심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

발효기 종류에 따른 Cordyceps militaris에 의한 생물고분자 생산

이중헌,김경주 조선대학교 생산기술연구소 2005 生産技術硏究 Vol.27 No.1

The effects of fermenter types on biopolymer production with Cordyceps militaris has been studied in this articles. Since the shear stresses of stirred tank ferementor and bubble column fermenter were different. the mycelium growth and biopolymer production were different, The mycerial growth was high with the bubble column fermenter for the early stage but biopolymer production was lower than that with stirred tank fermenter. The production of biopolymer was closely related to shear stress to the cells and biopolymer production was increased with increased shear stress.

정전 열 접합을 이용한 Multi-Substrate Bonding

이덕중,주병권,최우범,한정인,조경익,이광배,장진,오명환 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

We performed silicon-to-glass bonding using silicon direct bonding followed by anodic bonding(SDAB). Initial bonding between glass and silicon was caused by the hydrophilic surfaces of silicon and glass ensemble using silicon direct bonding(SDB) method. We found that the bonded specimen using SDAB process had higher strength than one using anodic bonding process only. We performed multiple layer bonding by SDAB, which is glass- silicon -glass as sandwich structure. In the silicon wafer, the (1mm x 2mm x 500μm)-sized cavity was formed by the anisotropic etching of the silicon substrate in EPW(Ethylendiamin-Pyrocatechol-Water). And, the cavity was sealed with glass wafers by SDAB method.

특수형 방사성 동위원소 운반캡슐의 안정성 평가

이주찬,서기석,구정회,방경식,한현수,박성원 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.1

특수형 방사성물질 운반캡슐은 국내외의 수송관련 법규에 규정된 기술기준을 만족하도록 설계, 제작되어야 한다. 본 연구의 목적은 하나로에서 생산된 192Ir 특수형 동위원소 운반캡슐의 건전성을 평가하는데 있다. 법규에서 규정된 낙하시험, 타격시험, 굽힘시헝 및 가열시험조건에 대한 안전성 시험을 수행하였으며, 각각의 시험 전후에 누설시험을 수행하였다. 또한, 안전성시험과 더불어 컴퓨터코드를 이용한 전산해석을 수행하여 안전성시험 전에 시험결과에 대한 예측자료로 활용되었다. 낙하시험 및 가열시험 결과 캡슐 표면에서 약간의 흠집과 변형이 발생하였으나, 각각의 시험에서 평가기준이 되는 캡슐의 손상이나 용융 등은 발생하지 않았다. 또한 각 시험 후 수행한 누설시험 결과 누설이 발생하지 않았다. 따라서 특수형 방사성물질 운반캡슐은 법규에서 규정하는 기술기준을 만족하도록 설계, 제작되었음이 입증되었다. All of sealing capsules to transport a special form radioactive material should be designed and fabricated in accordance with the design criteria prescribed in IAEA standards and domestic regulations. The objective of this study is to demonstrate the safety of a shipping capsule for 192Ir special form radioisotope which produceed in the HANARO. The safety tests were carried out for the impact, percussion, bending and heat test conditions. And leakage tests were carried out before and after the each test. Also, the safety analyses were performed using computer codes in order to verify the test results. The capsule showed slight scratches and deformation, and maintained its structural and thermal integrities in all tests without any severe damage or melting. It also met the allowable limits of leakage rate after earth test. Therefore, it has been verified that the capsule was designed and fabricated to meet all requirements for the special form.

중합효소연쇄반응을 이용한 도말양성 폐결핵 환자에서의 결핵균 DNA 검출방법에 관한 연구

이종진,김애경,조해정,한표성,홍석철,김주옥,김선영 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

Polymerase chain reaction (PCR) is the most sensitive and rapid method for the diagnosis of M.tuberculosis infection. Many reports have shown different methods for mycobacterial DNA extraction, but revealed many differences in simplicity and time-consumption. We studied which method was the best among 7 different ones for DNA extraction from 32 smear-positive sputa, using PCR of targeting 123bp DNA fragment of IS6110. The methods were the following : SDS-Microwave oven method, NaOH Lysis method, Triton X-100, Proteinase K method, Lysis buffer method. SDS-Proteinase K method, Bead Beater method, and Bead Beater/CTAB method. The amplification products were identified by electrophoresis on ethidium bromide-stained agarose gels, and confirmed by restriction enzyme, Southern blot hybridization, and DNA sequencing. All 32 cases were positive (100%) by the 7 different methods. It took 1 hour or more to detect DNA in SDS-Microwave oven method, NaOH Lysis method, and Bead beater/CTAB method. It took 2 hours or less in the others. SDS-Proteinase K method and Bead Beater/CTAB method were simpler and more convinient than the others. These results suggest that SDS-Proteinase K method and Bead Beater/CTAB method might be better than the others for the extraction of mycobacterial DNA in terms of simplicity and time-consumption, although all the methods were sensitive.

침적 모형에 의한 습성침적 플럭스 수치모의

이화운,문난경,임주연 한국환경과학회 2002 한국환경과학회지 Vol.11 No.12

The purpose of this study is to estimate wet deposition flux and to investigate wet deposition characteristics by using the ADOM model. Wet deposition flux of high reactive SO_2 is estimated by applying observed meteorological parameters and concentrations of chemical species to the ADOM model. Wet deposition is largely dependent on large scale precipitation and cloud thickness. Wet deposition flux of sulfate increases, but wet deposition flux of SO_2 is small. On the whole, the pattern of sulfate flux agrees with the typical pattern of sulfate wet deposition that is high in the summer(July) and low in the winter(January)

일개 대학병원에 내원한 원발성 폐암 환자의 인구학적 및 병리학적 특성

주혜원,강경필,김민근,박민석,임현민,이현경,이성순,이영민,김주인,염호기,최수전,이혁표 인제대학교 2006 仁濟醫學 Vol.27 No.-

Background : Recently, the lung cancer mortality rank first in Korea. The prognosis of lung cancer is not good enough with current treatments and multimodality treatments are required. So we are interested in the characteristics of lung cancer patients for better treatment. Methods : We searched lung cancer patients since 1994. Then we collected the data of primary lung cancer patients about the demographic features, histologic types and diagnotic methods. We divided the total period into 2 haves and specific analysis was tried. Results : 1) Total 850 patients were included. 633 (74.5%) were male and 217 (25.5%) were female. 2) The mean age was 65 ± 11 years old. and the peak age was 7th decades. 3) Squamous cell carcinoma(334/850, 39.3%) was slightly more prevalent than adenocarcinoma(302/850, 35.5%). Conclusion : From these results, we expected that older persons will be diagnosed to have lung cancer and adenocarcinoma will be more dominant histologic type with time.

아연배소광 황산침출액의 이온평형에 미치는 온도영향

이만승,이경주 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.4

To simulate the sulfuric acid leaching solutions of zinc calcine, synthetic solutions with the composition of ZnSO_4-Fe_2(SO_4)_3-Na_2SO_4-H_2SO_4-NaOH-H_2O were prepared and solution pH was measured at the temperature of 25, 50 and 75℃. The effect of temperature on the ionic equilibria of these solutions was analyzed by considering chemical equilibria, mass balance and charge balance equations. Activity coefficients of solutes and activity of water were calculated by using Pitzer equation. The mole fractions of iron containing species were greatly affected by solution temperature and the concentration of Fe_2(SO_4)_3. In the experimental ranges of ionic strength of solution up to 9m, the pH values calculated in this study were in good agreement with those measured.

Alamine336염에 의한 FeCl₃ 용매추출평형

이만승,이경주 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.2

Solvent extraction experiments of FeCl_(3) with Alamine336 salt were performed. It was found from the oading capacity of Alamine336 salt that the solvent extraction reaction depended on the ratio of initial concentration of Alamine336 to FeCl_(3). When the concentration of Alamine336 was in excess compared to that of FeCl_(3), alamine336 participated in the extraction reaction as a dimer. When the initial concentration ratio of Alamine336 to FeCl_(3) was below three, ferric chloride was extracted by monomeric Alamine336. The equilibrium constants of solvent extraction, K_(ex)-2.22×10^(4) and K_(ex)=6.41×10^(5) for monomeric and dimeric Alamine336 respectively, were determined from extraction data by considering activity coefficient of solutes in the aqueous phase. The predicted distribution coefficients of iron agreed well with those experimentally measured.

급성호흡부전증 환자에서 초기 인공환기방식의 중요성 : 인공환기시 혈역학적으로 유의한 부정맥의 유발요인 분석

이영주,김원,김영득,천석천,임경수 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The purpose of this article was to identify the risk factors related to development of hemodynamically significant cardiac arrythmias in patients with mechanical ventilation. Methods and Results: Holter recording and echocardiogram were performed after 30 minutes of ventilator initiation in patients on mechanical ventilation(MV) owing to respiratory failure(RF) from various reasons. From 68 patients, hemodynamically significant cardiac arrythmias were detected in 18 patients(26.5%). Initial mean arterial pressure, maximal heart rate, and initial pH were identified as risk factors for hemodynamically significant cardiac arrythmlas. Additionally, the patients with pressure-controlled ventilation as an initial ventilatory mode developed hemodynamically significant cardiac arrythmias less frequently than the patients with other modes(15.8% vs. 40%, p=0.03). In multivariate analysis, initial mean arterial pressure(<70mmHg, odds ratio[OR]: 5.5; 95% confidence interval[CI]: 1.2 to 24.2, p=0.026), maximal heart rate(>120/min, OR: 19.7; 95% CI: 2.0 to 190.9, p=0.01), and pressure-controlled ventilation(OR: 0.13, 95% CI: 0.03 to 0.55, p=0.006) were associated with the development of hemodynamically significant cardiac arrhythmias. Conclusion: Theses findings suggest that during the early stages of mechanical ventilation with acute respiratory failure, hemodynamically significant cardiac arrhythmias are directly associated with tachycardia(>120/min), initial MAP(<70 mmHg), and, inversely, the initial use of pressure-controlled ventilation.