Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Yong Soon Kim,Min Won Baek,Jae Hyuck Sung,Hyun Youl Ryu,Jin Sik Kim,Hyun Sun Cho,Byung Gil Choi,Min Sub Song,Moon Yong Song,Eun Ju Baik,Young Kuk Choi,Jong Kyu Kim,Il Je Yu,Kyung Seuk Song 한국독성학회 2009 Toxicological Research Vol.25 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 ㎎/㎏ body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 ㎎/㎏ body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 ㎎/㎏ body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Kim, Yong-Soon,Baek, Min-Won,Sung, Jae-Hyuck,Ryu, Hyun-Youl,Kim, Jin-Sik,Cho, Hyun-Sun,Choi, Byung-Gil,Song, Min-Sub,Song, Moon-Yong,Baik, Eun-Ju,Choi, Young-Kuk,Kim, Jong-Kyu,Yu, Il-Je,Song, Kyung-Se Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

초등학생용 진로성숙도 검사 개발 및 타당화

송인섭 ( In Sub Song ),정미경 ( Mi Kyung Chung ),김효원 ( Hyo Won Kim ),최영미 ( Young Mi Choi ) 한국아동교육학회 2011 아동교육 Vol.20 No.3

본 연구는 초등학교 고학년을 대상으로 발달계에서 주어지는 진로문제들에 대해 대처할 수 있는 준비도인 진로성숙도를 측정할 수 있는 검사를 개발하고 타당화하는 데 그 목적이 있다. 이를 위해 먼저, 국내·와 진로성숙도에 대한 각종 논문과 이론을 참고하여 진로성숙도를 개념화하고 관련 검사 문항들을 검토하여 문항을 개발하였다. 예비검사와 타당화 과정을 거쳐 총 78문항을 선정하고 요인분석과 문항난이도, 문항변별도 등을 구하여 검사를 타당화하였다. 그 결과 태도검사의 문항들이 .30 이상의 단일요인 부하량을 나타내어 각 척도가 단일성 요인임을 설명해주고 있으며 능력검사의 신뢰도는 Cronbach α계수 .52~.86으로 나타났다. 계획성 요인의 경우 .52로 일반적인 신뢰도 기준에는 낮은 신뢰도로 판단되나 진위형 척도의 특성상 신뢰도가 낮게 추정된 것으로 보인다. 그 이외의 하위용인에서는 적절한 신뢰도를 나타내었다. 그리고 진로성숙도의 내적 구조를 분석한 결과 진로성숙도의 구조는 진로에 대한 능력과 태도로 구성되며, 태도는 결정성, 독립성, 계획성으로, 능력은 직업이해. 직업선택, 그리고 직업성으로 구성된 모형이 적합함을 알 수 있었다. 본 연구는 지로성숙도를 측정하기 위해 Crites의 CMI모형을 근간으로 측정요인을 선정하고 초등학생에 맞는 연구모형을 재정립하였다는 점에서 이론적 의의가 있으며, 연구의 특성에 적합한 접근 방법으로 도구를 타당화하였다는 점에서 방법론적 의의가 있다. 그리고 아동이 진로를 선택하는 데 있어서 어떠한 정의적 태도와 지적 사고를 가지고 있는가에 대한 정보를 제공함으로써 자신에 대한 이해와 직업에 대한 이해를 바탕으로 올바른 진로선택을 할 수 있도록 도울 수 있으며 진로교육과 관련된 프로그램을 개발하는 데 기초자료로 활용될 수 있다는 점에서 실제적인 의의가 있다. The purpose of this study is 1) to define the concept of the career maturity: 2) to develop and validate the scale of career maturity for elementary school students. In order to answer these purposes, we first reviewed related documents and inventories, as to research the constructed factors which to develop an career maturity scale, then defined the concept of career maturity and the theological constructive model. The were included in 2 components of attitude and cognitive abilities for career maturity accordingly in 6 sub-components 195 elementary school students were analysed at pilot test and 1010 students were conducted final test. Based on factor analysis and item analysis, 77 items were selected to final test items. And this scale was validated through the evidence based on internal structure. Significance, limitations, and future research directions were discussed.

사람 태아간의 산호성 과립백혈구형성에서 산호성 과립형성에 대한 미세구조 연구

송재섭,김경용,이원복,김동창 중앙대학교 의과대학 의과학연구소 1992 中央醫大誌 Vol.17 No.4

The developmental processes of eosinophilic granule formation were ultrastructural investigation of eosinophilic granulopoiesis in 15 cases of human fetal livers from 8 to 34 weeks of gestation. 1) Numerous vesicles, microgranules and small agranular and granular vacuoles were distributed around the distended Golgi apparatus in myeloblast and eosinophilic promyelocyte. 2) Granular matrix of vacuoles contained small granular vacuoles, serveral vesicles and mutilamellar structures. The granular substance exhibited higher electron density than that of cystic rough endoplasmic reticulum(RER) and was similar partly to that of immature eosinophilic granules. 3) Distended cystic RER was fused to produce matrix of maturing granules with granular vacuoles and immature eosinophilic granules. 4) Immature eosinophilic granule which began to be produced in eosinophilic promyelocyte, had myelin sheath-like structure and debris of vesicles and granular vacuoles and those disappeared immediately. The charicteristic crystalloid inclusions began to develop in immature eosinophilic granule of myelocyte. In summary, it is suggested that vesicles and granular vacuoles as well as RER in the myelocyte and promyelcyte are participating in the formation of immature eosinophilic granules which become mature with the appearance of charicteristic crystalloid inclusion

溫胞散이 생쥐의 排卵과 受精卵 生産率 및 發達率에 미치는 影響

宋炳基,李京燮,李鎭武 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

In order to study the effect or Onposan applied to sterile women, a series of expriments were conducted on the mice regarding the in vitro developmental effect of mouse embryos of the medium of Onposan, the ovulation of normal ovum, the production rate of embryos in mice, the in vitro developmental effect of mouse embryos, the level of serum of LH, FSH, Estradiol 17-β, Progesterone in mice, after administered the drug orally. The results were as follows. 1. The culture medium of the drug was not significantly the in vitro developmental effect of mouse embryos. 2. The ovulation or normal ovum was significantly increased after continuous the drug administered. 3. The production rate of embryos in mice was significantly increased after the drug administered. 4. The in vitro developmental effect of mouse embryos was significantly increased after the drug administered. 5. The levels of serum LH and FSH in mice were not significantly increased after the drug administered. 6. The levels of serum Estradiol 17-β in mice was few increased in a very small amount, but was not significantly. 7. The levels of serum Progesterone in mice was significantly increased after the drug administered.

귀출파징탕藥鍼의 抗血栓, 抗炎症, 鎭通 및 抗酸化效果

宋炳基,李京燮,宋銀姬 慶熙大學校韓醫科大學韓醫學硏究所 1999 慶熙韓醫大論文集 Vol.22 No.1

This study was projected to investigate the effects of Kwuichulpajing-tang aqua-acupuncture solution manufactured by water-alcohol method. In vivo, to observe the anticoagulative, antiinflammatory and analgesic effects of Kwuichulpajing-tang aqua-acupuncture at Kwanwon(CV4), the experimental animals were divided into a normal, control and two experimental groups. Each of them had 6 animals. As the normal group was untreated, the control group was injected with normal saline(0.1㎖/100g) at Kwanwon(CV4) s.c., and then injected with induction medicine. One of the experimental groups (Sample I group) was injected with 25.0 ㎎/㎖ Kwuichulpajing-tang aqua-acupuncture solution(0.1㎖/100g) at Kwanwon (CV4) s.c., and then injected with induction medicine. The other experimental group(SampleⅡgroup) was injected with 50.0 ㎎/㎖ Kwuichulpajing-tang aqua-acupuncture solution (0.1㎖/100g) at Kwanwon(CV4) s.c., and then injected with induction medicine. The results of the experimental groups were compared with that of the control group. In vitro, the effects of Kwuichulpajing-tang aqua-acupuncture solution on hyaluronidase activity, hydrolysis of casein by trypsin, heat-induced hemolysis and the antioxidative effect were observed. The results were as follows : 1. The effects of Kwuichulpajing-tang aqua-acupuncture at Kwanwon on the intravascular coagulation in rats induced by endotoxin(0.5㎎/㎏) i.v. were that the blood platelet and white blood cell counts were significantly increased in both experimental groups. the blood fibrinogen content was significantly increased in SampleⅡgroup and the prothrombin, the activated partial thromboplastin and thrombin times were significantly shortened in both experimental groups. 2. The carrageenin-induced mice paw edema was significantly decreased in both experimental groups. 3. The histamine-induced mice paw edema was significantly decreased in both experimental groups. 4. The histamine-induced vascular permeability was significantly decreased in SampleⅡgroup. 5. The writhing syndrome induced by acetic acid was significantly decreased in SampleⅡgroup. 6. The response time of mice on 70℃ heat plate was significantly prolonged in SampleⅡgroup. 7. The hypnotic duration induced by pentobarbital-Na was significantly increased in both experimental groups. 8. Kwuichulpajing-tang aqua-acupuncture solution had antioxidative effect and inhibited hyaluronidase activity, trypsin activity on hydrolysis of casein and heat-induced hemolysis in vitro.

배기 저항의 능동제어를 통한 배기 시스템의 최적화에 관한 연구

임경빈,류봉조,이규섭,김상덕,송시영,이상훈 한밭대학교 생산기반기술연구소 2002 생산기반기술연구소 논문집 Vol.2 No.1

Automobile exhaust system has difficulty in concentrating contrary technology, which has diminishing effect of maximum exhaust noises and mininum exhaust pressure for output efficiency improvement into on system. This thesis has the purpose in management of basis study for silence and output efficiency improvement which can be satisfy low noises and low exhaust pressure at the same time through maximizing engine efficiency dealing with activity as the condition of engine controlling exhaust impedance actively. In this thesis, we obtained positive result by making experiment high efficiency exhaust induced shaped silencer in order to satisfy contrary matters which device the improvement of engine efficiency and low perception of exhaust noises at the same time. That is, we proved that it has more excellent in low perceiving noises of exhaust system and output improving efficiency than existing muffler by active controlling the exhaust impedance.

牧丹皮 玄胡索이 姙娠에 미치는 影響

裵恩敬,李京燮,宋炳基 慶熙大學校韓醫科大學韓醫學硏究所 1995 慶熙韓醫大論文集 Vol.18 No.2

It is acknowledged that Moutan cortex radicis and Corydalis tuber are contraindicated drugs of pregnancy. The present work was done to investigate the influences of Moutan cortex radicis and Corydalis tuber on pregnancy. The extracted and condenced liquid of Moutan cortex radicis and Corydalis tuber were administered to experimental animals and the influences were evaluated on pregnant maintenance, corpus lutein functions and toxic action of kidney and liver during pregnancy. The results of this work were summerized as follows: 1. For white pregnant rats, Moutan cortex radicis showed insignificant decrease of the fertilized eggs while Corydalis tuber showed insignificant increase of the fertilized eggs as the pregnant days pass by. 2. For false pregnant rabbits, Moutan cortex radicis and Corydalis tuber showed significant decrease of HCG. 3. For white pregnant rats, Moutan cortex radicis and Corydalis tuber showed insignificant decrease of GOT, GPT and ALP levels. 4. In serum of white pregnant rats, Moutan cortex radicis showed significant decrease of BUN level while Corydalis tuber showed insignificant increase. 5. In serum of white pregnant rats, Corydalis tuber showed increase of creatinine level while Moutan cortex radicis did not show changement. 6. Moutan cortex radicis and Corydalis tuber showed insignificant increase of serum uric acid and uric protein levels of white pregnant rats.

손마사지가 허혈성 심질환 환자의 불안에 미치는 효과

현경선,이향련,공송심,윤경자,김현섭,김효남,최지원,김운정 성인간호학회 2001 성인간호학회지 Vol.13 No.2

The purpose of this study was to investigate the effect of a hand massage program on anxiety, vital sign and pain in clients with ischemic heart disease. The design utilized for this stuffy was quail-experimental with a nonequivalent control group non-synchronized design The subjects were fifty-four patients, twenty-eight for the experimental and twenty-six for the control group, who were admitted with ischemic heart diease at a cardiac intensive care unfit in K medical center of K university. This study was carried out from May, 1999 to March, 2000. The level of anxiety and pain measured by Visual Analogue Scale, systolic blood pressure, diastolic blood pressure and pulse rate were measured before and after hand massage, the state of Anxiety was measured by the Spielberger (1970) scale at admission and after hand massage for three days. The collected data were processed by using the SPSS PC program and analyzed using χ2-test and t-test. The result of this study are as follows : 1. The scores of VAS anxiety and State of anxiety of the experimental group were lower than those of the control group. 2. The degree of systolic blond pressure, diastolic blood pressure and pulse rate of the experimental group were lower than that of the control group. 3. The score of VAS pain of the experimental group was lower than that of the control group. The results suggested that hand massage can decrease VAS anxiety, State of anxiety, vital signs and VAS pain of patients who were admitted with ischemic heart disease at cardiac intensive care unit Therefore, It Is proposed that hand massage is an appropriate nursing intervention to relieve anxiety of the patients who were admitted with ischemic heart disease at a cardiac intensive care unit.

남북 체육교류 강화를 대비한 태권도 활성화 방안

김경지,송길섭 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

The purpose of this research is to find out the ways Revitalizing Taekwondo Preparing for Strengthening Sports Exchange Between the South and [North Korea. The data sources include sports literature, government pubiications, and so on. Through examination of these sources, the following was concluded 1) Building the hall of Taekwondo would do the important role not orily in the development of Korean Taekwondo but also in opening the gate of the water of the exchange of the sports between the South and INorth epochally not to speak of international development of Taekwondo, and at the same time there we see the absolute necessity of Taekwondo with the concerns and participation of the people of Taekwondo more than any time in the past. 2) The situations of the progress of Taekwondo appeared in the contest and conference between the South and North have shown the propriety of Taekwondo as the diplomatic dimeneion, especially the exchange of the example of Taekwondo between the two sides through the conference of ministerial class during Pusan Asian Came had greatly dedicated to the harmony of the people of two sides with the simultaneous entrance of the players of the two sides. 3) The business of the hall of Taekwondo has been rapidly developed this year by starting the political business of the nation We expect that it would do the important role and function for the exchange of the sports between the South and [North through glrobalization with the significance of suzerain state of Taekwondo. 4)Korean government has been putting all its strengths in the development of human resources and leadership to strengthen national competitive power. Here Taekwondo has been training and distributing prfessional human resources more than any other game.