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Weight Loss as a Nonpharmacologic Strategy for Erosive Esophagitis: A 5-Year Follow-up Study
( Ki Bae Bang ),( Jung Ho Park ) 대한소화기학회 2018 Gut and Liver Vol.12 No.6
Background/Aims: Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI reduction could resolve EE. Methods: A retrospective cohort study was performed to assess the natural course of EE according to changes in BMI. Participants undergoing health check-ups from 2006 to 2012 were enrolled, and 1,126 subjects with EE were included. The degree of esophagitis was measured by upper endoscopy and serially checked over a 5-year follow-up. Logistic regression and Cox proportional hazards models were used to investigate the association between BMI reduction and EE resolution. Results: Substantial weight loss is associated with EE resolution. The adjusted odds ratio for EE resolution was 1.44 (95% confidence interval [CI], 1.09 to 1.92) among participants with a decrease in BMI compared to those with no decrease in BMI. The EE resolution rate was related to the degree of BMI reduction. The effect of weight loss on EE resolution was higher among subjects who lost more weight. Compared with subjects with no decrease in BMI, the hazard ratios for EE resolution were 1.09 (95% CI, 0.89 to 1.35), 1.31 (95% CI, 1.01 to 1.72) and 2.12 (95% CI, 1.44 to 3.12) in subjects with BMI reductions of ≤1, 1-2, and >2 kg/㎡, respectively. Conclusions: EE resolution is associated with a decrease in BMI, and weight loss is potentially an effective GERD treatment. (Gut Liver 2018;12:633-640)
내시경괄약근절개술과 담낭절제술은 급성 담석성 췌장염의 재발을 줄일 수 있는가?
방기배 ( Ki Bae Bang ),김홍주 ( Hong Joo Kim ),조용균 ( Yong Kyun Cho ),전우규 ( Woo Kyu Jeon ) 대한소화기학회 2015 대한소화기학회지 Vol.65 No.5
Background/Aims: Practice guidelines from international societies have recommended cholecystectomy during the same hospitalization for acute biliary pancreatitis (ABP). The aim of this study is to investigate the question of whether endoscopic sphincterotomy (EST) and/or cholecystectomy during the same hospitalization can reduce the recurrence rate of ABP. Methods: A total of 119 patients with ABP admitted to our institution between May 2005 and May 2010 who had complete follow-up data until May 2012 were enrolled. Results: No significant differences in initial CT severity index and Charlson comorbidity index were observed between EST (n=64) and non-EST group (n=55) and among subgroups classified according to interventions performed. In Kaplan Meier analyses, significantly higher recurrence rates of ABP were observed in the non-EST group compared to the EST group (p<0.01), and in the conservative treatment group compared to other intervention groups (p<0.01). The frequency of complications from ABP was significantly higher in the conservative treatment group (35.7%) and lowest in the EST plus cholecystectomy group (5.0%, p=0.008). In multivariate analysis, conservative treatment without EST and/or cholecystectomy, and non-EST group were independent risk factors for recurrence after the initial attack of ABP. Conclusions: ERCP with EST and cholecystectomy during the index admission is associated with reduced recurrence rates of ABP. (Korean J Gastroenterol 2015;65:297-305)
방기배 ( Ki Bae Bang ),조용균 ( Yong Kyun Cho ),이상혁 ( Sang Hyuk Lee ),박은혜 ( Eun Hye Park ),설지수 ( Ji Soo Seol ),채승완 ( Seoung Wan Chae ),조상원 ( Sang Won Jo ) 대한내과학회 2013 대한내과학회지 Vol.84 No.2
영아 간혈관내피종은 양성 혈관 질환으로 성인에서 진단되는 경우는 매우 드물다. 저자들은 일반적인 종양의 자연경과와 달리 69세 성인에서 진단된 영아 간혈관내피종을 경험 하였으며 이에 대한 국내보고가 없어 문헌고찰과 함께 보고 하는 바이다. Infantile hepatic hemangioendothelioma is a rare disorder. It is a benign entity and usually resolves spontaneously. Most patients present in infancy and early childhood. Because of its natural course and symptom onset, most cases are discovered during childhood. We experienced a rare case of infantile hepatic hemangioendothelioma in an adult. (Korean J Med 2013;84:259-264)
위장관 , 입원환자에서 Polyethylene Glycol 용액을 이용한 대장내시경 전처치 시 Bisacodyl을 병행하여 복용했을 경우의 효과 비교: 전향적 무작위 비교연구
방기배 ( Ki Bae Bang ),정은행 ( Eun Haeng Jeong ),정우신 ( Woo Shin Jeong ),채현범 ( Hyun Beom Chae ),김남희 ( Nam Hee Kim ),이태훈 ( Tae Hoon Lee ),김지연 ( Ji Yeon Kim ),정윤숙 ( Yoon Suk Jung ),박정호 ( Jung Ho Park ),손정일 ( 대한소화기학회 2014 대한소화기학회지 Vol.64 No.5
Background/Aims: Inpatient status can cause inadequate bowel preparation. The majority of previous studies regarding bowel preparation have focused on comparing the effects of different purgative regimens in outpatients. However, data on bowel preparation for inpatients are lacking. The aim of this study was to investigate whether bisacodyl plus polyethylene glycol (PEG) can improve bowel preparation in hospitalized patients. Methods: A prospective, randomized and observer-blind study was performed. A total of 196 hospitalized patients undergoing colonoscopy were randomized to receive 4 L PEG (PEG only group) or 4 L PEG+bisacodyl 10 mg (bisacodyl added group). The adequacy of bowel preparation was scored using the Ottawa bowel preparation scale. Results: One hundred and eighty-three subjects completed the study, 96 in the bisacodyl added group and 87 in the PEG only group. There were no significant differences between the bisacodyl added group and the PEG only group with respect to the score of bowel cleansing (3.59±2.81 vs. 3.82±3.03, p=0.607), quality of bowel cleansing (adequate preparation 89.6% vs. 85.1%, p=0.380), and overall adverse events (66.7% vs. 52.9%, p=0.057). However, a larger proportion of patients in the PEG only group were able to ingest the entire solution as prescribed than in the bisacodyl added group (98.9% vs. 75.0%, p<0.001). Conclusions: In hospitalized patients, the quality of bowel preparation did not differ depending on whether bisacodyl is added or not. In addition, patient compliance based on consumption of cleansing agent was better in the PEG only group. (Korean J Gastroenterol 2014,64:268-277)
Song, Ki Bang,Bae, Kyoung Sook,Lee, Yong Bok,Lee, Ki Young,Rhee, Sang Ki 전남대학교 약품개발연구소 2000 약품개발연구지 Vol.9 No.1
A microorganism producing levan fructotransferase was isolated from sugar-disclosed soil and it was identified as Arthrobacter ureafaciens. The major product from levee by enzyme reaction was identified as di-D-fructofuranose 2,6':6,2' dianhydride by mass spectrometry, nuclear magnetic resonance, and chemical analyses. Small amounts of several oligosaccharides and free fructose were also formed by enzyme reaction. An extracellular enzyme that produces di-D-fructofuranose 2,6':6,2' dianhydride from levan was purified from the culture broth of A. ureafaciens K2032. The enzyme had optimum activity around pH 5.8 and 45℃ and had a dimeric form in solution. The N-terminal amino acid residues of the purified enzyme were SAPGSLRAVYHMTPPSGXLXDPQ. The enzyme has narrow substrate range and converts the levee to di-D-fructofuranose 2,6':6,2' dianhydride with around 62.5% conversion yield.
Antifungal Activity of Magnolol and Honokiol
Bang, Kyu-Ho,Kim, Yoon-Kwan,Min, Byung-Sun,Na, Min-Kyun,Rhee, Young-Ha,Lee, Jong-Pill,Bae, Ki-Hwan The Pharmaceutical Society of Korea 2000 Archives of Pharmacal Research Vol.23 No.1
Two neolignan compound, magnolol $(5,5^{l}-diallyl-2,2^{l}-dihydroxybiphenyl, 1)$ and honokiol $(5,5^{l}-diallyl-2,4^{l}-dihydroxybiphenyl, 2)$ were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of $25-100{\mu}g/ml$. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel antifungal agents.
Bae, Hagyoul,Bang, Tewook,Kim, Choong-Ki,Hur, Jae,Kim, Seyeob,Jeon, Chang-Hoon,Park, Jun-Young,Ahn, Dae-Chul,Kim, Gun-Hee,Son, Yunik American Scientific Publishers 2017 Journal of nanoscience and nanotechnology Vol.17 No.5
<P>We report an accurate extraction technique of effective mobility (mu(eff)) by considering gate-bias (V-GS) dependent effective inversion charges (Q(inv,eff)) as a normalized correction factor (sigma(V-GS)) when using the gate-to-source/drain capacitance-voltage (C-V) measurement in a p-channel Si/SiGe MOSFET with a floating body structure. In the proposed technique, two different capacitance-voltage configurations: a gate-to-source/drain (CG-SD) configuration without body contact and a gate-to-source/drain/body (CG-SDB) configuration with body contact are utilized for the accurate extraction of mu(eff).</P>
Low-Frequency Noise Characteristics in SONOS Flash Memory With Vertically Stacked Nanowire FETs
Bang, Tewook,Lee, Byung-Hyun,Kim, Choong-Ki,Ahn, Dae-Chul,Jeon, Seung-Bae,Kang, Min-Ho,Oh, Jae-Sub,Choi, Yang-Kyu IEEE 2017 IEEE electron device letters Vol.38 No.1
<P>Low-frequency (LF) noise in a vertically stacked nanowire (VS-NW) memory device, which is based on the silicon-oxide-nitride-oxide-silicon(SONOS) configuration is characterized in two different operational modes, an inversion-mode and a junctionless-mode (JM). The LF noise showed 1/f-shape behavior regardless of the operational mode and followed the carrier number fluctuation model. With regard to the device-to-device variation and quality degradation of the LF noise after iterative program/erase operations, the five-story JM SONOS memory showed comparatively high immunity arising from its inherent bulk conduction and no-junction feature. Despite the harsh fabrication condition used to construct five-story VS-NW, even the five-story JM SONOS memory exhibited LF noise characteristics comparable to those of one-story JM SONOS memory. Thus, the five-story JM SONOS memory is attractive due to its high-performance capabilities and good scalability.</P>
Metastatic breast cancer from a hepatocellular carcinoma: a case report
Bang Hyewon,Kim Nam-Hee,Choi Seung Hye,Bae Si Hyun,Jung Eun Sun,Min Ki Ouk,Eom Yong Hwa 대한종양외과학회 2022 Korean Journal of Clinical Oncology Vol.18 No.2
Breast metastases from extramammary malignancies are rare. Here, we report a case of breast metastasis from hepatocellular carcinoma (HCC) after breast mass excision in a 63-year-old woman. A new breast nodule was noticed after transarterial chemoembolization, transarterial radioembolization, and stereotactic body radiation therapy for HCC. Breast ultrasound and core needle biopsy were performed to differentiate between the breast tumors. The biopsy result was invasive breast carcinoma, and wide excision of the breast was performed. The final pathological diagnosis was HCC breast metastasis based on histological findings and immunohistochemical staining results. After 9 months of follow-up, HCC and breast metastasis recurred. Despite palliative treatment, the patient died due to complications and general health deterioration. Although breast metastasis due to HCC is very rare, HCC breast metastasis should be considered when a new breast mass is discovered in a patient with a history of HCC for effective treatment and management.