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재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과
김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.
림프종 환자에서의 갈륨, TI-201 그리고 Tc-99m MIBI 섭취의 비교
천경아,조인호,원규장,이경희,이형우,현명수,이재태,이규보 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.2
Purpose; Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. Materials and Methods: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. Results: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. Conclusion: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.
이제호,손홍규,전승준,최형준 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.2
An object definition of the anomaly is not avaliable and most investigators define the term differently or fail to describe their criterion.Because dental anomaly may lead to many complications,early detection and diagnosis of dental anomalies are essential steps in the evaluation of the child patient and in treatment planning.These procedures require detailed medical and dental histories,through clinical examination and the use of radiographs.So,this study was designed to find out the prevalece of dental anomalies.The clinical and roentgenographic examination was undertaken for 8,054 children at age from 0 to 15 years and statistical analysis was done.The results were as follows: 1.Among the examined subjects 2,134 subjects(26.5%) showed dental anomalies.The prevalance of individure dental anomalies were as as follows:Supernumerary teeth 15.6% congenitally missing teeth 6.6%,fusion 2.2%,odontoma 0.35%,microdontia 1.2%,macrodotia 0.05%,gemination 0.22%,talon cusp 0.36%,dens evaginatus 0.24%,dens invaginatus 0.15%,dilaceration 0.27%,taurodontism 0.09%,abnormal tooth position 1.7%,natal $ neonatal teeth 0.92%,amelogenesis imperfecta 0.01%. 2.Significant correlations between the groups with individual dental anomalies were as follows:between groupⅠand other groups,there was nagative correlation,especially groupⅠ and groupⅡ.And the correlation coefficient between male and female showed differences. 3.For the supernumerary teeth group,the prevalence of male was higher than female(p<0.001).While for the congenitally missing teeth,macrodontia,microdontia,abnormal tooth position group,the prevalence of female was greater than male(p<0.001). 4.For the congenitally missing teeth group,the mandibular primary lateral incisor showed the highet incidence in primary dentition,while mandibular lateral incisor in permanent dentition.In the mandible(72.5%),this site showed higher prevelence than in maxilla.In this case with deciduous congenitally missing teeth,the prevelence of successive permanent congenitally missing teeth was about 33.9%,the incidence was highet in mandibular lateral incisors. 5.Most supernumerary teeth existed on middle area and showed inverted position and unerupted state.In addition,supernumerary teeth showed higher incidence on maxilla(99.3%). 6.In the case with deciduous fused teeth,the prevelence of successive permanent congenitally missing teeth was 39.9%,while that of successive permanent fused teeth was 2.7%.And the highet rate of the prevalence(40.3%) appeared in fusion of mandibular deciduous lateral incisor and canine. 7.In the case of odontoma,the prevelence was higher in maxilla(78.6%) and anterior region(82.7%) the mandible and posterior region.
수종 치과재료의 제I급 와동에서의 변연 누출에 관한 실험적 연구
이선희,손흥규,최형준 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.1
Microleakage is a problem of all filling materials of losted teeth structure and is clinically undetectable. Because marginal leakage may be responsible for pulp irritation, pulp inflammation, necrosis and recurrent caries, it is essential to prevent and control it. For the evaluations of microleakage of various class I filling materials, 175 extracted teeth were filled with amalgam, light curing composite resin, glass inomer cement, IRM and Fermit-N. After thermocycling, speciemens were placed in 1% methylene blue dye solution for 24 hours in an incubator set 37℃. The teeth were sectioned at filling body center and margin and degree of dye penetration was observed with a stereomicroscope. The following results were obtained. 1. Light cured composite resin has the excellent results and microleakage is increased in the order of amalgam, IRM, Fermit-N, glass ionomer cement.(SAS-6.0 system) and there was a statistically significancy in marginal leakage for each filling materials.(Kruskal-Wallis analysis, P<0.05) 2. Microleakage of the center and margin was statistically insignificant (Mann-Whitney analysis P<0.05) 3. There was less microleakage for amalgam than light cured composite resin but was statistically insignificant (Mann-Whitney analysis, P<0.05) and also showed less marginal leakage for Fermit-N compared to glass ionomer cement but also was statistically insignificant. (Mann-Whitney analysis, P<0.05).
이규식,정호삼,이민형,백두진,기춘석 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1
Prospidin, a new alkylating agent, has antimitotic and anticancer effect. Incubation with prospidin increases the stability of DNA and suppresses the incorporation of uridine into RNA by 15-20 percent. Prospidin is cytostatic for suspension culture and cells are blocked in G₂ phase of the cell cycle. The authors have demonstrated the effect of prospidin on the liver of mice histologically and histochemically and observed the cellular changes, loss of pyroninophilic granules and accumulation of fat in the hepatic parenchymal cells. Sixty-five healthy mice of ICR strain, average weight being 20g, were divided into two groups; control and prospidin-treated groups. All experimental animals were administered foo and water ad libitum. Animals of the prospidin-treated groups were administered prospidine 500mg per kg of body weight intraperitoneally fter dilution in the water for injection. Animals of the control group were administered only water for injection. Prospidin treated animals were sacrificed at intervals of 6, 12, 24, 36 and 48 hours after administration of prospidin. Histological preparations were made by way of hematoxylin and eosin stain for the cellular changes, methyl green-pyronin stain for pyroninophilic granules and oil red O stain for fat accumulation in the mouse liver. The results obtained are as follows. 1. Cellular swelling associated with vesicular formation were observed in the hepatic parenchymal cells of entire hepatic lobule at 24 and 36 hours after administration of prospidin. 2. A marked reduction of the pyroninophilic granules were observed in the hepatocyte of he whole hepatic lobule at 24, 36 and 48 hours following drug administration. 3. Fat deposits in the hepatic lobule were seen at 36 hours after administration of prospidin. It is suggested that prospidin acts as a cytotoxic agent and causes cellular swelling with vesicular formation, loss of pyroninophilic granules, and fat accumulation in the parenchymal cells of the liver.
정신과 외래환자의 약물치료 반응과 심박동 변이의 변화 양상
이상규,이홍석,김인주,김형태,김도훈,손봉기 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6
Objectives : The purpose of this study was to investigate the change of heart rate variability after antidepressant treatment in depressed or anxious patients. We tried to find the usefulness of heart rate variability as a predictive marker of response to pharmacological treatments in the psychiatric field. Methods : Forty-seven patients with major depression, anxiety disorder, and somatoform disorder were treated over 4 weeks with antidepressants and were then classified as responders or nonresponders according to Hamilton depression scales or CGI scores. The HRV variables were measured and compared among the responders/nonresponders and the matched normal control. Results : The responders group exhibited low heart rate, low PSI, high SDNN, RMSSD, HRV index, NN50, pNN50, LNTP, LNLF, and LNHF compared with the nonresponders after 4 weeks antidepressant treatment. However, no significant differencein HRV vanables was observed between the responders group after treatment and the nonnal control group and the responsegroup after treatment. Conclusion : These results indicate that HRV variables would are normalized after successful antidepressant treatment and it that HRV has some possible uses as a predicting marker of antidepressant response.
이정은,이제호,최형준,김성오,송제선,손흥규,최병재 대한소아치과학회 2009 大韓小兒齒科學會誌 Vol.36 No.4
유치의 정상적인 치근 흡수는 계승 영구치의 맹출 압력으로 단핵구 세포가 방출되어 파골세포로의 분화가 촉진되어 일어나며, 계승 영구치의 맹출 경로를 따라 유치의 치근이 흡수되어서 유치가 탈락하게 된다. 계승 영구치가 선천적으로 결손되었을 때에도 유치의 치근은 흡수될 수 있는데, 유치의 비정상적 치근흡수는 외상이나 염증, 교합압의 증가, 지지조직의 약화 등으로 발생할 수 있다. 치아의 선천적 결손은 인간에서 가장 흔한 발육이상이며, 영구치가 결손되었을 때 유치는 만기 잔존할 수 있다. 영구치의 선천적 결손은 전신질환이 있는 경우뿐만 아니라 국소적 원인이나 인류 진화에 따른 영향 등에 의해서도 발생한다. 이 증례들은 계승 영구치가 선천적으로 결손된 어린이에서 유치의 치근이 비정상적으로 흡수된 경우로 계승 영구치가 결손 된 유전치와 유견치, 유구치의 치근이 1/2 ~ 3/4정도까지 흡수 되었으며 흡수 부위는 불규칙적인 형태를 보였다. 원인으로는 흡수에 감수성이 높은 유치의 치주인대, 그리고 성장에 따라 증가되는 저작근육과 저작력, 혼합치열기에 유발되는 비정상적 교합 등을 생각할 수 있다. 계승 영구치가 결손된 유치가 비정상적인 치근 흡수를 보이는 경우에 유치는 유지될 수도 있지만, 여러 요인에 의하여 탈락될 경우에는 공간을 유지 할 것인지 판단해야 하며, 향후 보철치료나 교정치료를 요하므로 장기적인 치료계획을 수립해야 한다. Root resorption of primary teeth usually occurs as the succeeding permanent teeth erupt, which induces differentiation of the hemopoietic cells into osteoclasts. Their root resorption pattern reflects the eruption path of the succeeding permanent teeth, and eventually the primary teeth shed as their succeeding permanent teeth erupt. Even when a permanent tooth germ is congenitally missing, root resorption of the corresponding primary tooth may still occur due to various factors, such as inflammation, traumatic occlusal force, and weakness of periodontium etc. Such congenital missing of permanent teeth is a commonly observed phenomenon in human be ing, and it often accompanies delayed retention of primary teeth. The etiologic factors for congenital missing in elude not only systemic diseases, but also local factors and human evolution process. In the radiographs of the cases in this report, the primary teeth without succeeding permanent teeth show pathologic root resorption. Root resorption progressed about 1/2~3/4 of the roots, and the surfaces of the resorption area were irregular. Considering high susceptibility of the periodontal ligament of primary teeth to root resorption, pathologic root resorption of primary teeth with delayed retention can be explained by the increased masticatory muscle force and abnormal occlusion developed during the mixed dentition. When the primary teeth without succeeding permanent teeth are lost, decision for space maintenance is required and long-term treatment plan for further prosthetic or orthodontic treatment should be establsihed.
Dimethylformamide가 Mouse 肝細胞의 微細構造에 미치는 影響
이형록,정호삼,이규식 한양대학교 의과대학 1985 한양의대 학술지 Vol.5 No.2
Dimethylformamide (DMF) has been widely used in the synthetic textile industry as an organic solvent. However, it is known that DMF irritates to skin and mucous membranes and causes several toxic symptoms when dermal and respiratory exposure to DMF is prolonged. It is supposed that DMF provoked toxic reaction in the liver during the metabolic process of the DMF-injected experimental animal. Therefore, the authors observed changes cytoplasmic organelles of the hepatic parenchymal cells in order to demonstrate the effect of DMF on the mouse liver. Healthy male mice of ICR strain were used in this experiment and the weight of the experimental animals were around 20gm. The animals of the experimental group were administered DMF diluted in the water for injection, by intraperitoneal injection in a dose of 1.5ml per kg of body weight in a volume of 0.2ml. The animals of the control group were amdinistered only water for injection. The experimental animals were killed at intervals of 6, 12, 24 and 48 hours after administration of DMF, respectively. Liver specimens of 1mm³ size were prefixed in the 2% glutaraldehyde-2.5% paraformaldehyde phosphate buffer solution (pH 7.2) and post-fixed in the 1% osmic acid. After specimens were dehydrated and embedded in the epon 812, ultrathin sections(600-800A°thickness) were made and double stained with uranyl acetate and lead citrate. These preparations were observed with JEM 100B electron microscope. The results obtained were as follows: 1. Cisternae of rough endoplasmic reticulum were intensely dilatated and fragmented partly. 2. Smooth endoplasmic reticulum was markedly proliferated and glycogen particles were markedly decreased or depleted. 3. The atrophies of the Golgi complex were found. 4. Primary lysosomes and secondary lysosomes-residual bodies, autophagic vacuole and multivesicular bodies were increased in number. 5. Numerous lipid droplets of irregular size were produced. Consequently, it is concluded that DMF would induce the degenerative changes in cytoplasmic organelles of the hepatic parenchymal cell in the mouse.
이규형 한국스포츠리서치 2001 한국 스포츠 리서치 Vol.12 No.4
I studied on the Artistic Meaning Research and Philosophy of Taekwondo Demonstration. The Conclusion is as followed : First, after having studied the Artistic meaning of Taekwondo Demonstration, it is considered that the Artistic Meaning of Taekwondo Demonstration represents the historical background and training experience as an art and that the artistic nature of its beauty is the aesthetic experience only Taekwondo can have. Second, the study of Philosophy of Taekwondo Demonstration shows that the Meaning of Philosophy of Taekwondo Demonstration contains the essence and the philosophy which makes Taewondo a true Taekwondo itself. As for the expression of the inside and outside of Taekwondo Demonstration, it has two principles. One, a profound thought in respect of the great absolute in spiritual, and two, the movement of expression of a beautiful arts around the beautiful body, in the arts of physical activity.