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Clinical Experience in 200 Renal Transplants at Catholic Medical Center
Park, Yong Hyun,Whang, Tae Gon,Lee, Yong Kak,Yoon, Young Suk,Yoon, Moon Soo,Bang, Byung Kee,Shin, Kyung Sub,Koh, Yong Bock,Kim, Sung Nyeun CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1
Between March, 1969, and April, 1986, two hundred of renal allograft recipients were treated with either cyclosporine (CsA)+prednisone (n=53) or azathioprine (Aza)+prednisone (n=147). On October 31,1986, the actuarial patient survival rate at two years was 75% for all patient group. The corresponding graft survival rate at two years was 68% for all patients. The actuarial patient survival rate at two years was 71% in the Aza group, and 94% in the CsA group including recipients converted from CsA to Aza (3 cases), which was statistically significant (P<.001), and the corresponding graft survival rate was 65% and 80%: the difference was not statistically significant. In the CsA-treated group, excluding converter from CsA to Aza (3 cases), however, the graft survival rate at two years was 91%, which was statistically significant (p = .0056). There was no significant difference of graft survivial rate between the recipients who received DST vs non-DST in CsA-treated group. It was difficult to evaluate the recipients who were given DST due to a small number of cases and short follow-up period. In either, the Aza- or the CsA-treated group, the graft survival retes were higher in HLA identical LRD group than in either haplo-identical or mismatched LRD group. Total of 63 patients, who received kidney transplantation expired. The most frequent cause of death in 17.5% of cases was uremia per se due to graft failure, followed by infection (14.7%), vascular (14.3%), and cardiac (11.1%). The most commonly encountered posttransplant complications in order of frequency were as follows: erythrocytosis (18.0%), pneumonia (15.0%), urinary tract infections (14.0%), herpetic infections (12.0%), fungal infection (11.5%), posttransplant diabetes (8.5%), technical (5.0%) and others.
박상진,강진경,박인서,전재윤,한광협,정재복,한기준,홍범기 대한소화기내시경학회 1995 Clinical Endoscopy Vol.15 No.4
Primary gallbladder cancer is a highly malignant tumor and is characterized by early metastasis and rapid progression of disease. Since the majority of patients have unresectable disease, laparotomy, instead of providing relief of symptoms, often adds to the morbidity and needs to be avoided in patients with advanced disease. Clinical features, peritoneoscopic findings, and comparison of peritoneoscopy with radiologic studies were reviewed in 29 patients, who underwent peritoneoscopy, with primary gallbladder cancer at Severaace Hospital, College of Medicine, Yonsei University between Aug. 1982 and Mar. 1994. The results were as follows; 1) The ratio of male to female was 1.6 : 1 and the mean age was 57.9 years. 2) The most common presenting symptom and sign were abdaminal pain (72%) and palpable mass (49%), respectively. There were 7 cases (24.1%) who had no specific presenting sign. 3) The gallbladder was completely or partly seen in 22 patients and not seen in 7 due to adhesion under peritoneoscopy. Of visible 22 cases, the peritoneoscopic features in order of frequency were hard consistency (18 cases), tense cystic (13 cases), white thick wall (8 cases), and neovascularization (8 cases). There were 10 cases with intraabdominal metastasis to liver (2 cases) and peritoneum (8 cases). 4) Peritoneoscopic diagnosis were as follows; inoperable due to intraabdominal metastasis (10 cases), loco-regional (12 cases), and inconclusive (7 cases) due to invisible gallbladder without intraabdorninal metastasis (6 cases) and the possibility of benign disease (1 case, gallbladder anomaly). 5) Diagnostic accuracies of ultrasonography and camputerized tomography were 68.2%(15 of 22) and 88.9% (14 of 18), respectively. 6) The diagnostic methods in order of diagnostic accuracy for intraabdominal metastasis were peritoneoscopy (81.8%), computerized tomography (81.3%) and ultrasonography (73.3%), but, these differences were not significant. 7) Peritoneoscopic biopsies were performed in 14 cases and confirmations were done in 10 cases. 8) Surgical procedures were performed in l7 cases, including radical cholecystectomy in 8, simple cholecystectomy in 2 cases, cholecytectomy with T-tube choledochostomy in 5 cases, and exploratory laparotorny in 2 cases, in which one had liver metastasis. 9) There was no serious complication of peritoneoscopy. These results suggest that peritoneoscopic evaluation is safe and useful method for diagnosis and staging of primary gallbladder cancer, and could prevent unnecessary surgery in patients with advanced disease by careful preoperative evaluation for pperability.
NANB 간질환 환자에서 2세대 효소 면역 검사법과 중합효소 연쇄 반응법을 이용한 C형 간염바이러스 감염의 진단
이복근(Bock Gyeon Lee),권기호(Ki Ho Kwon),박양훈(Yang Hun Park),김한성(Han Sung Kim),정찬수(Chan Su Jeong),제영성(Young Sung Jae),이준상(Joon Sang Lee),유방현(Bang Hyun Liu),박영홍(Young Hong Park),이기영(Kee Young Lee) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5
N/A The first-generation enzyme linked imrnumosorbent assay(ELISA) method to detect hepati- tis C virus(HCV) has been used with relatively good sensitivity in the diagnosis of chronic non A non B hepatitis infecton, but its sensitivity in cases of acute hepatitis remains poor. The secondeneration ELISA which uses recombinant proteins and synthetic peptides from both structural and nonstructural regions increases the sensitivity in diagnosing HCV infection, and diminishes the number of false-positive reactions. The polymerase chain reaction(PCR) has been used to detect infectivity of anti HCV positive patients more accurately, to evaluate ver- tical transmission, and to monitor the response to antiviral ther~apy for chronic HCV infection. Serum samples from 35 patients with non A non B type liver disease were tested by the secondeneration ELISA and the PCR to evaluate the roles of hepatitis C viral infections in NANB patients. HCV RNA was detected by single polymerase c~t~ain reaction technique using primers deduced from the 5noncoding region of HCV genome. Among the 35 patients, 27 pa- tients were positive for anti HCV (Group A), while 8 were negative for anti HCV(Group B). Among anti HCV positive patients, 11% and 33% o~f patients were related to the transfu- sion and acupuncture, respectively. We could detect HCV RNA in the sera from 27 patients (100%) in the group A and 4 patients(50%) in the group B. We conclude that the combination methods of secondeneration ELISA plus PCR reduce the chance of false diagnosis of HCV infection compared to the first generation ELISA and the PCR can be used to diagnose HCV infection in anti HCV negative hepatitis patients.(Ko- rean J Gastroenterol 1994; 26; 825 832)
무화과 콘서브 처리에 의한 품종별 쇠고기의 이화학적 특성 변화
박복희(Bock-Hee Park),김영옥(Young-Ok Kim),기해진(Hae-Jin Kee),조영자(Young-Ja Cho),최희경(Hee-Kyung Choi) 한국식품영양과학회 1999 한국식품영양과학회지 Vol.28 No.3
무화과에 존재하는 단백질 분해효소인 ficin의 열에 대한 안정 범위인 55℃에서 가열한 무화과 콘서브를 제조하고, 한우, 젖소육, 젖소 거세우 및 수입육에 첨가하여 육연화 효과를 조사하기 위해서, 유리아미노산 조성, hydroxyproline 분석, 조직 측정과 가열후 육즙 용출량, 형태학적 변화 및 관능검사를 실시하였다. 무화과 콘서브를 처리한 쇠고기의 유리아미노산 함량과 육즙 용출량은 대조군보다 높았으나 hydroxyproline과 shear force는 낮았다. 콘서브 첨가시 glutamine 함량은 상대적으로 크게 감소하였으나 asparagine의 함량은 증가하였고, hydroxyproline은 젖소육, 젖소 거세우, 수입육 및 한우의 순으로 낮게 나타났다. 부위별로는 등심이 안심보다 유리아미노산 함량, hydroxyproline, shear force가 높게 나타났으나 육즙 용출량은 낮았다. 무화과 콘서브가 첨가된 쇠고기의 광학현미경 관찰결과 근섬유가 일부 소실되어 세포간 간격이 하얗거나 빈 공간으로 나타났다. 쇠고기를 가열하지 않았을 때의 관능검사에 의하면 색깔은 콘서브를 첨가하지 않은 경우가 첨가한 경우보다 붉은 색이 강하게 나타나(p<0.01~p<0.05) 유의적으로 차이를 보였으며, 다즙성은 무화과 콘서브를 첨가한 경우가 첨가하지 않은 경우에 비해 훨씬 높게 나타났다. 무화과 콘서브를 첨가한 쇠고기를 가열하여 관능검사 한 결과, 젖소 거세우와 수입육의 다즙성은 증가하였고(p<0.001), 질긴 정도는 감소하였다(p<0.01~p<0.001). To prevent the denaturation of ficin(EC 3.4.22.3) that is a proteolytic enzyme in fig(Ficus carica L.), fig conserve was heated to 55℃. The fig conserve was added as a tenderizer to native Korean cattle beef(KCB), dairy cattle beef(DCB), castrated dairy cattle beef(CDCB), and imported beef(IB). The composition of free amino acids, hydroxyproline content, shear force, cooking loss, morphological changes and sensory evaluation were then investigated to observe the effect of tenderizing beef with fig conserve. Free amino acids and cooking loss of treated beef were higher than those of control, whereas hydroxyproline and shear force were lower. Glutamine in treated beef decreased relatively but asparagine increased. Hydroxyproline was found, in increasing order of abundance, in DCB, CDCB, IB and KCB. By portion, loin was higher than tenderloin in free amino acids, hydroxyproline and shear force but was lower in cooking loss. Observation with a light-microgram revealed a surprising loss of muscle fiber in treated beef. In sensory evaluation of uncooked beef, the control was redder than the treated beef(p<0.01~p<0.05). Treatment with fig conserve increased the juiciness of both cooked CDCB and IB(p<0.001) and decreased their hardness(p<0.01~p<0.001).