 영상의 Attenuation Correction 방법들에 대한 비교

조진우,김창호,나수경,이귀원,Jo, Jin U,Kim, Chang Ho,Na, Soo Kyung,Lee, Gui Won 대한핵의학기술학회 2012 핵의학 기술 Vol.16 No.2

이 연구의 목적은 Brain SPECT (Single Photon Emission Computed Tomography)의 Non-attenuation correction (AC-non) 영상에 대한 attenuation correction(AC) 방법 중 Chang's method와 CT based attenuation correction(AC-CT) 사이의 count를 비교하기 위함이다. phantom study는 증류수로 채워진 hoffman 3D phantom에 $^{99m}Tc$ 37Mbq을 투여하였고, patient study는 normal volunteer에 $^{99m}Tc$-HMPAO 750Mbq를 정맥주입하고 Siemens사의 Symbia T6로 Brain SPECT 영상을 획득하였고 뇌 정량 분석을 하였다. 각각의 방법들을 적용한 transverse image는 같은 위치에서 재구성 되었으며 각각 10, 20, 30번째 slice에서 6개의 region of interest(ROI)를 그려 AC-non 과 AC-CT 그리고 Chang's method의 count를 비교하였다. phantom study에서 AC-non, AC-CT, Chang's method의 각각 평균 count는 $4606.8{\pm}511.3$, $16794.6{\pm}2429.4$, $8752.6{\pm}896.5$이었으며 patient study에서 $5460.8{\pm}519.6$, $15320{\pm}1171.6$, $12795{\pm}1422.1$이었다. phantom study에서 AC-CT와 AC-non 사이의 비는 3.70이고 Chang's method와 AC-non 사이의 비는 1.92였으며 patient study에서는 각각 2.85, 2.38이었다. 우리는 이 연구를 통하여 AC-CT가 Chang's method보다 더 높은 AC을 해준다는 걸 알 수 있었다. 그리고 Chang's method는 patient study에서의 AC 값이 phantom study에서의 AC값보다 더 높다는 것을 알 수 있었다. brain SPECT/CT를 시행하는 경우 scatter correction을 같이 시행하고 bone에 의한 감쇠 정보를 반영할 수 있는 AC-CT가 chang's method보다 정확하다 할 수 있겠다. Purpose : The purpose of this study was to compare count between Chang's method and CT-based attenuation correction (AC-CT) among the attenuation correction (AC) methods for non-attenuation correction (AC-non) images of Brain SPECT (Single Photon Emission Computed Tomography). Materials and Methods : We injected $^{99m}Tc$ 37Mbq in a Hoffman 3D phantom filled with distilled water in the phantom study, and injected intravenously $^{99m}Tc$-HMPAO 740Mbq in a normal volunteer in the patient study, and then obtained Brain SPECT images with Symbia T6 of Siemens and conducted quantitative brain analysis. Transverse images to which each method was applied were rebuilt at the same position, and 6 regions of interest (ROI) were drawn on each of Slice No. 10, 20 and 30 and then the counts of AC-non, AC-CT and Chang's method were compared. Results : The mean counts of AC-non, AC-CT and Chang's method were $4606.8{\pm}511.3$, $16794.6{\pm}2429.4$, and $8752.6{\pm}896.5$, respectively, in the phantom study and $5460.8{\pm}519.6$, $15320{\pm}1171.6$ and $12795{\pm}1422.1$, respectively, in the patient study. In the phantom study, the ratio of AC-CT to AC-non was 3.70 and the ratio of Chang's method to AC-non was 1.92, and in the patient study, they were 2.85 and 2.38, respectively. Conclusion : From this study, we found that AC-CT makes higher AC than Chang's method. In addition, when Chang's method was used, AC in the patient study was higher than that in the phantom study. These results need to be considered also in other examinations.

Effect of Total Hip Arthroplasty on Ipsilateral Lower Limb Alignment and Knee Joint Space Width: Minimum 5-Year Follow-up

Choi Yun Seong,Park Jung-Wee,Kim Tae Woo,Kang Kee Soo,Lee Young-Kyun,Koo Kyung-Hoi,Chang Chong Bum 대한의학회 2023 Journal of Korean medical science Vol.38 No.20

Background: This study aimed to 1) assess the effect of total hip arthroplasty (THA) on coronal limb alignment, namely, the hip–knee–ankle angle (HKA), 2) identify factors that determine changes in the HKA, and 3) determine whether alignment changes influence the knee joint space width. Methods: We retrospectively evaluated 266 limbs of patients who underwent THA. Three types of prostheses with neck shaft angles (NSAs) of 132°, 135°, and 138° were used. Several radiographic parameters were measured in the preoperative and final radiographs (at least 5 years after THA). A paired t-test was used to confirm the effect of THA on HKA change. Multiple regression analysis was performed to identify radiographic parameters related to HKA changes following THA and changes in knee joint space width. Subgroup analyses were performed to reveal the effect of NSA change on the HKA change, and the proportion of total knee arthroplasty usage and changes in radiographic parameters between maintained joint space and narrowed joint space groups were compared. Results: The preoperative mean HKA was 1.4° varus and increased to 2.7° varus after THA. This change was related to changes in the NSA, lateral distal femoral angle, and femoral bowing angle. In particular, in the group with a decrease in NSA of > 5°, the preoperative mean HKA was largely changed from 1.4° varus to 4.6° varus after THA. The prostheses with NSA of 132° and 135° also led to greater varus HKA changes than those with an NSA of 138°. Narrowing of the medial knee joint space was related to changes in the varus direction of the HKA, decrease in NSA, increase in femoral offset. Conclusion: A large reduction in NSA can lead to considerable varus limb alignment after THA, which can have adverse effects on the medial compartment of the ipsilateral knee.

무증상 갑상선기능저하증 환자에서 Thyroxine 치료에 따른 혈청 지질 및 아포지단백의 변화

조보연,신찬수,김원배,고창순,김성연,박혜영,박건상,이홍규,박형규,김숙경 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.1

Background: Subclinical hypothyroidism(SCH) is a common biochemical abnormality which can be found in routine screening tests of thyroid function. We are increasingly faced with the question of whether its an indication for thyroxine replacement therapy. The effect of thyroxine replacement on lipid profile in SCH has aroused a great interest because of an association of overt hypothyroidism(OVH) with hyperlipidemia and increased risk of coronary artery disease. Method: We prospectively evaluated the changes in lipids and apoproteins before and after thyroxine replacement therapy in 23 patients with SCH and in 37 patients with OVH. We measured serum total cholesterol and triglyceride using autoanalyzer, high density lipoprotein(HDL) chole-sterol by dextran sulfate method, Apo A1 and Apo B by immunonephelometric assay. Results: Thyroxine replacement therapy significantly decreased total cholesterol, low density lipoprotein(LDL) cholesterol and apo B levels, but did not affect the level of triglyceride, HDL cholesterol or apo AI in patients with OVH. In SCH, thyroxine replacement therapy with the doses to normalize serum TSH concentrations also decreased significantly the level of cholesterol and LDL cholesterol albeit apo B levels did not change. Moreover, in most of patients with OVH (11 of 12) and in all of patients with SCH(5 of 5) who had had hyperchlesterolemia before treatment, thyroxine replament normalized their cholesterol and LDL cholesterol levels. Conclusion: In regard to the beneficial changes in blood lipid levels, patients with SCH should be treated, especially in cases who have other risk factors for the development of atherosclerosis. If thyroxine replacement only will reduce the incidence of coronary artery disease in SCH remains to be elucidated by long-term prospective studies(J Kor Soc Endocrinol 11:41-51, 1996).

생약제제인 이공산(異功散)의 Cisplatin 유도 신장독성 보호 및 항산화 효과

Lee, Kyung-Tae,Ahn, Kyoo-Seok,Chang, Sung-Goo,Oh, Soo-Myung,Jung, Jee-Chang 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung-Tae Lee, Kyoo-Seok Ahn¹, Sung-Goo Chang², Soo-Myung Oh²and Jee-Chang Jung²¹College of Pharmacy, ²Oriental Medicine and ³College of Medicine, and East-West Medical Reserch Institute, Kyung Hee University, Seoul, Korea. Preventive and Antioxidative Effects of Crude Drug Preparation(E-kong-san) on Cisplatin Induced Nephrotoxicity. Proceedings of International Symposium on East-West Medicine, Seoul. 201-211, 1999. -Nephroprotective effects of a crude drug-prearation (E-kong-san) were determined from cisplatin on rabbit kidney proximal tubule and human renal cortical cells by MTT assays and sustained glucose consumption on ciplatin-induced human renal cortical tissue. Levels of creatinine and blood ure nitrogen(BUN) in serum after administration of cisplatin(0.75mg/kg,i.p.) to E-kong-san(0.75g/kg/day,p.o.)-pretreated rats were markedly lower compared to those of cisplatin-treated rats. Moreover, the administration of E-kong-san significantly inhibited the loss of body weight of cisplatin injected rts. These findings suggest that E-kong-san on the cisplatin induced nephrotoxicity led us to investigate whether the effect of this water extract was a result of anti-oxidation. E-kong-san showed strong free radical scavenger activities on 1,1-dipheny1-2picrylhydrazil(DPPH) radical and xanthine/xanthine oxidase(XOD) generated superoxide anion radical(O2-). We further studied the effects of E-kong-san on lipid peroxidation in rat liver microsomes induced by enzymatic and nonenzymatic methods. E-kong-san exhibited significant inhibition on both ascorbic acid/Fe2+and ADP/NADPH/Fe3+ induced lipid peroxidation in rat liver microsomes. Based on these results, we suggest that-E-kong-san attenuate the cisplatin induced cytotoxicity and its mechanism can be eplained by antioxidant.

Fluoxetine과 Haloperidol의 병합투여시 정신병리 및 추체외로 증상의 변화

이민수,한창수,김제원,원경식,곽동일,Lee, Min-Soo,Han, Chang-Su,Kim, Jae-Won,Won, Kyung-Sik,Kwak, Dong-Il 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

본 연구는 정신분열증 환자 38명을 대상으로 하여 haloperidol과 fluoxetine을 8주간 병합투여 하였고, PANSS, CGI, Simpson-Angus 척도를 투여전과 투여후 2, 4, 6, 8주에 시행하여 임상증상 및 추체외로 부작용을 평가하였다. 결과는 다음과 같다. 1) 8주간의 연구기간동안 양성, 음성증상의 유의한 변화가 없었다. 2) 8주의 연구기간동안 추체외로 부작용의 증가가 나타나지 않았다. 이는 기존 연구에서 fluoxetine에 의해 haloperidol의 혈중농도가 증가하여 효과 및 부작용이 증가한다는 연구보고와는 다르며, 이 결과는 haloperidol과 fluoxetine의 병합사용을 안전하게 할 수 있다는 것을 의미한다고 하겠다. Objectives : The authors have intended to know the drug interaction of fluoxetine and haloperidol when coadministering two drugs to the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. Method : We selected 38 patients, the chronic schizophrenics with no physical problems. they are randomly assigned to placebo group and drug group. And then, placebo or fluoxetine 20mg were administered to the subjects of each group during 8 week period. We have assessed their psychopatholgy and extrapyramidal symptoms using Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), Simpson-Angus Scale at 0, 2, 4, 6, 8 week during the period. Results : 38 patients have completed the study during 8 weeks. 1) PANSS, CGI : no significant difference between groups and no significant change according to the times. 2) Simpson-Angus Scale : no significant changes. Conclusion : When co-administering fluoxetine and haloperidol, there were no significant changes of psychopathology and extrapyramidal symptoms. These results suggest that it is safe to coadminister fluoxetine to schizophrenic patients with haloperidol treatmemt.

측두하악장애 치료 후 하악 안정위의 고경 변화에 관한 연구

김창현,한경수 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.3

This study was performed to investigate the change of the mandibular vertical dimension, especially at the several rest positions, induced by speech and swallowing after treatment of temporomandibular disorders and to compare the vertical dimemion among those several mandibular rest positions. Thirty patients with temporomandibular disordem participated in this study, and the mean follow-up period after the first visit was 9.7 months. Clinical parameters related to pain, mandibular mobility, occlusion, and parafunction were examined. Subjects were asked to sit upright with relaxed natural head posture and then the two mandibular movements were performed, and recorded with BioEGN of Biopak system(Bioresearch Inc., Milwaukee, USA). A sentence of 'Sue is missing her house' was used to record the speech pattern. The positions observed and named in speech movement were rest, 'ssi', 'her', 'ha', and 's' position, and in swallowing movement were rest before swallowing, swallowing-early, swallowing-late, 0.5 sec. after swallowing, and rest after swallowing. Data obtained were processed and analysed by SPSS windows(ver. 10.0) program, and the results of this study were as follows: The mandibular positions showing vertical difference between before and after treatment were 'her', 'ha', and 's' in speech, and were swallowing-late, 0.5 sec. after swallowing, and rest after swallowing in swallowing. All these positions were located in the late half of the movements and the vertical dimension of rest positions in swallowing were increased after treatment. Rest positions in both of the movements did not show any significant difference for the vertical distance from habitual intercuspal position among them before treatment, however, which were changed and allowed differentiation after treatment. The vertical dimension of rest positions ranged 1.0-2.5mm in both of the movements. The ratio of the maximum opening range at the swallowing-late position in swallowing movement to the maximum Opening range at the 'ha' position in speech before and after treatment were 31% and 36%, respectively. Correlation between the vertical dimension of rest positions and the clinical maximum opening range were significantly negative at the 'mi' and 's' position only in speech movement before treatment. In conclusion, it was not easy to decide which position of all the mandibular positions observed in speech and in swallowing was the optimal mandibular rest position. However, the author suggested that the optimal mandibular rest position could be induced by and after swallowing movement.

오징어젓 숙성 중 N-nitrosamine 생성에 관한 연구

오창경,김수현,송대진,오명철,김성수 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.1

본 연구는 오징어에 식염 20%를 첨가하는 고식염구와 식염 10%에 솔비톨, 에탄올, 젖산 등을 첨가한 저식염구로 나누어 오징어젓을 제조한 후, 이들을 숙성시키면서 N-nitrosamine의 생성 여부와 숙성 중 그의 전구물질인 아질산염과 질산염, DMA 및 TMA와 TMAO의 변화를 검토하였다. 오징어젓 숙성 중 pH는 저식염구가 5.79∼6.07, 고식염구가 6.05∼6.21 사이에서 변화하였다. 아질산염질소와 질산염질소는 각각 0.75∼1.04mg/kg 및 1.22∼1.42mg/kg 사이에서 변화하였다. TMA-N는 숙성 중 계속하여 증가하여 숙성 140일에는 고식염구가 20.1mg%, 저식염구가 14.9mg%였으며, TMAO-N는 생시료에서 27.9mg%이었던 것이 숙성 중기까지 완만하게 증가하다가 그 이후에는 다시 감소하였다. DMA-N는 숙성 중 계속하여 증가하였으며 숙성 140일에는 고식염구는 19.7mg/kr, 저식염구는 13.3mg/kg이었다. 오징어젓의 N-nitrosamine으로는 NDMA만이 검출되었고, 숙성 40일째에 저식염구에 흔적량, 고식염구에 3.8㎍/kg의 양으로 생성되었으며 숙성 중 계속해서 증가하여 57.5∼74.7㎍/kg에 이르렀다. Possibility of formation of carcinogenic N-nitrosamines and changes in their precursors during the fermentation of high salt-fermented squeid, Sepiell maindroni, group with 20% of salt and low salt-fermented squid group with 10% of salt, 6% of ethanol, 6% of sorbitol and 0.5% of lactic acid were investigated. pH during the fermentation of squid changed in the ranges of 5.79∼6.07 and 6.05∼6.21 in low and high salt group, respectively. The contents of nitrite- and nitrate-N during the fermentation were in the ranges 0.75∼1.04 and 1.22∼1.42mg/kg, respectively. Trimethylamine(TMA) was continuously increased during the fermentation and showed 20.1 and 14.9mg% in high and low salt group after 140 days of the fermentation, respectively, while trimethylamine oxide(TMAO) was gradually increased from the beginning until the middle period of fermentation and then was again decreased. Dimethylamine(DMA) was continuously increased during the fermentation and showed 19.7 and 13.3mg/kg in high and low salt group after 140 days of the fermentation, respectively. N-nitrosamines in salt-fermented squid was detected only N-nitrosodimethylamine(NDMA), which its amount was trace in low salt group and 3.8㎍/kg in high salt group on 40 days of the fermentation and then continuously increased in the ranges of 57.5∼74.7㎍/kg in both groups during the fermentation.

오징어젓 숙성 중 제4급 암모늄 화합물의 변화

김성수,오창경,오명철,송대진,김수현 濟州大學校 産業技術硏究所 1996 산업기술연구소논문집 Vol.7 No.1

The changes in precursors of N-nitrosarnines, such as choline-N, betaine-N and total creatinine-N, during the fermentation of high salt-fermented squid, sepiell maindroni, group with 20% of salt and low salt-fermented squid group with 10% of salt, 6% of ethanol, 6% of sorbitol and 0.5% of lactic acid were investigated. During the fermentation, the contents of VBN were rapidly increased from the beginning of the fermentation until 140 days, and these contents were more in high salt groups as compared with low salt groups. The contents of choline-N were little changed until 80 days of the fermentation and slowly decreased after 80 days of the fermentation to 120 days, but the different of the contents between both salt groups were little. Betaine-N also showed the similar tendency to choline-N, but the changes in low salt groups were slowly increased and decreased as compared with these in high salt group. Total creatinine-N was slowly increased from the beginning of the fermentation until 60 days in both salt groups, but rapidly decreased after this to 120 day.

고등어 염장중 N-Nitrosodimethylamine 생성 및 그 전구물질들의 변화

金洙賢,吳昌璟 제주대학교 1993 논문집 Vol.36 No.-

여러 식품에서 아질산염과 제2급 및 제3급 아민 또는 제4급 암모니윰 화합물과의 상호작용에 의해 형성 되어지는 N-nitrosamine은 상당한 관심의 대상이 되고 있다. 본 연구는 5℃에 저장된 염장고등어에서 발암성 N-nitrosamine의 생성과 이의 전구물질인 DMA-N, TMA-N, betaine-N choline-N 및 총 creatinine의 변화를 10일 주기로 조사하였다. 또한, Ames의 표준평판 혼성시험법의 변법인 예비배양법을 이용하여 NDMA의 돌연변이유발 활성을 검정하였다. 본 연구에서 얻은 결과를 요약하면 다음과 같다. 1) pH는 10% 및 20% 염장품이 각각 5.62-5.73과 5.68-5.93으로 N-nitrosamine 생성 최적 pH보다 높은 범위에서 변화하였다. 수분은 생시료에 비해 훨씬 낮은 양으로 변화하였다. 수분은 생시료에 비해 훨씬 낮은 양으로 변화하였다. 염도는 각각 저장 20일 경과후에 5.7 및 11.4%이었고, 이 후 서서히 증가하여 저장 말기에는 각각 7% 및 13%의 염분침투가 이루어 졌다. V.B.N.은 저장초기에 급격히 증가하였으며 전반적으로 V.B.N.은 10%가 20% 염장품보다 약간 높은 함량 변화를 보였으나, 어류의 초기 부패치인 30mg/100g을 초과하지 않은 것으로 보아 저장기간 전반에 걸쳐 부패가 진행되지 않았음을 알 수 있었다. 2) 총 creatinine-N과 betaine-N 등의 제4급 암모니윰 화합물은 저장 중기에 상당히 증가하였으나, 저장 중기 이후에는 감소한 반면, cholone-N는 저장중에 조금씩 계속 증가하였다. 3) TMAO-N와 TMA-N 함량은 저장 초기에 변화가 심하였으나, 대체적으로 TMAO-N는 증가하고 TMA-N는 감소하는 역상관관계를 보였다. 4) DMA-N 함량은 저장중에 계속 증가하였으며, 10%과 20% 염장품간의 차이는 거의 없었다. 5) NDMA는 10% 및 20% 염장품이 각각 저장 20일 및 30일 경과시부터 검출되었으며 그 함량은 극히 낮았다. 반면, 아질산염 첨가구의 경우, 비첨가구 보다 약 500배 낮은 함량 변화를 보였으며, 대체적으로 저장기간중에 조금씩 증가하였다. 6) 돌연변이유발 활성은 plate당 1㎍(10ppm)의 NDMA를 첨가한 TA100 균주에서 가장 높게 나타났다. 결론적으로, 고등어 염장중 NDMA 생성 가능성은 아질산염과 DMA간의 상호작용에 의해서는 물론, 아질산염과 제3급 amine 및 제4급 ammonium염과의 상호작용에 의해 영향을 받으며, 저염 및 고염 염장품의 차이는 거의 없는 것으로 나타나기 때문에 저염고등어 제법을 개발하였을 때 NDMA 생성과는 무관하다고 판단되었다. NDMA의 돌연변이유발 활성은 10-100ppm의 농도에서 나타났다. The possibility of formation of carcinogenic N-nitrosodimethylamine and changes of their precursors in salted mackerel, Scomber japonicus, stored at 5℃ were periodically investigated, and changes of precursors between low (10%) and high (20%) salted mackerel was compared. The results were as follow; 1) Changes of pH were in the ranges of 5.62-5.73 and 5.68-5.93 in 10% and 20% salted mackerel during their storage, respectively. 2) Moisture changes in very low contents in compared with fresh sample. 3) Salinity gradually increased in low and high salted mackerel and salt permiation of 7 percent and 13 percent was accomplished during storage of both groups, respectively. 4) The contents of total creatinine and betaine remarckably increased at the middle of storage, while choline contents was scarcely changed. 5) The contents of trimethylamine oxide and trimethylamine severely varied at the beginning of storage. Changes of contents between TMAO and TMA showed, apparently, reverse relationship. 6) The contents of dimethylamine showed nearly same increasing pattern and continuously increased during storage in both groups. 7) In the low salted mackerel, N-nitrosodimethylamine was detected from 20 days of storage, while in the high salted mackerel, it was detected from 30 day of storage. In both salted mackerel added sodium nitrite, the contents of NDMA were more 500 times than those in both salted mackerel without sodium nitrite. In conclusion, it was found by this study that the possibility of formation of NDMA might be affected not only by the interaction between nitrite and DMA but also by the interaction between nitrite and TMA, TMAO, choline, betaine, and creatinine in salted mackerel during storage. No difference of the contents of precursors and NDMA between both Samples(10% & 20% NaCl) was nearly.