항암화학요법 중 호중구감소증이 발생한 저위험군 발열 환자들을 대상으로 한 경구 항균제 요법의 임상적 유용성 및 안정성에 대한 연구

김연숙,이혁,기현균,김춘관,김신우,김성민,백경란,김원석,윤성수,이홍기,강원기,박찬형,박근칠,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 항암화학요법 중 호중구감소증을 동반한 발열이 발생하는 암환자들을 치료하기 위한 다양한 항균제와 여러 가지 방법들이 시도되고 있는 가운데, 합병증과 사망률의 발생가능성이 적은 저위험군 환자들을 대상으로 초기 72시간동안 정주 항균제를 투여한 이후 경구 항균제로 전환하는 요법의 유용성과 안정성을 평가해보고자 본 연구를 시행하였다. 방법 : 1998년 2월부터 1999년 9월까지 본원에서 항암화학요법 중 호중구감소증과 발열이 발생한 환자들 가운데 기저 암질환이 고형암이거나 림프종이고, 입원당시 패혈증의 증후가 없으며 입원 72시간이내에 해열되고 백혈구수치가 증가 추세인 환자들을 대상으로 하여 72시간 동안 정주 항균제를 투여한 이후 경우 ciprofloxacin 750㎎을 하루 2회씩 투여하여 총 4일간 투여하였다. 모든 환자들은 열이 떨어지고 호중구감소증이 회복될 때까지 입원하도록 하였다. 결과 : 총 38명 환자의 40예가 등록이 되었고, 환자들의 기저암 질환은 고형함이 72.5%, 림프종이 27.5%였다. 입원당시 평균 호중구치수는 156/㎕였고, 호중구수치가 100/㎕미만인 경우는 65%였으며, 호중구감소증이 지속된 기간의 평균은 2.4일이었다. 40예 중 39예가 항균제의 변형이나 추가 없이 호중구감소증과 발열로부터 회복이 되어 97.5%의 성공율(95% 신뢰구간: 86.8-99.9%)을 보였다. 부작용으로 피부발진이 있었던 경우가 한 예 있었는데, 증상이 경하여 경구 항균제를 지속할 수 있었다. 심와부의 동통으로 복용을 지속할 수 없어서 대상에서 제외된 예가 또 한 예 있었다. 결론 : 항암요법 중 호중구감소증과 발열을 동반한 환자들 가운데 저위험군 환자들에서 항균제 72시간정주 이후 경구 항균제로의 전환요법은 효과적이고도 안전한 치료방법이라고 할 수 있다. Background : Oral antibiotic therapy following empirical intravenous antibiotics may be effective and safe for febrile neutropenic patients with lowrisk for complications. Methods : We conducted a prospective clinical trial of oral antibiotic therapy in the patients with neutropenia and fever during chemotherapy for cancer. Underlying malignancies were solid tumor or lymphoma with short duration of neurtropenia and the patients had no evidence of clinically or microbiologically documented infections. Oral ciprofloxacin was given to the patients who lacked signs of sepsis on admission, had a rising tendency of neutrophil count (ANC >100 /㎕ ) at 72 hours, and were afebrile at 72 hours. All patients were hospitalized until neutropenia and fever resolved. Results : A total of 40 episodes of 38 patients were enrolled from February 1998 to September 1999. The mean neutrophil counts on admission were 156/㎕ and the mean duration of neutropenia was 2.4 days. The episodes which had neutrophil count below 100 /㎕ were 26 (65%). Treatment was successful in 39 of 40 episodes (97.5% : 95 % confidence interval, 86.8% to 99.9%). Adverse reactions of oral ciprofloxacin were skin rash and epigastric soreness in two cases, respectively. There were no deaths during the study. Conclusions : For low-risk febrile patients with neutropenia during cancer chemotherapy, switch therapy to oral ciprofloxacin at 72 hours following intravenous broad-spectrum antibiotics is effective and safe,

결장직장암에서의 Cyclooxygenase-2와 Inducible Nitric Oxide Synthase의 발현

양근호,배병노,김정연,김기환,한세환,김홍주,김영덕 대한대장항문학회 2003 Annals of Coloproctolgy Vol.19 No.3

Poster Session : PS 1401 ; Hemato-Oncology(Hematology) : A Case of atypical Peripheral T Cell Lymphoma with Both Skeletal Muscle and Pleural Effusion Involvement

( Keun Mo Kim ),( Mi Kyong Kim ),( Ki Man Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Introduction: Peripheral T-cell lymphoma is a disease that accounts for approximately 5-20% of all non-Hodgkin`s lymphomas. The organs that it mainly affects are known to be the skin, liver, and lungs, and invasions in muscles and pleural fiuids are relatively unknown. This paper reports a rare case of atypical peripheral T-cell lymphoma that was confirmed through special immunochemical staining in muscular tissues, Nasal polyp and pleural fiuids` examination. Case Report: A 79 year old woman was transferred to the author`s hospital with continual febricity for two months and Right Shoulder pain. In the Laboratory tests, Alkaline Phosphatase, Aspartate aminotransferase and C reactive Protein was elevated. In the proton computed tomography in the Nasal cavities, Sphenoidal sinus, Both Pleura and Right infraspinatus muscle, the SUVmax increased and showed the possibiity of malignancy. In the tissue biopsy on the soft tissue in the right infraspinatus muscle, atypical cells that were suspected as lymphoma were shown, but their necrosis was so severe that special immunohistochemical staining was impossible. In the biopsy on the left nasal cavity, the CD3, CD56, Ki-67, UCHL-1, and Granzyme B were all positive, so the condition was diagnosed as peripheral T-cell lymphoma. Also, Same diagnosis was confirmed in the pleural fiuid`s cell block examination. Conclusion: The authors experienced a rare form of peripheral T-cell lymphoma that invaded the pleural fiuid and the skeletal muscle. Thus, when there are symptoms such as pain and edema related to the skeletal muscle of an elderly patient, an active biopsy on associated parts of the body and confirmation of tumor invasion of other parts of the whole body are considered useful in making a diagnosis.

Range data의 표면분할과 파라메타 추출

김근중,김두영,김명기,김순백 東亞大學校 附設 情報通信硏究所 1993 情報通信硏究所論文誌 Vol.1 No.1

최근 컴퓨터 시각 분야에 기존의 영상 데이터가 아니고 range data가 이용되기도 한다. 본 논문에서는 range data를 이용한 3차원 물체 인식의 중간 단계로 표면 분할과 표면을 수식적으로 기술할 수 있는 파라메타 추출방법을 연구 하였다. range data의 특성을 이용하여 곡률 계산에 의해 표면을 몇개의 조각(patch)으로 분할하고 이를 수식적으로 기술하는 방법을 제시하였다. 표면의 특징점을 정확히 추출하기 위해 곡률 계산시 가우시안 평활화와 공간 scaling 기법을 도입하였고, 4가지 방향에 대한 곡률을 계산하여 jump 경계와 crease 경계를 찾은 후 이들을 폐곡선으로 연결하여 표면 조각을 얻었다. 표면 조각들은 labeling 기법에 의해 분리되고 각 표면 조각을 수식적으로 기술하기 위해 표면 근사화 기법을 사용하였다. 표면의 분할과 수식적 기술의 타당성을 확인하기 위해 복원 처리 결과를 검토 하였다.

목재가 선적된 선창에서 발생한 산소결핍에 의한 질식사

김동훈,김기권,장태정,김정란,이구,김수근,임현술 大韓法醫學會 2001 대한법의학회지 Vol.25 No.1

Oxygen deficiency has been frequent in a clouted space. Wood consumes oxygen and discharges carbon dioxide Instead of photosynthesis in closed space without light, so do some microorganisms on the surface. We experienced a case that a healthy Insect-proofer fell down and died of asphyxia on stair-board at 7 m below the hatch of the cargo-hold shipping wood Analysis of gases in cargo-hold revealed O2; 12.3%, CO; 105 ppm, CH4; 2.7%, and H2S; 1.9% at 1 m below the hatch, and then O2; 6.1%, CO; 220 ppm, CH4; 2.9%, and H2S, 2.3 ppm at 2.5 m below the hatch. Autopsy findings were unremarkable. We justiced the cause of death asphyxia due to oxygen deficiency. As seen in this case, the serious oxygen deficiency was accounted for oxygen consumption by wood and microorganisms.

상악 제2유구치와 상악 제1대구치의 치관 형태: 치아계측학적 연구

김지인,현홍근,김영재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2011 大韓小兒齒科學會誌 Vol.38 No.4

The basic structure of the primary crowns usually resemble their succeeding permanent teeth. However, maxillary second primary molars resemble ipsilateral first permanent molars. Accordingly in this study, odontometric data of the two teeth was obtained, then analyzed to verify the morphological relationship and sex difference between the two teeth. Dental study casts were examined for their mesiodistal and buccolingual width of the crowns, diameter of each cusps, and intercuspal distances. Photographs of the crowns were taken to measure the angles between each cusp tip. The results are as follows : 1. In boys, PrI, PaI, DBC angle, and MBC angle did not show any statistically significant difference between the two teeth(p>0.05), and moderate level of correlations were observed. 2. In girls, crown index, DBC angle, and MBC angle of the two teeth did not show any statistically significant difference(p>0.05), and moderate level of correlations were recognized. 3. Measurements that did not show statistically significant difference between the two teeth in both boys and girls were DBC angle and MBC angle(p>0.05). In DLC angle, however, statistically significant difference was observed(p<0.01). 4. Most of the measurements showed sex differences, except DBC angle, which did not show any sex difference in both teeth(p>0.05). 유치 치관의 기본적인 구조는 대개 계승 영구치를 닮는다. 그러나 제2유구치는 계승 영구치인 제2소구치보다 오히려 제1대 구치와 더 유사한 경향이 있다. 이에 본 연구는 한국인에서 상악 제2유구치와 제1대구치의 치아계측학적 자료(odontometric data)를 얻어 두 치아의 형태와 크기 사이의 연관성을 살펴보고, 나아가 남녀간의 차이점 유무를 고찰해 보고자 하였다. 남아 150명, 여아 150명 총 300명의 모형을 이용하여 상악 제2유구치와 상악 제1대구치의 근원심 치관 폭경, 협설측 치관 폭경, 각 교두의 직경, 교두정간 거리를 계측하였고, 치관의 교합면 사진을 촬영하여 각 교두정 사이의 각도를 측정하여 다음과 같은 결과를 얻었다. 1. 남아에서 Protocone index, Paraconeindex, Distobuccal cusp(DBC)각, Mesiobuccal cusp(MBC)각은 상악 제1대 구치와 제2유구치 사이에 통계적 유의차가 관찰되지 않았고(p>0.05), 중등도의 상관관계가 확인되었다. 2. 여아에서 crown index, Distobuccal cusp(DBC)각, Mesiobuccal cusp(MBC)각은 상악 제1대구치와 제2유구치 사 이에 통계적 유의차가 관찰되지 않았고(p>0.05), 중등도의 상관관계가 확인되었다. 3. 남, 여 모두에서 Distobuccal cusp(DBC)각, Mesiobuccal cusp(MBC)각은 두 치아 사이에 유의할만한 차이를 보이 지 않았고(p>0.05), Distolingual cusp(DLC)각에서는 통계적 유의차가 관찰되었다(p<0.01). 4. 대부분의 계측치에서 남녀 차이를 나타냈지만, Distobuccal cusp (DBC)각은 상악 제1대구치와 제2유구치 모두에서 남녀 차이를 보이지 않았다(p>0.05).

성장기 아동의 single tooth scissors bite의 교정 치료: 증례 보고

김지인,현홍근,김영재,김정욱,장기택,이상훈,한세현,김종철 大韓小兒齒科學會 2011 大韓小兒齒科學會誌 Vol.38 No.4

A scissors bite in the posterior teeth occurs when the upper teeth are positioned totally buccal to the lower teeth in centric occlusion, either unilaterally or bilaterally. This malocclusion can result from either excessive width of the maxilla or deficient width of the mandible, or sometimes combination of the both. Scissors bite, when left untreated without a proper dental intervention, interferes with the normal mandibular growth leading to a state where consequent disharmony in dental arch width evokes occlusal disturbances. Therefore, early preventive orthodontic treatment is necessary in patients with scissors bite. Scissors bite rarely involves anterior and posterior sites concuttently across the dental arch but usually affect single tooth. Even in the single tooth scissors bite cases, more likely to be met in the clinical fields, immediate dental intervention is indicated because continuous occlusal forces that exacerbate the already adverse axis of the posterior teeth. In this case study, patients with single tooth scissors bite, each 7, 14, 12, and 16 years old, were each treated with criss-cross elastic, fixed appliance, removable appliance, and miniscrews. With the proper selection of appliances appropriate to each specific cases, good treatment outcome can be achieved without resulting any side effects. 중심교합위의 상태에서 편측 혹은 양측으로 상악 구치부의 치아가 하악 구치부의 협측으로 위치한 경우를 scissors bite라 고 한다. 이는 상악의 폭경이 크거나 하악의 폭경이 좁은 경우 발생한다. Scissors bite의 경우 방치하게 되면 하악의 성장이 방해받게 되고 그 결과, 악궁 폭경의 부조화가 심해져 저작 장애를 일으킬 수 있으므로 조기 차단 교정이 반드시 필요하다. 실제 임상에서는 여러 치아의 scissors bite보다 최후방 구치 혹은 그 외 하나의 구치만의 single tooth scissors bite(STSB)을 보이는 경우가 많다. 이러한 STSB의 경우도 방치하게 되면 저작력으로 인하여 구치의 각도가 더욱 악화되므로 즉각적인 치료가 필요하다. 본 증례에서는 STSB를 보이는 7세, 14세, 12세, 16세의 환자에게 각각 criss-cross elastic, 고정성 장치, 가철성 장치, miniscrew를 사용하여 치료한 증례를 보고하였다. 각 환자의 증례에 적합한 장치를 잘 선택하여 사용한다면 치아를 정출시키는 등의 부작용을 야기하지 않고 양호한 결과를 얻을 수 있을 것이다

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

한우거세우의 도체 육질등급과 쇠고기 이화학적 성질과의 상관관계

김대곤,성삼경,정근기 대구산업정보대학 2000 논문집 Vol.14 No.2

The study was conducted to investigate the effect of castration on the carcass grade of Hanwoo reared under the same feed and feeding condition. The carcass grading scores were measured by the Korean carcass grading standards. The results were compared with respect to Hanwoo by sex. Hanwoo steers showed significantly higher marbling degree than Hanwoo bulls. In Hanwoo steers, moisture content was lower while crude fat was higher than in Hanwoo bulls. Water holding capacity and L value of rib loin were higher in steers than in bulls. Collagen content was higher in bulls than in steers. The degree of hardness and chewiness in steers were significantly lower than those in bulls. Moisture contents and cooking loss of water were decreased where crude fat contents and water holding capacity were increased as marbling degree increased.

지하철 역사 승강장의 스크린도어 도입에 관한 연구

김상운,성기창,강병근 한국의료복지시설학회 2004 의료·복지 건축 Vol.10 No.2

In this paper, the problem of subway platform is analyzed and the alternative as a screen door is suggested. This paper aims to improve the facility law in subway platform. Because facility law related to platform is absent, the study scope is limited to detail design that is matched to rules. Field survey is performed to 300 persons that are 150 men and 150 women in Shingil station in which the screen door is established. Also the persons are used the screen door at least 3 times. It makes the field survey credible. The study is proceeded as follows ; First, the law related to platform, the problem of platform, and the plan and status of screen door are analyzed. Second, the definition, and composition of screen door are examined. Then, kinds of screen door is analyzed and the advantage and disadvantage of each kind of screen door are compared. Third, the necessity of establishing the, screen door is examined through field survey and error range of stop position is investigated. Through this flow, final results is abstracted. Direction of facility related to subway platform, applied objective and range are suggested based on this study. This study focuses the stability of platform, pleasantness, and energy saving and suggests facility improvement direction through introducing the screen door and further study.