사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

전북대학교병원 간호원 실무교육에 관한 연구

李明河,金紀美 全北大學校 1988 論文集 Vol.30 No.-

The purpose of this study was to provide the basic information needed to plan effective in-service education program for the nurses in Cheonbuk University Hospital. The data were obtained from 2ways. Data for general characteristics of nurses, past experience about in-service education and attitude on in-service education in future were collected by questionaire developed by researcher. Data for the status of in-service education were collected by interview with a nursing supervisor charging in-service education.

생쥐 대장 평활근 세포에서 내향 정류성 칼륨 전류의 특성 연구

이은주,김명,정명섭,조향훈,김기훈,하현철,김준수,최석,전제열 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Objectives: K^(+) channels play an important role in regulating cellular excitability. The aim of this study was to know whether or not inward rectifier K^(+) channel exists in colonic smooth muscle cells. Methods: Mouse colonic smooth muscle cells were isolated using collagenase, and then we recorded their membrane currents using a whole-cell patch clamp technique. Results: With 90 mM K^(+) in bath, hyperpolarization-induced inward currents from -120 mV to 20 mV with 400 ms duration at a holding potential of -10 mV showed rapid activation, inactivation and inward rectification. The inactivation showed single exponential time course. Reduction of external K^(+) to 60 mM decreased the amplitudes of the currents in whole test voltage range and shifted the reversal potential to more negative potential. The inactivation process and peak currents of hyperpolarization-induced inward currents were not affected by removing external Na^(+). External Ba^(+) blocked hyperpolarization-induced inward currents by dose-dependent manner and pure Ba^(+)-sensitive currents showed strong inward rectification. Cs^(+) also suppressed hyper- polarization-induced inward currents. Ba^(+) and Cs^(+)-induced inhibitiOn of hyperpolarization-induced inward currents was voltage-dependent, and the extent of inhibition increasing with membrane hyperpolarization. Conclusions: These results suggest that inward rectifier KU channels may exist in proximal colonic smooth muscle and may play an important role in regulating membrane potential.

연산동에서 집단발생한 장티브스환자에 대한 세균학적 관찰

李潤日,金慶淑,金明淑,黃基銑,李鍾訓 中央醫學社 1973 中央醫學 Vol.25 No.3

An attempt was made to isolate the causative agent from a group of febrile patients in a construction camp, where the endemic was occurred in a fashion of explosive, and it seemed to be a salmonellosis on the clinical symptoms. Direct rectal swabs and' food samples were taken repeatedly from febrile patients, and only the rectal swabs from the healthy persons to obtain the bacteriological specimens. Sera were also obtained from both healthy persons and febrile patients. Water of glen which penetrates through the camp could be worthy of notice as an infectious source, because one chronic typhoid carrier was found in a slum which was located on a steep ascent just outside of the camp. Typhoid bacilli was isolated from the specimens of 17 patients (58.8%) out of 29 febrile patients, and from 5 out of 92 healthy persons. Widal agglutinin rise was so delayed that it was found not so worthy of examination in the situation of the early management of the patients for prevention of the endemic.

개항기 소설과 야담에 나타난 서구 인식

이윤석,정명기 洌上古典硏究會 2003 열상고전연구 Vol.17 No.-

이 연구는 개항이 시작된 19세기 중반부터 서양의 활판인쇄술을 받아들여 활판본으로 고소설과 야담집이 출판되기 시작하는 1910년대까지로 시기를 한정해서, 이 시기에 읽힌 서사물에 나타나는 서구에 대한 인식을 보는 것이다. 이 연구에서 분석의 대상으로 삼는 서사물은, 소설은 고소설과 신소설이고, 야담은 개항기 이전에 이미 알려진 야담과 개항기에 나온 단형서사물이다. 고소설과 전통 야담에는 서구에 대한 내용이 없으므로, 이들이 1910년대에 활판본으로 출간되면서 일어난 변이 가운데 서구에 대한 인식이 들어 있는 것을 찾아보았다. 그러나 이들 활판본 고소설과 야담은 전대의 것을 그대로 옮겨놓은 것이므로 야담과 고소설에서는 서구에 대한 인식을 찾아볼 수 없었다. 개항이라는 사회변화가 전통 서사물의 독자들에게는 아무런 영향을 미치지 못했다는 것을 알 수 있었다. 개항기의 단형 서사물과 신소설에는 서구에 관한 내용이 많이 나타나지만, 이들 서구에 관한 내용은 매우 피상적일뿐 아니라, 이야기의 진행에 필수적인 것이 아니다. 서구에 대한 내용이 자주 나타나는 것이 서구에 대해 긍정적인 시각을 드러내는 것 같지만, 자세히 살펴보면, 서구에 대한 언급은 통속적인 이야기의 흥미를 더하기 위한 보조 역할만을 한다. 개항기를 해명하는 데 있어서 이 시기에 읽힌 서사물은 중요한 자료가 될 것이다. 개항기 이전부터 서구에 대한 비판적 시각을 갖고 있는 한시는 말할 것도 없고 개항기의 시가에는 서구에 대한 비판적 인식이 일찍부터 제기되었는데, 왜 서시물에서는 서구에 대한 비판적 인식이 잘 나타나지 않는가 하는 문제도 앞으로 관심을 갖고 연구해야할 과제라고 생각한다. This research is about the perception of The West in Korean narrative literature from 1860's when Korea began to open its door to the West till 1910's when old novel and Yadam(野談) started to be published in movable type printing. The Narrative literature we were focusing on includes old novel(古小說) and new novel(新小說) in novel part and traditional Yadam and editorial(敍事的新聞論說) published during this period. As there is no clear mention on The West in old novel and traditional Yadam, we attempted to find some perception of The West in movable type printing in 1901's were only the copies of previous version, we could not find any of the sort. It seems that social changes had no influence upon traditional narrative literature readers in those days. We found that in editorial and new novel contain many details about The West. However, those details were not only superficial, but also not vital for threads of the stories. Details of The West were mentioned frequently in those days in affirmative manner, but as we looked through carefully on this subject we found that mentions on The West only played the role of increasing readers' interest.

구강내에서 재광화용액 "R"의 법랑질 초기 우식병소에 대한 재광화의 정량적 평가

김명은,정일영,금기연,이찬영,노병덕 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.2

Dental caries is a chronic disease that causes the destruction of tooth structure by the interaction of plaque bacteria, food debris, and saliva. There has been attempts to induce remineralization by supersaturating the intra-oral environment around the surface enamel, where there is incipient caries. In this study, supersaturated remineralized solution "R" was applied to specimens with incipient enamel caries, and the quantitative ananlysis of remineralization was evaluated using microradiography. Thirty subjects volunteered to participate in this study. Removable appliances were constructed for the subjects. and the enamel specimen with incipient caries were embedded in the appliances. The subjects wore the intra-oral appliance for 15 days except while eating and sleeping. The removable appliance were soaked in supersaturated solution "R", saline, or Senstime® to expose the specimen to those solutions three times a day, 5 minutes each time. After 15 days, microradiography was retaken to compare and evaluate remineralization. The results were as the following: 1. The ratio of remineralized area to demineralized area was significantly higher in the supersaturated solution "R" and Senstime® than in the saline (p<0.05) 2. Remineralization in the supersaturated buffer solution "R" occurred in the significantly deeper parts of the tooth, compared to the Senstime® group containing high concentration of fluoride.(p<0.05) As in the above results, the remineralization effect of remineralized buffer solution "R" on incipient enamel caries has been proven. For clinical utilization, further studies on soft tissue reaction and the effect on dentin and cementum are necessary. In conclusion compared to commercially available fluoride solution, remineralization solution "R" showed better remineralization effect on early enamel caries lesion. so it is considered as effecient solution for clinical application

영양제로서 결정 NH₄H₂PO₄를 첨가한 피혁 공장 폐수의 생물학적 처리

전명순,임병란,최기덕,이수구 서울산업대학교 산업대학원 1993 大學院論文集 Vol.2 No.-

피혁 공장 폐수의 생물학적 처리에 있어서 유입 폐수의 급격한 부하변동, 독성물질의 유입 및 미생물의 성장에 필요한 각종 영양소의 불균형 등으로 인해 처리효율이 낮고 운전관리상 어려움이 많다. 따라서 본 연구에서는 피혁공장 폐수의 생물학적처리효율을 높이기 위하여 각종 영양제의 주입에 따른 처리효과에 관한 실험을 실시하여 적절한 영양제를 선정하고, 최적 주입량 등을 결정 하였다. 실험대상 폐수는 반월공단내의 피혁 공단 폐수로서 중화 및 응집참전 밥법으로 전처리 한 후 포기조에 유입되는 폐수를 대상으로 하였다. 영양제로는 회분식 실험에서 피혁폐수의 처리효율이 가장 우수한 것으로 나타난 결정 APM (ammonium phosphate monobasic, NH₄H₂PO₄)을 이용하였다. 연속식 활성 슬러지 공장에 있어서 폐수의 유량, 슬러지 반송율, 결정 APM 주입량 등을 변화시켜 그에 따른 처리효율에 미치는 영향을 실험 고찰하였으며, 생물 반응공학적인 반응해석을 통하여 설계에 필요한 반응상수 등을 구하였다. 연속식 활성슬러지법에서체류시간 12시간의 조건에서 영양제 미주입시 BOD 제거효율은 68%에 불과하였으나, 영양제로서 요소와 인산을 주입한 경우 73%로 증가하였으며 결정APM을 주입한 경우 90% 이상의 높은 처리율을 얻을 수 있었다. 결정 APM의 최적 주입량은 회분식 실험의 경우 300㎎/L이었으나, 연속식 실험의 경우 50㎎/L로 낮게 나타났는데, 이는 반송되는 슬러지내의 높은 인농도와 미량원소에 기인한다. 결정 APM을 50㎎/L 주입한 후 수리학적 체류시간을 6∼30 시간의 범위로 변화시켜 실험한 결과, BOD 제거효율은 체류시간 6시간에서는 67%에 불과하였으나, 12시간의 경우 93%, 30시간의 경우 98%이었다. 따라서 BOD제거효율 90%이상을 얻기 위해서는 수리학적 체류시간은 11시간 이상, F/M비는 0,65 ㎏ BOD/㎏ MLVSS·d 이하로 운전하여야 하는 것으로 나타났다. This study was performed to enhance the treatment efficiency of leather wastewater adding APM(ammonium phosphate monobasic, NH₄H₂PO₄) crystal as nutrient which contained the sufficient mineral components. The effect of APM crystal on biological treatment were studied and its optimum dosage and kinetic coefficients were determined. In the continuous activated sludge system for field wastewater of Banwol leather complex, BOD removal efficiency could be obtained over 90% with adding APM crystal, while it was 68% without nutrients and 73% with urea and phosphoric acid in the condition of HRT 12hr and SRT 3 days. The optimum dosage of APM crystal was 50㎎/L which was low compared with 300㎎/L in batch test due to recycling sludge contained high content of phosphate and mineral nutrients. In the condition of adding APM crystal 50㎎/L and hydraulic retention time in the range 6∼30hr, BOD removal efficiencies were 67% for HRT 6hr, 93% for 12hr and 98% for 30hr. In order to obtain over 90% of BOD removal efficiency, HRT should be maintained over 11 hr and F/M ratio within 0.65 ㎏ BOD/㎏ MLVSS·d.

1998-1999년 절기에 부산지역에서 유행한 인플루엔자 바이러스의 분리

정영기,정명주,이주연,안정배,김지희,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

Investigate the epidemics for influenza outbreaks. The outbreak pattern of the internal and external patients housed in the 10 designated hospitals was monitered to investigated and the characteristics of the virus isolates are as follows. 232 strains of influenza virus was isolated from the oral specimen of 1,320 respiratory disease patients in Pusan from Oct. 1998 to Jun. 1999. Among these isolates, 222 strains were A-type and the rest were B-type. The outbreak pattern for sex-and age-group is as follows. The male outbreak was similar to the female outbreak: male outbreak, 47.4% and female outbreak, 52.5%. Most of the patients were less than 10 years old. The monthly influenza outbreak was consistent from Dec. 1998 to Apr. 1999. and The 113 strains from the A-type isolates were A/Sydney/05/97(H3N2)-like, the 109 strains were A/Beijing/262/95(H1N1)-like, and all of the 10 B-type isolates were B/Harbin/07/94-like.

동해안 일부 연안해수의 COD 및 중금속함량

채명준,홍태기,이수영 漢陽大學校 環境科學硏究所 1992 環境科學論文集 Vol.13 No.-

위락시설이 위치한 동해안의 연안해수에 대한 수질환경자료로 COD와 아연, 카드뮴, 납 및 구리 등의 중금속을 중심으로 조사하였다. COD(1.24∼1.41mg/L), Zn(4.34∼7.84ppb), Pb(1.56∼2.19ppb), Cu(0.90∼2.45ppb) 및 Cd(0.17∼0.30ppb)로 나타났다. 이로 부터 오염상태의 정도를 꼬집어 말할 수는 없으나 아직은 오염지역에서 벗어나 있다고 볼 수 있으며, 앞으로의 오염상태를 비교할 수 있는 자료로써 기여할 것이다. The COD and the concentrations of Zn, Cd, Pb, and Cu have been determined in some coastal areas of the Eastern Sea, reflecting the influence of the pollution sources along the shore line. Applying spectrophotometric rapid method for COD and the voltammetric determination procedure in particular suitable for heavy metals at the trace level, significant contributions to a consistent data basis for the distribution of heavy metals in the sea could be achieved.

Electron Cyclotron Resonance O_2 Plasma에서 증착한 규소 산화 박막의 특성

안명환,서문석,장재선,서성모,이기방,윤창주,이형재,남기석,최규현,손춘배,김용섭,강석희 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.17 No.-

규소 산화막을 ECR-CVD(electron cyclotron resonance-chemical vapor deposition) 증착방법으로 5인치 기판위에 상온에서 증착하고, 증착공정조건인 증착율, 기판온도, 마이크로파의 세기변화 및 플라즈마 혼합기체의 비에 따른 규소 산화막의 특성을 조사하였다. 또한 산화막의 구조적인 특성을 비교하기 위해 FTIR을 이용하여 ECR-CVD 증착한 산화막, RPE-CVD(remote plasma enhanced-CVD) 증착한 산화막 및 열 산화막의 stretching frequency를 측정하였다. 측정된 결과 ECR-CVD로 증착된 산화막이 구조적인 면에서 열 산화막과 거의 같음을 보였다. ECR-CVD로 증착된 산화막의 전기적인 특성을 전류-전압 및 축전-전압 측정에의하여 분석하였다. 축전된 산화막의 전기적인 특성은 산화막의 전하 밀도는 1×10 exp (11)/㎠이였고, 평균 절연 파괴 전압은 약 6 MV/㎝이다. We have grown thin films of SiO_2 at room temperature by using an ECR-CVD system and have investigated the changes in the properties of the deposited films with changes in the processing conditions such as the deposition rate, the substrate temperature, the microwave power and the plasma gas mixing ratio. We also measured the stretching frequency of three kinds of oxides, and ECR-CVD-grown oxide, a PECVD-grown oxide, and a thermally grown oxide, using FTIR analysis to compare their structural properties. The result shows that the structural properties of the ECR-grown oxide are similar to those of the thermally grown oxide. Additionally, the electrical properties of the ECR-grown oxide were investigated by using current-voltage and capacitance-voltage measurements. These electrical results indicate that the oxide charge density and the average breakdown voltage are 1×10 exp (11) ㎝^-2 and 6 MV/㎝, respectively.