Poster Session : PS 0831 ; Upper GI Tract : Clinical Factors to Predict Angiographically Detectable Non-Variceal Upper Gastrointestinal Bleeding in Patients Refractory to Endoscopic Treatment

( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.

성상세포종의 MIB-1, AgNORs 및 PCNA 발현에 대한 비교연구

최양문,김태영,김종문,윤기중,문형배 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.4

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

SILICA 및 ALUMINA 擔持 鐵觸媒의 H_2 및 CO 化學吸着 特性

尹奇俊,金寅泰,崔祉勳 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.2

H_2 and CO chemisorption experiments were performed on silica-and alumina-supported iron catalysts and the chemisorption characteristics of H_2 and CO were compared. Effects of the supports on the chemisorption characteristics, dispersion, and reducibility of the catalysts were also compared. In addition, effects of the metal loading and the methods of catalyst preparation were investigated. The catalysts were prepared by the incipient wetness method with varying preparation conditions and Fe loadings. The adsorption experiments were carried out at various temperatures from 195K to 473K. Oxidation of the catalysts were performed in order to determine the degree of reduction of Fe. The results were as follows : (1) The amount of CO chemisorbed on the silica-supported catalysts decreased with temperature. That on the alumina-supported catalysts decreased with temperature up to 373K, but it became larger at 473K. (2) The amount of chemisorbed H_2 increased with temperature up to 473K for all the catalysts. The amount of chemisorbed H_2 was much lower than that of CO chemisobed at 195K. (3) The percentage reduction of the silica-supported catalysts was higher than that of the alumina-suppoted catalysts. The dispersion of the silica-supported catalysts was lower than that of the alumina-supported catalysts. (4) The catalysts perpared by different methods did not show different chemisorption characteristics, but exhibited different dispersion or percentage reduction.

계열별 고등학생집단의 뇌기능특성화 경향에 대한 연구

윤규태,최기수,안의태,고정식,양남길,박경호 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

본 연구에서는 계열에 따른 고등학생들의 대뇌반구기능의 특성화 또는 편재화의 경향을 알아보고, 전공분야에 대한 적응력과의 상관관계를 검토하고자 했다. 일반고등학교 인문계열 학생 359명, 자연계열 학생 371명, 음악과 미술전공 학생을 포함한 예능계열 196명, 체육특기자를 포함한 체육계열 학생 151명 등 1,077명을 대상으로 각 계열별, 남녀별, 성적별 고등학생 집단들의 대뇌반구의 특성화, 편재화 경향을 시나가와(품川)질문지법을 이용하여 분석하였으며, 다음과 같은 결과를 얻었다. 1. 인문계열 고등학생의 뇌기능의 편재화 경향은 우뇌형 54.3%, 양쪽뇌형 32.6% 및 좌뇌형 13.1%였다. 남녀별로는 남학생은 우뇌형 62.9% 양쪽뇌형 27.9% 및 좌뇌형 9.5%로 나타났으며, 여학생은 각각 43.7%, 38.6% 및 17.7%로서 여학생이 남학생에 비하여 죄뇌화 경향을 보였다. 2. 자연계열 고등학생의 경우는 우뇌형 56.9%, 양쪽뇌형 29.9% 및 좌뇌형 13.2%로서 인문계열 고등학생과 비슷한 분포를 보였다 이를 남녀별로 구별하여 보면 남학생은 62.2%, 27.1% 및 10.2%, 여학생은 51.5%, 32.5%및 16.0%의 분포를 보여, 역시 여학생의 좌뇌화 경향이 뚜렷했다. 3. 예능계열 고등학생의 경우는 우뇌형 56.1%, 양쪽뇌형 35.2% 및 좌뇌형 8.7%의 분포를 보였으며, 이를 전공별로 세분해서 살펴보면 음악전공학생의 경우 53.7%, 35.5% 및 10.7%로서 전체 평균과 거의 비슷한 분포를 보였으나, 미술전공학생의 경우 60.0%, 34.7% 및 5.3%로서 , 특히 좌뇌형의 경우 음악전공에 비해 절반수준에도 못 미치는 경향을 보였다. 4. 체능계열 고등학생 집단의 경우 우뇌형 50.3%, 양쪽뇌형 37.7% 및 좌뇌형 11.9% 분포를 보였다. 5. 성적별로 보면 일반고등학교 학생 가운데 성적 우수 집단은 뚜렷하게 좌뇌형 경향(25.6% 및 25.0%)을 보였다. 6. 예능계열의 우수집단은 양쪽뇌형의 분포비율(50.0% 및 44.4%)이 특히 높았다. 7. 체육계열의 우수집단은 좌뇌형 분포(21.6%)가 높았다. According to the advanced study on differential theory of brain function, the left hemispheric functions are concerned more on the verbal, logical, sequential and arithmetic abilities, whereas the right hemisphere has characteristics of non-lingual, general, creative and aesthetic abilities. The authors compared the tendency of hemispheric specialization in high school students with different educational condition and facilities. Sinakawa's questionnaire method was the instrument for this study. The results obtained were as follows: Among 1,077 of whole subjects, right hemispheric dominant type was 55.0% (59.1% in male, 51.0% in female), bilateral type was 32.9% (10.6% in male, 35.1% in female) and left hemispheric dominant type was 12.2% (10.4% in male, 13.9% in female). 1. Of the 359 subjects in the field of humanity science, right hemispheric dominant type was 54.3% (62.9% in male, 43.7% in female), bilateral type was 32.6% (27.9% in male, 38.6% in female) and left hemispheric dominant type was 13.1% (9.5% in male, 17.7% in female). 2. Of the 371 subjects in the field of natural science, right hemispheric dominant type was 56.9% (62.2% in male, 51.5% in female), bilateral type was 29.9% (27.1% in male, 32.5% in female) and left hemispheric dominant type was 13.2% (10.2% in male, 16.0% in female). 3. Of the 196 art school students, 56.1% was regraded as right hemispheric dominant type, students majoring music was 53.7%, 35.5% and 10.7%, respectively, whereas the frequency for students majoring find art was 60.0%, 34.7% and 5.3%. 4. In students majoring physical education, 50.3% were shown in right hemispheric dominant type, 37.7% were bilateral type and 11.9% were left hemispheric dominant type. 5. Laterality patterns of students who adapt more successfully to their specific studying fields show following characteristics; Successful students of general high school show pronounced left shift in their laterality pattern, whereas successful students of art school exhibit more bilateral type. And successful students of physical education school show left shift in their laterality patterns.

악안면 유형에 따른 측모 연조직 양상에 대한 연구

태기출,김상철,국윤아,권영택 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.5

본 연구의 목적은 악안면유형에 따라 측모 연조직 양상에 차이가 있는지를 알아보고자 17세 이상의 연령을 가진 다양한 수직적 양상을 보이는 Ⅱ급 및 Ⅲ급 남, 녀 79명을 선택하여 각 계측치를 계측하고 통계처리하여 다음과 같은 결과를 얻었다. 1. Nasolabial angle, interlabial angle, lower lip angle, mentolabial angle, symphyseal angle이 골격성 Ⅱ급군과 Ⅲ급군간에 유의한 차이를 보였고, nasofrontal angle, upper lip angle, mentolabial angle, symphyseal angle이 high angle군과 low angle군간에 유의한 차이를 보였다. 2. 악골의 시상적관계를 나타내는 ANB값이 연조직의 nasolabial angle, symphyseal angle, interlabial angle과 정상관 관계를 보였고, lower lip angle과는 역상관 관계를 보였다. 3. 악골의 수직적관계를 나타내는 SN-GoMe값은 연조직의 mentolabial angle, symphyseal angle, nasofrontal angle, upper lip angle과 정상관 관계를 보였다. 4. 골격성 Ⅲ급군에 비해 Ⅱ급군에서 SN-GoMe값에 따른 측모연조직 양상의 차이가 현저하였다. The purpose of this study was to investigate the variations of the soft tissue profile contour in relation to the skeletal patterns and to confirm the correlation of soft tissue angles to the sagittal or vertical skeletal elements. Lateral cephalograms of 79 cases which were older than 17 years in age, were traced and statistically analyzed The obtained results were as follows: 1. Nasolabial, interlabial, lower lip, mentolabial, and symphyseal angles showed the significant differences between skeletal ClassⅡ and skeletal. Class Ⅲ group, but nasofrontal, upper lip, mentolabial, and symphyseal angles showed the significant differences between high angle and low angle group. 2. ANB value showed the significant positive correlation to nasolabial, symphyseal, and interlabial angles and the significant negative relation to lower lip angle. 3. SN-GoMe value showed the significant positive correlation to mentolabial, symphyseal, nasofrontal, and upper lip angles. 4. Soft tissue profile contour in SK. ClassⅡ group showed greater accordance to SN-GoMe value than those in SK. class Ⅲ group.

노인의 대사성 증후군의 위험 요인에 체구성, 심폐기능 및 근력과의 상관관계

윤규태,최기수,강현주 순천향대학교 기초과학연구소 2004 순천향자연과학연구 논문집 Vol.10 No.2

We investigated the association of body composition, cardiorespiratory fitness and muscle strength to the metabolic syndrome risk factors in elderly persons. 53 elderly persons aged 65-75 years evaluated the metabolic syndrome risk factors(centeral obesity, high blood pressure, HDL-cholesterolemia, hypertriglyceridemia, hyperglycemia), as defined by the criteria given in the Adult Treatment Panel Ⅲ. In the relation of body composition among the metabolic syndrome risk factors, WC had a positive correlation with weight, BMI, and WHR, and DBP had a negative correlation with WHR,FBG had a positive correlation with weight, BMI, and WHR, and HDL-C had a negative correlation with weight, BMI, and WHR. In the health related physical fitness, WC had a positive correlation with UMS, LMS, and TMS, LMS, and TMS, TG had a negative correlation with VO_(2)max and HDL-C had a positive correlation with VO_(2)max, UMS, LMS, and TMS. This study suggest that the metabolic syndrome risk factors are affected by body composition, cardiorespiratory fitness and muscle strength.

중추신경계에 침범한 속립성 결핵 : 증례보고

이태환,김헌주,허철,한용표,홍순기,변진수,김명순,조미연,김윤미 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.11

in recent times, central nervous system(CNS) tuberculosis has been rare and the prevalence of the focal form, the tuberculoma, varies from 1 per 200 to 1 per 1000. CNS tuberculosis occurs as a result of hematogenous spread from a primary focus. mostly pulmonary tuberculosis. It can be diffuse exudative leptomeningitis or a localized tuberculoma ; the former is more common. We report a case of miliary cerebral tuberculosis in a 24-year-old female who had been having headaches for 4 months. Magnetic resonance imaging showed numerous small round Gadolinium-enhanced supratentorial and infratentorial lesions scattered throughout the brain. Histologic examination confirmed well defined tuberculous granulomas with central caseous necrosis in open biopsy, containing several acid-fast bacilli, the patient was treated with isoniazid, rifampin, ethambutol, pyrazinamide in combination with prednisolone.

양측 하악과두 골절에 대한 관혈적 정보술후 나타난 근약화와 시력장애 : 증례보고

정기훈,신용길,김태열,신재명,윤규호,전인성 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

The condylar fracture show high occurrence rate in the following of symphysis and angle, because it is easy to have concentration of outer pressure due to its long and narrow anatomical shape and mouth opened state when trauma is attacked. For the clinical findings, there are trismus, opening deviation, mal-occlusion and open bite The classification of condylar fracture is varied due to the location of condylar bone fragment, fracture site. There are conservative and surgical methods for treatment modalities. Because of many advantages, conservative method is widely used it has no particular limits of treatment adjustment but the cases of absolutely surgical correction indication are easily found in clinical experience. Although many methods are suggested for treatments of condylar fracture, there are no particular surgical methods for precise reduction due to difficult accessibility in high condylar neck fracture. For precise reduction of condyle, we used Nam's method. However, in Nam's method, because condyle is fixed when once it is kept off externally reduced in avascular state, so complication such as condyle resorption is pointed out as a problem. In our clinic, we obtained some knowledge by treating a patient who had muscle weakness and vision disorder after temporary airway obstruction follownig the both condylar fracure operated using Nam's method, so here we reported the case with a study of documents.

화상을 입힌 생쥐의 흉선과 비장 임파구아형과 조직학적 소견의 변화

한기택,안상태,강윤섭,임 풍 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.4

Due to various documented abnormalities of cell mediated immunity, sepsis still remains the major cause of morbidity and mortality after initial survival from extensive thermal burn. However, the exact mechanisms of immunosuppression after extensive thermal burn remains uncertain. For th observation of immune state, changes of lymphocyte subpopulation have been usually measured in lymphocyte samples from peripheral blood by many reports, but it is only a small fraction of the total lymphocyte pool in the body, and may not present valid picture of the immunological state of the individual. Therefore, analysis of lymphocyte phenotype in thymus and spleen is thought to be necessary in understanding more exact mechanism of immunological changes in extensive thermal burn. The aim of this study is to evaluate the changes of immunocompetency by observing the changes of subpopulation of spleen and thymus lymphocyte using monoclolnal antibodies and changes of tissue with light microscope in burned mice. Cell populations were isolated from spleen and thymus of control and burned mice on the 1st, 3rd, 5th, 7th, 14th and 21st postburn days(PBD). The cell populations were measured with monoclonal antibody by flow cytometry. The results were as follows: 1.In thymus, Thy 1.2+, L3T4+ and LYt2+ cells decreased markedly on the 3rd PBD. Thy 1.2+ and L3T4+ cells decreased also on 5th, 7th, 14th PBD and returned to control level on 21st PBD, but Lyt2+ cells increased more significantly than control after 3rd PBD and returned to normal on 21st PBD. Qa2+ cells revealed most significant reduction on 7th PBD. 2.In spleen, Thy 1.2+, L3T4+ and Ia+ cells increased on 3rd PBD and then decreased on 7th and 14th PBD. Lyt2+ cells increased in all the burned groups. Qa2+ cells increased on 3rd, 5th PBD and returned to normal level. L3T4+ cell/Lyt2+ cell ratio revealed signicant reduction, but they recovered by the 21st PBD. 3.In histopathologic findings of the spleen & thymus, the all cell subpoulations decreased at 1st PBD, but more increased than that of group of 3rd PBD. And then they revealed normal architecture after 5th PBD.