쇄골하 정맥 카테터 제거 후 발생한 일과성 피질맹

김지훈,이규환,한시령,최영빈,김영인 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

LPC열의 상관 차원에 의한 화자인식

최성재,이헌규 경원전문대학 2000 論文集 Vol.22 No.-

The thesis is about the methods of speaker recognition by applying strange attractor of linear prediction coefficient series to speaker recognition. We have accomplished speaker recognition experiments by utilizing strange attractor of time series as well as of linear prediction coefficient series. The results were 94% recognition ratios. Therefore, the strange attractor of linear prediction coefficient series was more appropriate characterized parameter in increasing speaker recognition ratios.

흰쥐 내후야의 아미노산 함량에 대한 복측 또는 배측 뇌 해마 제거 영향

최석형,김종규,양훈모,민영기 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

This study was planned to analyze amino acids in the entorhinal cortex of dorsal and ventral hippocampectomized rats by high performance liquid chromatography (HPLC). Male albino rats were used. Under chloral hydrate anesthesia (20%, 2 ㎖/㎏ body weight), a hole was made in each parietal bone about 4 mm lateral to the sagittal suture, and 4 mm rostral to the lambda suture. The cortical tissue on each side was removed and, through this opening, the hippocampal tissue anterodorsal and posteroventral to the hippocampal flexures on both sides was removed by aspiration. This preparation served as the dorsal and the ventral hippocampal animals, respectively. The cortical control animal received the same surgery short of hippocampectomy. The normal rats served as normal control animal. One week later, the animals were sacrificed by decapitation in the cold room. Two to three milligrams of tissue was obtained from the entorhinal cortex in one side of the brain. The tissue samples were homogenized and centrifuged. Then content of each amino acid was measured by HPLC from the brain tissue. 1) The contents of aspartate were decreased significantly more in the dorsal and ventral hippocampal groups than in the normal and the cortical control groups, while there were no significant differences between the 2 hippocampal and 2 control groups. 2) The contents of glutamate were decreased significantly more in the dorsal hippocampal group than in the normal and the cortical control groups. The contents of glutamate were increased significantly more in the ventral hippocampal group than in the dorsal hippocampal, the normal control, and cortical control groups. while there was no significant difference between the 2 control groups. It is inferred from the above mentioned results that glutamate and aspartate of many amino acids may he used as a excitatory transmitter in entorhinal cortex, and that the dorsal hippocampus may be facilitatory to the entorhinal cortex, but the ventral hippocampus would be inhibitory/facilitatory to the cortex.

정상교하 아동의 두개안면부 성장에 관한 종적 연구

양규호,박창헌,손정수,김낙현,최남기,김선미,김기백,신혜성 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

혼합치열기 정상교합 아동 24명(남:14명 여:10명 초진 시 평균 나이 9±1.3세, 평균 관찰 기간: 13±1.3개월)에 대한 성장량을 측정하여 기능적 교정장치의 순수 치료효과를 평가하는데 도움이 되기 위해 3회(5~8개월 간격) 촬영한 측모 두부 방사선 규격 사진에 대한 분석 결과 다음과 같은 결론을 얻었다. 1. 남아는 상악골은 전하방, 하악골은 전방성장하였고, 여아는 상하악골이 전하방 성장하였다(p<0.05). 2. 상하악골의 남녀간 차이에서 수평적 성장상태는 여아가 컸고(A point 여아: 2.39mm, 남아: 1.26mm, p<0.05), 수직적 성장상태는 유의한 차이가 없었다. 3. 상악 전치의 치축은 두개저에 대해서 순측 경사하였고(p<0.01) 하악 전치의 치축은 큰 변화가 없었다. The purpose of this study was to provide the reference data evaluating the treatment effect of orthopedic appliances. The skeletal and dental growth increments were measured in 24 normal mixed dentition children(boys: 14, girls: 10) by three serial lateral cephalograms: initial mean age: 9±1.3 years, mean observation period: 13±1.3 months, Cephalometric changes were analysed. The results were as follows: 1. In boys, the maxilla showed forward and downward growth pattern and the mandible showed forward growth pattern(p<0.05). In girls, the maxilla and mandible showed forward and downward growth pattern(p<0.05). 2. Horizontal growth of both maxilla and mandible in girls was superior to those in boys(A point: girls: 2.39mm, boys: 1.26mm, with p<0.05), whereas vertical growth of both maxilla and mandible in boys was similar to those in girls. 3. The change in tooth axis showed labioversion of upper incisor(p<0.01) and comparatively stable lower incisor position.

고상 에피텍시 성장을 이용한 elevated source/drain 공정연구

金湘薰,崔在植,崔圭鎭,金亨駿 弘益大學校 科學基術硏究所 1999 科學技術硏究論文集 Vol.10 No.2

Recently, semiconductor devices require the ultrashallow junctions and low leakage current. Self-implantation to make preamorphization prevents channeling and minimizes junction depth. But in this way, implantation with high energy makes defects like dislocation loop in depletion region and interface between amorphous silicon and silicon wafer. But solid phase epitaxy using low pressure chemical vapor deposition prevents channeling, allows the easy control of junction depth by amorphous layer thickness, and improves the conventional processes. Amorphous silicon films in source and drain by LPCVD are elevated from the Si substrate. This structure is called "elevated source/drain". The elevated source/drain process improves metal contact and simplify the fabrication process. Usually, the amorphously-deposited Si films by chemical vapor deposition are crystallized to polycrystalline films due to a formation of SiO₂layer at the amorphous Si/Si substrates interfaces. Formation of SiO₂layer on Si surface can be effectively prevented by flowing the Si₂H?? gas during the heating-up procedure for amorphous Si depositions. In this way, amorphously deposited Si layer onto (100) Si substrates was grown epitaxially during the post-deposition heat treatments. The suppression of surface SiO₂can be explained in terms of adsorption of SiHx adspecies, instead of oxygen from residual gases in the reactors, to Si surfaces after desorption of hydrogen from H-passivated Si surfaces. Employing Si₂H?? flowing and solid phase epitaxial growth, high-quality epitaxial Si layer was obtained at low temperatures below 500℃ without conventional high temperature cleaning procedures. Amorphous Si films on Si substrate are epitaxially grown and amorphous Si films on SiO₂layer remain as amorphous with proper heat treatments. Uncrystallized amorphous Si films on SiO₂layer can be selectively etched using the HNO₃/HF/HNO₃/CH₃COOH solution with proper mixing ratio and elevated source/drain regions were formed.

PWM 인버터 시스템에서의 전도노이즈 저감을 위한 출력필터 설계에 관한 연구

金利勳,朴奎炫,元忠淵,金榮石,崔世琓 성균관대학교 2002 학술회의지원논문목록집 Vol.2002 No.-

본 논문에서는 PWM 인버터-유도전동기 구동시스템의 전도노이즈 저감을 위한 출력필터 설계에 관한 연구를 수행하였다. 전도 노이즈는 고전압 압력, 고용량 구동시스템, 그리고 긴 전동기 터미널 등의 경우에서 크게 문제가 된다. 고압력을 갖는 시스템에서는 높은 압력에 비례한 직류 링크 전압을 갖고 이에 따라 스위칭 시 dv/dt가 순간 최대 CM 접지전류를 발생시킨다. 그러므로 이에 대한 대책에 필요하다. 따라서 최근 산업 현장에서 많이 사용되고 있는 PWM 인버터를 설계 제작하여 유도전동기를 구동하고 이에 따라 발생되는 전도노이즈 성분을 감쇠 시킬 수 있는 출력필터를 설계하였고 제작 및 실험을 통하여 그 타당성을 입증하였다. In this paper, filtering techniques to reduce the adverse effects of motor leads on high-frequency PWM inverter fed AC motor drives are presented. The filter was designed to keep the motor terminal from the cable surge impedance to reduce overvoltage reflections, ringing, and the dv/dr, di/dt, at the motor terminals. Specially, the output filter is used to limit the rate of the inverter output voltage and reduce common mode noise to the motor. The performance of the output filter is evaluated through simulations and experiment on PWM inverter-fed AC motor drive. An experimental PWM drive system reduction of conducted EMI was implemented on an available TMS320C31 micoprocessor controd board. Finally, experimental result shows inverter output filter reduces more common mode voltage than low pass filter also reduce overvoltage and ringing at the motor terminal.

심미수복 재료의 마모와 화학적 분해

양규호,최남기,김훈주,김선미 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.2

수복재료의 요건으로서 치아의 저작기능과 심미성을 회복할 수 있는 물리적, 화학적 성질뿐만 아니라 생물학적 적합성과 구강내 환경변화에 대한 내구성을 들 수 있다. 불소 방출의 장점을 갖는 컴포머나 시술시간을 줄이는데 유리한 재료인 유동성 복합레진을 유구치부에 사용하려고 할 때 마모저항성과 구강내 환경에서의 분해저항성은 중요한 물성 중 하나이다. 실험에 사용된 복합레진은 최근에 시판되고 있는 Charmfil(Denkist, Korea)과 유동성인 Charmfil flow(Denkist, Korea)이고, 컴포머는 Compoglass F(Ivoclar Vivadent, Liechtenstein)와 유동성인 PrimaFlow(DMG Hamburg, Germany)이었다. 각 제품의 분해저항성과 마모도를 평가하고자 마모시험 후 마모된 면의 깊이를 측정하였고 알칼리성 용액에 보관 시 각 제품의 분해저항성을 무게손실, 표면하 분해층 깊이, 용출된 Si 농도를 기준으로 평가하였고 주사전자현미경과 공촛점 레이저 현미경으로 분해층을 관찰하여 다음과 같은 결과를 얻었다. 1. 무게손실량은 각 제품간 차이를 보이지 않았다(p>0.05). 2. 분해층 깊이는 Compoglass F가 가장 깊었고, PrimaFlow, Charmfil, Charmfil flow 순이었고 Compoglass P와 다른 제품 간에는 유의한 차이를 보였다(p<0.05). 3. Si 용출량은 Charmfil flow가 가장 많았고, Compoglass F가 가장 작았으며 두 제품 간에는 유의한 차이를 보였다(p<0.05). 4. 주사전자현미경 관찰시 표면 양상 및 분해층 깊이를 관찰할 수 있었고 공촛점 레이저 현미경 관찰시 NaOH 용액에 보관한 후 수복재의 기질과 충전제 사이의 결합의 파괴 양상인 분해층 깊이를 관찰할 수 있었다. 5. 마모는 Compoglass F에서 가장 많이 일어났으며, PrimaFlow, Charmfil, Charmfil flow 순이었고 각 제품 간에는 유의한 차이를 보였다.(p<0.05). 6. 각 제품의 Si 용출량과 분해층 깊이 사이(r=0.602, p<0.05), 마모 최대 깊이와 비커스 경도 사이(r=0.501, p<0.05)에는 유의한 상관관계를 보였으나 Si 용출량과 마모 최대 깊이 등 다른 항목간에는 유의한 상관관계를 보이지 않았다.(r=-0.052, p>0.05). 본 연구에서 Compoglass F는 불소 함량은 가장 높았으나 화학적 분해층과 마모깊이가 가장 깊은 것으로 나타났으며 flowable type의 복합레진과 컴포머는 표면 경도와 마모도에서 양호한 결과를 보였다. 이상의 결과 복합레진과 컴포머의 평가요소로서 마모도와 함께 가수분해도 고려되어야 할 것으로 사료된다. The aim of this study was to evaluate the resistance to degradation and to compare the wear resistance characteristics of four esthetic restorative materials in an alkaline solution. The brands studied were Charmfil, Charmfil flow(composite resin), Compoglass F and PrimaFlow(compomer) . The results were as follows: 1. The mass loss were not significantly different among the materials(p〉0.05). 2. The sequence of the degree of degradation layer depth was in descending order by Compoglass F, PrimaFlow. Charmfil, and Charmfil flow. There were significant differences between Compoglass F and the others(p<0.05). 3. The sequence of the Si loss was in descending order by Charmfil flow, Charmfil, PrimaFlow, and Compoglass F. There were significant differences among these materials(p<0.05). 4. When observed with SEM, destruction of bonding between matrix and filler was observed and when observed with CLSM, the depth of degradation layer of specimen surface was observed. 5. The sequence of maximum wear depth was in descending order by Comfoglass, PrimaFlow, Charmfil, and Charmfil flow. There were significant differences among these materials(p<0.05). 6. The correlation coefficient between Si loss and degradation layer depth (r=0.602, p〈0.05), Vicker's hardness number and maximum wear depth (r=0.501, p〈0.05) were relatively high. These results indicate that wear and hydrolytic degradation may be considered to be evaluation factors of composite resins and compomers.

TMS320F240을 이용한 PWM 인버터 유도전동기 구동 시스템의 전도노이즈 저감을 위한 스위칭 기법

朴奎炫,金利勳,元忠淵,金奎植,崔世琓,咸年根 성균관대학교 2003 학술회의지원논문목록집 Vol.2003 No.-

PWM 인버터에 의해 구동되는 유도전동기에 발생되는 고주파 커먼 모드 전압은 전도성 EMI, 전동기 접지전류, 베어링 전류 및 다른 원치 않는 결과의 주원인이 된다. 인버터 제어의 무효벡터 스위칭 상태는 나머지 유효벡터 스위칭 상태에 비교하여 큰 커먼 모드 전압을 일으킨다. 그러므로 이 논문은 커먼 모드 전압을 완화하는 스위칭기법을 다룬다. 즉 정현파 PWM기법을 기본으로 한 커먼 모드 전압 제거방법을 제안하였다. PWM 신호는 각각의 정현파 기준신호와 120˚위상차가 나는 3개의 캐리어 파형과 비교하여 발생된다. 시뮬레이션과 실험적결과는 제안된 PWM 기법에서 커먼 모드 전압이 종래의 PWM 기법보다 약 66% 더 저감됨을 보였다. High frequency common mode voltage produced by PWM inverter fed induction motor is a major cause of conducted EMI. creation motor ground currents, bearing currents and other hamful products. The zero switching states of inverter control invoke large in comparison with the non-zero switching state of inverter control. We proposed a common mode voltage reduction method based on sinusoidal PWM technique. PWM signal are generated by comparing respective sinusoidal reference signal with three triangular carrier wave displaced of 120˚. Simulation and experimental result show that common mode voltages in the propsed PWM technique are reduced by approximate 66% more than conventional PWM technique.

사마귀양 혈관종 1예

김웅,정헌,정병수,최규철 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Verrucous hemangioma is a structural variant of capillary, cavernous or mixed hemangioma which undergoes a reactive proliferative epidermal change. Most verrucous hemangiomas are present at birth, but in some cases, they appear during infancy. In most cases, the Iesions arise on the lower extremity. The differentiation of verrucous hemangioma from angiokeratoma circumscriptum is important because they are different on the therapeutic and prognostic aspects. We report a case of verrucous hemangioma which develop on the left lateral malleolar process of 18-year-old girl. The lesion was 3.2×2.6×1.5 cm sized, dark and keratotic. Histopathological examination revealed hyperkeratosis, papillomatosis and irregular acanthosis in the epidermis. Greatly dilated vessels were seen just beneath epidermis or enclosed within the papillomatous epidermis in upper dermis. There were numerous capillary luminas and proliferation of endothelial cells in the lower dermis and subcutis. Treatment was by wide surgical excision and skin graft.

말기 신부전 환자에서 투여 경로에 따른 유전자 재조합 인 Erythropoietin(Epokine^(�))의 효과와 안정성에 대한 연구 : 제 4상 연구 A Phase 4 Single Center Study

송현용,윤향숙,강신욱,최규헌,하성규,이호영,한대석 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

목 적 : 국내 독자적 기술로 첫 개발된 유전자 재조합 인 에리트로포에틴(Epokineⓡ)의 투여방법에 따른 유효성과 안정성을 알아보고자 하였다. 방 법 : Epokineⓡ을 주당 100-150 U/kg, 주 2회, 12주간 피하 주사하여 목표 또는 안정된 혈색소치 유지 후 무작위로 피하 및 정맥 주사군으로 나누어 12주간 혈액투석 및 복막투석 환자13명, 28명에서 유효성, 안정성을 분석하였다. 결 과 : 양군에서 혈색소치와 헤마토크릿은 Epokineⓡ 투여 2주 후부터 증가, 혈색소치가 혈액투석 환자는 투여 전 7.3 g/dL, 투여 12주 9.5 g/dL, 24주 10.6 g/dL로, 복막투석 환자는 6.8g/dL에서 12주 10.2 g/dL, 24주 10.8 g/dL로 증가하였다. 양군에서 교정 망상적혈구수(%)는투여 1주 후부터 전 기간동안 증가하였다. 혈청 내 철분, ferritin치는 양군에서 투여 2주 후부터감소, 총 철분 결합능은 투여 2주 후부터 증가하였다. 12주째 혈액투석 환자에서 많은 Epokineⓡ용량이 필요했으나(142.2±20.5 vs 117.3±33.6 U/kg/wk, p<0.001) 24주 후 양군의 용량차이는 없었다(123.6±41.5 vs 99.2±49.3 U/kg/wk, p>0.05). 혈액투석 환자에서 피하 주사가Epokineⓡ 투여용량이 더 적었으나(97.4±15.4 vs 145.4±2.9 U/kg/wk, p<0.002) 복막투석 환자는 차이가 없었다(93.0±60.2 vs 105.4±9.7 U/kg/wk, p>0.05) 연구기간 중 9명(18.8%)에서혈압강하제 추가가 필요한 혈압상승, 근육통 동반 상기도 감염 유사증상 및 두통 등의 부작용이 있었다. 대부분 자연소실 혹은 대증요법으로 치유되었고 2명이 부작용으로 탈락하였다. 결 론 : 말기 신부전 환자의 빈혈 개선에 사용하는 Epokineⓡ의 효과는 복막투석 환자에서 더 좋았으며 투여 경로는 정맥주사보다 피하주사가 높음을 알 수 있었다. Background : We evaluated the clinical efficacy and safety of recombinant human erythropoietin(Epokine^(ⓡ)). Methods : A comparative prospective study of intravenously and subcutaneously administrated Epokine^(ⓡ) conducted 13 patients performing hemodialysis and 28 patients performing continuous ambulatory peritoneal dialysis with end-stage renal disease. Epokine^(ⓡ) was given initially at a dosage of 100 unit/kg, subcutaneously, two times a week. The patients had achieved stable or more than 10 g/dL of hemoglobin level for 12 weeks and then we randomized switching intravenously or subcutaneously administrated Epokine^(ⓡ) for another 12 weeks. Results : Hemoglobin(g/dL) and hematocrit(%) increased significantly from baseline levels beginning from 2 weeks after Epokine^(ⓡ) administration. In HD patients, hemoglobin increased significantly from 7.3 to 9.5 after 12 weeks and to 10.6 after 24 weeks. In CAPD patients, hemoglobin increased significantly from 6.8 to 10.2 after 12 weeks and then 10.8 after 24 weeks(p<0.05). Corrected reticulocyte count(%) was significantly increased from baseline levels beginning from 1 week after Epokine^(ⓡ) administration and continuously increased during study period in both group. Serum ferritin and serum iron decreased significantly and total iron binding capacity increased significantly after 2 weeks. At 12 weeks, HD patients were significantly needed more dosage of Epokine^(ⓡ) than CAPD patients(142.2±20.5 vs 117.3±33.6 U/kg/wk, p<0.001), but at 24 weeks, the dosage was not different(123.6±41.5 vs 99.2±49.3 U/kg/wk, p> 0.05). In HD patients, intravenously administrated Epokine^(ⓡ) group was more dosage than subcutaneously group(97.4±15.4 vs 145.4±2.9 U/kg/wk, p< 0.002), but CAPD patients were not different by administration method(93.0±60.2 vs 105.4±9.7 U/kg/ wk, p>0.05). The 9 cases(18.8%) were suffered from headache and flu-like syndrome, but these side effects were not severe and disappeared from conventional therapy. Conclusion : Epokine^(ⓡ) administration is safe and effective in treating anemia of ESRD patients and subcutaneously administration is significantly more effective than intravenously. (Korean J Nephrol 2002;21(2):190-198)