한국 제2형 당뇨병 환자의 병인

윤건호 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.4

과학영재 교육기관 운영에 관한 연구 : 과학고등학교를 중심으로 Focus on the Science High Schools

윤건호 성균관대학교 사범대학 교육연구소 2002 敎育硏究 Vol.1 No.1

이 연구는 과학영재 교육기관으로서의 과학고등학교 교육이 만족스럽게 운영되고 있는가를 연구하고자 한 것이다. 이를 위해 과학고등학교의 교육을 6개 영역(학생 영재성, 교수학습활동, 교직자체, 교과 외 활동, 근무여건, 행정제도)으로 나누고, 6개 영역에 대한 과학고등학교 교사들의 만족도를 설문지를 통한 조사연구를 통해 밝혔다. 만족도의 측정은 '매우 불만족'에서 '매우 만족'까지 6단계를 1, 2, 3, 4, 5, 6의 순으로 배점하였다. 연구내용에 따라 그 결과를 요약·제시하면 다음과 같다. 과학고등하교 교육운영에 있어서는 교육운영 전체 영역에 대한 만족도는 '조금 만족한다(3.772)'에 가깝게 나타났다. 각 집단별 만족도 수준으로는 학생 영재성 관련 영역의 만족도는 4.284, 교수 학습활동 영역의 만족수준은 3,963, 교직자체 영역 만족수준은 4.27, 교과 외 활동 영역의 만족수준은 4.00, 근무여건 영역의 만족수준은 3.973, 행정제도 영역의 만족수준은 2.344로 나타났다. 과학고등학교 교육운영 관련 문항의 만족 수준은 4.687에서 1.845까지의 수준을 나타냈다. The purpose of this study was to examine whether the education operations of science high schools were offered satisfactorily in that sort of school. for attaining the purpose, six research questions were posed covering the satisfaction level at education operations. In order to see if education was offered satisfactorily in science high schools, questionnaire survey was conducted over teacher satisfaction level at six areas of science high schools education operations : student giftedness, teaching-learning activity, teaching profession, extracurricular activity, working condition and administrative system. The brief findings of the study of the satisfaction level at science high schools education operations were as below: The satisfaction level of the teachers investigated at the overall areas of science high schools education operations(3.772) were between a little dissatisfaction and a little satisfaction. Every group's satisfaction level ranged from 2.344 to 4.284. The area they expressed most satisfaction at was student giftedness(4.284), which was more than a little satisfaction. The administrative system appeared to be unsatisfactory(2.344), and the teachers expressed the least satisfaction at this area. The item the teachers showed most satisfaction at(4.687) was students' interest and participation in math or science contest, which could be nearly said to be satisfactory. The item that gave the next most satisfaction to the teachers(4.442) was students' task performance, which was more than a little satisfaction. The item that gained the least satisfaction from the teachers(1.620) was the abolition of school achievement comparison system, which could be said to be very unsatisfactory.

산업 자동화 시스템을 위한 안정된 인터페이스 기술 개발 및 구현

윤호군,정화영 목원대학교 자연과학연구소 1999 自然科學 硏究論文集 Vol.8 No.-

In general, industrial automation systems(IASs) deals with very sensitive data about operation and production and operates at the poor environment. IASs consist of a control part and a GUI(Graphical User Interface) part. The control part mainly takes charge of controling each operational device and the GUI part takes charge of communication mode for data and controls between the user and IAS. Thus communication information between the two parts includes production, control and operation information. It is very important to make sure that the GUI correctly processes and analyses the communication information, because GUI delivers such information between the operation part and the user. There has been difficulties in implementing GUI communication part without losing such important operational data. Therefore this paper presents development and implementation of a new stable processing method of GUI communication using a combined mechanism of message interrupt and timing. Several systems with this method have been implemented and tested in various conditions, and they show us that lose of the unstable operational data can be prevented.

한국 제조기업의 유연성전략, 생산활동기법과 성과측정에 관한 연구

윤재홍,이근호 한국경영과학회 1999 經營 科學 Vol.16 No.1

Flexibility is a competitive weapon in the changing environment in order to pursue the flexibility, Korean manufacturing companies must define the flexibility dimension clearly, build the appropriate manufacturing infrastructures and measure the right flexibility performance indicators This paper found out as follows First, Korean manufacturing companies' flexibility strategy groups were formed three types They are flexibility superior group, middle flexibility group and flexibility inferior group Second, when different types of flexibility strategy group measured their performances, the degree of importance of flexibility performance indicators were different among groups Third, when different types of flexibility strategy group were pursued, the different manufacturing methods such as product/process design technology, analysis technology, production system management technology and non technological factors were used Lastly, when different types of flexibility strategy group were pursued, the actual flexibility performances were different among groups

이동국 위치 추정을 위한 TOA와 TDOA방법의 비교 분석

윤현성,이창호,변건식 동아대학교 2001 大學院論文集 Vol.26 No.-

This paper is aimed at developing an location tracking system of mobile station based on currently available mobile communication network of mobile phone and PCS(Personal Communication System). When the location tracking of mobile stations is in services, Emergency-119, all of crime investigation, effective urban traffic management and the safety protection of Alzheimer's patients can be available. In order to track the location of the mobile and base station, assumption in this paper is to use the statistic characteristics of LOS when modeling the standard noise in case that radio path is LNOS environment. The standard variation of the standard noise is ±150. First, location is estimated by the positioning algorithms of TOA and TDOA and compared each other. Second, after canceling the standard noise by Kalman filter, location is estimated by the above two positioning algorithms. Finally, the location by the Kalman filter and two positioning algorithms is estimated by smoothing method. As a result, 2 dimensional average location error is improved by 51.2m in TOA and 34.8m in TDOA when Kalman titer and two positioning algorithms are used, compared with the two positioning algorithms used. And there is 3 more meter improvement after smoothing than Kalman falter and two positioning algorithms used.

이동국 위치 추정을 위한 TOA와 TDOA방법의 비교분석

윤현성,호인석,이창호,변건식 동아대학교 정보기술연구소 2000 情報通信硏究所論文誌 Vol.8 No.1

This paper is aimed at developing an location tracking for mobile station employing currently available mobile communication network of cellular phone and PCS(Personal Communication System), When the location tracking of mobile stations is in services, the services such as Emergency-119, crime investigation, effective urban traffic management or the safety protection of Alzheimer's patients, can be available. This paper is to track the mobile station in communication network in NLOS environment. To achieve reduction of the standard noise, Kalman filter is used. In terms of the distance, positions are located by using TOA and TDOA methods in LOS environment that removes NLOS bias in the measured data. And then smoothing method is used. to achieve reduction of the position error values.

7두의 개에서 배설성 요로조영술을 통한 신장 기능 평가

최윤정,이기자,최형준,이용진,박성준,송근호,정성목,최호정,이영원 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

Excretory urography is a type of contrast study used to verify and localize upper urinary tract disease. It is an inexpensive and easy way to visualize of anatomic and functional status of the kidney and has been used as a primary imaging modality for the evaluation of urinary tract abnormalities. We describe urological signs of 7 dogs who examined with excretory urography and ultrasonography. Six cases were referred to veterinary medical teaching hospital. Chungnam national university (VMTH, CNU) to evaluate renal function after the treatment for renal failure and one case was referred showing hematuria. In case 1, 2 and 4, blood test and urinalysis was normal and the results of excretory urography presented that renal function were normal range. In case 3, the results of urinalysis, ultrasonography, and excretory urography except blood test presented abnormal kidney and hydronephrosis was diagnosed. In case 5 and 6, blood test, urinalysis, ultrasonography and excretory urography indicated renal failure. In case 7, blood test, urinalysis and ultrasonography presented partially abnormal signs, however, the results of excretory urography was normal range.

船體 FRAME 製作時 熱加工이 强度 低下에 미치는 影響

임건호,윤한용 木浦大學校 工業技術硏究所 1999 工業技術硏究誌 Vol.9 No.-

In a ship frame manufacturing, for hot working by employed a gas welding machine without bender, the rate of strength reduction generally not considered dearly. In this study, tensile and fatigue test have been carried out by using specimens manufactured by hot working in the same way applied for at the shipyard. The results obtained from this study are as follows: 1. The static strength reduction of specimens by pre-heating and post-heating becomes not so large. On the other hand, that of specimens, by post-heating only or without pre and post-heating in significantly large. It means that the effect of the residual stress and the change of micro-structure appeared greatly in the course of hot working. 2. Fatigue life of specimens by hot-working is not only reduced greatly, but also shorted to the limit of 0.1 times according to a stress level. 3. In a ship Frame manufacturing, the strength reduction to the parts of bending working can be reduced to a minimum if pre and post-working have been done.

제2형 당뇨병 동물모델인 OLETF 쥐에서 장기간 라미프릴 투여가 내당능 및 췌도 베타세포에 미치는 효과

고승현,윤건호,김명미,안유배,송기호,유순집,손현식,차봉연,이광우,손호영,강성구 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.25 No.6

연구배경:최근 소개된 HOPE(Heart Outcomes Prevention Evaluation)study의 결과에 의하면, 심혈관질환이나 이에 대한 위험인자가 1가지 이상인 9,541명을 대상으로 안지오텐신 전환효소 억제제의 일종인 라미프릴을 투여하여 사망율과 뇌졸증, 심부전, 당뇨병 합병증이 개선되었을 뿐 아니라 다른 항고혈압제에 비해 새롭게 당뇨병으로 진단되는 환자가 줄었음을 보고한바 있다. 이에 저자들은 라미프릴(ramipril)을 제2형 당뇨병 동물모델에 장기간 투여함으로써 당뇨병을 예방하거나 고혈당 상태 또는 인슐린 감수성을 개선시킬수 있는지를 알아보고자 하였다. 방법:생후 24주된 체중 400∼450g의 OLETF와 LETO 쥐를 대상으로 6개월간 라미프릴 경구투여 하였고 혈압, 24시간 단백뇨 및 인슐린 내성검사를 시행하였다. 6개월 이후로는 8주간 투여군과 대조군의 체중을 비슷하게 맞추어 내당능 상태를 평가하였고 이후 다시 8주간 고농도 포도당을 투여하였다. 경구당부하검사를 시행한 후 희생시켜 조직표본을 만들어 guinea pig anti­human insulin 항체로 염색후 DAB로 발색하여 point count 법으로 베타세포를 정량하였고, 면역염색으로 췌도의 변화와 섬유화의 정도를 관찰하였다. 결과:라미프릴을 6개월간 투여하였을 때 OLETF 쥐에서 1)체중 증가가 적었으며 2)경구 당부하검사시 포도당하 면적은 의미있게 감소하였고 3)인슐린 내성검사상 Kitt가 증가되는 경향을 보였으며 4)수축기, 이완기 혈압과 24시간 단백뇨양이 의미있게 감소하였고 5)체중을 맞추면 내당능 상태가 비슷해졌다가 고농도 포도당 주입시 다시 포도당하 면적이 대조군에서 더 증가되었다. 라미프릴 투여군에서 췌도변형 및 파괴와 탈과립, 췌도내 섬유화가 감소하였다. 결론:본 실험에서는 인슐린 비의존성 당뇨병 동물 모델인 OLETF 쥐에서 당뇨병 발생 이전 단계부터 장기간 라미프릴을 투여할 경우 체중증가가 적었고, 투여군과 대조군의 체중을 맞추었을 때는 내당능상태의 차이가 없아가 고혈당 투여시 다시 투여군과 대조군에서 의미있는 차이를 보였다. 라미프릴 투여가 베타세포의 기능면에서 이로운 효과를 보일 것으로 생각되었다. 따라서 비만한 환자에서 안지오텐신 전환효소 억제제의 장기투여는 단백뇨 감소, 혈압강하 효과 이외에 체중증가의 억제 및 당뇨병 발생을 억제할 가능성을 시사한다. Background : In a Heart Outcomes Prevention Evaluation HOPE study, ramipril, a long-acting angiotensin-converting enzyme (ACE) inhibitor, significantly reduced the death rates the number of myocardial infarctions, strokes, heart failure as well as the risk of complications related to diabetes and of diabetes itself. However, it is known that ACE inhibitors improve glucose tolerance or insulin sensitivity or reduce the incidence of diabetes. Methods : 24 week-old OLETF (Otsuka Long Evans Tokushima Fatty) rats weighing 400 ~ 450 g were used in this study. 4 groups of rats were examined in parallel for 40 weeks. The OLETF rats were randomized for treatment with an aqueous solution of ramipril (5 mg/Kg) daily [OL (RMP), n=10)] and with saline [OL (CON), n=10)]. The LETO rats were also randomized in the same was as the OLETF rats (LT(RMP), n=10, LT (CON), n=10). The blood glucose level, body weight, systolic and diastolic blood pressure was assessed every month. At 3 and 6 months, the 24hrs urinary protein concentration was measured, and as insulin tolerance test and oral glucose tolerance test were conducted in all experimental groups. After 6 months, the body·weight was matched for 2 months in each corresponding group. Subsequently, a 15% sucrose loading was done for 2 months. After the glucose tolerance test, the pancreas was excised and immuno histochemical staining was conducted for insulin to quantify the beta cell mass by a point-counting method. In addition, the islet morphology was evaluated in the pancreas. Results : Ramipril treatment for a period of 6 months improved the 2hr blood glucose level, the area under the glucose curve in the oral glucose tolerance test, insulin sensitivity in addition to lowering significantly systolic and diastolic blood pressure and 24hrs urinary protein level significantly in OLETF rats. Of note, a lower weight gain was observed in both the ramipril-treated animals at 6 months. After weight matching, the AUC g and 2hr blood glucose level values were similar between the corresponding groups, but a 15% sucrose loading worsened the AUC g value. Histologically, the islets were less disorganized and the extent of fibrosis was lower in the ramipril-treated OLETF rats in the trichrome stain. Conclusion : Long-term treatment of ramipril, a long acting angiotensin-converting enzyme inhibitor may be useful for suppressing weight gain and proteinuria in addition to having a protective effect on the islet to harmful stimuli such as hyperglycemia (J Kor Diabetes Asso 25:469~482, 2001).

제2형 당뇨병 환자에게 적용한 표준진료지침이 혈당, 당화혈색소, 당뇨지식 및 재원일수에 미치는 효과

김희승,윤건호,유양숙,오정아,송민선,신미옥,김경희,송복례 대한당뇨병학회 2002 임상당뇨병 Vol.3 No.1

연구배경 : 당뇨병 환자의 평균 재원기간을 단축시키고, 제한된 입원기간 내에서 질적인 면과 비용효과성을 고려한 총체적인 건강관리체계의 필요성이 요구됨으로써 생겨난 것이 당뇨병 표준진료지침(Critical Pathway: CP)이다. 현재 개발된 당뇨병 CP를 통한 진료가 환자의 당뇨병에 관한 지식을 개선시키고 이에 따라 장기적으로 당뇨병 환자의 혈당조절이 개선되었다는 과학적인 검증은 당뇨병 CP를 여러 병원에 정착시키기이전에 반드시 선행되어야 할 과제이다. 이에 본 연구는 2000년 3월부터 1년간 강남성모병원에 입원하는 당뇨병 환자를 대상으로 현재 개발된 1주일 CP를 적용한 실험군의 혈당, 당뇨병 관련 지식 및 재원일수가 대조군에 비하여 차이가 있는지를 조사하였다. 방법 : 1주일 CP를 적용한 실험군은 내과병동에 입원한 당뇨병 환자 89명이었고, 대조군은 기타병동에 입원한 당뇨병 환자 22명이었으며 CP를 적용하지 않았다. CP를 적용하기 전인 입원시에 실험군과 대조군의 공복혈당, 식후 2시간혈당, 당화혈색소 및 당뇨관련 지식을 측정하였고, 퇴원 시에 실험군과 대조군에게 공복혈당과 당뇨관련 지식을 재측정하고 재원일수를 파악하였다. 그리고 두 군에게 퇴원 3개월 후의 공복혈당, 식후 2시간 혈당 및 당화혈색소를 조사하였다. 결과 : 1) 실험군의 공복혈당은 입원 시 238.7: 1) 실험군의 공복혈당은 입원 시 238.7mg/dL에서 퇴원 시 139.4mg/dL로 감소하는 경향이었으나 퇴원 3개월 후에는 150.6mg/dL로 약간상승하는 경향을 보였다. 대조군은 입원 시 251.5mg/dL에서 퇴원 시 136.2mg/dL로 감소하는 경향이었으나, 퇴원 3개월 후에는 219.3mg/dL로 현저히 증가하는 경향이었다. 2) 실험군의 입원 시 식후 2시간 혈당은 312.5mg/dL에서 퇴원 3개월 후 248.5mg/dL로 감소하는 경향이었다. 대조군도 입원 시 식후 2시간 혈당이 300.1mg/dL에서 퇴원 3개월 후 262.5mg/dL로 감소하는 경향이었으나 실험군보다 감소의 폭이 적은 경향이었다. 3) 실험군과 대조군의 입원 시 당화혈색소는 각각 10.3%와 9.7%로 유의한 차이가 없었으나,퇴원 3개월 후 실험군은 7.5%로 대조군의 9.1% 보다 유의하게 감소하였다. 4) 실험군의 입원 시 당뇨지식 점수는 실험군이 12.1점 대조군은 12.0점으로 유의한 차이가 없었으나 퇴원 시는 실험군이 15.5점으로 대조군의 14.6점 보다 높은 경향이었다. 5) 재원일수는 실험군이 8.4일로 대조군의11.0일 보다 유의하게 적었다. 결론 : 따라서 당뇨병 환자를 위한 CP는 재원일수의 감소뿐만 아니라 환자의 자가관리에 대한 체계적인 교육과 개선의 기회를 가짐으로써 장기적인 혈당 조절의 향상을 도모할 수 있는 효과적인 방법이라고 생각한다. Background: The aim of this study was to examine the effects of the critical pathway for the admitted patients with type 2 dia betes me llitus on glycemic control, the knowledge on the disease, and the length of hospital stay. Methods: 89 diabetic in-patients were applied with the 1 week critical pathwa which was consisted of intensive education program for self-management of diabetes me llitus such as glucose monitoring, excercise prescription, diet control, self-a djustment of the drugs and so on. The results were compared with 22 diabetic inpatients who were treated with conventional way. We assessed the effects of critical pathway on the degree of glycemic control, the knowledge on the disease, and the length of hospital stay. Results: Although fasting and postprandial 2 hours blood g lucose levels did not showed sta tistically significantd ifference between critical pathway group and conventional group on discharge , HbA1c was significantly decreased in critical pathwa group compared with the conventional group (7.5±1.8% vs 9.1±2.6%) on 3 months after discharge . Knowledge on the disease tended to increase in critical pathway group compared with the conventional group on discharge. The Length of hospital stay was significantly decreased in critical pathway group compared with the conventional group (8.4±2.8day vs 11.0±3.9da ) Conclusion: These results showed that critical pathway for the patients with diabetes mellitus might be a usefulway for improving the long term glycemic control through motivation, enhancing the knowledge on the disase as well as reducing the length of hospital stay.