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      • 기혼여성의 여가활동 참여빈도와 여가태도의 관계

        송강영,양광희,김이정 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

        The main purpose of this study is to investigate The Contribution Frequency of Leisure Participation to Leisure attitude among Married Women. The subjects of this study are married women residing in Seoul using a systematic stratified cluster random sampling. From our target sample of 500, excluding those who dropped out in the course of research or those questionnaires that were judged unreliable, the sample number used in actual analysis was 349 people. In order to analyze the data, this study used a SPSSWIN 11.0 program for statistical analysis. Correlation and Regression Analysis were conducted to examine hypothesis Based on the above research methods and procedures, this study produced the following results. The frequency of leisure participation influences leisure attitude. The higher the frequency of leisure participation the greater leisure attitude.

      • 흰쥐에서 음경발기 평가의 척도로서 음경해면체내압측정술 확립

        송윤섭,김용준,이광우,김준모,문기혁,박영호,민영기,유형균,김형건 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

        Purpose: Because studies about the control of penile erection at the entral nervous system was dependent on the animal experiments, establishment of measuring penile erection is important to evaluate the effects changes at the central nervous system on the penile erection. Intracavernous pressure measurement in rats has been introduced as a suitable index for the evaluation of penile erection but this method is invasive and technically difficult. So, we established the intracavernous pressure measurement in rats as the experimental index for penile erection. Materials and Methods: 42 male adult Sprague-Dawley rats (250-300gm) were divided to saline or papaverine treated group. Rats were placed on a heating table to maintain their body temparature and anesthetized with 50mg/kg of pentobarbital sodium by intraperitoneal injection. A cannula was inserted to the left carotid artery to measure systemic blood pressure. Saline (0.05, 0.1ml), papaverine(0.05, 0.1, 0.25, 0.5, 1.0, 2.0mg) were injected intracavernously via 26 guage needle filled with saline or papaverine which connected to pressure transducer and polygraph was inserted into the corpus cavernosum on one side to inject the drug and to measure intracavernous presure. Results: Properly executed insertion and intracavernous administration produced a instantaneous but transient rise in intracavernous pressure that substantially stabilized and maintained at 5.4±0.4mmHg. Intracavernous pressure and duration of penile blood flow following intracavernous injection of papaverine are increased comared to those of saline. Conclusions: Monitoring intracavernous pressure in rats represents a suitable index for the evaluation of penile erection in small laboratory animals.

      • KCI등재
      • Fe^++이 6-Hydroxydopamine에 의한 Synaptosome의 변성에 미치는 영향

        송영명,이정수,이광수 중앙대학교 의과대학 의과학연구소 1986 中央醫大誌 Vol.11 No.3

        Metal ions such as Fe^++ and Cu^++ are reactive cations which are know to catalyze eventual production of either hydroxyl radical(OHㆍ) or singlet oxygen(^10_2) In the Haber-Weiss reaction. These metal ions have been suggested to simulate the autoxidation of several autoxidizable compounds, among them catecholamines and hemoglobin. The autoxidation of 6-OHDA is also stimulated by metal ions and it is reported that neuronal damages caused by 6-OHDA are affected by metal ions. In the iron-catalyzed Haber-weiss reaction to produce OHㆍ the only function of 0^-_2 is to reduce Fe^+++ to Fe^++. This role or 0^-_2 may be replaced by other reducing agents and ascorbate may be one of such reducing agents occuring in bioiogical system. In the present study, the possible role of Fe^++ was investigated in the autoxidation of 6-OHDA and 6-OHDA induced inactivation of synaptoiomal Na^+-K+ ATPase and Mg^++ ATPase. These effects were studied with respect to generation of reactive oxygen species during autoxidation of 6-OHDA, lipid peroxidation and oxidation of sulfhydryl group. Also, the effect of ascorbate on inactivation of synaptosomal ATPase caused by 6-OHDA with and without Fe^++ was investigated. The synaptosomal Na^+- K^+ ATPase and Mg^++ ATPase activities were significantly reduced by S-OHDA, and this inactivation was effectively prevented by catalase, a scavenger of H_2O_2, SOD, a scavenger of 0^-_2 and histidine, a scavenger of ^1O_2. Generation of H_2O_2 and 0_2 during autoxidation of 6-OHDA and antoxidation were inhibited by catalase and SOD. Fe^++ stimulated the rate of autoxidation og 6-OHDA and enhance inactivation of ATPase caused by 6-0HDA. Inactivation of ATPase caused by Fe^++ and 6-0HDA was apparently inhibited by catalase, SOD and histidine. Fe^++ reacted with O^-_2 which was released during autoxidation of 6-OHDA and formed other reactive oxygen species including H_2O_2. When synaptosomes were incubated with 6-OHDA, both the production of malonyldiaidehyde from synaptosomes and the oxidation of sulfhydryl groups were increased with time, and these phenomena were further enhanced by Fe^++ or Cu^++ Generation of H_20_2 and inactivation of ATPases due to interaction of Fe^++ and 6-OHDA were faciliated by ascorbate. The results obtained suggest that reactive oxygen species which take pare in autoxidation of 6-OHDA or which were released primarily during autoxidation of 6-OHDA may be the less reactive oxygen species such as 0^-_2 and Immediate oxidants of destruction processes appear to be due to more reactive oxygen species such as ^1O_2 Fe^++ acted as catalyst for autoxidation of 6-0HDA and enhanced the inactivation of ATPases caused by 6-OHDA. These effects were further stimulated by ascorbate. It is therefore suggested that inactivation of ATPases caused by 6-OHDA or Fe^++ and 6-OHDA may be associated with lipid peroxidation and oxidation of sulfhydryl groups of synaptosomes, and these events may be attributable to O_2, H_2O_2 and particularly, ^1O_2.

      • KCI등재

        구연산과 칼슘이 치아침식증의 발생에 미치는 영향

        송인경,이광희,김대업,양영숙 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

        산성 음료의 치아침식증 유발력을 감소시키기 위한 연구의 일환으로, 0.1%, 0.3%, 0.5%, 1.0% 구연산용백의 5분, 15분, 30분, 60분간의 사람 소구치 법랑질의 치아침식증 유발력 및 구연산용액에 첨가되는 칼슘 0.05%, 0.1%, 0.2%에 따른 치아침식증 발생 억제효과를 표면미세경도를 측정하여 연구하였다. 전체적으로 볼 때, 구연산 농도가 높을수륵, 탈회시간이 길수록, 칼슘농도가 낮을수록 탈회후 경도가 하락하였다. 탈회 5분 후 경도는 칼슘 무첨가의 경우에 76~90%이었고 칼슘 첨가에 따른 5분간의 탈회억제량은 2~l5%이었다. 탈회 15분 후 경도는 칼슘 무첨가의 경우에 65~84%이었고 칼슘 첨가에 따른 15분간의 탈회억제량은 3~l7%이었다. 탈회 30분 후 경도는 칼슘 무첨가의 경우에 53~72%이었고 칼슘 첨가에 따른 30분간의 탈회억제랑은 6~22%이었다. 탈회 60분 후 경도는 칼슘 무첨가의 경우에 43~66%이었고 칼슘 첨가에 따른 60분간의 탈회억제량은 7~l9%이었다. 탈회억제량의 분포를 전체적으로 보면, 구연산 농도에서는 1.0%에서 가장 크게 나타났고, 칼슘농도에서는 0.2%에서 가장 크게 나타났으며, 탈회시간에서는 0,1% 구연산용액에서는 탈회시간이 증가함과 더불어 탈회억제량도 함께 커지는 경향을 보였으나, 0.3% 이상의 구연산용액에서는 30분에 가장 크고 60분에 약간 감소하는 경향을 보였다 이상의 결과는 구연산에 의한 치아침식증 발생에 칼슘이 억제효과를 나타낼 수 있음을 시사한다. The purpose of study was to observe the effect of calcium and citric acid on the dental erosion of human premolar enamel. Enamel specimens were demineralized in 0.1%, 0.3%, 0.5%, or 1.0% citric acid solutions with 0.05%, 0.1%, or 0.2% calcium for 5, 15, 30, and 60 minutes, and then the surface microhardness of the enamel was measured. The hardness decreased as the concentration of citric acid and the demineralization time increased. Hardness after 5 minutes was 76~90% in case of no calcium and the inhibition of dental erosion by calcium addition was 2~15%. Hardness after 15 minutes was 65~84% in case of no calcium and the inhibition of dental erosion by calcium addition was 3~17%. Hardness after 30 minutes was 53~72% in case of no calcium and the inhibition of dental erosion by calcium addition was 6~22%. Hardness after 60 minutes was 43~66% in case of no calcium and the inhibition of dental erosion by calcium addition was 7~19%. The inhibition was the highest in 1.0% citric acid and 0.2% calcium. In 0.1% citric acid the inhibition increased as the demineralization time increased, but in 0.3% to 1.0% citric acid the inhibition was most high at 30 minutes and decreased a little at 60 minutes. These results suggest that calcium has a inhibitory effect on the citric acid induced dental erosion.

      • KCI등재후보

        합성피혁제조업체 근로자들의 요중 N-Methylformamide 농도의 계절적 변이

        이광영,변주현,송혜란,김진하,고광욱,이용환 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.2

        목적: 본 연구는 여름과 겨울의 계절적 차이에 따른 디메틸포름아미드의 체내 흡수의 변화를 알아보고자 시행되었다. 방법: 일개 합성피혁제조업체에서 직접적으로 디메틸포름아미드를 취급하는 22명의 근로자들을 대상으로 2001년 2월(겨울)과 7월(여름)에 작업환경측정을 통해 기중 DMF농도를 측정하였고 특수건강검진을 실시하여 요중 NMF의 배설량을 측정하고 간기능 검사를 시행하였다. 또한 검사 당일의 평균 기온과 평균 습도를 측정하고 설문지를 통해 알코올 음주 정도, 피부 질환의 유무, 보호구 착용 유무 등을 조사한 후 여름과 겨울의 자료를 비교 분석하였다. 결과: 겨울과 여름의 평균 공기 중의 디메틸포름아미드 기하 평균 농도는 각각 11.55ppm, 13.78ppm으로 통계적으로 유의한 차이는 없었으나 요중엔-메틸포름아미드 배설량의 기하 평균은 겨울이 31.23㎎/g creatinine인 것에 비해 여름이 96.09㎎/g creatinine으로 겨울에 비해 여름의 요중 엔-메틸포름아미드 배설량이 유의하게 높았다(p<0.05). 공기 중 디메틸포름아미드 농도(ppm)에 대한 요중 엔-메틸포름아미드 배설량 (㎎/g creatinine)의 비는 여름(1:6.97)이 겨울(1:2.70)에 비해 약 2.6배 정도 높았다. 결론: 여름과 겨울의 요중 NMF배설량의 차이는 아마도 연구 대상 사업장의 환기 시설이 미약하고 근로자들이 DMF에 적합한 보호구를 적절하게 사용하지도 않았기 때문이고, 무엇보다도 높은 온도와 습도에서 짧은 옷을 입고 근무함으로써 피부 노출면적이 증가되어 DMF의 피부 흡수의 양이 많아졌기 때문으로 판단된다. Objectives: This study was carried out to identify seasonal variations of urinary concentrations of N-methylformamide(NMF) among workers employed at a synthetic leather factory. Methods: Study subjects consisted of 16 male and 6 female workers who were involved in the direct treatment of dimethylformamide(DMF) in a synthetic leather factory. By using health examination data and the results of air measurements and biologic monitoring conducted in February and July, 2001, we identified seasonal variations of the DMF concentrations in the air and NMF concentrations in urine. Results: 1) In winter and summer, average temperatures at the working sites were 3.2℃ and 26.5℃, respectively and average humidities were 35.4% and 84.5%, respectively. 2)Airborne DMF concentrations were not significantly different between summer(13.78ppm) and winter(11.55ppm). 3)NMF concentrations in urine were found to be significantly higher in summer(96.09㎎/g creatinine) than in winter(31.23㎎/g creatinine) (p<0.001). Conclusions: The seasonal difference in the urinary excretion values of NMF may be due to increased dermal absorption of DMF with the higher ambient temperature and humidity in summer and the increased area of exposed skin.

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