양격산화탕(凉膈散火湯)의 항염증(抗炎症) 효과에 대한 연구

탁미진,탁명림,강경화,고우신,윤화정,Tak, Mi-Jin,Tark, Myoung-Rim,Kang, Kyoung-Hwa,Ko, Woo-Shin,Yoon, Hwa-Jung 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1

Objective: Yang Geouk San Hwa - Tang (YGSHT) has been widely used in Sasang Constitutional Medicine of Korea for treatment of acute inflammatory symptom, such as palatine tonsillitis, polydipsia, headache, papule, pimple however, the mechanism of its anti-inflammatory activity has not been clarified. In this study, therefore, we investigated the mechanism of the inhibitory effect of YGSHT on LPS-induced inflammation. Materials and methods: The effect of YGSHT was analyzed by ELISA, RT-PCR and Western blotting in LPS-stimulated RAW264.7 cells. Results: We found that YGSHT suppressed not only the production of pre-inflammatory cytokines (IL-$1{\beta}$ and TNF-$\alpha$), the generation of nitric oxide (NO) and prostaglandin E (PGE)2, but also the mRNA expression of pre-inflammatory cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2. Furthermore, YGSHT was shown to inhibit the phosphorylation of ERK1/2 and JNK1/2 and the activation and translocation of NF-kB from cytosol to nuclear in LPS-stimulated RAW264.7 cells. Conclusions: These results suggest that YGSHT exerts an anti-inflammatory effect through the regulation of the ERK1/2 and JNK1/2 pathway and NF-kB pathway, thereby decreasing production of pre-inflammatory cytokines, NO, and PGE2.

탄성반력의 영향에 따른 직교 이방성 복합판의 고유 진동 해석

정영화,심도식,김경진,이세진 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-

In this paper, the result of application of vibration method to the orthotropic plates with free edges supported on elastic foundation and with a pair of opposite edges under axial forces is presented. Such plates represent the concrete highway slab and hybrid composite pavement of bridges. The reinforced concrete slab can be assumed as a special orthotropic plate, as a close approximation. The highway slab is supported on elastic foundation, with free boundaries. Sometimes, the pair of edges perpendicular to the traffic direction amy be subject to the axial forces. The plate is subject to the concentrated load/loads, in the form of traffic loads, or the test equipments. Finite difference method is used to obtain the deflection influence surfaces needed for vibration analysis. The influence of the modulus of the foundation, the aspect ration of the plate, and the magnitudes of the axial forces and the concentrated attached mass on the plate, under the natural frequency is thoroughly studied.

산후에 발병한 특발성 부갑상선 기능저하증 I 예

김정인,김상용,신병철,김경남,서영욱,이범주,김진화,배학연 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Hypoparathyroidism is usually the result of an inadvertent surgical removal of all the parathyroid glands, In some instances, not all the tissues are removed, but the remainder undergoes vascular supply compromise secondary to the fibrotic changes in the neck after surgery, Previously, the surgery for hyperthyroidism was the most frequent cause of acquired hypoparathyroidism. Idiopathic hypoparathyroidism is a relatively rare disease that is characterized by hypocalcemia and hyperphosphatemia due to a parathyroid hormone deficiency of an unknown cause, It usually develops at a young age, and shows various clinical symptoms and signs accompanied with hypocalcemia. In addition, it is rarely associated with polyglandular autoimmune syndrome during the follow-up. Hypocalcemia and idiopathic hypoparathyroidism associated with labor and lactation are rarely reported condition previously. We here describe a case of a woman in whom the symptomatic severe hypocalcemia appeared after her delivery. We reviewed all the previously reported cases and suggest a possible physiological explanation for the association between pregnancy, lactation, and the appearance of symptomatic hypocalcemia.

법률비서 : 합동법률사무소 변호사 비서를 중심으로

구은경,송화영,문선화,이유경,정혜영,최보인 이화여자대학교 법정대학 비서학과 1995 비서학연구 Vol.- No.15

고등급 이형성을 보인 편평톱니샘종

권경주,정성애,심기남,정정화,강석형,송도경,전승정,김혜인 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.1

Until recently, colorectal polyps were classified predominantly as hyperplastic or adenomatous. While adenomatous polyps are well-characterized precursor lesions of adenocarcinomas, hyperplastic polyps have been considered as benign lesion. However, some hyperplastic polyps with serrated morphology of the crypts have been recognized to have distinctive features and these polyps were termed ‘serrated adenomas’. Recent data show that sessile serrated adenomas (SSA) might be the precursors of serrated colonic cancers, underlining the necessity of identifying them. SSA is approximately 3% of all polyps, commonly appears as flat or sessile and yellowish due to mucus production. In the pathogenesis of SSA, progression to high grade dysplasia or early invasive carcinoma may be associated with serrated neoplasia pathway different from adenoma-carcinoma sequence. We report a case with a colon polyp diagnosed as sessile serrated adenoma with high grade dysplasia after endoscopic submucosal dissection.

영아보육 일과에 나타난 질적 보육의 장애요인 분석

유연화,최경애,이정란 경복대학 2004 京福論叢 Vol.8 No.-

본 연구는 질적 연구를 통해 영아보육일과에 나타난 질적 보육의 장애요인을 분석함으로써 우리나라 영아보육 현장의 생태학적 특성을 이해하는데 목적이 있다. 보육시설의 질적 수준과 관련된 생태적 특성을 분석하기 위해 서울·경기 지역의 9개 보육시설을 참여관찰하고 영아반 교사와 시설장을 심층 면접하였다. 연구 결과, 협소한 보육실 등 물리적 환경의 열악함, 영아기 프로그램에 대한 이해 및 영아에게 적합한 교수전략의 부족, 지나치게 집단적인 교육과정 운영 및 일과지도, 비위생적인 건강관리태도, 영아용 실외놀이 환경의 부족, 보육교사의 열악한 근무 여건, 조기 학습에 대한 학부모의 압력 등이 관찰대상 영아보육 프로그램의 질을 저하시키는 장애요인으로 지적되었다. The purpose of this study is to understand the ecological characteristics of infant/toddler care program by analyzing major factors of barriers about the quality of infant/toddler care center. The main research consisted of the qualitative research, and 9 infant/toddler centers locate in Seoul and Gyeong-gi province. As findings of research, It pointed out some problems of infant/toddler care program which were observing target. It's problems were 1)lack of physical environment, specially small-crowded room, 2)lack of understand on the developmentally appropriate practice and instruction for infant/toddler care, 3)excessive grouping of activity and care, 4)unsuitable attitude of health care, 5)lack of out door environment for infant/toddler, 6)bad working condition of teachers, 7)negative attitude and pressure of parents toward ealy learning.

강원지역의 자원관리를 위한 지리정보시스템 개발

서백수,임길재,정영준,송화선,류창희,민경원,서희정 강원대학교 석재복합신소재제품연구센터 1997 석재연 논문집 Vol.2 No.-

강원도는 오랫동안 금속, 비금속, 석재 및 석탄과 같은 지하자원들을 공급하는 국내 주요생산지로 알려져 왔으나, 장기적인 채광과 비 계획적인 생산으로 인하여 매장량이 고갈되고 있으며, 대외적으로 생산 경쟁력 마저 잃어가고 있다. 이러한 문제점에 대한 해결방안의 일환으로 본 연구에서는 강원도내에 산재되어 있는 지하자원의 분포, 자원 생산시설 및 생산량, 경제성, 자원개발, 환경문제 등 자원관리에 필요한 제반사항을 수행할 수 있는 강원지역 자원 종합관리 GIS 시스템을 개발하였다. 이 시스템의 개발은 방대한 양의 정보 조사 및 저장, 오랜 개발기간, 많은 소요인력 및 개발 비용이 요구되기 때문에 본 연구에서는 조기에 자원관리 GIS 시스템을 개발하여 이와 관련된 생산 및 연구 분야에 조기에 적용할 수 있도록, 일차년도에는 현재 석재복합 신소재제품 연구센터의 집중적 연구대상 지역인 태백지역에 대한 탄광지역을 중심으로 자원 종합관리 GIS 시스템을 개발하였다. The Kangwon province has been well-known to be one of major underground resource producing districts which are mainly supplying metals, non-metals, stones, and coals. However, due to the long-term mining and unplanned production, the natural resource reserves have been rapidly drained and oversea production competition has been losing. In this study, we has developed a GIS system for regional resource management in the Kangwon province, which can operate, maintain, and manage the distribution of underground resources, resource production facilities, production and economic development, and environmental issues. The development of this system requires the collection, analysis, evaluation, and storage for a huge amount of research data, and in addition, the long period of time, the big research man power, and big development cost. Accordingly, to shorten the development period of time and to early apply itself to production, this stage of study has been intensively developed a regional resource GIS system for managing the mines scattered in the Tabak province, which is one of hottest RRC's research areas.

A 27-Year-Old Woman Diagnosed as Polycystic Ovary Syndrome Associated with Graves' Disease

Jung, Jung Hwa,Hahm, Jong Ryeal,Jung, Tae Sik,Kim, Hee Jin,Kim, Ho Soo,Kim, Sungsu,Kim, Soo Kyoung,Lee, Sang Min,Kim, Deok Ryong,Choi, Won Jun,Seo, Yeong Mi,Chung, Soon Il The Japanese Society of Internal Medicine 2011 Internal medicine Vol.50 No.19

<P>Polycystic ovary syndrome (PCOS) and Graves' disease are the common causes of menstrual irregularity leading to infertility in women of child-bearing age. A 21-year-old female patient visited us with complaints of oligomenorrhea and hand tremor. She was diagnosed as having PCOS and hyperthyroid Graves' disease, simultaneously. She had low body weight (BMI: 16.4 kg/m<SUP>2</SUP>), mild hirsutism, and thyrotoxicosis. The patient was treated with anti-thyroid drug and beta-blocker for about two years, and then recovered to normal thyroid function. Although some studies have suggested a connection between PCOS and autoimmune thyroiditis, no study indicated that PCOS is associated with Graves' disease until now. Here, we describe the first case report of a lean woman with normal insulin sensitivity presenting PCOS and Graves' disease simultaneously.</P>

Poster Session : Cytokine analysis of anthrax Lethal toxin-intoxicated murine macrophages

( Kyoung Hwa Jung ),( Giw Moon Seo ),( Kwang Keun Oh ),( Seung Joo Kim ),( Ji Chon Kim ),( Young Gyu Chai ) 한국생화학분자생물학회 (구 한국생화학회) 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-

Electroacupuncture preconditioning reduces ROS generation with NOX4 down-regulation and ameliorates blood-brain barrier disruption after ischemic stroke

Jung, Yeon Suk,Lee, Sae-Won,Park, Jung Hwa,Seo, Hyung Bum,Choi, Byung Tae,Shin, Hwa Kyoung BioMed Central 2016 JOURNAL OF BIOMEDICAL SCIENCE -BASEL- Vol.23 No.1

<P><B>Background</B></P><P>Electroacupuncture (EA) is a modern application based on combination of traditional manual acupuncture and electrotherapy that is frequently recommended as an adjuvant treatment for ischemic stroke. EA preconditioning can ameliorate blood-brain barrier (BBB) dysfunction and brain edema in ischemia-reperfusion injury; however, its mechanism remains unclear. This study investigated the preventive effects of EA preconditioning, particularly on BBB injury, followed by a transient middle cerebral artery occlusion (MCAO) model in mice.</P><P><B>Results</B></P><P>Mice were treated with EA (20 min) at Baihui (GV20) and Dazhui (GV14) acupoints once a day for 3 days before ischemic injury. Infarct volume, neurological deficits, oxidative stress, Evans blue leakage and brain edema were evaluated at 24 h after ischemia-reperfusion injury. EA preconditioning significantly decreased infarct volume and improved neurological function even after ischemic injury. In addition, both Evans blue leakage and water content were significantly reduced in EA preconditioned mice. Whereas the expression of tight junction proteins, ZO-1 and claudin-5, were remarkably increased by EA preconditioning. Mice with EA preconditioning showed the reduction of astrocytic aquaporin 4, which is involved in BBB permeabilization. In addition, we found that EA preconditioning decreased reactive oxygen species (ROS) in brain tissues after ischemic injury. The expression of NADPH oxidase 4 (NOX4), not NOX2, was significantly suppressed in EA preconditioned mice.</P><P><B>Conclusions</B></P><P>These results suggest that EA preconditioning improve neural function after ischemic injury through diminishing BBB disruption and brain edema. And, the reduction of ROS generation and NOX4 expression by EA preconditioning might be involved in BBB recovery. Therefore, EA may serve as a potential preventive strategy for patients at high risk of ischemic stroke.</P>