비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

중부지역 옥수수 파종기에 따른 생육단계 및 수량성 변화

서종호, 문중경, 정건호, 서민정, 구자환, 박장환, 배환희, 신성휴, 권영업 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

Maize hybrids were planted on April 1, April 25, May 20 and June 15 in 2012, 2013 at the experimental paddy and upland fields in Suwon city , respectively to know changes of growth stage and yield according to different planting time. Maize planting on April 1 was not recommended because total growing days at planting on April 1 was not different with that at planting on April 25 due to many days from planting to emergence over 20 days at planting on April 1. Total growing days were not much different among three planting time after April 25 because days from silking to maturity was lengthened though days from planting to silking was shortened at later planting time. Stalk weight was decreased as planting time was delayed, particularly at planting times after May 20 at paddy field by excess water injury during early growth stage. But, grain yield was not low as in May and June. It is needed to introduce early maturity maize variety as Yanganok at late planting for higher grain yield and enough time for soil preparation for next winter crops

Helicobacter pyloir 양성 소화성 궤양에서 lansoprazole 포함 삼제요법의 제균율 및 제균판정에 있어서 요소호기검사의 유용성

정혜경,곽재진,유민아,배기선,권정미,이종수,김도영,문일환 대한감염학회 2003 감염과 화학요법 Vol.35 No.3

목적 : 본 연구는 Helicobacter pylori (이하 H. polyri) 양성인 소화성 궤양 환자에서 lansoprazole 포함 삼제요법의 제균율을 알아보고, 제균 치료 후 제균 판정에 있어서 요소 호기 검사(Urea breath test, 이하 UBT) 및 신속요소분해(rapid urease test, 이하 RUT test)와의 일치율에 대하여 알아보고자 하였다. 방법 : 상부위장관내시경 검사에서 H. polyri 양성인 소화성 궤양환자에서 lansoprazole 60㎎+amoxicillin 2g+clarithromycin 1g의 약제를 2회 분복하여 1주간 복용하는 삼제요법을 실시하였다. 최소 4주후 추적 상부위장관내시경을 실시하였고, 전정부와 체부에서 각각 RUT를 실시하였으며 UBT(5분, 20분)를 시행하였다. 결과 : 대상환자는 총 46명으로 남자 34명(48±13세), 여자 12명(53±14세)이었다. LAC 삼제요법의 제균율은 40/46명(87.0%)이었고, 궤양의 치유율도 42/46명(91.3%)이었다. RUT와 20분 UBT 결과가 모두 음성이었던 경우는 41예, 모두 양성이었던 경우는 4예로 RUT와 UBT는 97.8% (45/46)의 일치율을 보였고, 1예는 UBT는 음성이었으나 체부에서 시행한 RUT가 양성이었다. 5분 UBT 검사가 양성이었던 예는 14/34 (41.2%) 이었고, 이 14예 중 12예(85.7%)는 20분 UBT 검사 음성, RUT 음성이었다. 결론 : Lansoprazole과 amoxicillin, clarithromycin 1주일 병합요법은 H. polyri 양성인 소화성 궤양 환자에서 87.0%의 제균율을 나타내어 우수한 효과를 보였고, 요소호기검사는 제균 치료 후 제균 판정에 유용한 비침습적인 방법임을 확인할 수 있었다. Background : There are only a few studies on Helicobacter pylori (H. pylori) for its eradication rates of lansoprazole-based triple therapy in Korea, and the results are controversial. Therefore, we undertook to investigate the eradication rate of lansoprazole-based triple therapy, and compare the concordance rate of urea breath test (UBT) and rapid urease test (RUT) in evaluating H. pylori eradication. Methods : Patients with acute peptic ulcer who were H. pylori-positive were recruited by prospective, consecutive manner. They received lansoprazole 30 ㎎ b.d., amoxicillin 1 g b.d. and clarithromycin 500 ㎎ b.d. for 1 week. Upper endoscopy was performed after 4 weeks to check for ulcer healing, and UBT and RUT were performed to evaluate H. pylori eradication status. Results : A total of 46 patients were recruited, and they were all compliant. H. pylori eradication rate was 87.0% (40/46) and ulcer healing rate was 91.3% (42/46). Forty one patients showed negative in both UBT and RUT, and 4 patients revealed positive in both tests, therefore, the concordance rate of UBT and RUT was 97.8% (45/46). Conclusion : Our study showed that 1-week lansoprazole-based triple therapy was effective in H. pylori eradication and ulcer healing. UBT can be an effective, noninvasive method for evaluating H. pylori status after H. pylori eradication.

수정된 Elman 신경회로망을 이용한 제어방식

정경권,김주웅,엄기환 동국대학교 대학원 1998 大學院硏究論集-東國大學校 大學院 Vol.28 No.-

The neural network is a static network that consists of a number of layer: input layer, output layer and one or more hidden layer connected in a feedforward way. The popularity of neural network appear to be related to its ability of learning and approximation capability. The Elman Neural Network proposed the J.Elman, is a type of recurrent network. It has the feedback links from hidden layer to context layer. So Elman neural network is the better performance than the neural network. In this paper, we propose the Modified Elman Neural Network. The structure of a MENN is based on the basis ENN. The recurrency of the network is due to the feedback links from the output layer and the hidden layer to the context layer. In order to certify the usefulness of the proposed method, the MENN apply to the multi tracking control and the X-Y Cartesian tracking. Simulation shows that the proposed MENN method is better performance than the multi layer neural network and the ENN.

변형된 신경회로망을 이용한 PID 제어 방식

정경권,김경수,엄기환 동국대학교 산업기술연구원 1999 산업기술논문집 Vol.13 No.-

본 논문에서는 산업 현장에서 일반적으로 많이 사용되고 있는 PID 제어기의 비례, 적분, 미분 파라미터를 다층 신경회로망을 이용하여 자동으로 동조하는 방법을 제안한다. 제안한 방식은 자기 궤환 뉴런을 가진 다층 신경회로망이 플랜트의 입력과 출력을 이용하여 PID 제어기의 파라미터들을 학습에 의하여 자동 동조한다. 다층 신경회로망은 자기 궤환 뉴런을 이용하여 입력층, 은닉층, 출력층의 3층으로 구성되고, 출력은 3개 값을 갖는다. 이것은 PID 제어기의 비례(P), 적분(I), 미분(D) 파라미터로 사용된다. 이 값들은 특정한 값으로 고정되는 것이 아니라 제어 수행과정 중에서도 다층 신경회로망의 학습에 의해 계속 변화된다. DC 서보 모터를 대상으로 추종 제어 시뮬레이션 및 실험을 통해서 제안한 방식의 유용성을 확인하였다. In this paper, we propose a modified neural network for the auto-tuning of proportional, integral, and derivative parameters of PID controller, which is widely used in the industries. The proposed method uses a multi-layer neural network with self-feedback neuron for the auto-tuning of the parameters of PID controller using input and output of the plant by learning. The neural network consists of three layers ; input-layer, hidden-layer, and output-layer. The output layer will have three outputs and each will be used as P, I, D parameters. Those values are not specific not fixed but being modified according to the learning of multi-layer neural network. The simulation and experiment results showed the effectiveness of proposed control method.

Saccharomyces cerevisiae에서 myo-Inositor 결핍에 의한 Respiratory Capacity의 감소

정경환,이준식 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.4

Saccharomyces cerevisiad (S. cerevisiae)의 growth factor중의 하나인 myo-Inositol은 membrane-associated 효소인 phosphatidylinositol 합성효소에 의해 세포막의 구성 성분인 phosphatidylinositol로 incorporation 되는 것으로 알려져있다. 그래서 myo-inositol이 결핍되면 막구조와 기능에 좋지 않은 영향을 주는 것으로 알려져 있다. 이러한 myo-inositol의 생화학적 기능을 근거로 myo-inositol의 결핍이 호기적 포도당 대사에 미치는 영향을 조사하기 위하여 S. cerevisiae의 respiratory capacity를 대변하는 인자인 specific oxygen uptake rate (Q_O2)를 회분배양과 연속배양을 이용하여 측정하였다. 그리고, S. cerevisiae의 호기적 포도당 대상의 respiratory capacity를 myo-inositol이 결핍된 경우와 그렇지 않은 경우에 연속배양에서 포도당 pulse-addition을 한 후 관찰하였다. 그 결과 회분배양과 연속배양에서 myo-inositol이 결핍된 경우 maximum specific oxygen uptake rate (Q_O2. max)이 감소되는 현상을 관찰하였고, 포도당 pulse-addition 실험에서 얻은 결과를 정량적으로 분석하여 본 결과 myo-inositol의 결핍이 respiratory capacity의 감소를 초래하는 것이 관찰되었다. myo-Inositol, a growth factor for Saccharomyces cerevisiad (S. cerevisiae), has been know to be incorporated into phosphatidylinositol (PI), which is a kind of phospholipid in the cell membrane, by a membrane-associated PI-synthesizing enzyme. The deficiency of myo-inositol in S. cerevisiae adversely affected the membrane structure and function. On the basis of biochemical functions of myo-inositol, the effect of deficiency of myo-inositol on the aerobic glucose metabolism was investigated by measuring specific oxygen uptake rate(Q_O2) used as an indicator representing the respiratory capacity of S. cerevisiae in batch and continuous cultures. The respiratory capacity of aerobic glucose metabolism in S cerevisiae was also monitored after glucose pulse-addition in a continuous culture (D=0.2, 1/hr), in which glucose was utilized through respiratory metabolism. The deficiency of myo-inositol was found to lead to both the decrease of the maximum specific oxygen uptake rate (Q_O2. max) observed from the batch as well as in the continuous culture experiment and the decrease of the respiratory capacity of aerobic glucose metabolism of S. cerevisiae determined from the glucose pulse-addition experiment, in which the glucose flux into respiratory and fermentative metabolism was quantitatively analyzed.

지방산 유지 원료에 따른 고형비누의 특성에 관한 연구

정명선,배한수,이봉연,민경혜,류덕환 계명대학교 생활과학연구소 2001 科學論集 Vol.27 No.-

The experimental results on the washing efficiency of detergent made from corn oil, wasted cooking oil and pig fat oil are as follows ; Laundry factors in this experiment are detergent concentration, laundry temperature and laundry time. 1.The surface tension of each detergent showed the lowest in 0.2% concentration corn oil 60.84, wasted cooking oil 61.11, pig fat oil 60.73dyne/cm. 2.The wasthing efficiency based on different concentration of detergents showed the highest in 0.2% concentration. 3.The highest washing efficiency appeared in 0.2% concentration 40℃ temperature and 40~50 min. time. There showed no difference in the washing efficiency according to the volume of water. It can be said that the frictional force of bearing rather than the volume of water worked on the efficiency.

치료 저항성 환청을 나타내는 만성 정신분열병 환자에서 측두두정부 반복 경두개자기자극의 효과

정경희,최충식,박진수,이규항,함웅,이승환,채정호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.5

Objectives : It has been reported that repetitive transcranial magnetic stimulation (rTMS), which stimulate the focal region of brain may relieve auditory hallucination in patient with schizophrenia. This study was aimed to evaluate the effect of rTMS on left and right temporopahetal cortex in schizophrenic patients with treatment-resistant auditory hallucination. Methods : Twenty-six patients with chronic schizophrenia with treatment -resistant auditory hallucination were randomly a1-located to rTMS group on left and right temporoparietal head regions. The rTMS was applied to TP3/4 region by EEG 10-20 international system at 1 Hz for 20 minutes per day for 101reatment days. A Figure of eight TMS coil with a solid core was used for rTMS at 100% of individual motor threshold. Efficacy was evaluated with Auditory Hallucination Rating Scale (HRS), Positive and Negative Symptoms Scale (PANSS), Clinical Global Impression (CGI) Scale on 5 and 10 days of treatment. Results : Ten days administration of l-Hz rTMS to temporopahetal cortex significant improved frequency (p<0.001) and attentional salience (p=0.038) of auditory hallucination, Positive (p<0.001) and negative symptom (p=0.02), and CGI-impro-vement (p<0.001). There were no significant differences between right and left side stimulations. Conclusion : These results suggest that the low frequency rTMS on temporopahetal cortex may be useful in treating Schizo-phrenic patients with treatment-resistant auditory hallucination and it could be a useful novel treatment option.

구동용 3상 3중 쵸퍼방식

정연택,한경희,이승환,김성남 明知大學校 産業技術硏究所 1987 産業技術硏究所論文集 Vol.6 No.2

This paper, in case of chopper controlling D.C. Motors, suggested three phase chopper system in order to reduce a source current and amature current ripple, and it's characteristic proves study on the theory and experiment. As a result of consideration, it was found that chopper system had reduced current ripple compare with two phase chopper system and impressed voltage of motor could be continuously controlled from 0 to the source voltage by adjusting chopper's time ratio α from 0 to 1.

유전자 알고리즘을 이용한 비선형 시스템 동정

정경권,정성부,엄기환 동국대학교 산업기술환경대학원 1998 산업기술논총 Vol.4 No.-

In this paper, we propose a nonlinear system identification method using genetic algorithm. We represent the nonlinear system as a parameter vector and a measurement vector. In order to identify the nonlinear system, we find the parameter vector using genetic algorithm. The parameter vector is regarded as a chromosome of gene. The error between the desired output and estimated output every sampling period is used to calculate the fitness of one gene. The simulation results showed the effectiveness of using the genetic algorithm in the nonlinear system identification.