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- 저자 : ( Kyoung Ae Kong ) (검색결과 32 건)
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Association of Adiponectin Gene Polymorphism With Birth Weight in Korean Neonates
Kong, Kyoung Ae,Suh, Young Ju,Cho, Su Jin,Park, Eun Ae,Park, Mi Hye,Kim, Young Ju Cambridge University Press 2013 TWIN RESEARCH AND HUMAN GENETICS - Vol.16 No.3
<P>Adiponectin has been associated with insulin resistance and type 2 diabetes mellitus and possibly fetal growth. Our aim was to assess the association between the single nucleotide polymorphisms (SNPs) of the adiponectin gene (<I>ADIPOQ</I>) and the birth sizes. We investigated four SNPs of <I>ADIPOQ</I> (rs182052, rs2241766, rs1501299, and rs266729) and birth height and weight in 237 healthy full-term neonates. The neonates with the rs182052 G allele had a greater birth weight (<I>p</I> = .043 in the dominant model) and a higher ponderal index (<I>p</I> = .028 in the additive model). The rs2241766 G allele was associated with a greater birth weight (<I>p</I> = .016 in the recessive model). In a logistic regression analysis, the homozygotes for the rs182052 G allele and those for the rs2241766 G allele showed a significant association with a greater birth weight above 90 percentile (OR 2.75, 95% CI 1.13-6.70 and OR 5.15, 95% CI 1.66-15.99, respectively). In conclusion, we found an association between rs182052 and rs2241766 and birth weight and ponderal index among healthy neonates and suggested that adiponectin might have some roles in fetal growth.</P>
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Kong, Kyoung Ae,Jung-Choi, Kyung-Hee,Lim, Dohee,Lee, Hye Ah,Lee, Won Kyung,Baik, Sun Jung,Park, Su Hyun,Park, Hyesook Japan Epidemiological Association 2016 Journal of epidemiology Vol.26 No.3
<P><B>Background</B></P><P>Smoking is a major modifiable risk factor for premature mortality. Estimating the smoking-attributable burden is important for public health policy. Typically, prevalence- or smoking impact ratio (SIR)-based methods are used to derive estimates, but there is controversy over which method is more appropriate for country-specific estimates. We compared smoking-attributable fractions (SAFs) of deaths estimated by these two methods.</P><P><B>Methods</B></P><P>To estimate SAFs in 2012, we used several different prevalence-based approaches using no lag and 10- and 20-year lags. For the SIR-based method, we obtained lung cancer mortality rates from the Korean Cancer Prevention Study (KCPS) and from the United States-based Cancer Prevention Study-II (CPS-II). The relative risks for the diseases associated with smoking were also obtained from these cohort studies.</P><P><B>Results</B></P><P>For males, SAFs obtained using KCPS-derived SIRs were similar to those obtained using prevalence-based methods. For females, SAFs obtained using KCPS-derived SIRs were markedly greater than all prevalence-based SAFs. Differences in prevalence-based SAFs by time-lag period were minimal among males, but SAFs obtained using longer-lagged prevalence periods were significantly larger among females. SAFs obtained using CPS-II-based SIRs were lower than KCPS-based SAFs by >15 percentage points for most diseases, with the exceptions of lung cancer and chronic obstructive pulmonary disease.</P><P><B>Conclusions</B></P><P>SAFs obtained using prevalence- and SIR-based methods were similar for males. However, neither prevalence-based nor SIR-based methods resulted in precise SAFs among females. The characteristics of the study population should be carefully considered when choosing a method to estimate SAF.</P>
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공경애 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.1
The reliability of clinical measurements is critical to medical research and clinical practice. Newly proposed methods are assessed in terms of their reliability, which includes their repeatability, intra- and interobserver reproducibility. In general, new methods that provide repeatable and reproducible results are compared with established methods used clinically. This paper describes common statistical methods for assessing reliability and agreement between methods, including the intraclass correlation coefficient, coefficient of variation, Bland-Altman plot, limits of agreement, percent agreement, and the kappa statistic. These methods are more appropriate for estimating reliability than hypothesis testing or simple correlation methods. However, some methods of reliability, especially unscaled ones, do not clearly define the acceptable level of error in real size and unit. The Bland-Altman plot is more useful for method comparison studies as it assesses the relationship between the differences and the magnitude of paired measurements, bias (as mean difference), and degree of agreement (as limits of agreement) between two methods or conditions (e.g., observers). Caution should be used when handling heteroscedasticity of difference between two measurements, employing the means of repeated measurements by method in methods comparison studies, and comparing reliability between different studies. Additionally, independence in the measuring processes, the combined use of different forms of estimating, clear descriptions of the calculations used to produce indices, and clinical acceptability should be emphasized when assessing reliability and method comparison studies.
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Employment status and mortality among Korean men over a 13-year period
Dohee Lim,Kyoung Ae Kong,Hyesook Park,Kyunghee Jung-Choi 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: This study explored the effect of employment status on mortality over a 13-year period in Korean men. METHODS: Data were used from the Korean Labor and Income Panel Study from 1999 to 2012. This study started with 2,737 subjects and included employed men in good health, aged 30-69 years. Deaths were tracked for 13 years from 2000 to 2012. Employment status classifications were: (1) regular employees, (2) precarious employees, (3) petty bourgeoisie, and (4) employ-ers. Hazard ratios (HRs) were calculated using a Cox proportional hazards model, and were adjusted for age, education, in-come, and occupation, with regular employees as the reference category. To examine the effect of employment status and in-clude employment history, the risk ratios of mortality were measured using the Poisson regression model, considering the dura-tion of each employment and using 0 years as the reference category. RESULTS: Over the course of the 13-year study, being a precarious employee (HR, 1.84) or petty bourgeoisie (HR, 1.87) at a particular point in time had a negative effect on mortality when compared with regular employees. Furthermore, working as precarious employees or petty bourgeoisie had no positive effect on mortality. A positive effect was observed, however, on the overall mortality risk for regular employees. CONCLUSIONS: These results suggest that a healthy social policy is needed for precarious employees and petty bourgeoisie to avoid disadvantages in the workplace and the social safety net.
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( Seok Jeong Lee ),( Kyoung Ae Kong ),( Yon Ju Ryu ),( Jin Hwa Lee ),( Jung Hyun Chang ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Osteoporosis is an important comorbidity in patients with COPD. Osteoporosis and its complication such as fracture cause poor quality of life and even mortality. We investigated risk factors of osteoporosis in COPD patients. Methods: We analyzed data from the 2008-2011 KNHANES. Subjects who aged 40 years or more and performed acceptable and qualified spirometry, dual-energy X-ray absorptiometry, the nutrition examination survey, and serum vitamin D measurements were enrolled. COPD was defined as an FEV₁/FVC < 0.7. Osteoporosis was defined as a bone mineral density (BMD) T-score =-2.5 at femur or lumbar spine. Results: A total of 881 subjects with COPD were enrolled, and 141 (16%) had osteoporosis. Epidemiologic and nutritional variables and serum vitamin D levels of osteoporosis group were compared with those of non-osteoporosis group, and variables for multiple logistic regression model were selected. Old age (60-69 years vs. 40- 49 years, OR 33.78, 95% CI 3.60-317.14), female (OR 15.54, 95% CI 6.71-36.00), low body mass index (BMI) (< 18.5 kg/m² vs. 18.5-25 kg/m², OR 14.24, 95% CI 4.38-46.31), lack of moderate exercise (exercise vs. lack of exercise, OR 0.41, 95% CI 0.19-0.88), and lower intake of carotene (per 1000 mg increase, OR 0.88, 95% CI 0.79-0.97) were independently associated with osteoporosis in COPD subjects. Although vitamin D deficiency, defined as serum levels < 20 ng/mL, was more prevalent in COPD subjects with osteoporosis, multiple logistic analysis failed to show statistical significance. Conclusions: Old age, female, low BMI, lack of exercise, and lower carotene intake were risk factors of osteoporosis in COPD. Acknowledgement: This was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-0027945).
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( Seok Jeong Lee ),( Kyoung Ae Kong ),( Yon Ju Ryu ),( Jin Hwa Lee ),( Jung Hyun Chang ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Osteoporosis is an important comorbidity in patients with COPD. Osteoporosis and its complication such as fracture cause poor quality of life and even mortality. We investigated risk factors of osteoporosis in COPD patients. Methods: We analyzed data from the 2008-2011 KNHANES. Subjects who aged 40 years or more and performed acceptable and qualified spirometry, dual-energy X-ray absorptiometry, the nutrition examination survey, and serum vitamin D measurements were enrolled. COPD was defined as an FEV₁/FVC < 0.7. Osteoporosis was defined as a bone mineral density (BMD) T-score =-2.5 at femur or lumbar spine. Results: A total of 881 subjects with COPD were enrolled, and 141 (16%) had osteoporosis. Epidemiologic and nutritional variables and serum vitamin D levels of osteoporosis group were compared with those of non-osteoporosis group, and variables for multiple logistic regression model were selected. Old age (60-69 years vs. 40-49 years, OR 33.78, 95% CI 3.60-317.14), female (OR 15.54, 95% CI 6.71-36.00), low body mass index (BMI) (< 18.5 kg/m² vs. 18.5-25 kg/m², OR 14.24, 95% CI 4.38-46.31), lack of moderate exercise (exercise vs. lack of exercise, OR 0.41, 95% CI 0.19-0.88), and lower intake of carotene (per 1000 mg increase, OR 0.88, 95% CI 0.79-0.97) were independently associated with osteoporosis in COPD subjects. Although vitamin D deficiency, defined as serum levels < 20 ng/mL, was more prevalent in COPD subjects with osteoporosis, multiple logistic analysis failed to show statistical significance. Conclusions: Old age, female, low BMI, lack of exercise, and lower carotene intake were risk factors of osteoporosis in COPD. Acknowledgement: This was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-0027945).
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Cha, Eun Shil,Kong, Kyoung Ae,Moon, Eun Kyeong,Khang, Young-Ho,Lee, Won Jin The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.3
<P>To examine the relationship between birth characteristics and childhood cancer mortality, a retrospective cohort study of Korean children was conducted using data collected by the national birth register between 1995 and 2006, which were then individually linked to death data. A cohort of 6,479,406 children was followed from birth until their death or until December 31, 2006. Poisson regression analyses were used to calculate rate ratios of childhood cancer deaths according to birth characteristics. A total of 1,469 cancer deaths were noted and the childhood cancer mortality rate was found to be 3.43 per 100,000 person-years in Korea during the period of 1995-2006. The birth characteristics examined in this study (i.e. , birth weight, gestational age, multiple births, parental ages, and number of siblings) were generally found to be not significantly associated with childhood cancer mortality, and the associations did not vary meaningfully with gender nor with cancer sites. However, among children aged 5-11 yr, higher birth weight was associated with elevated childhood cancer mortality (rate ratio = 1.28, 95% confidence interval 1.04-1.58). Our results offer no overall associations between childhood cancer mortality and birth characteristics, but suggest that the association may be specific to age group.</P>
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Effect of Preexisting Musculoskeletal Diseases on the 1-Year Incidence of Fall-related Injuries
Lee, Won-Kyung,Kong, Kyoung-Ae,Park, Hye-Sook The Korean Society for Preventive Medicine 2012 Journal of Preventive Medicine and Public Health Vol.45 No.5
Objectives: People who have chronic diseases, as well as gait imbalance or psychiatric drug use, may be susceptible to injuries from falls and slips. The purpose of this study was to evaluate the effect of musculoskeletal diseases on incidental fall-related injuries among adults in Korea. Methods: We analyzed data from the 4th Korea National Health and Nutrition Examination Survey (2007-2009), which are national data obtained by a rolling survey sampling method. The 1-year incidence of fall-related injuries was defined by health service utilization within the last year due to injury occurring after a slip and fall, and musculoskeletal diseases included osteoarthritis, rheumatoid arthritis, osteoporosis, and back pain. To evaluate the effects of preexisting musculoskeletal diseases, adults diagnosed before the last year were considered the exposed group, and adults who had never been diagnosed were the unexposed group. Results: The weighted lifetime prevalence of musculoskeletal disease was 32 540 per 100 000 persons. Musculoskeletal diseases were associated with a higher risk of fall-related injury after adjustment for sex, age, residence, household income, education, occupation, visual disturbance, paralysis due to stroke, and medication for depression (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.03 to 1.93). As the number of comorbid musculoskeletal diseases increased, the risk of fall-induced injuries increased (p-value for trend <0.001). In particular, patients who had any musculoskeletal condition were at much higher risk of recurrent fall-related injuries (OR, 6.20; 95% CI, 1.06 to 36.08). Conclusions: One must take into account the risk of fall-related injuries and provide prevention strategies among adults who have musculoskeletal diseases.
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Soo In Kim,Kyoung Ae Kong 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.4
Objective We examined the performance of attention tests related to suicidal ideation in mood disorder patients and to explain the difference of attention test performance in relation to suicidal ideation after controlling clinical and psychological variables of mood disorder patients. Methods Seventy-three in- and outpatients with major depressive disorder (n=41) or bipolar disorder (n=32) completed a self-rating questionnaire assessing socio-demographic characteristics, and clinical and psychological variables. Comprehensive Attention Test (CAT) also was conducted. Results Thirty-three patients were the high-suicidal ideation (SI) group, and forty patients were the low-SI group. The errors of commission (CEs) of visual sustained attention in the high-SI group was 6.3 times higher on average than that of the low-SI group. After controlling for sex, age, and diagnosis, a higher number of CEs on visual sustained attention tasks predicted higher SI score. However, after controlling for sex, age, diagnosis, and depressive mood, this predictive ability was no longer observed. Conclusion This study showed that CE on the visual sustained attention task seems to influence suicidal ideation as a result of interaction with depressive symptoms.
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