진동에 의한 혈관 내 폐 보조장치의 산소전달 특성

김기범,권대규,이삼철,김성종,정인수,오인혁,김기주,변윤섭,정경락 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2

본 연구는 급성호흡부전환자를 치료하기 위하여 사용되고 있는 혈관 내 폐 보조장치의 기체전달을 향상시키기 위하여 중공사막에 진동기법을 사용하여 기체전달을 향상시키고자 시도하였다. 그리고 혈관 내 폐 보조장치를 정맥에 삽입하기 전, 혈관 내 폐 보조장치의 설계조건을 실험적 모델을 통하여 기체전달을 예측할 수 있는 예측식을 만들고자 하였다. 실험결과, 본 연구에서는 진동기법이 기체전달을 향상시키는데 효과적임을 확인할 수 있었다. 뿐만 아니라, 충진율과 가징 주파수의 함수관계를 이용하여 기체전달을 예측 할 수 있었다. 실험에 의하여 얻어진 결과는 예측식에 의하여 얻어진 결과와 유사한 결과를 얻었다. 그러므로 본 연구에서는 충진율과 가진 주파수의 함수를 이용하여 VIVLAD의 기체전달을 예측할 수 있었다. In this paper, we tried to improve gas exchange of the vibrating intravascular lung assist device(VIVLAD) using vibrating method in the hollow fiber membrane, for the patients suffering from acute respiratory distress syndrome(ARDS). And we tried to formularize prediction equations to make a prediction about gas transfer for designing intravenous artificial lung assist device, and designed modules under various conditions were studied through an experimental modeling before inserted the artificial lung assist device into as venous. As a result, we are convinced that vibration method is very useful for the has transfer increasing. Also, we can estimate the gas transfer as a function of the packing density and excited frequencies. The gas transfer obtained from the experiment was similar to that from the prediction equation, confirming the usefulness prediction equation. Therefore, we can estimate the gas transfer of the VIVLAD as a function of the packing density and excited frequencies.

Gh Partially Mediates α1-Adrenergic Receptor-Stimulated Cardiac Hypertrophy Independent of Gq Regulation

( Young Sup Byun ),( Woo Chul Chang ),( So Yeon Lim ),( Byeong Wook Song ),( Hye Jung Kim ),( Min Ji Cha ),( Yang Soo Jang ),( Nam Sik Chung ),( Ki Chul Hwang ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4

In cardiac myocytes, stimulation of α1-adrenoceptor(α1-AR) leads to hypertrophic phenomenon. The Gh protein is tissue type transglutaminase and transmits the intracellular signal with GTPase activity. Little is known about Gh-mediated intracellular signal transductions to develop the hypertrophy. The aim of this study was to elucidate how Gh mediates norepinephrine(NE)-stimulated intracellular signal transductions leading to the hypertrophic responses in neonatal rat cardiomyocytes. NE-induced protein/DNA ratio and ERKs activation were inhibited by a α1-AR blocker(prazosin), but not by a β,-AR blocker(propranolol). Gq mainly regulated protein/DNA ratio and genetic markers of hypertrophy but inhibition of Gq did not induce a decrease of hypertrophic response to the normal control. The treatment with siRNA for Gh suppressed NE-induced PKC/MEK1,2/ERKs activation. NE-induced β- MHC reorganization was inhibited by small interfering RNA targeting Gq or Gh. Cell surface area level of Gq inhibition was not the same as control but atrial natriuretic peptide(ANP), a cardiac hypertrophy marker, was inhibited by Gh and Gq suppression and coincidently inhibition of both Gh and Gq reduced the gene expression. These findings suggest that Gh is partially involved in the hypertrophic response induced by NE in cardiomyocytes through PKC/ MEK1,2/ERKs signal pathways via α1-AR/Gh.

GO-07 : Clinicopathologic Review of Ovarian Masses in Korean Premenarchal Girls

( Eun Young Ki ),( Seung Won Byun ),( Sun Jung Hwang ),( Keun Ho Lee ),( Jong Sup Park ),( Sung Jong Lee ),( Soo Young Hur ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

To review the clinicopathological characteristics of ovarian masses in Korean premenarchal girls. Design: The data collected from hospital medical records were reviewed retrospectively regarding age, presentation, diagnosis, treatment, and outcome. Participants: There were 65 premenarcheal girls who underwent surgery at Seoul St. Mary`s Hospital between January 1990 and March 2012. The most common presenting symptom was abdominal pain (n=31, 47.7%), followed by palpable abdominal masses 16 (n=16, 24.6%), abdominal distension (n=8, 12.3%), vaginal bleeding (n=4, 6.2%), incidental finding (n=3, 4.6%), difficulty in urination or defecation (n=2, 3.1%), and prenatal sonographic findings (n=1, 1.5%). Of the patients with benign tumors, including non-neoplastic lesions and benign cysts, 26 (51%) underwent cystectomy, 6 (11.8%) underwent oophorectomy, 17 (33.3%) underwent unilateral salpingo-oophorectomy and none underwent bilateral salpingo-oophorectomy. Of the patients with malignant tumors, 2 (14.3%) underwent bilateral salpingo-oophorectomy, 7 (50%) underwent unilateral salpingo-oophorectomy, 2 (14.3%) underwent oophorectomy, and 2 (14.3%) underwent cystectomy. : Abdominal pain was the most common symptom. However, the incidence of ab- dominal distension was higher in patients with malignant tumors than in those with benign tumors. We assessed clinical features, operative outcomes, and histological classifications of Korean prememarchal girls with ovarian masses. Further studies with a larger number of subjects are needed to confirm our results.

GO-09 : Benign metastasizing leiomyoma of the lung

( Eun Young Ki ),( Seung Won Byun ),( Sun Jeong Hwang ),( Keun Ho Lee ),( Jong Sup Park ),( Soo Young Hur ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

Benign leiomyomas of the uterus are uncommonly found in association with benign smooth muscle tumors beyond the confines of the uterus. Benign metastasizing leiomyoma (BML) is a rare disease in which the lung is described to be the most afflicted extrauterine organ. We present 4 patients who were followed up after resection of the pulmonary lesion or after pathological confirmation by biopsy. The clinical course of BML varies from chronic asymptomatic appearance to rapid proegression leading to respiratory failure and death. Our BML patients did not complain of pulmonary symptoms, such as cough, dyspnea, or chest tightness. Pathology revealed benign leiomyomas with no atypia and mitotic activity <5 per 10 high-power field. Immunohistochemical staining was positive for actin and desmin. The standard treatment of BML has not yet been established. Because of the hormone-sensitive characteristics of BML, treatments are based on hormonal manipulation along with either surgical or medical oophorectomy. BML can be observed in postmenopause. We observed 4 patients who did not receive adjuvant hormonal therapy because they were in postmenopause or in perimenopause. All patients are still healthy and show no evidence of recurrence or progression of the disease. We report herein 4 cases of BML with a brief review of the literature.

GO-08 : Comparison of the Cobas 4800 HPV Test and the Seeplex HPV4A ACE with the Hybrid Capture 2 Test

( Eun Young Ki ),( Kuen Ho Lee ),( Seung Won Byun ),( Sun Jeong Hwang ),( Ah Won Lee ),( Seock Nyun Bae ),( Soo Young Hur ),( Jong Sup Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-

It is well-known that persistent cervical infections with high-risk human papillomavirus (HPV) are related to the development of high-grade cervical intraepithelial neoplasia and invasive cervical cancer and that infection with HPV 16 and HPV 18 accounts for approximately 70% of all cases of invasive cervical cancer. We performed 3 HPV molecular tests―the Cobas 4800 HPV test, the Seeplex HPV4A ACE, and the hybrid capture 2 (HC2) test―in 146 cervical swab samples to compare between these three tests. There was a concordance rate of 82.8% between the results of the Cobas 4800 HPV and the HC2 test and a concordance rate of 84.9% between the results of the Seeplex HPV4A ACE and the HC2 test. Between the Cobas 4800 HPV test and the Seeplex HPV4A ACE, there was a concordance rate of 89.6% in the detection of high-risk HPV between the results and a concordance rate of 98.7% in the detection of HPV 16 or 18. When an abnormal Pap test was defined as ≥low grade squamous intraepithelial lesion (LSIL), the sensitivity of the Cobas 4800 HPV test, the Seeplex HPV4A ACE and the HC2 test were 71.1%, 80.0%, and 88.9%, respectively, while their specificities were 76.4%, 74.5%, and 67.9%, respectively. The results of this study suggest that the Cobas 4800 HPV test and the Seeplex HPV4A ACE may be as effective as the HC2 test in detecting HR HPV and that the concordance between the results of the Cobas 4800 HPV test and the Seeplex HDV4A ACE may be higher in the detection of HPV 16 and HPV18 than concerning high-risk HPV.

ADCYAP1, PAX1, CADM1 and MAL Gene Promotor Methylation Level Is Not Different Between Human Papillomavirus Persistent Infection Group and Clearance Group In Korean HPV Cohort Study

( Seung Won Byun ),( Eun Young Ki ),( Jong Sup Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

It has been well known that cervical intraepithelial neoplasia is preceded by persistent infections with human papillomavirus (HPV) types that carry a high oncogenic risk. About 80% of young women who become infected with HPV have transient infections that clear within 12-18 months. Only a small fraction of women with HPV infection will eventually develop persistent infections. There are no definite molecular evidence that is associated with persistent infection. In this study, we aim to determine the difference of promotor methylation level in cervical cell gene(ADCYAP1, PAX1, CAMD1 and MAL) between persistence and clearance with HPV infection. Exfoliated cervical scraps from HPV persistent group (n=25) and HPV clearance group (n=25) in Korean HPV Cohort Study were used to interrogate the methylation patterns of four host nuclear genes(ADCYAP1, PAX1, CAMD1 and MAL) each group at 6, 12 month follow-up DNA isolated from exfoliated cervical scraps was treated with bisulfite, specific regions of host genome were PCR amplified and CpG mehtylation was quantified using pyrosequencing HPV persistent infection group is not significantly different from HPV clearance group in global methylation level over time. In analysis with high risk HPV infection subgroup, MAL (-190bp) CpG site methylation level of high risk HPV infection persistent infection group(n=16) at 6 months follow-up was significantly lower than the one of high risk HPV infection clearance group (n=11) at that time. But the methylation levels of both group were below 5 %, not biologically significant because the lower detection level of pyrosequencing is 5 %. To validate this finding, we need more sensitive tool to detect methylation level. ADCYAP1,PAX1, CADM1 AND MAL Gene promotor methylation level is not different between human papillomavirus persistent infection group and clearance group in Korean HPV Cohort Study

Intracardiac metastasis from known cervical cancer

( Seung Won Byun ),( Sung Taek Park ),( Eun Young Ki ),( Hyun Song ),( Suk Hee Hong ),( Jong Sup Park ) 대한산부인과학회 2011 대한산부인과학회 학술대회 Vol.97 No.-

Changes in Plasma Cortisol in Patients with Bronchial Asthma

Kim, Kwan Hyoung,Han, Ki Don,Song, Jeong Sup,Moon, Hwa Sik,Park, Sung Hak,Byun, Hae Won CATHOLIC MEDICAL CENTER 1987 Bulletin of the Clinical Research Institute Vol.15 No.1

To examine the possible contribution of the circardian rhythm of plasma cortisol level to pathogenesis of bronchial asthma, the levels of plasma cortisol were measured at 8 A.M., 11 P.M., before and after ACTH infusion for 8 hours. The observed results were as follows : 1. In patients with bronchial asthma without nocturnal dyspnea, the value of plasma cortisol at 8 A.M. was 15.1 ± 7.0 ug/dl and at 11 p.M.8.8 ± 5,7 ug/dl. 2. In 17 patients with nocturnal or morning dipper asthma, the value of plasma cortisol at 11 P.M. was 3.2 ± 1.1 ug/dl and was lower than that of bronchial asthmatics without noctural dyspnea (p < 0.01). 3. In 20 bronchial asthmatics without nocturnal dyspnea. The value of plasma cortisol before ACTH infusion was 12.6 ± 5.9 ug/dl and after ACTH infusion 35.1 ±3.2 ug/dl. The results of present study show that the patients with bronchial asthma have normal circardian rhythm of cortisol level, but the bronchial asthamtics with nocturnal dyspnea have lower level of plasma cortisol at 11 P.M. than that of bronchial asthmatics without nocturnal dyspnea. The function of adrenal cortisol secretion after stimulation with ACTH infusion was normal. The circardian rhythm of coirticosteroid secretion seems to be a possible factor of nocturnal asthma.

심장내로 연장된 정맥내 평활근종증 1예 : 심장내 평활근종증 intracardiac leiomyomatosis-case report and literature review

정재헌,민필기,박소영,변영섭,홍그루,임세중,심원흠 대한내과학회 2003 대한내과학회지 Vol.65 No.2

정맥내 평활근종증은 병리학적으로는 양성 질환이나 진행 양상은 악성으로 모든 종양의 적출술이 시행되어야 하며, 자궁적출술시 병리학적으로 정맥내 평활근종증을 진단받은 경우 정기적인 검사를 통해 종양의 재발이나 하대정맥과 심장내로의 연장을 확인하여야 한다. 우측 심장내 종양이 발견된 경우는 점액종을 포함한 원발성 심내 종양 외에도 다른 원인 질환을 확인하여야 하며, 반드시 정맥내 평활근종증을 감별진단하여야 한다. Intravenous leiomyomatosis is a rare benign vascular tumor defined as the extension into venous channels of a histologically benign smooth muscle tumor arising either from a uterus or from the walls of uterine vessels, and about 10% spread to the heart. The treatment of choice is complete resection of the tumor. Hormonal therapy should be considered in cases of unresectable residual tumor. A 46-year-old woman was admitted for abdominal discomfort and pain. She was found to have intravenous leiomyomatosis of the uterus with extension into inferior vena cava and right atrium. The patient underwent surgery employing simultaneous sternotomy and laparotomy. Radical excision was achieved using cardiopulmonary bypass. We herein describe a patient in whom complete removal of intravenous leiomyomatosis with cardiac extension was successfully performed.

스킨 일체형 외장형 Active Air Flap 구조

김장호(Jang Ho, Kim),변재섭(Jae Sup, Byun),박종은(Jong Eun, Park),김명기(Myeong Ki, Kim),최재섭(Jae Sup, Choi) 한국자동차공학회 2022 한국자동차공학회 학술대회 및 전시회 Vol.2022 No.11

AAF(Active Air Flap) is a system that mounted on the front bumper of the vehicle and controls the air flowing through the bumper grill to improve the fuel efficiency of the vehicle. However, exterior type AAF system is not applied various cars because that negatively affected the exterior design of the vehicle. In this study, we developed a zero gap-flush active air flap system that improves the design problem of external AAF, and studied optimized system dessign through various case analysis.