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Blood vessel remodeling in the cerebral cortex induced by binge alcohol intake in mice
Hasegawa Hiroshi,Tanaka Toshiya,Kondo Mari,Teramoto Koji,Nakayama Kei,Hwang Gi-Wook 한국독성학회 2023 Toxicological Research Vol.39 No.1
Ethanol is toxic to the brain and causes various neurological disorders. Although ethanol can directly exert toxicity on neurons, it also acts on other cell types in the central nervous system. Blood vessel endothelial cells interact with, and are affected by blood ethanol. However, the effects of ethanol on the vascular structures of the brain have not been well documented. In this study, we examined the effects of binge levels of ethanol on brain vasculature. Immunostaining analysis indicated structural alterations of blood vessels in the cerebral cortex, which became more tortuous than those in the control mice after ethanol administration. The interaction between the blood vessels and astrocytes decreased, especially in the upper layers of the cerebral cortex. Messenger RNA expression analysis revealed a unique downregulation of Vegfa mRNA encoding vascular endothelial growth factor (VEGF)-A among VEGF, angiopoietin, endothelin family angiogenic and blood vessel remodeling factors. The expression of three proteoglycan core proteins, glypican-5, neurocan, and serglycin, was also altered after ethanol administration. Thus, binge levels of ethanol affect the expression of VEGF-A and blood vessel-supporting proteoglycans, resulting in changes in the vascular structure of the cerebral cortex.
Clinical utility of CA-125 in the management of uterine carcinosarcoma
Koji Matsuo,Malcolm S. Ross,Mayu Yunokawa,Marian S. Johnson,Hiroko Machida,Kohei Omatsu,Merieme M. Klobocista,Dwight D. Im,Shinya Satoh,Tsukasa Baba,Yuji Ikeda,Stephen H. Bush,Kosei Hasegawa,Erin A. B 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.6
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Selection of appropriate terms for a subjective evaluation of video game contents
Junji Yoshida,Koji Iwasaki,Eishiro Kunikane,Hiroshi Hasegawa,Masao Kasuga 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
This study investigated appropriate evaluation terms representing video game characteristics. First, many terms for evaluating video games were collected from game magazines and user questionnaires. Next, an experiment of video game evaluation, in which experimental subjects evaluated the game characteristics after playing 20 video games, were performed for extracting the appropriate evaluation terms. As a result, six kinds of evaluation terms of ”innovative,” ”fantasy,” ”length of waiting time,” ”reality,” ”comical,” and ”enjoyable with many people” were selected as the appropriate evaluation terms for video games using statistical analysis.
Wireless Technology for Process Automation
Hisanori Hayashi,Toshi Hasegawa,Koji Demachi 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Activities concerning an industrial wireless have become more active in the process automation (PA). In this paper, ZigBee, WirelessHART and ISA100.11a are introduced as typical industrial wireless standards, and the comparison between WirelessHART and ISA100.11a those are installed or are expected in PA field is explained. In addition, activities of international standardization and regional radio regulations are shown. Moreover, as featuretechnologies for application of wireless to industrial use, frequency hopping, mesh networking and channel blacklisting are introduced.
Polarimetric Observation of (3200) Phaethon, in Preparation for the Upcoming DESTINY+ Space Mission
Jooyeon Geem,Masateru Ishiguro,Jun Takahashi,Hiroshi Akitaya,Koji S. Kawabata,Tatsuya Nakaoka,Ryo Imazawa,Fumiki Mori,Daisuke Kuroda,Sunao Hasegawa,Fumi Yoshida,Ko Ishibashi,Tomoko Arai,Tomohiko Sekig 한국천문학회 2022 天文學會報 Vol.47 No.1