정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Synergistic Renoprotective Effect of Melatonin and Zileuton by Inhibition of Ferroptosis via the AKT/mTOR/NRF2 Signaling in Kidney Injury and Fibrosis

Jung Kyung Hee,Kim Sang Eun,Go Han Gyeol,Lee Yun Ji,Park Min Seok,Ko Soyeon,Han Beom Seok,Yoon Young-Chan,Cho Ye Jin,Lee Pureunchowon,Lee Sang-Ho,Kim Kipyo,Hong Soon-Sun 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.6

According to recent evidence, ferroptosis is a major cell death mechanism in the pathogenesis of kidney injury and fibrosis. Despite the renoprotective effects of classical ferroptosis inhibitors, therapeutic approaches targeting kidney ferroptosis remain limited. In this study, we assessed the renoprotective effects of melatonin and zileuton as a novel therapeutic strategy against ferroptosis-mediated kidney injury and fibrosis. First, we identified RSL3-induced ferroptosis in renal tubular epithelial HK-2 and HKC-8 cells. Lipid peroxidation and cell death induced by RSL3 were synergistically mitigated by the combination of melatonin and zileuton. Combination treatment significantly downregulated the expression of ferroptosis-associated proteins, 4-HNE and HO-1, and upregulated the expression of GPX4. The expression levels of p-AKT and p-mTOR also increased, in addition to that of NRF2 in renal tubular epithelial cells. When melatonin (20 mg/kg) and zileuton (20 mg/kg) were administered to a unilateral ureteral obstruction (UUO) mouse model, the combination significantly reduced tubular injury and fibrosis by decreasing the expression of profibrotic markers, such as α-SMA and fibronectin. More importantly, the combination ameliorated the increase in 4-HNE levels and decreased GPX4 expression in UUO mice. Overall, the combination of melatonin and zileuton was found to effectively ameliorate ferroptosis-related kidney injury by upregulating the AKT/mTOR/ NRF2 signaling pathway, suggesting a promising therapeutic strategy for protection against ferroptosis-mediated kidney injury and fibrosis.

한강 하류의 남조류 및 환경요인의 연간 (2000 ${\sim}$ 2003) 변화에 대하여

서미연,김백호,배경석,한명수,Suh, Mi-Yeon,Kim, Baik-Ho,Bae, Kyung-Seok,Han, Myung-Soo 한국하천호수학회 2005 생태와 환경 Vol.38 No.2

한강 중하류의 남조류 및 환경요인의 연간변화 (2000 ${\sim}$ 2003)를 파악하기 위하여, 2000년 4월부터 2003년 10월까지 4년간 성수대교에서 성산대교까지 총 5개 지점을 선정하여, 수계의 기초환경요인 및 식물플랑크톤 현존량 변화를 조사하였다. 조사기간 동안, 남조류의 현존량은 점차적으로 감소하여 장기간 강우가 가장 많았던 2003년에는 거의 관찰되지 않았으며, 총 식물플랑크톤 현존량에 대한 남조류의 기여도는 약 10%범위내였다. 이러한 현상은 매년 강우집중기 동안 팔당댐으로부터 많은 방류수가 유입됨으로서 수온감소는 물론 광량감소, 영양염류 희석 등에 의한 남조류의 성장이 제한된 것으로판단되며, 동일시기에 다른 조류 (녹조, 규조 등)의 높은 성장으로 엽록소 a와 식물플랑크톤 현존량이 뚜렷하게 증가하였다. 따라서 한강 하류의 고온기 동안 남조류 성장은 잦은 강우와 방류에 의해 제한을 받지만 규조나 녹조와 같은 다른 조류들의 높은 성장으로 대치되는 천이현상을 보였으며, 기후영향을 크게 받는 전형적인 하천생태계의 특성을 나타냈다. For 4 years (2000 ${\sim}$ 2003), annual fluctuations of standing crops of cyanobacteria and physicochemical factors were examined at five sites from Bridge of Seungsoo to Bridge of Seungsan in the lower part of Han River. The cyanobacterial abundance (ND to 4,167 cells $mL^{-1}$) was strongly decreased during the heavy rains in every year. During the similar periods in 2003, cyanobacteria hardly observed, and comprised below of 10 percentage of total phytoplankton. In the period of little cyanobacteria, some green algae and diatom dominated the phytoplankton community, while the concentration of chlorophyll a has not largely change. These results indicate that heavy frequent precipitation strongly limited the growth of cyanobacteria, and lead an algal succession by the appearance of new algal groups.

鷄糞의 飼料利用性에 關한 硏究 : 乾燥鷄糞의 採卵鷄育成에 있어서의 經濟性 Economic returns of Dried poultry waste in brooding of Laying hens

扈敬鎭,印致雄,한기영,許康七 안성산업대학교 1978 論文集 Vol.10 No.-

1. In order to decide a feasibility for partial substitution of dried poultry waste for complete formula feed and to decide an eligible levels for the substitution, growing trials were carried out under four treatments with three veplications in randomized block design, and the treatments were based upon the substitution rates such as 5%, 10%, 15% and check for two groups of chicks for Layer, namely, 7 to 12 weeks aged one and 13 to 20 weeks aged one. 2. While no significant differences were found in the increased body weight, feed consumption and egglaying rate among the treatments, partial substitution of the D. P. W, for complete formula feed seemed to be feasible, like as that of grain or grain bran, since no any interruptions were occurred in the way of the substitution. 3. The reason that the feeding efficiency of substitution of D. P. W. for complete formula feed to those of 13 to 20 weeks aged chicks, was shown far better than that of those of 7 to 12 weeks aged chicks, seemed to be attributable to the less nutrient deficlency derived from those substitutions. Therefore, such results might be reflected to those advantages for 13 to 20 weeks aged chicks over those of the other chicks. 4. While no significant differences were found in egg laying rate and egg weight among the treatments, 15% substitution plot showed a little over that of check plot, and this result might indicate that the egg laying may not be influenced by the substitution of feeding. 5. Refering to economic returns of substitution utilization of D. P. W for complete formula feed, while the advantages were shown top grade at 5% and in order of 10%, 15% of the substitution on 7 to 12 weeks aged chicks, advantages were also shown in order of 5%, 10%, 15% of the substitution on 13 to 20 weeks aged chicks. These results seemed to be feasible even in beyond of 15% of the substitution. 6. Since it was not able to find out the eligible levels of the substitution D. P. W. for complete formula feed for 13 to 20 weeks aged chicks in this study, the following studies shall be desirable in the future. (1) eligible substitution levels of D. P. W. for complete formula feed in those of 13 to 20 weeks aged chicks. (2) economic returns for Laying Hens through substitution D. P. W. for complete foumula feed in growing.

중심위에서의 하악과두위치와 과두운동간의 관계에 관한 연구

한경수,진태호 圓光大學校 1988 論文集 Vol.22 No.2

측두하악관절은 악구강계의 일부로서 교합과도 밀접한 관계를 가지고 있으며 그 운동양상이 다양하고 복잡하여 많은 학자들의 연구대상이 되어지고 있다. 그러나 이러한 악관절에 대한 연구는 주위 근육, 신경등 신체의 여러 요소들이 상호작용하기 때문에 매우 어려운 것으로 알려져 있다. 이에 저자는 환자와 정상인을 대상으로 관절와내에서의 과두의 위치와 과두의 운동 상호간의 관계를 연구하고자 Pantronic (Dear Corp., U.S.A)와 transcranial radiography를 이용하여 연구한 결과 다음과 같은 결과를 얻었다. ;관절강폭은 이환측의 경우 비이환측에 비해 다소 감소된 경향을 나타냈으나 통계학적인 유의성은 없었으며, 이환측에서 ISS (Immediate Side Shift)와 상방 및 후방 관절강폭간에는 역상관관계를 나타냈으나, 비이환측에서는 과두운동과 과두의 위치간에는 상관관계가 없는 것으로 나타났다. The purpose of this study was to investigate the relationship between the condylar movement and condylar position in centric relation in the temporomandibular joint. 23 out patients in Wonkwang University Dental hospital and 10 Dental students were participated in this study. For the measure of condylar movement, the Pantronic (Denar Corp., U.S.A.) was used, and for evaluation of the condylar position, transcranial radiography was used. The results were as follows ; The joint space of affected group was some narrower than that of unaffected group, but there was no statistical significance, and in the affected group, there was a negative correlationship between Immediate side shift and upper or posterior joint space. In the unaffected group, there was no correlationship between condylar movement and condylar position in centric relation.

80年代를 위한 農村 單位部落 構造改善에 關한 硏究

韓相謙,朱京在,李好璡 건국대학교 1979 學術誌 Vol.23 No.2

Recent change of our rural environment is very rapid and living environment of rural inhabitants should be ceaselessly improved to keep pace with their increasing income and requirements . Basic unit village is the most essential living zone to human beings, which can make change in living pattern. To suggest reasonable unit village relocation plan, following 3 villages were selected as pilot projects ; 1)Duckpyong-ri, Majang-myon, Ihchon-kun, Kyonggi-do. 2)Bon-dong, Homyong-myon, Yechon-kun, Kyongsang-pukdo. 3)Dosan-ri, Kochang-eup, Kochang-kun, Chulla-pukdo. In planning process of these 3 villages, it is emphasized that ; 1)To keep tradition of Korean rural area and economic efficiency by sufficient application of natural land formation. 2)Most housing sites are relocated to higher places for the improvement of housing environment and enlargement of farm land. 3)Street flow lines are planned along the curved contour line to express Korean traditional road line. 4)Site location keeps certain height difference, if possible, for good view, ventilation and application of sun shine. 5)Location of annex buildings for farm using is separated from dwelling units to make better living environment. 6)To give variations in community, size of housing site is prepared within range from 265 m2 (80 pyong) to 395 m2 (120 pyong). 7)To exclude monotoneous mood from continuously located housing site, some green areas are provided at several spots between curved road line and steeply sloped housing lot. 8)To install athletic field and play groung for children, open spac s are reserved as much as possible.

세 갈래로 가른 전두근판을 이용한 안검하수증의 교정

한기환,이경호 大韓成形外科學會 1988 Archives of Plastic Surgery Vol.15 No.1

The aim of blepharoptosis surgery is normal restoration of eyelid cosmetically and functionally. Methods of the correction of ptosis are many. While most of the operations can produce improved or even satisfactory results in mild ptosis, none is entirely satisfactory for the severe case. In 1982 Song reported a procedure using frontalis muscle which sutured to the anterior surface of the tarsus. Using his method, the authors have experienced arching of the upper eyelid margin. The authors divided distal portion of the frontalis muscle flap to 3 parts like a tripartite. The authors have used this tripartite frontalis muscle flap technique to severe and moderate cases with satisfactory results. The results were as follows: 1. In order to prevent an ectropion, the tunnel underneath the orbicularis oculi muscle is made so small that only the frontalis muscle flap can be passed through. 2. The height and curvature of the corrected lid margin is good and lasting. 3. Excision of excessive lid skin must be adequate in order to construct a complete and natural supratarsal fold. 4. Little or no ptosis was developed when looking forward and upward gazes. 5. The lagophthalmos during sleeping spontaneously disappeared about six month. 6. Recorrection is easy in the cases of over or undercorrection. 7. The wrinkles on the forehead disappeared by themselves.

인삼사포닌이 백서의 실험적 치아이동 후 치주조직 재배열에 미치는 영향

한성호,김경근 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.1

This study was performed to analyze the effects of ginseng total saponins on the activity of human periodontal ligament cells in vitro and on the in vivo periodontal rearrangement of experimentally moved molar in the rat. For in vitro experiment, the periodontal ligament cells were isolated from extracted sound tooth of patient who was taken the orthodontic treatment. Ginseng total saponins of 0, 1, 10, 100, 500 ㎍/㎖ was administered into each cultured cells. The cell proliferation and activity were examined through measurement of absorbance and RT-PCR analyses. For in vivo experiment, the latex elastic band was inserted between the first and second maxillary molars on right and left sides of rats for 3 weeks. From 3 days before the removal of elastic latex band, they were injected intraperitoneally with ginseng total saponins of 50, 100, 200 mg/kg in each experimental group and saline solution in control group everyday. And they were sacrificed according to the 5-day periods from the day of removal of elastic latex bands and were compared by histological examination among the groups. The results were obtained as follows. 1. There was no difference of the absorbance in human periodontal ligament cells between the experimental of 0, 1, 10, 100 ㎍/㎖ ginseng saponins and control groups, while it was decreased in the group of 500 ㎍/㎖ ginseng saponins. 2. The gene expression of ALP, fibronectin, DSP3, and COL1 was increased in the group of 1, 10 ㎍/㎖ ginseng saponins, while it was decreased greatly except COL1 in the group of 100 ㎍/㎖. 3. There was no difference of the gene expression of TGF-β_(1) between the experimental of 1, 10 ㎍/㎖ and control groups, while it was decreased greatly in the group of 100 ㎍/㎖. 4. The rearrangement of collagen fibers in the periodontal ligament of rats appeared faster in the experimental groups than in the control group. 5. The remodelling of alveolar bone of rats appeared faster in the experimental groups than in the control group. These results indicate that ginseng total saponins from red ginseng increased the activity of periodontal ligament cells and suggest that ginseng total saponins may stimulate the periodontal rearrangement after orthodontic treatment. So retention period after tooth movement can be decreased.

항암제 AG60이 흰생쥐 위점막 상피세포의 DNA합성에 미치는 영향 : 자기방사법적연구

박경호,안의태,고정식,하상선,한영복,정영신,홍은경,유보림,김상건,이경영,강종구 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

IgG GM₁ 항체와 Campylobacter jejuni 항체와 관련된 급성 운동축삭형 신경병증

홍경훈,김승현,이영배,이영주,김희태,김주한,김명호 대한신경과학회 1997 대한신경과학회지 Vol.15 No.5