정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Circuit Weight Training이 비만 여고생의 신체조성 및 혈청지질에 미치는 영향

한재웅,고기준,이재규 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

The purpose of this study was to determine the effects of Circuit Weight Training (CWT) on body composition and serum lipids in obese high school girls. The subjects were 11 obese highschool girls(BMI≥27㎏/㎡). They were to perform the Circuit Weight Training with 40~55% intensity of 1RM, for 50 mins/day, 3 times/week during 12 weeks. Before and after training, 10 ml blood was extracted from the antecubital vein of each subject for the purpose of analyzing its effects on serum lipids. The conclusion of this study is as follows : 1. In body composition and anthropometry profile after 12-week Circuit Weight Training was decreased significantly in %fat, BMI, body weight but LBM had no statistical signification. 2. 1. In serum lipid profile after 12-week Circuit Weight Training was increased significantly in TC, HDL - C and decreased significantly in PL but LDL - C had no statistical signification.

무용학습경력이 사회성에 미치는 영향

기한준,이지은 圓光大學校 附設 體力科學硏究所 2003 體力科學硏究 Vol.26 No.2

The purposen of this study is to understand the effcet of dance learning in career on sociality. The study of sbjects were total 203(female=201, male=2). They were devided into group A(n=70), group B(n=48), group C(n=50), group D(n=35) according to dance learning in career. The depandent variable was the dance learning in career(group A, B, C, D). The results are as follows: On the endurence was significant difference between the group A and C(p<.05). On the concentration was the group D showed the best point more than the group A, B and C(p<.001). On the self-control ability was the group D showed the best point more than the group A, B and C(p<.001).

당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

한국 고대 제천의례의 스포츠과학적 고찰

한상준,박기동 江原大學校附設 體育科學硏究所 1991 江原大學校附設體育科學硏究所論文集 Vol.- No.16

Korean ancient Checheon Ceremony(祭天儀禮) is examined and recognized the theory that sport is originated from amunement, as forementioned. It is because of human general liking nature for play that have continued until now. In this sense, the relationships btn play and festiveal, btn play and sport, and btn play and labour are examined. As the result, play belonged tho festival should be revived in relation to today's sport. Sport can be existed beyond selfish mind of both individual and group, and beyond historical viewpoint. In spite of all threats and obtacles corresponding that, sport can become one of the most far-reaching and important thing among the every human cultural attitudes.

외경 0.25 ㎜ 동맥의 단단 및 단측문합법

전대우,정재홍,강진성,한기환 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.3

Microvascular surgery has rapidly developed in the last 30 years and vessels of 1.0 mm can be anastomosed easily with a patency rate over 90 percent and is widely used in clinical practice with remarkable success. To obtain more successful microvascular anastomosis in smaller vessels, the improvement in methods of microanastomosis, the development of microvascular instruments including the operating microscope along with microsutures, and anticoagulants are needed. These improvements made microvascular anastomoses of vessels that are less than 0.5mm in extemal diameter possible. Huang et al.? performed anastomoses of the vessels in rats with an external diameter of 0.2 mm using a high magnification operating microscope, specially designed microinstruments, and fine sutures, and achieved a patency rate of 76 percent in the second postoperative week. However, we tried to anastomose vessels with an external diameter of 0.25 mm with ordinary instruments and 11-0 nylon. Animal studies on 180 rats were carried out by doing end-to-end anastomoses and 180 end-to-side anastomoses. In the end-to-end and end-to-side anastomoses, each 180 rats were then divided into 3 groups each. Group A was the control group. Aspirin and persantin were given orally in group B. Ticlopidine hydrochloride was given orally in group C. The method of end-to=end anastomosis was as follows : A superficial epigastric artery as small as 0.25 mm in diameter was severed transversely and longitudinal incisions, the length of the arterial diameter, were made down opposite sides of each end. Each flared fragment of the proximal end is approximated with each distal end and sutured together by only two stitches. The method of end-to-side anastomosis was as follows. In the side of the femoral artery an elliptical hole was made the same length of the circumference of the superficial epigastric artery, then the superficial epigastric artery was incised in the same manner as the end-to-end anastomosis. The flared ends of the superficial epigastric artery were then inserted into the hole of the femoral artery and sutured by four stitches. Light microscopic and scanning electron microscopic observation was performed serially at 3 days, 2 weeks, 3 weeks after the microvascular anastomosis for studying change of vessel diameter and histopathological changes at the microvascular anastomotic sites. The results were as follows : 1. The patency rate for the end-to-end anastomoses in the third postoperative week was 25% in the control group(A), 35% in the aspirin-persantin group(B), and 40% in the ticlopidine group(C) ; in the end-to-side anastomoses, 45% in group A, 50% in group B, and 60% in group C. 2. In the patency rate, the ticlopidine group is slightly higher than the aspirin-persantin group and even higher than the control group (P<0.05) in the end-to-end and end-to-side anastomoses. However, the end-to side group is higher in all 3 groups than the end-to-end one (P<0.1). 3. The intimal regeneration in all arteries was completed at end of the third postoperative week in the end-to-end and end-to-side anastomoses. 4. Changes of the internal diameter in anastomosed vessels showed luminal narrowing in the vessels at the third postoperative day and still narrowing at the second and third postoperative week in the end-to-end anastomoses. However, initial postoperative widening continued into the third postoperative week in the end-to-side anastomoses. The authors got a high success rate of anastomoses of very small arteries approximately 0.25 mm in external diameter, by developing a method of using an ordinary microscope and instruments, 11-0 nylon suture, and the administration of ticlopidine hydrochloride which is a more powerful anticoagulant than aspirin-persatin.

관골골절의 새로운 외부견인법

전대우,한기환,강진성 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

In the modern era of increasing motorization and industrialization, traffic and industrial accidents are becoming more frequent and serious, which in turn have brought about an increase in facial bone fractures and the pattern of fractures have become more compound and comminuted. The malar eminence is so prominent in oriental people that the zygomatic bone is more frequently fractured than other facial bones. Even a markedly depressed zygomatic fracture can be well reduced with three point interosseous wire fixations including a zygomaticomaxillary buttress, a late depression of the malar eminence occurs frequently due to the pull of the masseter muscle. In order to antagonize the pull of the masseter muscle the authors have devised a new method of external traction using an Ⅳ pole and weights which were all available on the wards. Fifty-seven patients who were admitted at Keimyung University Dong-San Medical Center from November 1987 to August 1988, were treated with 3 point interossous wire fixations and myotomy of the insertion of the masseter muscle. Of the 57, 32 were then managed with the authors' external traction method and the remaining 25 were managed with external traction using Georgiade's halo apparatus. The following results are obtained by comparing our method to Georgiade's : 1. Although the authors' external traction method tends to produce a slight overcorrection(P〉0.05), the results should be improved with experience. 2. Advantages of the authors method are as follows: 1) There is no cost because all needed equipments are obtainable on the wards. 2) The traction apparatus can be easily assembled. 3) It does not annoy the patients and does not necessitate scalp wounds. 4) It is useful for treatment of the patients who have concomitant cranial or cervical bone fractures. 3. Disadvantages are: 1) The authors method is contraindicated in the patient who is not cooperative because the direction of traction can be varied. 2) There is a brief limitation of sustained traction whenever the patient is moved. In summary, the authors external traction method using an IV pole and weights can be used alone and/or as aid to Georgiade's halo apparatus in the post-operative management of depressed zygomatic fractures.

객체 관계형 데이타베이스 관리 시스템을 이용한 디지털 앨범의 설계 및 구현

이준서,장염승,한기준 건국대학교 산업기술연구원 2000 건국기술연구논문지 Vol.25 No.-

As the storage capacity of a computer system is rapidly increasing and the cost of computer hardware is decreasing continuously, users can easily manage multimedia data on the personal computer. Especially, various image view programs are widely used to manage image files at the present time. However, since most of these programs do not use a database management system(DBMS), it is very difficult for users to use them efficiently. In this paper, we designed and implemented a Digital Album by using an object-relational database management system, called PARODY(Persistent, Almost, Relational Object Database sYstem) that implements a persistent object database with a relatively simple interface to its C++ class library. Since PARODY is used as a data storage manager of the Digital Album, users can manage(i.e., insert, update, and delete) an image database and search for the required image data from the image database easily. In addition, we use OWL(Object Windows Library) of Borland C++ to implement the user interface of the Digital Album efficiently.

악교정 수술 환자에서 수술부 술전소독에 사용되는 소독제의 항균성에 대한 임상적인 비교 : POVIDONE-IODINE AND CHLORHEXIDINE

엄기훈,한세우,유준영,양병은,김용관 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

For prevention of bacteremia and surgical field contamination, various concentration are used in preoperative skin preparation. Of these, povidone(PVP)-iodine has been known as one having believable effect. But, application of PVP-Ⅰon pral and maxillofacial field has some problems-skin discoloration, hypersensitivity, corneal irritation,etc. Therefore chlorhexidine has been tried to replace PVP-Ⅰ. More recent studies of antibacterial effect of chlorhexidine and PVP-Ⅰ has been achieved on the other field. The purpose of this study was to compare the antibactreial effect of two kinds of skin disinfectants used in oral and maxillofacial surgical field.-chlorhexidine and PVP-Ⅰ. We studied the 40 patients who have taken operation of orthognathic surgery in Dept. of oral & Maxillofacial Surgery, Kangnam General Hospital Public Corp..Results of bacterial culture taken from facial skin and intraoral mucosa after application 10% PVP-Ⅰ and 0.5% chlorhexidine were compared.

여고 테니스 우수선수와 비우수선수의 호흡순환기능에 관한 연구

고기준,이재규,김종인,이광무,한재웅,신군수,김태운,안병철,문혜경 釜山大學校 附設 體育科學硏究所 1999 體育科學硏究所 論文集 Vol.15 No.-

The purpose of this study was to evaluate a study on Cardiorespiratory Functions of Elite Tennis Player and Non-Elite Tennis Player in Female High-School. The subjects were included 2 group(each group n=7); Elite Tennis Player group and Non-Elite Tennis Player group. The conclusion of this study was as follows: 1. Elite Tennis Player group showed significantly high in VO2max(p<.001) 2. Elite Tennis Player group showed significantly high in VCO2(p<.001) 3. Elite Tennis Player group showed significantly high in VO2max/kg(p.05)