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Helicobacter pylori 편모 유전자의 클로닝 및 염기서열 분석
이광호,이우곤,조명제,도영미,백승철,강경희,박필성,이상룡 경상대학교 유전공학연구소 1993 遺傳工學硏究所報 Vol.12 No.-
A λgt11 expression libary of H. pylori DNA in E. coli Y1090 was screened with flagellin-specific rabbit antiserum for molecular cloning of the flagellin gene of H. pylori. A positive clone, λHPF4, was obtained and the recombinant antigen expressed from λHPF4 was a fusion protein with the molecular weight of 168kd. Sequence analysis of antigen-encoding DNA showed that an open reading frame composed of 1,536 nucleotides encodes a polypepride with a oredicted molecular size of 54kd. This open reading frame did not show the homology with flaA gene encoding 56kd protein of H. pylori and was confirmed as a unique sequence through homoligy searching. Therefore, the cloned antigen is supposed to be the carboxy-terminal region of the other flagellin protein of H. pylori, flaB, with the molecular weight of 58kd.
치료시기에 따른 상악골 전방견인효과 : 사춘기전과 사춘기의 비교 A comparison of prepubertal and pubertal patients
김경호,최광철,백형선,이지현 대한치과교정학회 2002 대한치과교정학회지 Vol.32 No.5
상악골 전방견인 장치를 이용한 골격성 Ⅲ급 부정교합 환자의 악정형적 치료에서 치료시기는 치료효과에 지대한 영향을 미칠 수 있으며 이상적인 치료시기는 연구자에 따라 다소의 차이는 있으나 다른 형태의 부정교합보다는 다소 이른 사춘기 이전의 어린 나이라는 것이 선학들의 공통된 의견이었다. 하지만 통계적 자료들을 바탕으로 한 최근의 논문들은 과거 선학들의 의견을 뒷받침 해주는 논문과 그렇지 않은 논문들로 나뉘고 있어 이상적 치료시기에 대한 정립된 의견이 없는 실정이다. 이에 본 연구에서는 119명의 환자들의 수완부골 방사선 사진을 평가하여 골성숙도에 따라 사춘기전군과 사춘기군으로 분류하고 치료전후 측모두부방사선 사진을 분석하여 상악골 전방견인에 대한 치료효과를 비교하였다. 평균 치료기간은 사춘기전군은 6.5개월, 사춘기군은 6.1개월이었으며 치료전후의 측모두부방사선 사진을 분석한 결과 다음과 같은 결론을 얻었다. 1. 상악골의 전방이동양은 사춘기전군과 사춘기군간에 차이에 없었다. 2. 상악골의 하방이동양은 사춘기전군과 사춘기군간에 차이가 없었다. 3. 하악골의 하방이동양과 후하방회전양은 사춘기전군과 사춘기군간에 차이가 없었다. 4. 치성이동양은 사춘기전군과 사춘기군간에 차이가 없었다. 이상의 결과로 사춘기전 뿐 아니라 사춘기에서도 상악골 전방견인에 의해 상악골 성장촉진과 함께 성공적인 악정형 치료가 가능함을 알 수 있었다. Treatment timing is a very important factor to consider in treating skeletal Class Ⅲ patients by means of maxillary protraction. According to the literature maxillary protraction should be carried out at an early age before puberty. However, no scientific data were presented to support this statement and recent studies supported by statistical data showed disagreement concerning the optimum treatment time of maxillary protraction. Therefore, there is no agreement about the optimum treatment time of maxillary protraction. In this study hand-wrist X-rays were taken from 119 patients and subjects were grouped into prepubertal and pubertal group according to their skeletal maturity . Preagreement and posttreatmrnt lateral cephalometric X-rays were taken and treatment effects were compared. The average treatment time was 6.5 months for the prepubertal group and 6.1 months for the pubertal group. The obtained results were as follows : 1. The amount of maxillary forward movement was the same for prepubertal and pubertal group. 2. The amount of maxillary downward movement was the same for prepubertal and pubertal group. 3. The amount of mandibular downward and backward rotational movement was the same for prepubertal and pubertal group. 4. Dental effects were the same for prepubertal and pubertal group.
흉부외상 없이 발생한 흉부대동맥 절단증의 조기 진단 : 2례 보고 Two Cases Report
한승백,전영진,백광제,김준식,김정택,김광호,선경 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4
Aortic transection or interruption is a rare condition which developed after an acute deceleration injury. Its occurrence depends on the location and direction of the force applied and is usually from motor vehicle accident or falling down. The exact incidence of aortic transection in trauma is not known but, when develops, only about 10-15% of the victims can survive and be transported to the hospital. Even in the survivors, majority of them will be fatal within a few days if a prompt diagnosis and surgical treatments are not made. Aggressive diagnostic work-up is recommended for the patients with high suspicious index, which would salvage the victims with this fatal condition. We report the experience of two cases of aortic transection or interruption following motor vehicle accidents.
위암종과 Epstein-Barr 바이러스와의 연관성에 대한 연구
심광용,김호영,김효열,백순구,권상옥,조미연,이창훈,이종인 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Objectives: Epstein-Barr virus (EBV) has been known to be linked to a spectrum of neoplastic conditions, including nasopharyngeal carcinoma, Burkitt's lymphoma, peripheral T-cell lymphoma and Hodgkin's disease. This study aims to investigate the association of EBV with gastric carcinoma in Korea. Methods: Fifty-three cases of gastric adenocarcinoma were studied for evidence of EBV infection by EBV-encoded small RNA (EBER) in situ hybridization (ISH) on the paraffin sections and amplifying the EBV genome encoding envelop glycoprotein (gp220) with polymerase chain reaction (PCR) in fresh gastric cancer specimens. Results: EBER was detected in 7 (13.2%) of 53 gastric carcinomas and all cases were male. In 6 (85.7%) of 7 EBER-positive cases, the tumors were located in the upper and middle part of the stomach. EBER ISH study showed strong positivity in all the tumor cells, but negativity in surrouning lymphocytes, stromal cells and normal gastric mucosa. DNA PCR was positive in 23 (43.4%) of 53 gastric carcinomas, including all of 7 EBER-positive cases. Conclusion: We could observe some association of EBV with gastric carcinoma, and our findings about the charateristics of EBV-positive gastric cancers involving sex, site and histological type are similar to those in Japan. However, EBV-positive rate of gastric cancer is higher than in Japan and lower than in Western countries. Further studies to elucidate oncogenic mechanism of EBV in gastric cancer should be performed.
Spin-Peierls 전이를 하는 CuGeO₃계의 이온 치환 효과
이영배,채광표,권우현,백서욱,이성호 건국대학교 자연과학연구소 1998 建國自然科學硏究誌 Vol.9 No.1
Spin-Peierls 전이를 하는 CuGeO₃계에 원소를 치환했을 때의 자기적 및 결정학적 특성을 비교 검토하고, 직접 Cu₁-xGe₁-xFe₂O₃(x=0.05, 0.1) 시료를 제조하여 SQUID, Mssbauer 분광기, X-선 회절 방법으로 연구하였다. 이 시료의 결정구조는 orthorhombic 이고 격자 상수는 x= 0.05 때 a = 4.795Å, b=8.472Å, c=2.904Å 이고 x=0.1때는 a=4.784Å, b=8.472Å, c=2.904Å였다. 상온에서 Mssbauer 스펙트럼은 Fe³+ 이온의 사면체 자리에 의한 이중선과 팔면체 자리에 의한 Zeeman 선으로 중첩되어 나타났고 자기감수율의 극대점과 Mssbauer 변수의 불연속으로부터 본 시료의 spin-Peierls 전이 온도는 13K 임을 알아냈다. The magnetic and crystallograpic properties of the substituted spin-Peierls transition CuGeO₃ system have been reviewed, and we synthesized the Cu₁-xGe₁-xFe₂xO₃ (x=0.05 and x=0.1) system and studied by superconducting quantum interference device, Mossbauer spectrometer and x-ray diffractometer. The crystal structure is orthorhombic and the lattice constants are decreased as increasing iron contents. That is, in Cu₁-xGe₁-xFe₂xO₃ system a=4.795Å, b=8.472Å and c=2.932Å for x=0.05, and a=4.784Å, b=8.472Å and c=2.904Å for x=0.1 respectively. The Mossbauer spectra are superposition of the doublet due to the Fe³+ ions at tetrahedral sites and the sextet due to the Fe³+ ions at octahedral sites at room temperature. From the cusp of the magnetic susceptibility and the discontinuity of Mossbauer parameters we found the spin-Peierls transition temperature of our samples is 13K.