Review : Progress in Nanocomposite of Biodegradable Polymer

( Ke Ke Yang ),( Xiu Li Wang ),( Yu Zhong Wang ) 한국공업화학회 2007 Journal of Industrial and Engineering Chemistry Vol.13 No.4

Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging

Yongfang Wang,Xin Zhang,Bin Wang,Yang Xie,Yi Wang,Xuan Jiang,Rongjia Wang,Ke Ren 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.5

Objective: To examine the potential of intravoxel incoherent motion (IVIM) and blood oxygen level-dependent (BOLD) magnetic resonance imaging for detecting renal changes after iodinated contrast-induced acute kidney injury (CI-AKI) development in a diabetic rabbit model. Materials and Methods: Sixty-two rabbits were randomized into 2 groups: diabetic rabbits with the contrast agent (DCA) and healthy rabbits with the contrast agent (NCA). In each group, 6 rabbits underwent IVIM and BOLD imaging at 1 hour, 1 day, 2 days, 3 days, and 4 days after an iohexol injection while 5 rabbits were selected to undergo blood and histological examinations at these specific time points. Iohexol was administrated at a dose of 2.5 g I/kg of body weight. Further, the apparent transverse relaxation rate (R2*), average pure molecular diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f) were calculated. Results: The D and f values of the renal cortex (CO) and outer medulla (OM) were significantly decreased compared to baseline values in the 2 groups 1 day after the iohexol injection (p < 0.05). A marked reduction in the D* values for both the CO and OM was also observed after 1 hour in each group (p < 0.05). In the OM, a persistent elevation of the R2* was detected for 4 days in the DCA group (p < 0.05). Histopathological changes were prominent, and the pathological features of CI-AKI aggravated in the DCA group until day 4. The D, f, and R2* values significantly correlated with the histological damage scores, hypoxiainducible transcription factor-1α expression scores, and serum creatinine levels. Conclusion: A combination of IVIM and BOLD imaging may serve as a noninvasive method for detecting and monitoring CIAKI in the early stages in the diabetic kidney.

Breastfeeding and the Risk of Childhood Hodgkin Lymphoma: A Systematic Review and Meta-analysis

Wang, Ke-Lai,Liu, Chun-Lan,Zhuang, Yan,Qu, Hong-Yi Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Purpose: Numerous observational epidemiological studies have evaluated associations between breastfeeding and the risk of childhood Hodgkin lymphoma; however, the existing results are inconsistent. We therefore conducted a systematic review and meta-analysis. Methods: Medical literature was searched in the Pubmed and Embase databases to identify all English-language relevant studies up to April 10, 2013. Reference lists were thereafter hand-searched for additional articles. Studies that reported relative risk ratios (RRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were included. This meta-analysis was conducted in accordance with the guidelines for the meta-analysis of observational studies in epidemiology. Results: We finally included 10 case-control studies in our meta-analysis, involving 1,618 childhood Hodgkin lymphoma cases and 8,181 controls. Overall, we did found a borderline significant association between breastfeeding and reduced risk of childhood Hodgkin lymphoma comparing ever breastfed children to never breastfed children (pooled OR =0.79; 95%CI, 0.58-1.08; P=0.13), with limited evidence for between-study heterogeneity (P =0.12, $I^2$ = 35.70%). Conclusion: There is limited evidence for an inverse association between breastfeeding and risk of childhood Hodgkin lymphoma.

IDH1 Overexpression Induced Chemotherapy Resistance and IDH1 Mutation Enhanced Chemotherapy Sensitivity in Glioma Cells in Vitro and in Vivo

Wang, Ju-Bo,Dong, Dan-Feng,Wang, Mao-De,Gao, Ke Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Isocitrate dehydrogenase (IDH) is of great importance in cell metabolism and energy conversion. IDH mutation in glioma cells is reported to be associated with an increased overall survival. However, effects biological behavior of therapy of gliomas are unclear. Here, we investigated the influence of wild-type and mutated IDH genes on glioma cell biological behavior and response to chemotherapy. Relevant mechanisms were further explored. We designed our study on the background of the IDHR132H mutation. Stable cell lines were constructed by transfection. The CCK-8 method was used to assess cell proliferation, flow cytometry for the cell cycle and cell apoptosis, and the transwell method for cell invasion. Nude mouse models were employed to determine tumorigenesis and sensitivity to chemotherapy. Western blotting was used to detect relevant protein expression levels. We found that overexpression of wild IDH1 gene did not cause changes in the cell cycle, apoptosis and invasion ability. However, it resulted in chemotherapy resistance to a high dose of temozolomide (TMZ) in vivo and in vitro. The IDH1 mutation caused cell cycle arrest in G1 stage and a reduction of proliferation and invasion ability, while raising sensitivity to chemotherapy. This may provide an explanation for the better prognosis of IDH1 mutated glioma patients and the relative worse prognosis of their wild-type IDH1 counterparts. We also expect IDH1 mutations may be optimized as new targets to improve the prognosis of glioma patients.

Graphene transistor based on tunable Dirac fermion optics

Wang, Ke,Elahi, Mirza M.,Wang, Lei,Habib, K. M. Masum,Taniguchi, Takashi,Watanabe, Kenji,Hone, James,Ghosh, Avik W.,Lee, Gil-Ho,Kim, Philip National Academy of Sciences 2019 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.116 No.14

<P><B>Significance</B></P><P>We report an electrically tunable graphene quantum switch based on Dirac fermion optics (DFO), with electrostatically defined analogies of mirror and collimators utilizing angle-dependent Klein tunneling. The device design allows a previously unreported quantitative characterization of the net DFO contribution and leads to improved device performance resilient to abrupt change in temperature, bias, doping, and electrostatic environment. The electrically tunable collimator and reflector demonstrated in this work, and the capability of accurate in situ characterization of their performance, provide the building blocks toward more complicated functional quantum device architecture such as highly integrated electron-optical circuits.</P><P>We present a quantum switch based on analogous Dirac fermion optics (DFO), in which the angle dependence of Klein tunneling is explicitly utilized to build tunable collimators and reflectors for the quantum wave function of Dirac fermions. We employ a dual-source design with a single flat reflector, which minimizes diffusive edge scattering and suppresses the background incoherent transmission. Our gate-tunable collimator–reflector device design enables the quantitative measurement of the net DFO contribution in the switching device operation. We obtain a full set of transmission coefficients between multiple leads of the device, separating the classical contribution from the coherent transport contribution. The DFO behavior demonstrated in this work requires no explicit energy gap. We demonstrate its robustness against thermal fluctuations up to 230 K and large bias current density up to 10<SUP>2</SUP> A/m, over a wide range of carrier densities. The characterizable and tunable optical components (collimator–reflector) coupled with the conjugated source electrodes developed in this work provide essential building blocks toward more advanced DFO circuits such as quantum interferometers. The capability of building optical circuit analogies at a microscopic scale with highly tunable electron wavelength paves a path toward highly integrated and electrically tunable electron-optical components and circuits.</P>

Zero-Current Phenomena Analysis of the Single IGBT Open Circuit Faults in Two-Level and Three-Level SVGs

Wang, Ke,Zhao, Hong-Lu,Tang, Yi,Zhang, Xiao,Zhang, Chuan-Jin The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.2

The fact that the reliability of IGBTs has become a more and more significant aspect of power converters has resulted in an increase in the research on the open circuit (OC) fault location of IGBTs. When an OC fault occurs, a zero-current phenomena exists and frequently appears, which can be found in a lot of the existing literature. In fact, fault variables have a very high correlation with the zero-current interval. In some cases, zero-current interval actually decides the most significant fault feature. However, very few of the previous studies really explain or prove the zero-current phenomena of the fault current. In this paper, the zero-current phenomena is explained and verified through mathematical derivation, based on two-level and three-level NPC static var generators (SVGs). Mathematical models of single OC fault are deduced and it is concluded that a zero-current interval with a certain length follows the OC faults for both two-level and NPC three-level SVGs. Both inductive and capacitive reactive power situations are considered. The unbalanced load situation is discussed. In addition, simulation and experimental results are presented to verify the correctness of the theoretical analysis.

朝鮮使臣海路使行路線中山東登州之地名考證與重構(二) 從黃縣界至山東半島招遠縣

Wang Ke,한종진,당윤희 중앙대학교 외국학연구소 2018 외국학연구 Vol.- No.45

In this article, we investigated the location of geographical names of Dengzhou(登州) shown in Yanxinglu(燕行錄) on site and obtained unknown data from local historians. Moreover, we interviewed residents in the area and recorded their anecdotes which were passed down, and took pictures to have data to compare the past and present humanistic views. Based on the analysis and field surveys, the present geographic names of the places passed by the Joseon envoys from Huangxian County(黃縣界) to Zhaoyuanxian(招遠縣) are reconstructed as follows: Zuoyangpu(柞羊鋪), Huangshuihe(黃水河), Nanwangpu(南王鋪), Huangxian-xiancheng(黃縣縣城), Huangxian-xiancheng-xiguan(黃縣縣城西關), Jiulidianpu(九里店鋪), Nanluanhe(南欒河), Nanluanpu(南欒鋪), Beimapu(北馬鎮), Guanzhuangpu(官庄鋪), Jieshoupu(界首鋪), Huangshan’guanyi(黃山館驛), Wangxuzhai(王徐寨), Zhaoyuanxian(招遠縣) of Dengzhou(登州) in Shandong(山東) China.

Banknote Image Defect Recognition Method Based on Convolution Neural Network

Wang Ke,Wang Huiqin,Shu Yue,Mao Li,Qiu Fengyan 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.6

There are shortcomings in the currently used traditional CCD imaging system which can automatically recognize banknote image defect, such as the need to manually extract the defect characteristics and low accuracy rate of detection results. This paper briefly introduced the advantage of convolution Neural Network (CNN) in image classification and designed a image defect identification method based on convolutional neural network (CNN). The experimental results on data sets show that the identification accuracy rate of this method is 95.6%, which is significantly better than traditional identification method.

Once-weekly Subcutaneous Administration of Bortezomib in Patients with Multiple Myeloma

Wang, Liang,Wang, Ke-Feng,Chang, Bo-Yang,Chen, Xiao-Qin,Xia, Zhong-Jun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

In patients with multiple myeloma (MM), once-weekly intravenous injection or twice-weekly subcutaneous injection (SC) of bortezomib has been proven to offer non-inferior efficacy to standard twice-weekly intravenous administration, with an improved safety profile. However, whether once-weekly SC bortezomib can further reduce the incidence rate of peripheral neuropathy (PN) and not compromise the efficacy remains to be investigated. 25 patients of MM treated with once-weekly SC bortezomib were reviewed in this study. The median treatment cycles were 4 (range, 2-9 cycles). Complete response (CR) rate was 52%, ${\geq}$very good partial response (VGPR) rate was 72%, and ${\geq}$partial response (PR) rate was 84%. 1-year and 2-year PFS rate was 63.0% and 34.3%, respectively, and 2-year OS rate was 100%. Any grade of PN was reported in 9 patients (36.0%), with 7 patients (28.0%) had grade 1 PN, and 2 patients (8.0%) had grade 2 PN. No patients reported grade 3/4 PN in this cohort. In conclusion, once-weekly subcutaneous administration of bortezomib offers excellent efficacy with a further improved safety profile, especially with regard to PN. It needs to be validated in future prospective randomized trials.

Energy factor of high-strength-steel frames with energy dissipation bays under repeated near-field earthquakes

Ke Ke,Michael C.H. Yam,Xu-Hong Zhou,Fuming Wang,Fei Xu 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.40 No.3

This investigation contributes to quantification of the inelastic seismic demands for high strength steel moment resisting frames equipped with energy dissipation bays (HSSF-EDBs) subjected to seismic sequences composed of repeated near-field ground motions. The emphasis is placed on the energy factor demand. A statistical examination of a database with more than eighty million energy factor demands of single-degree-of-freedom (SDOF) oscillators representing HSSF-EDBs responding in different yielding stages is conducted. The research findings show that in the damage-control stage, the energy factor which quantifies the peak seismic demand of a HSSF-EDB structure is insensitive to the repeated near-field earthquake motions. In contrast, a remarkable elevation of the energy factor is observed when oscillators characterising HSSF-EDBs progress into the ultimate stage. In addition, an increasing post-yielding stiffness ratio of the nonlinear force-displacement response in the damage-control stage may produce a detrimental effect on HSSF-EDBs progressing into the ultimate stage under repeated near-field earthquakes due to the corresponding evident increase of seismic demands. A nonlinear regression model quantifying the mean energy factor demand of the system under repeated near-field earthquake motions is proposed to facilitate performance-based seismic design of HSSF-EDBs.