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유길종 ( Kil Jong Yu ),배종석 ( Jong Seok Bae ),서영진 ( Young Jin Seo ),이준엽 ( Juhn Yeob Lee ),임경진 ( Kyung Jin Lim ),조유리 ( You Lee Joh ),윤원찬 ( Wern Chan Yoon ),김채기 ( Chae Gi Kim ),송용호 ( Yong Ho Song ),최정윤 ( Ju 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.4
Adult onset Still`s disease (AOSD) is a rare, distinct clinical entity which affects predominantly young adults aged 16-35. It affects multiple organs, and at present, the etiology is still unclear. Because this disease has few diagnostic or confirmative test, the diagnosis is made by the differential diagnosis and by excluding other diseases. Several reports have suggested a viral trigger in the pathogenesis of this disease. It has some common clinical features; abrupt onset, high fever, sore throat, transient maculopapular rash, lymphadenopathy, and hepatosplenomegaly. We describe a 17-year-old man who fulfilled the proposed diagnostic criteria of AOSD and had evidence of acute Epstein-Barr virus infection. He complained of intermittent high fever and myalgia for a week. He also had maculopapular rash, sore throat, multiple right cervical lymphadenopahty, and right ankle pain and swelling. After admission, intermittent fever persisted for a month, but diffuse myalgia and migrating arthralgia fluctuated.
Yu, Hyeon-Hee,Hur, Jong-Moon,Seo, Se-Jeong,Moon, Hae-Dalma,Kim, Hyun-Jin,Park, Rae-Kil,You, Yong-Ouk World Scientific 2009 The American journal of Chinese medicine Vol.37 No.4
<P>The fruits of Cornus officinalis have been used in traditional oriental medicine for treatment of inner ear diseases, such as tinnitus and hearing loss. In the present study, we investigated the protective effect of C. officinalis on hydrogen peroxide-induced cytotoxicity in HEI-OC1 auditory cells. The results from bioassay-guided fractionation of methanol extract of C. officinalis fruits showed that ursolic acid is a major active component. Ursolic acid (0.05-2 μg/ml) had protective effect against the HEI-OC1 cell damage and reduced lipid peroxidation in a dose-dependent manner. In addition, pre-treatment with ursolic acid significantly attenuated the decrease of activities of catalase (CAT) and glutathione peroxidase (GPX), but superoxide dismutase (SOD) activity was not significantly affected by ursolic acid. These results indicate that ursolic acid protects hydrogen peroxide-induced HEI-OC1 cell damage through inhibition of lipid peroxidation and induction of antioxidant enzymes, CAT and GPX, and may be one of the active components responsible for these effects of C. officinalis fruits.</P>
( Jong Kil Park ),( Ihn Cheol Seong ),( Baek Jo Kim ),( Woo Sik Jung ),( Ri Yu Lu ) 한국환경과학회 2014 한국환경과학회지 Vol.23 No.1
In the present study, we analyzed precipitation patterns and diurnal variation trends of hourly precipitation intensity due to climate change. To that end, we used the hourly precipitation data obtained from 26 weather stations around South Korea, especially Busan, from 1970 to 2009. The results showed that the hourly precipitation was concentrated on a specific time of day. In particular, the results showed the so-called "morning shift" phenomenon, which is an increase in the frequency and intensity of hourly precipitation during the morning. The morning shift phenomenon was even more pronounced when a higher level of hourly precipitation intensity occurred throughout the day. Furthermore, in many regions of Korea, including Busan, this morning shift phenomenon became more prevalent as climate change progressed.
CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice
HONG, Yu Ri,LEE, Hyun,PARK, Min Hee,LEE, Jong Kil,LEE, Ju Youn,SUH, Hwa Deok,JEONG, Min Seock,BAE, Jae-Sung,JIN, Hee Kyung The Japanese Society of Veterinary Science 2015 The Journal of veterinary medical science Vol.77 No.6
<P>Niemann-Pick type C disease (NP-C) is a rare and ultimately fatal lysosomal storage disorder with variable neurologic symptoms. Loss of neuronal function and neuronal cell death occur in the NP-C brain, similar to the findings for other neurodegenerative diseases. Targeting of neuronal cells in the brain therefore represents a potential clinical intervention strategy to reduce the rate of disease progression and improve the quality of life. We previously reported that bone marrow stem cells show a neurogenic effect through CCL2 (also known as monocyte chemoattractant protein-1, MCP-1) secretion in the brains of NP-C mice. However, the direct effect of CCL2 on neurogenesis has not been ascertained. Here, to define neurogenic effects of CCL2 in NP-C, we applied human recombinant CCL2 to neural stem cells (NSCs) derived from NP-C mice. CCL2-treated NSCs showed significantly increased capacity for self-renewal, proliferation and neuronal differentiation. Similar results were observed in the subventricular zone of NP-C mice after CCL2 treatment. Furthermore, infusion of CCL2 into the NP-C mouse brain resulted in reduction of neuroinflammation. Taken together, our results demonstrate that CCL2 is a potential new therapeutic agent for NP-C.</P>