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안가영 ( Ka Young Ahn ),홍재식 ( Jae Shik Hong ),김나영 ( Na Young Kim ),이현주 ( Hyun Joo Lee ),이희정 ( Hee Jung Lee ),최노미 ( Noh Mi Choi ),한호섭 ( Ho Seup Han ),성석주 ( Suk Joo Sung ),김주명 ( Joo Myung Kim ),주관영 ( Kwan 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.6
목적: 증상 있는 자궁탈출증의 수술적 치료로서 천골가시인대 고정술을 시행한 경우 자궁적출술을 시행한 경우와 자궁을 보존한 경우 효과를 비교하고자 하였다. 연구방법: 1998년 3월부터 2002년 3월까지 천골가시인대 고정술을 시행한 155명의 의무기록을 후향적으로 조사하였다. 자궁을 보존한 경우는 83예 (A군)였으며, 자궁적출술을 시행한 경우는 72예 (B군)였다. 결과: 평균 수술시간, 수술 전과 수술 후 1일 째 헤모글로빈 차이, 요도관 제거까지 기간, 입원기간은 A군에서 통계학적으로 유의하게 감소하였다. 수술 후의 재발은 A군에서 14.5%, B군에서 12.5%로 양 군 간에 유의한 차이는 보이지 않았고, 재수술이 필요한 경우도 양 군 간에 유의한 차이를 보이지 않았다. (7.2% vs, 6.9%). 결론: 자궁을 보존한 상태에서 천골가시인대 고정술을 시행함이 자궁적출술을 시행하는 것과 비교하여 자궁탈출증의 수술적 치료로서 차이가 없고, 따라서 자궁탈출증의 수술적 교정 시에 자궁적출술이 필수적인 것은 아닌 것으로 사료된다. Objective: The aim of this study was to compare the efficacy of sacrospinous colpopexy without hysterectomy and with hysterectomy for symptomatic uterine prolapse. Methods: A retrospective chart review was performed in the women who underwent sacrospinous ligament suspension between March 1998 and March 2002. A hundred fifty five women with a symptomatic uterine prolapse were treated with either sacrospinous colpopexy without hysterectomy and/or anterior-posterior repair (83 cases=Group A) or sacrospinous colpopexy with hysterectomy and/or anterior-posterior repair (72 cases=Group B). Results: The mean duration of surgery, hemoglobin change, catheter days and inpatient days were shorter in group A compared with group B. (Group A 102.5±33.4 min, 2.4±0.7 ㎎/dL, 5.2±1.4 days, 7.6±2.2 days vs. Group B 135.3±33.9 min, 2.9±0.8 ㎎/dL, 6.1±2.1 days, 9.4±3.7 days, p<0.05 respectively) Recurrent pelvic organ prolapse developed in 14.5% in group A and 12.5% in group B. Six patients (7.2%) in group A and 5 patients (6.9%) in group B required repeat operation for recurrent pelvic organ prolapse. Conclusions: Sacrospinous colpopexy without hysterectomy and with hysterectomy are equally effective surgical operation for uterine prolapse. This study shows that hysterectomy is not essential for the correction of uterine prolapse.
김지영(Jee young Kim),신가영(Ka yeong Shin),임보영(Bo young Lim),안지영(Ji Young Ahn) 한국산업경영학회 2015 경영연구 Vol.30 No.2
전통적으로 경력이란 한 조직 안에서 위계서열상의 진보를 의미하는 개념이었으나 고용안정성이 저하되어 이직과 해고가 빈번한 오늘날의 기업환경 하에서는 새로운 경력 개념이 필요해졌다. 이에 다중경력은 개인의 심리적인 성공에 초점을 맞춘 개념으로 자기 주도적 학습을 통해 조직의 심리적, 물리적 이동을 통해 형성하는 경력을 의미한다. 이러한 다중경력은 변화하는 환경에 적합한 경력의 형태이나 특정 조직에 국한되지 않는 무경계성과 조직의 성공보다 개인의 심리적 성공을 추구하는 속성으로 조직몰입을 약화시킬 수 있다. 따라서 본 연구에서는 다중경력과 조직몰입의 관계를 실증적으로 검증하고 또한 다중경력과 조직몰입의 부정적 관계를 완화시킬 수 있는 조직 내 변인으로서 조직신뢰와 조직문화의 조절 효과를 입증하고자 하였다. 한국직업능력개발원에서 2009년 실시한 인적자본 기업패널(HCCP)을 사용하여 연구를 진행한 결과 다중경력은 조직몰입에 부정적인 영향을 주며 조직신뢰가 높은 조직에서는 다중경력이 조직몰입에 갖는 부정적인 효과가 조직신뢰에 의해 완화될 수 있음을 보였다. 그러나 개발문화의 경우 조절효과를 발견하지 못했다. This research examined the conceptualization of “multiple career” and empirically tested its effect on organizational commitment. While a traditional career implies advancement in a hierarchical organization, employee career could be established in multiple organizations under dynamic environment where a new career should be needed. Multiple career could be developed by employee self-directed learning and also focuses on psychological success beyond the organizational boundary. Using the HCCP data, we found that multiple career is negatively related to organizational commitment. Moreover, we also tested that its negative effect of multiple career on organizational commitment can be mitigated by a high level of organizational trust and developmentoriented culture. It showed that only organizational trust moderated the negative effect of multiple career on organizational commitment.
Ahn, Yo Han,Kim, Seong Heon,Han, Kyoung Hee,Choi, Hyun Jin,Cho, Heeyeon,Lee, Jung Won,Shin, Jae Il,Cho, Min Hyun,Lee, Joo Hoon,Park, Young Seo,Ha, Il-Soo,Cheong, Hae Il,Kim, Su Young,Lee, Seung Joo,Ka Williams & Wilkins Co 2018 Medicine Vol.97 No.46
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P><B>Background:</B></P><P>The anti-CD20 monoclonal antibody rituximab (RTX) has been proposed as a rescue therapy for difficult-to-treat nephrotic syndrome (NS). We conducted a clinical trial to evaluate the efficacy and safety of RTX in children with difficult-to-treat NS dependent on or resistant to steroids and calcineurin inhibitors (CNIs).</P><P><B>Methods:</B></P><P>A multicenter open-label trial was performed at 8 major pediatric nephrology centers in Korea. The investigation consisted of a randomized controlled trial for steroid- and CNI-dependent NS (DDNS; randomization into the RTX group and the control group, at a ratio of 2:1) and a single-arm study of steroid and CNI-resistant NS (DRNS). DDNS patients in the RTX group and DRNS patients received a single dose of intravenous RTX (375 mg/m<SUP>2</SUP> of body surface area) for B-cell depletion. A second RTX dose was administered at week 2 if the first dose failed to achieve depletion of CD19(+) cells. The primary endpoint was rate of maintaining remission at 6 months after treatment for DDNS and rate of remission achievement for DRNS.</P><P><B>Results:</B></P><P>Sixty-one children with DDNS were enrolled while in remission and randomized to the control group (21 patients) or the RTX group (40 patients). At 6 months after treatment, the remission rates were 74.3% in the RTX group and 31.3% in the control group (<I>P</I> = .003). The mean duration of remission maintenance was significantly higher in the RTX group than in the control group (9.0 vs 2.9 months, <I>P</I> = .004). Of the 23 patients with DRNS enrolled in the single-arm study and treated with RTX, 9 (39.1%) achieved partial or complete remission within 6 months. Depletion of B cells occurred in all patients with RTX therapy. Thirty patients (50.8% of 59 patients analyzed) experienced mild and transient infusion reaction during RTX administration, and most adverse events were mild.</P><P><B>Conclusions:</B></P><P>RTX administration was safe and effective in patients with difficult-to-treat NS. One or 2 doses of RTX may be sufficient to deplete B cells and achieve better control of pediatric NS.</P></▼2>
Antioxidant and Acetylcholinesterase Inhibition Activity of Mulberry Fruit Extracts
Young Ju Lee,Ka-Hwa Lee,Chang-Bum Ahn,Soon-Sil Chun,Jae-Young Je 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.6
The objective of this study was to evaluate the antioxidant effects and acetylcholinesterase (AChE) inhibition activity of mulberry fruit extracts prepared by hot water (MFH) and 80% ethanol (MFE). Total polyphenolic contents of MFH and MFE were 195±3.4 ㎎ gallic acid equivalents/g MFH and 185±2.8 ㎎ gallic acid equivalents/g MFE. MFH and MFE significantly quenched 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide dose-dependently, and showed high chelating ability and reducing power in non-cellular systems. MFH and MFE also inhibited the formation of intracellular reactive oxygen species and lipid peroxidation, and elevated intracellular glutathione (GSH) levels in RAW264.7 cells. In addition, MFH and MFE also dose-dependently suppressed AChE activity.
Ahn, Chang-Bum,Lee, Ka-Hwa,Je, Jae-Young Blackwell Publishing Ltd 2010 International journal of food science & technology Vol.45 No.3
<P>Summary</P><P>Tuna liver is fish by-product, which is normally discarded and/or used as fish meal and animal feed because of poor functionality. In this study, we attempt to recover functional peptides from tuna liver protein by enzymatic hydrolysis using various proteases, and further hydrolysates were fractionated into four categories base on their molecular weight (MW) by ultrafiltration membranes. All fractionated hydrolysates produced by Alcalase, Neutrase and Protamex following Flavourzyme hydrolysis showed excellent antioxidant activities against DPPH, hydrogen peroxide and hydroxyl radical scavenging, and reducing power. Their bioactivity was dependent on treated enzymes, and antioxidant activities of fractions dependent on employing bioassay. Moreover, they confirmed antioxidant ability toward the protection effects on hydroxyl radical-induced DNA damage by the measuring the conversion of supercoiled pBR322 plasmid DNA to the open circular form. In addition, all fractionated hydrolysates inhibited acetylcholinesterase activity, which is involved in Alzheimer’s diseases, and high MW fractions showed high AChE inhibition activity than those of low MW fractions.</P>
Ryu, Ka Yeon,Sung, Dan-Bi,Won, Suk-Young,Jo, Ara,Ahn, Kyusang,Kim, Hyun Yeong,ArulKashmir, Arulraj,Kwak, Kyungwon,Lee, Chongmok,Kim, Won-Suk,Kim, Kyungkon Elsevier 2018 Dyes and pigments Vol.149 No.-
<P><B>Abstract</B></P> <P>New small molecular semiconductors with small band gap and low-lying highest occupied molecular orbital (<I>E</I> <SUB>HOMO</SUB>), namely TBDPPOT, TBDPPEH, and TBDPPEHT4 were synthesized by incorporating the B←N bridged thienylthiazole and diketopyrrolopyrrole (DPP) derivatives. TBDPPOT and TBDPPEH were prepared, respectively, using two different DPPs having 1-octyl and 2-ethylhexyl moiety as the solubilizing group. In addition, the band gap of the TBDPPEH is further reduced by introducing planar thienothiophene unit, which was used for the preparation of TBDPPEHT4. These synthesized SMs are blended with fullerene derivative to construct a photo-active layer for organic photovoltaics. Among OPVs utilizing those SMs, the TBDPPEH exhibits highest power conversion efficiency of 3.21% with an exceptionally high <I>V</I> <SUB>OC</SUB> of 0.92 V, which is ascribed to low-lying HOMO energy level of −5.62 eV. It is expected that the utilization of TBDPPEH as a photo-active layer for OPVs would enhance the oxidation stability of the OPVs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Small molecular semiconductors with low-lying HOMO were synthesized. </LI> <LI> These molecules contain B←N bridged thienylthiazole and diketopyrrolopyrrole derivatives. </LI> <LI> Solar cell based on those molecules exhibited high <I>V</I> <SUB>OC</SUB> values. </LI> </UL> </P>