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        Evaluation of the periodontal and pulpal healing of replanted rat molars with doxycycline root conditioning

        Nam, Ok Hyung,Cheon, Kyounga,Kim, Mi Sun,Lee, Hyo-Seol,Choi, Sung Chul Korean Academy of Periodontology 2019 Journal of Periodontal & Implant Science Vol.49 No.3

        Purpose: This study aimed to evaluate periodontal and pulpal healing in replanted rat teeth, preserved under different storage conditions, with or without root conditioning using doxycycline. Methods: A total of 40 maxillary first molars extracted from 20 Sprague-Dawley rats were stored for different durations under different conditions (5 minutes in dry storage and 60 minutes in Hank's balanced salt solution [HBSS]) and subsequently replanted. The rats were divided into 2 groups based on the use of root surface treatment: the doxycycline group (root surface treated with doxycycline) and the control group (no doxycycline treatment). Eight weeks after replantation, the animals were sacrificed, and the teeth were evaluated using micro-computed tomography (micro-CT) and histomorphometric analysis. Results: In the micro-CT analysis, the doxycycline group showed the same rate of occurrence of periapical radiolucency as was observed in the control group, but a lower degree of root resorption in teeth replanted after 60 minutes of storage in HBSS (P<0.05). In the histomorphometric analysis, the doxycycline group exhibited no improvement in either pulpal or periodontal healing of the replanted tooth after 5 minutes of dry storage, but showed a lower grade of surface root resorption ($1.37{\pm}0.77$) and inflammatory resorption in the teeth stored for 60 minutes in HBSS ($1.33{\pm}0.71$). Conclusions: In conclusion, doxycycline improved the periodontal healing of replanted teeth stored for 60 minutes in HBSS, whereas doxycycline did not improve periodontal healing of replanted tooth after 5 minutes of dry storage. Within the limits of this study, doxycycline showed more favorable periodontal healing despite delayed replantation.

      • Application of secondary intention for the restoration of the apical triangle after Mohs micrographic surgery

        ( Byung Ho Oh ),( Yeongjoo Oh ),( Shinwon Hwang ),( Jemin Kim ),( Sooyie Choi ),( Kyoungae Nam ),( Kee Yang Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

        Background: Restoring the apical triangle (AT) to maintain the symmetry of the face after Mohs micrographic surgery can be challenging. We have applied secondary intention (SI) after partial closure in cases with large defects. Objectives: To compare the cosmetic results between immediate closure (IC) and SI groups Methods: We retrospectively reviewed 22 patients (IC group: n = 13, SI group: n = 9). To evaluate the symmetry, the comparative ratio (CR; area of the AT of the involved side/area of the opposite normal side) was calculated. Results: Defect was much larger in the SI group than in the IC group (588.89±346.53 ㎟ vs. 261.92±211.05 ㎟, P < 0.05). Despite no statistically significant difference in average CR, the standard deviation was higher in the SI group (0.95±0.1 vs. 0.94±0.34, P = 0.5653), indicating the difficulty in predicting the results for SI healing. The average visual analog scale score evaluated by two dermatologists was higher in the IC group, albeit without significant difference (8.19±1.01 vs. 7.78±1.52, P = 0.5898). Conclusion: SI after partial closure can be a favorable option for large defects in the AT area.

      • Mohs micrographic surgery for dermatofibrosarcoma protuberans: Comparison of frozen and paraffin techniques

        ( Si-hyung Lee ),( Seung Ju Lee ),( Yeongjoo Oh ),( Kyoungae Nam ),( Byung Ho Oh ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

        Background: Due to the propensity for local recurrence, Mohs micrographic surgery (MMS) has been suggested for the treatment of dermatofibrosarcoma protuberans (DFSP) and it has shown improved clinical outcomes. Recently, some authors suggested that MMS using paraffin-embedded sections (paraffin MMS) is superior in DFSP treatment compared to the conventional frozen MMS method. However, there have been no studies comparing frozen and paraffin MMS for the treatment of DFSP. Objectives: To compare the outcomes between DFSP patients who underwent frozen MMS and paraffin MMS. Methods: Seventy-one DFSP patients treated with frozen MMS (n = 30) or paraffin MMS (n = 41) from 2003 to 2017 at a single institution were retrospectively reviewed. Recurrence rate and recurrence-free survival between frozen and paraffin MMS was assessed. Results: During the mean follow-up duration of 25.4 months, 4 patients (frozen MMS, n = 1; and paraffin MMS, n = 3) showed recurrence after MMS. Although the local recurrence rate of the frozen MMS group (3.3%) was lower than that of the paraffin MMS group (7.3%), the difference was not statistically significant. In addition, recurrence-free survival was not significantly different between the two groups (p = 0.168). Conclusion: Frozen MMS, which has the advantages of shorter surgery time and immediate closure, is as effective as paraffin MMS in the treatment of DFSP.

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