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RISS 인기검색어
- 검색키워드
- 저자 : ( Kh. G Khalikulov ) (검색결과 3 건)
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Modified Membranous Plasmapheresis in Complex Treatment of Patients with Liver Failure
( B. A Saidkhanov ),( D. B Saidkhanova ),( Kh. G Khalikulov ),( K. O Mahmudov ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: One of the challenging problem in modern medicine is a viral hepatitis, which can cause acute liver failure, liver cirrho sis and even HCC. In National Centre of Surgery named after acad. V. Vakhidov, we have many been conducting a number of researches dedicated to this pathology. One of them is plas mapheresis usage in complex treatment. Aim of research: to investigate the effect of advanced method of plasmapheresis conduction to patients with liver failure to efficacy of detoxica tion, peroxidase oxidation of lipids and antioxidant protection. Methods: therapeutic membranous plasmapheresis treatment procedures were conducted at 60 patients, 34 of them were men and 26 were female. Mean age was 37,2 years old. Except standart therapy, which included hepatoprotectors, infusions, immunomodulators and antibiotics, patients were indicated therapeutic membranous plasmapheresis. Our method consists of plasmapheresis without initial heparinization of patient, neutral anolit was used instead of citrate and isotonic solutions (Invention patent №IAP 03988 at 20.07.2009). Results: Most patients had high levels of average molecular peptides, bile acids, ALT, AST and CPR, which considerably de creased after 3rd procedure. Conclusions: Plasmapheresis with neutral anolitis results to detoxication effect, which is presented by free radicals process recuperation and enhancement of clinical and biochemical fea tures at earlier stages. This action is reached due to complex ef ferent and oxidase detoxication technologies, which in its turn approve feasibility of developed method.
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Activated Sorbent Hemosorption at Patients with Liver Failure
( D. Sh Saidkhanova ),( B. A Saidkhanov ),( Kh. G Khalikulov ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: In the last decade extracorporal hemosorption is success fully applied to elimination of pathological changes after liver operations complications. Methods: The hemosorption method is applied at 22 patients with liver failure caused by biliary tract obturation and puru lent cholangitis. At the same time at 14 patients hepatogenic encephalopathy was noted with heavy endogenic intoxication. After washing of a sorbent without preliminary geparinization of the patient the highway of a fence was connected to a vein. Results: The effectiveness of a hemosorption was estimated on clinical manifestations and data of laboratory analyses which were defined prior to the procedure, after 1 and 2 sessions of a hemosorption. Clinically at all patients after 1 session of a hemosorption significant improvement of a state with decrease of symptoms of intoxication of an organism is noted. The ef fectiveness of holding a procedure the sorbent modified by a neutral anolyte was much higher, than an unmodified analog. The clearance of toxiferous metabolites and main markers of endogenic intoxication was higher, than at patients of control group which the hemosorption was carried out by the same sorbent, but not activated solution of a neutral anolyte. After 2 sessions of a hemosorption at most of patients, along with a normalization of the studied biochemical indexes restitution of the immunologic status was noted. Conclusions: Thus, oxidizing modification of a sorbent allowed to increase effectiveness of treatment substantially at patients with liver failure.
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Modified Extracorporal Detoxication after Pankreatic Tumor Operations
( B. A Saidkhanov ),( D. B Saidkhanova ),( Kh. G Khalikulov ),( K. O Mahmudov ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The problem of treatment of acute postoperative pan creatitis and its complications is the complex problem after pancreatic tumor operations. Mortality rate remains high, and varies from 10% to 40%. Aim of research: to increase treat ment effectiveness of patients with acute pancreatitis. Methods: A complex of an intensive care the modified tech nique of plasma exchange with reinfusion of detoxicated ex fused blood by its indirect electrochemical oxidation is applied. Results: All patients in a reference group had strong indica tions of endointoxication with multiorgan failure phenomena. After completion it was succeeded to achieve the considerable decrease in practically all studied indexes from patients of both groups. However, the tendency to a normalization was more expressed at patients of evaluated group who needed carrying out smaller number of sessions of PAS. Conclusions: Neutral anolyte inclusion into technique of plas ma exchange carrying out allowed us to avoid development of above-stated complications from hemostasis system and to sub stantially increase effectiveness detoxication. The universality of developed technique and expediency of its use was proved by the conducted researches at wide range of diseases. Thus, in all cases, irrespective of the reasons which caused the necessity of carrying out detoxication actions we managed to reduce the number of sessions, i.e. to increase quality of detoxication. Especially it is necessary to emphasize positive influence of this technique on coagulation and anticoagulative mechanisms of hemostasis that is also the basic moment for the choice of this scheme of carrying out PAS in comparison with the working standard.
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