간암을 동반한 윌슨병(Wilson`s disease)1 예

김철,김은주,김대중,김홍수,이문호,김선주,박상흠,정일권,남기룡 대한소화기학회 1999 대한소화기학회지 Vol.33 No.3

Wilson's disease is an autosomal inherited disorder of copper metabolism; impaired copper excretion into the bile leads to copper accumulation in liver, brain and other organ. Hepatocellular carcinoma (HCC) has rarely been reported as a sequele of Wilson' s disease. It has been shown experimentally that copper has an inhibitory effect on the factors responsible for HCC development in rats, and the low prevalance of HCC in case with Wilson' s disease may result from hepatic copper deposition which has been postulated to have a protective effect against hepatic oncogenesis. The clinica features of these cases are characterized by relatively advanced age at diagnosis, the presence of cirrhosis and a male predominance. It is suggested that hepatic copper content in the patient with Wilson' s disease who was treated with penicillamine and subsequently developed HCC may be decreased toward a nonprotective range in response to penicillamine therapy. We report the one case of patient with Wilson' s disease combined with HCC.

Effect of Fermented Small Soybean Powder Mixed with Mulberry Leaf on Metabolic Improvement and Hexokinase Activity in Streptozotocin-induced Diabetic Rats

Kim, Sun-Mi,Han, Jin-Chul,Park, Hum-Dai,Ko, Ki-Sung,Lee, Dae-Hoon,Kim, Sung-Min,Kwon, Dong-Yeul,Kim, Jin-Sook,Kim, Ok-Hee,Hwang, Jin-Bong,Gung, Bae-Nahm,Choo, Young-Kug The Korean Nutrition Society 2006 Nutritional Sciences Vol.9 No.2

Beans are well known to be high-protein diets. Bean seeds contain arginine, lysine, or glycine-rich proteins which are effective to maintain lower glucose levels. In this study, the synergistic effect of fermented small soybean (Chounggukjang) and mulberry leaf on metabolism and hexokinase activity was investigated in streptozotocin (STZ)-induced diabetic rats. We divided 8 groups as follows: non-diabetic rat group fed with only water diet (NC: control), and STZ-induced diabetic rat groups fed with water (DC), fermented Rhynchosia Nulubilis (Bbc), fermented Glycine max Merr (Ybc), Bbc and YBc (BYbc), mulberry leaf and Bbc (MBbc), mulberry leaf and Ybc (MYbc), or the mulberry leaf, Bbc, and Ybc (MBYbc). Diabetes mellitus was induced in rats by subcutaneous STZ administration (70 mg/kg of body weight). All diet groups were fed with Chounggukjang in a powder form. Three ml of Chounggukjang solution (0.75 mg per gram of body weight) dissolved in distilled water was orally administered to all rat groups after STZ administration except for NC rat group. In groups fed with fermented soybeans, the body weight (increased), food efficiency ratio (FER) (increased), glucose level (decreased) and hexokinase (HK) activity (increased) significantly differed to NC. Among them, particularly in the groups fed with both fermented soybeans and mulberry leaf, kidney weight significantly decreased, whereas HK activity significantly increased compared to DC. These results suggest that Chounggukjang of both fermented soybeans and mulberry leaf is potentially used as an effective functional food to prevent diabetes complications.

Effect of Root-Zone Temperature Under Low Air Temperature on the Growth and Development of Cyclamen persicum

Ji Hum Park(박지흠),Wook Oh(오욱),Hyun Ki Kim(김현기),Yong Ha Lee(이용하),Ki Sun Kim(김기선) 한국원예학회 2005 한국원예학회 학술발표요지 Vol.2005 No.10

Root-Zone Heating Improves Growth and Development of Cyclamen persicum under Low Air Temperature

Ji Hum Park,Wook Oh,Hyun Ki Kim,Yong Ha Rhiet,Changhoo Chun,Ki Sun Kim 한국원예학회 2007 Horticulture, Environment, and Biotechnology Vol.48 No.2

This study was conducted to examine the effect of root-zone temperature (RZT) on growth and development of cyclamen (Cyclamen persicum cv. Metis Scarlet Red) under low air temperature regime for energy saving. Cyclamen plants with 6-7 unfolded leaves were exposed to RZT 12, 16, 20, or 24°C in a constant 12°C room equipped with floating hydroponic and nutrient-stagnant wick culture systems. Root-zone heating promoted growth, showing the maximum dry weight at 20°C. The number of leaves and visible buds (VB) at harvest increased as RZT increased from 12 to 20°C, but slightly decreased from 20 to 24°C. Root-zone heating promoted photosynthesis and hastened leaf unfolding and VB emergence. RZT of 20°C increased root activity as compared with that of 12°C, although there was no difference in leaf width and root length. Most favorable RZT for growth and development of cyclamen under low air temperature was 20°C. Therefore, root-zone heating improved growth and development in ‘Metis Scarlet Red’ cyclamen under low air temperature for saving heating energy.

Efficacy and Safety of Fermented Turmeric Powder in Subjects with Elevated Alanine Transaminase Levels

Hyang-Im Back,Ki-Chan Ha,Hye-Mi Kim,Soo-Hyun Park,Eun-Kyung Choi,Dae-Young Kwon,Hye-Jung Yang,Min-Jung Kim,Hee-Joo Kang,Hum-Young Baek,Yong-Jae Kim,Joon-Yeol Lee,Sang-Wook Kim,Soo-Wan Chae 한국식품영양과학회 2012 한국식품영양과학회 학술대회발표집 Vol.2012 No.10

Loquat (Eriobotrya japonica) extract prevents dexamethasone-induced muscle atrophy by inhibiting the muscle degradation pathway in Sprague Dawley rats

NOH, KYUNG KYUN,CHUNG, KI WUNG,SUNG, BOKYUNG,KIM, MIN JO,PARK, CHAN HUM,YOON, CHANGSHIN,CHOI, JAE SUE,KIM, MI KYUNG,KIM, CHEOL MIN,KIM, NAM DEUK,CHUNG, HAE YOUNG Spandidos Publications 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.3

<P>In the Orient, loquat (Eriobotrya japonica) extract (LE) is widely used in teas, food and folk medicines. The leaves of the loquat tree have been used for generations to treat chronic bronchitis, coughs, phlegm production, high fever and gastroenteric disorders. One of the major active components of loquat leaves is ursolic acid, which was recently investigated in the context of preventing muscle atrophy. The present study investigated the therapeutic potential of LE on dexamethasone?induced muscle atrophy in rats. Daily intraperitoneal injections of dexamethasone caused muscle atrophy and evidence of muscle atrophy prevention by LE was demonstrated using various assays. In particular, dexamethasone?induced grip strength loss was alleviated by LE and the increase in serum creatine kinase activity, a surrogate marker of muscle damage, caused by dexamethasone injection was reduced by LE. Western blot analysis and immunoprecipitation demonstrated that dexamethasone markedly increased the protein expression levels of muscle ring finger 1 (MuRF1), which causes the ubiquitination and degradation of myosin heavy chain (MyHC), and decreased the protein expression levels of MyHC as well as increased the ubiquitinated MyHC to MyHC ratio. However, LE reduced the dexamethasone?induced protein expression levels of MuRF1 and ubiquitinated MyHC. Additional experiments revealed that LE supplementation inhibited the nuclear translocation of FoxO1 induced by dexamethasone. These findings suggested that LE prevented dexamethasone?induced muscle atrophy by regulating the FoxO1 transcription factor and subsequently the expression of MuRF1.</P>

Impact of preoperative management in patients older than 80 years requiring cholecystectomy

Da-Kyum Shin,Seok-Hwan Kim,Deok-Bog Moon,Shin Hwang,Ki-Hum Kim,Chul-Soo Ahn,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Ki-Byung Song,Dae-Wook Hwang,Song-Cheol Kim,Young-Joo Lee 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.4

Backgrounds/Aims: Elderly patients aged >80 yr have high morbidity and mortality rates after biliary surgery, especially in emergency operations. We conducted this study to determine the effect of preoperative management on the outcome of elderly patients undergoing cholecystectomy. Methods: The medical records of 452 elderly (≥80 yr old) patients who underwent cholecystectomy from January 1997 to December 2015 were reviewed retrospectively. We divided the patients into 2 groups: intervention (preoperative biliary drainage) and non-intervention groups. We evaluated the effects of preoperative management on the American Society of Anesthesiology (ASA) score and perioperative outcomes. Results: Among the preoperative biliary drainage intervention group (n=286), 48 patients (51.7%) were diagnosed as having gallbladder stone combined with common bile duct stone. On admission, the proportion of patients with ASA score ≥3 and WBC counts were significantly higher in the intervention group than in the non-intervention group (p <0.05). The preoperative hospital stay was longer in the intervention group; however, operation-related factors such as operation type, time, conversion rate, complications, and mortality showed no difference between groups. Conclusions: With proper preoperative evaluations and preoperative biliary drainage, cholecystectomy can be a safe treatment option for elderly patients with cholelithiasis.

마취제가 수술 중 체성감각 유발전위에 미치는 영향

김정원,박영주,류진용,연준흠,홍기혁 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.37 No.3

Background : Many methods are available for the monitoring of spinal cord injury during an operation. During anesthesia, somatosensily evoked potentials (SSEP) may undergo substantial changes in the latencies and amplitudes which may be interpreted as pathological. It is essential for the anesthesiologist to know the potential interactions between anesthetic drugs and neurophysiologic responses during operation. The depressant effect of inhalation agents on the central nervous system exceeds commonly used intravenous anesthetics. Therefore, intravenous anesthesia is preferred to inhalation agents. This study was designed to compare the effects of intravenous anesthetics (propofol and fentanyl) and inhalational anesthetics (enflurane and nitrous oxide) used in the operation room. Methods : According to the inclusion criteria of ASA I-II, 40 patients who were free of neurologic disease with electric abdominal operations were randomly selected. The baseline of the SSEPs were recorded with stimulation of the posterior tibial nerve at the ankle. After obtaining the baseline (preinduction) of the SSEPs, intravenous anesthetics (propofol 10 mg/kg/h, fentanyl 1 2 μg/kg) and inhalational anesthetics (end tidal enflurane concentration 1.0 vol %, 50% nitrous oxide in oxygen) were administered. 30 minutes after induction (steady state), additional SSEPs were recorded. Mean arterial pressure, heart rate, temperature and arterial blood carbon dioxide tension were monitored. Results : There were no significant differences in the baseline of SSEPs between the intravenous anesthetics group and the inhalational anesthetics group. There were no significant differences in latencies and amplitudes between the preanesthesia state and the postanesthetia state in the intravenous anesthetics group. But the inhalational anesthetics group revealed prolonged latencies in the postanestesia state as compared with their preanesthesia state. Conclusions : The above findings suggest that the use of intravenous anesthetics can be beneficial t intraoperative SSEP monitoring for possible damage to the central nervous system during operations. (Korean J Anesthesiol 1999; 37: 368∼374)

Effects of Swimming Exercise and Joint Mobilization on HSP 70 Levels in Osteoarthritic Rats

Kim, Se-Hum,Nam, Ki-Won,Seo, Dong-Yel The Korean Society of Physical Therapy 2014 대한물리치료학회지 Vol.26 No.6

Purpose: This study was performed to investigate the effect of joint mobilization on pain relief and cartilage repair in an induced osteoarthritis rat model by analyzing the expression of heat shock protein 70 in articular cartilage. Methods: MIA was injected into SD rats to induce osteoarthritis. These rats were divided into 4 groups: control group (n=30), no further treatment after the MIA injection ; experimental group I(n=30), performed swimming exercise after the MIA injection experimental group II (n=30), underwent joint mobilization after the MIA injection and experimental group III (n=30), performed swimming exercise and underwent joint mobilization after the MIA injection. For the histologic and pathophysiologic evaluation, safranin-O staining and for the immunohistochemical evaluation, the expression of HSP 70 in articular cartilage was analyzed 1, 7, 14, and 21 days after the MIA injection. Results: The inflammatory response and loss of tissue declined in experimental groups I and II over time, whereas the greatest decreases were noted in experimental group III. In the articular cartilage, low expression of HSP 70 was observed in every group on day 1, whereas HSP 70 expression was elevated on days 7 and 14 in experimental groups II and III. After 21 days, experimental group II displayed the strongest positive reaction, whereas HSP 70 was higher in experimental group III at this time point compared to that after 14 days. Conclusion: Our results showed that swimming exercise and joint mobilization had positive effects on pain relief and histologic and functional recovery in an induced osteoarthritis rat model.

Anti-inflammatory Activity of Rhamnetin and a Model of Its Binding to c-Jun NH₂-Terminal Kinase 1 and p38 MAPK

Jnawali, Hum Nath,Lee, Eunjung,Jeong, Ki-Woong,Shin, Areum,Heo, Yong-Seok,Kim, Yangmee American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.2

<P>Rhamnetin (<B>1</B>), a commonly occurring plant O-methylated flavonoid, possesses antioxidant properties. To address the potential therapeutic efficacy of <B>1</B>, its anti-inflammatory activity and mode of action in mouse macrophage-derived RAW264.7 cells stimulated with lipopolysaccharide (LPS) or interferon (IFN)-γ were investigated. Rhamnetin (<B>1</B>) suppressed mouse tumor necrosis factor (mTNF)-α, mouse macrophage inflammatory protein (mMIP)-1, and mMIP-2 cytokine production in LPS-stimulated macrophages. A nontoxic dose of <B>1</B> suppressed nitric oxide production. It was found that the anti-inflammatory effects of <B>1</B> are mediated by actions on the p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and cyclooxygenase (COX)-2 pathways in LPS- or IFN-γ-stimulated RAW264.7 cells. It was determined that <B>1</B> binds to human JNK1 (9.7 × 10<SUP>8</SUP> M<SUP>–1</SUP>) and p38 MAPK (2.31 × 10<SUP>7</SUP> M<SUP>–1</SUP>) with good affinity. The binding model showed interactions with the 3′- and 4′-hydroxy groups of the B-ring and the 5-hydroxy group of the A-ring of <B>1</B>. Further, <B>1</B> exerted an anti-inflammatory effect, reducing the levels of pro-inflammatory cytokines and mediators.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-2/np400803n/production/images/medium/np-2013-00803n_0008.gif'></P>