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( Mun Hyuk Seong ),( Ho Kil ),( Jong Yeop Kim ),( Sang Soo Lee ),( Sook Hyang Jeong ),( Young Seok Kim ),( Si Hyun Bae ),( Youn Jae Lee ),( Han Chu Lee ),( Hae Sun Yun ),( Byung Hak Kang ),( Kisang Ki 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Hepatitis C virus (HCV) infection is attributable to about 15% of cause of chronic liver disease in Korea. We aimed to study the epidemiological and clinical features of a prospective, multicenter cohort of HCV infection in Korea. Methods: A total 1,173 adult patients showing positive results for anti-HCV were prospectively enrolled and offered to complete the questionnaire survey on the risk factors of HCV infection from January 2007 to December 2011 at 5 university hospitals. Predefined demographic, clinical, and virological variables were collected and analysed. Results: The 1,173 subjects of the HCV cohort showed that mean age of 55.4 years, and male proportion of 48.3%, and diagnostic category of acute hepatitis (n=64, 5.5%), past infection (n=54, 4.6%), chronic hepatitis (n=772, 65.8%), liver cirrhosis (n=183, 15.6%), and hepatocellular carcinoma (n=100, 8.5%). The HCV genotypes were distributed into 5 types: genotype 1 (n=489, 52.4%), genotype 2 (n=421, 45.1%, genotype 3 (n=7, 0.8%), genotype 4 (n=2, 0.2%), and genotype 6 (n=9, 1.0%) with mixed genotypes (n=5, 0.5%). Hepatitis B virus coinfection rate was 3.5%. Liver biopsy was undertaken in (n=298, 20.0%), and the antiviral therapy against HCV had been undertaken in 42.8%. The risk factors were found as below: blood transfusion before 1995 (55.9%), needle stick injury (7.4%), acupuncture (82.5%), tattooing (36.0%), piercing (35.0%), intravenous drug abuse (IVDU) (5.0%), multiple sex partners more than 3 (21.0%), living with HCV-infected person (2.6%). Interestingly, patients living in Busan area showed higher frequency of IVDU (10.3%) compared to those in Capital area (4.5%).
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