재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

림프종 환자에서의 갈륨, TI-201 그리고 Tc-99m MIBI 섭취의 비교

천경아,조인호,원규장,이경희,이형우,현명수,이재태,이규보 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.2

Purpose; Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. Materials and Methods: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. Results: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. Conclusion: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.

심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

3차원 전산화 단층촬영을 이용한 상악 정중 과잉치의 진단

이종갑,김성오,홍영우,손흥규 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.3

저자는 매복된 상악 정중 광잉치를 주소로 내원한 환아를 3차원 전산화 단층촬영술을 이용해 매복된 과잉치의 위치를 파악하였으며 다음의 결론을 얻었다. 1. 인접한 영구치에 대한 위해한 영향을 주지 않기 위해 상악 정중 매복 과잉치의 정확한 위치 편별이 요구된다. 2. 3차원 전산화 단층촬영법은 매복 과잉치의 위치판별에 있어서 객관적인 중요한 정보를 제공한다. The prevalence of the supernumerary tooth is 1~4%. It usually occurs in the permanent dentition. It frequently occurs in the maxillary midpalatal area. The presence of the supernumerary tooth causes the following problems;(1) interfering the eruption of successional tooth, (2) displacing the neighboring teeth, (3) resulting large diastema, (4) forming cystic change. So the supernumerary tooth should be remobed as soon as oissuble. To extract the supernumerary tooth, the exact position must be noticed first. Radiographic techniques that were used in the past are tube shift technique, right angle technique, sterioradiography, using radiopaque contrast media and conventional tomography. But these methods include the subjective opinion of the operator. So, a technique eliminating the operator's opinion and showing the position 3-dimentionally can be used. 3-dimentional computed tomography eqipped with dental softwares can show the position of the impated supernumerally tooth in 3-dimentionally position. It has an adzantage to eliminate the subjective opinion of the operator with a fast computer this techenique is done in a relatively short period of time . the data 3-dimentionally. sequential removal of the soft tissue and hard tissue(bone) CT number leaves the teeth alone in 3-dimentional position. The image can be seen from anywhere, so the operator can see the image in front, rear, upper, and lower positions. In both cases 1 and 2 the position of the impacted supernumerary tooth is viewed by the 3-dimensional computed tomography. And it made the operator easy to figureout the exact position.

제 Ⅲ급 부정교합자의 악교정 수술후 골격적 재발 양상에 관한 연구 : COMPARISON BETWEEN SSRO AND IVRO 구내 시상 분할 골절단술과 구내 상행지 수직 골절단술의 비교

이장열,유형석,유영규 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.3

하악 전돌증의 치료를 위해 외과적인 술식이 교정임상분야에 도입된 이래로 많은 임상적인 성공사례가 보고되어왔으며 최근에 와서는 하악골 후퇴술의 대표적 술식으로 구내 시상 분할 골절단술(SSRO)과 구내 상행지 수직 골절단술(IVRO)이 주로 시행되고 있다. 물론 이 두가지 술식 모두 만족스러운 술후 결과를 얻을 수 있으나 술후 안정성과 재발의 양상과 정도가 다르게 나타나고 있다. 그러나 하악 후퇴술후 시간경과에 따른 재발의 정도에 관한 국내의 연구는 국외에 비해 다소 부족한 상황이며, 특히 시상 분할 골절단술과 상행지 수직 골절단술후의 재발양상에 관한 비교연구는 아직 없는 실정이다. 이에 저자는 골격성 III 급 부정교합자의 악교정 수술 후 수술방법에 따른 재발 양상과 장기적 안정성을 알아보고자 구내 시상 분할 골절단술로 시행받은 24명(남자 10명, 여자 14명)과 구내 상행지 수직골절단술로 시행받은 26명(남자 10명, 여자 16명)의 수술 직전(T1), 수술 직후 48시간 이내(T2), 수술 후 4-8주(T3), 수술후 6개월 이상(T4)등 4장의 측모두부방사선 사진을 계측하여 두 군간의 기간별 재발 양상과 각 군내의 타 변수들과의 상관성에 관해 검증하여 다음과 같은 결과를 얻었다. 1. 하악골의 수평적인 초기 재발은 시상 분할 골절단술군에서는 전방 이동, 상행지 수직 골절단술군에서는 후방 이동양상을 보였다. 2. 두 군 모두에서 하악골의 수직적인 초기 재발과 후기 재발은 전안면고정이 감소하는 쪽으로 일어났으며 두 군간의 유의차는 없었다. 3. 시상 분할 골절단술군에서 수술시 근심절편의 후방회전이 많을수록 하악골의 수평적인 후기 재발이 더 전방으로 일어났다. 4. 두 군 모두에서 수술시 하악골 후퇴량이 많을수록 하악골의 수평적인 초기 재발이 더 전방으로 일어났다. To evaluate the relapse pattern and long-term stabilities depanding on surgical methods following orthognathic surgery of C1 III patients, the author selected 24 subjects(10 male, 14 female) operated by SSRO and 26 subjects (10 male, 16 female) operated by IVRO. Each subject took four lateral cephalograms : just before surgery (T1), within 48hrs after surgery(T2), 4-8 wks after surgery(T3), 6 month or more after surgery(T4), and the landmarks were digitized. The differences of relapse patterns in each interval between two groups were compared and the significance of correlation among the variable of each group was tested. The obtained results are as follows ; 1. Horizontal early relapse was forward movement of mandible in SSRO group, as compared to the backward movement in IVRO group, and there was a statistical significance between the two groups. 2. Vertical early and late relapses were decreases in anterior facial height in both groups and there was no statistical significance between two groups. 3. There was a statistical significance in negative correlation between mandibular horizontal late relapse and surgical change of articular angle in SSRO group. 4. There was a statistical significance in negative correlation between amount of mandibular set-back and mandibular horizontal early relapse in both groups.

Dimethylformamide가 Mouse 肝細胞의 微細構造에 미치는 影響

이형록,정호삼,이규식 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2

Dimethylformamide (DMF) has been widely used in the synthetic textile industry as an organic solvent. However, it is known that DMF irritates to skin and mucous membranes and causes several toxic symptoms when dermal and respiratory exposure to DMF is prolonged. It is supposed that DMF provoked toxic reaction in the liver during the metabolic process of the DMF-injected experimental animal. Therefore, the authors observed changes cytoplasmic organelles of the hepatic parenchymal cells in order to demonstrate the effect of DMF on the mouse liver. Healthy male mice of ICR strain were used in this experiment and the weight of the experimental animals were around 20gm. The animals of the experimental group were administered DMF diluted in the water for injection, by intraperitoneal injection in a dose of 1.5ml per kg of body weight in a volume of 0.2ml. The animals of the control group were amdinistered only water for injection. The experimental animals were killed at intervals of 6, 12, 24 and 48 hours after administration of DMF, respectively. Liver specimens of 1mm³ size were prefixed in the 2% glutaraldehyde-2.5% paraformaldehyde phosphate buffer solution (pH 7.2) and post-fixed in the 1% osmic acid. After specimens were dehydrated and embedded in the epon 812, ultrathin sections(600-800A°thickness) were made and double stained with uranyl acetate and lead citrate. These preparations were observed with JEM 100B electron microscope. The results obtained were as follows: 1. Cisternae of rough endoplasmic reticulum were intensely dilatated and fragmented partly. 2. Smooth endoplasmic reticulum was markedly proliferated and glycogen particles were markedly decreased or depleted. 3. The atrophies of the Golgi complex were found. 4. Primary lysosomes and secondary lysosomes-residual bodies, autophagic vacuole and multivesicular bodies were increased in number. 5. Numerous lipid droplets of irregular size were produced. Consequently, it is concluded that DMF would induce the degenerative changes in cytoplasmic organelles of the hepatic parenchymal cell in the mouse.

전위 배복된 상악 측절치와 상악 견치의 치험례

이기영,최형준,손홍규 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.4

치아의 전위는 매우 드문 치아 기형의 하나로서 발생 또는 맹출중 인접한 2개의 영구치의 위치가 서로 바뀐것을 말한다. 전위는 상악과 하악 모두에서 발생 가능한데 그중에서 상악에서의 발생이 더 흔하며 상악견치는 가장 호발하는 치아이다. 상악에서는 상악 견치와 제 1 소구치와의 전위가 가장 빈도 높고 그 다음으로 상악 견치와 측절치와의 전위가 많다. 전위는 완전 전위와 불완전 전위로 나눌수 있는데 완전 전위는 치관뿐 아니라 치근의 위치까지 전위된 경우를 말하고 불완전 전위는 치근의 위치는 정상이고 치관만 전위된 경우이다. 전위의 원인에 대하여 명확하게 밝혀진 것은 없으나 유치의 만기잔존이나 조기상실, 발생중의 전위나 정상 맹출 경로로부터의 이탈, 유치열시기의 안면외상 등이 제기되고 있고 이밖에 과잉치, odontoma 또는 odontogenic cyst, 염증성 병소 등을 그 원인으로 생각해 볼 수 있다. 본 증례는 유치열시기의 안면외상으로 인하여 상악 영구 견치와 측절치의 전위가 발생한 경우로서 치료후 전위된 위치로의 양호한 배열을 이루었다. Transposition has been described as an interchange of position of permanent tooth and is relatively rare dental anomaly. Transposition of teeth may occur both in the maxillary and mandibular arches. but it appears more often in the maxilla of individual teeth, the maxilla canine is the most often involved. A canine transposes most often with a first premolar and less frequently transposes with a lateral incisor. Incomplete transposition is a condition describing an interchange in the position of the crowns of two permanent teeth, while the root apices remain in their relative position. Complete transposition is a situation in which both the crowns and entire root structure are transposed. The etiologic factors of transposition are tooth buds interchange, retained deciduous canines, migration of the erupting canine, trauma to deciduous teeth etc. This report describes a case of a transposition between a maxillary left canine and a lateral incisor and impaction of a maxillary left central incisor due to trauma to deciduous dentition.

양식 넙치(Paralichthys olivaceus)에서 발생한 랩도바이러스성 질병의 병리조직학적 특징

이남실,강형길,최희정,전세규,박남규,허민도 한국어병학회 2002 한국어병학회지 Vol.15 No.1

2000년 4월경부터 (수온7-13℃) 우리나라 동해안과 남해안 육상 수조에서 사육되던 넙치에서 체색흑화, 복수저류, 비장종대의 육안적 소견을 보이는 질병이 발생하여 대량폐사를 불러왔다. 병리조직학적 소견으로, 비장과 신장의 조혈조직에서 괴사병변이 주로 나타났다. 비장과 신장의 간질조직에서 괴사소가 관찰되었으며, 임파구, 괴사세포의 침윤이 나타났다. 비장 조직의 전자현미경적 관찰에서 변성혈구 내 세포질에서 탄환형의 바이러스 입자가 관찰되었는데 직경과 길이가 각각 약 50nm, 170nm였다. 이상의 결과로 본 질병은 rhabdovirus에 의한 질병으로 판단되었다. On April of 2000 and February of 2001, a disease characterized by darkening, ascites and enlargement of the spleen occurred in flounder, Paralichthys olivaceus, farmed near northern and eastern coasts of Korea. Various degree of necrosis including liquefactive-type was observed mainly in hemopoietic tissue of spleen and kindney. Certain tissue such as branchial soft tissue including epithelium showed a similar necrotic findings. But some tissues such as intentine had several necrotic clusters of wandering cells, being possibly leukocytes. Necrotic evidences of blood cells were evident in various tissues including hemopoietic tissues. Necrobiotic bodies were frequently encountered in blood smear preparations. Bullet type-virious were detected in the spleenic cells. Each virion was about 500 nm in diameter and 170nm in length. From these results, this disease was thought to be a rhabdoviral disease.

수종 치과재료의 제I급 와동에서의 변연 누출에 관한 실험적 연구

이선희,손흥규,최형준 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.1

Microleakage is a problem of all filling materials of losted teeth structure and is clinically undetectable. Because marginal leakage may be responsible for pulp irritation, pulp inflammation, necrosis and recurrent caries, it is essential to prevent and control it. For the evaluations of microleakage of various class I filling materials, 175 extracted teeth were filled with amalgam, light curing composite resin, glass inomer cement, IRM and Fermit-N. After thermocycling, speciemens were placed in 1% methylene blue dye solution for 24 hours in an incubator set 37℃. The teeth were sectioned at filling body center and margin and degree of dye penetration was observed with a stereomicroscope. The following results were obtained. 1. Light cured composite resin has the excellent results and microleakage is increased in the order of amalgam, IRM, Fermit-N, glass ionomer cement.(SAS-6.0 system) and there was a statistically significancy in marginal leakage for each filling materials.(Kruskal-Wallis analysis, P<0.05) 2. Microleakage of the center and margin was statistically insignificant (Mann-Whitney analysis P<0.05) 3. There was less microleakage for amalgam than light cured composite resin but was statistically insignificant (Mann-Whitney analysis, P<0.05) and also showed less marginal leakage for Fermit-N compared to glass ionomer cement but also was statistically insignificant. (Mann-Whitney analysis, P<0.05).

정신과 외래환자의 약물치료 반응과 심박동 변이의 변화 양상

이상규,이홍석,김인주,김형태,김도훈,손봉기 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : The purpose of this study was to investigate the change of heart rate variability after antidepressant treatment in depressed or anxious patients. We tried to find the usefulness of heart rate variability as a predictive marker of response to pharmacological treatments in the psychiatric field. Methods : Forty-seven patients with major depression, anxiety disorder, and somatoform disorder were treated over 4 weeks with antidepressants and were then classified as responders or nonresponders according to Hamilton depression scales or CGI scores. The HRV variables were measured and compared among the responders/nonresponders and the matched normal control. Results : The responders group exhibited low heart rate, low PSI, high SDNN, RMSSD, HRV index, NN50, pNN50, LNTP, LNLF, and LNHF compared with the nonresponders after 4 weeks antidepressant treatment. However, no significant differencein HRV vanables was observed between the responders group after treatment and the nonnal control group and the responsegroup after treatment. Conclusion : These results indicate that HRV variables would are normalized after successful antidepressant treatment and it that HRV has some possible uses as a predicting marker of antidepressant response.