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P102 : Effect of escitalopram on erythematotelangiectatic rosacea
( Kyou Chae Lee ),( Sang Lim Kim ),( Jin Sub Lee ),( Yoon Hyuk Choi ),( Hyun Ho Son ),( Hong Dae Jung ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Weon Ju Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: There is no satisfactory treatment for erythematotelangiectatic rosacea. Objectives: To investigate the effect of escitalopram for the treatment of erythematotelangiectatic rosacea Methods: Twenty four subjects (male to female: 3:20, mean age: 44.4 years) were enrolled. Exacerbating factors were analyzed with questionnaire. Escitalopram was given at a dose of 5 mg/day for 8 weeks. Evaluation was performed at baseline and at week 8 and 24. Efficacy was evaluated through severity, investigator`s global assessment (IGA), subjective satisfaction score (SSS), chromameter and skin function test. Safety was monitored through adverse effects. Results: Exacerbating factors were sunlight, stress and hot bathing. At week 8, subjects achieved a significant decrease from 44 to 30 in severity (p<0.05). Out of 23 subjects, 5 were ranked fair, 12 good and 6 excellent in IGA. In addition, 4 were ranked fair, 12 good and 7 excellent in SSS. Chromameter showed statistically significant improvement after treatment with escitalopram, from 19.26 to 17.43 (P<0.05). Skin hydration by corneometer showed a statistically significant increase from 64.91 to 73.62 (p<0.05). Mild adverse effects, such as insomnia, facial swelling and drowsiness, were reported. At week 24, subjects achieved much more improvement in severity, IGA, SSS and chromameter. Conclusion: Escitalopram may be a useful and safe treatment option for the management of erythematotelagiectatic rosacea.
( Kyou Chae Lee ),( Soo Yuhl Chae ),( Hyun Wuk Cha ),( Yong Hyun Jang ),( Weon Ju Lee ),( Do Won Kim ),( Seok Jong Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Studies for prognostic factor of malignant melanoma (MM) were well performed in the west due to relatively high incidence rate. However, there are little data of MM, available in Korea. Objectives: To investigate the current status of clinicopathological features and prognostic predictors of MM. Methods: One hundred sixty patients diagnosed with MM at our hospital from 2007 to 2013 were enrolled. We analyzed age, sex, tumor location, duration, thickness, ulceration, tumor-infiltrating lymphocytes (TIL), microscopic satellite (Ms), angiolymphatic invasion, mitosis, clinicopathologic subtype, and clinical stage by review of medical records and histopathological slides. Univariate analysis and multivariate analyses for survival were performed by means of the Cox proportional hazard model. Results: The ratio of female to male was 1.22 to 1 and the mean age was 60.6 years. Most of the tumors were located on the hands and feet. Acral lentiginous melanoma was the most common (69.6%), followed by nodular melanoma (12.8%), superficial spreading melanoma (12.8%), and lentigo maligna melanoma/lentigo maligna (4.7%). The poor prognosis was related to sex, Ms, mitosis, and stage by univariate analysis, whereas it was related to sex and Ms by multivariate analysis. Conclusion: Our study showed the clinicopathological features and prognostic factor of MM in Korea. But further study is needed because our study has limitation result from loss to follow-up in confirmed death.
The epidemiology of d ermatophyte infection in southeastern Korea (1979-2013)
( Kyou Chae Lee ),( Min Ji Kim ),( Sang Lim Kim ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Yong Jun Bang ),( Jae Bok Jun ),( Weon Ju Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Dermatophytosis is common worldwide and isbelieved to affect more than 20-25% of the world’s population. The epidemiology of dermatophyte infection is influenced by variable factors. Objectives: To investigate the epidemiology of fungal skin infections through a retrospective analysis of patient’s medical records between 1979 and 2013. Methods: Of total 4,275,715 patients, 415,526 patients with clinically suspicious fungal infection were collected at Catholic Skin Disease Clinic in Daegu. KOH examination and culture were performed. Of 415,526 patients, 131,440KOH- and culture-proven patients were included in this study. Results: The annual number of patients with dermatophytosis ranged from 1,973 to 6,166 between 1979 and 2013. Trichophyton (T.) rubrum was the most commonly identified dermatophyte, followed by T. mentagrophytes, Microsporum (M.) canis, and Epidermophyton (E.) floccosum. T. rubrum infection was found predominantly in thirties, T. mentagrophytes infection in forties, and M.canis and T. tonsurans infection in teenagers. T. rubrum and T. mentagrophytes infection were most commonly seen in summer. M. canis infection was most commonlyseen in winter and T. tonsurans infection in spring and winter. The most common site was toe web in T. rubrum and T. mentagrophytes infection, scalp in M. canis infection, and trunk in T. tonsurans infection. Conclusion: This study will provide valuable information on current epidemiological trends for fungal infections in Korea.
( Kyou Chae Lee ),( Sang Lim Kim ),( Hyun Wuk Cha ),( Yong Hyun Jang ),( Weon Ju Lee ),( Do Won Kim ),( Seok Jong Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Incidence of cutaneous malignant tumor is increasing recently and the changes in pattern may be suggested. Nevertheless, there has been little research into the distribution, incidence of cutaneous malignant tumors in Daegu and Kyungpook Province. Objectives: To analyze changes of during recent two decade in incidence, clinical patterns of cutaneous malignant tumors in Kyungpook national university hospital(KNUH). Methods: We reviewed 1,527 cases of cutaneous malignant tumors from 1994 to 2013 at the Department of Dermatology in KNUH. We also devided subgroup into first (1994-2003) and second decade (2004-2014) to see changed over the years. Results: The average incidence of cutaneous malignant tumors among the total number of outpatients was 1.57% through whole study period. The incidence of cutaneous malignant tumors in the first half of the study period was 0.37% and in the second half was 2.05%. The highest average incidence was basal cell carcinoma (BCC) (first vs. second decade: 0.15% vs. 0.66%), followed by squamous cell carcinoma (SCC) (0.11% vs. 0.49%) and malignant melanoma (MM) (0.05% vs. 0.23). The most common site was the face in each decade. The overall recurrence was diagnosed in 55 of the 1,527 patients (3.60%). In each disease, the recurrence rate was 1.79% vs. 0.58% (BCC), 4.17% vs. 0.81% (SCC), and 0.60% vs. 1.47% (MM). Conclusion: This epidemiological study provided useful information for the distribution, incidence and prognosis of skin tumors.