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( Young Jung Lee ),( Dong Young Choi ),( Im Seop Choi ),( Ki Ho Kim ),( Young Hee Kim ),( Hwan Mook Kim ),( K Iho Lee ),( Won Gil Cho ),( Lea Kyung Jung ),( Sang Bae Han ),( Jin Yi Han ),( Sang Yoon N 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
BACKGROUND: Neuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced neuroinflammationcaused memory impairments. In the present study, we investigated the possible preventive effects of 4-O-methylhonokiol, a constituent of Magnolia officinalis, on memory deficiency caused by LPS, along with the underlying mechanisms. METHODS: We investigated whether 4-O-methylhonokiol (0.5 and 1 mg/kg in 0.05% ethanol) preventsmemory dysfunction and amyloidogenesis on AD model mice by intraperitoneal LPS (250 μg/kg daily 7 times) injection. In addition, LPS-treated cultured astrocytes and microglial BV-2 cells were investigated for anti-neuroinflammatory and anti-amyloidogenic effect of 4-O-methylhonkiol (0.5, 1 and 2 μM). RESULTS: Oral administration of 4-O-methylhonokiol ameliorated LPS-induced memory impairment in a dose-dependent manner. In addition, 4-O-methylhonokiol prevented the LPS-induced expression of inflammatory proteins; inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) as well as activation of astrocytes (expression of glial fibrillary acidic protein; GFAP) in the brain. In in vitro study, we also found that 4-O-methylhonokiol suppressed the expression of iNOS and COX-2 as well as the production of reactive oxygen species, nitric oxide, prostaglandin E2, tumor necrosis factor-α, and interleukin-1β in the LPS-stimulated cultured astrocytes. 4-O-methylhonokiol also inhibited transcriptional and DNA binding activity of NF-κB via inhibition of IκB degradation as well as p50 and p65 translocation into nucleus of the brain and cultured astrocytes. Consistent with the inhibitory effecton neuroinflammation, 4-O-methylhonokiol inhibited LPS-induced Aβ1-42 generation, β- and γ-secretase activities, and expression of amyloid precursor protein (APP), BACE1 and C99 as well as activation of astrocytes and neuronal cell death in the brain, in cultured astrocytes and in microglial BV-2 cells. CONCLUSION: These results suggest that 4-O-methylhonokiol inhibits LPS-induced amyloidogenesisvia anti-inflammatory mechanisms. Thus, 4-O-methylhonokiol can be a useful agent againstneuroinflammation-associated development or the progression of AD.
이철호,최경희,정기현,노상욱,Lee, Cheo-Iho,Choi, Kyung-Hee,Jung, Gi-Hyun,Noh, Sang-Guk 한국정보처리학회 2003 정보처리학회논문지 C : 정보통신,정보보안 Vol.10 No.3
본 연구에서는 웹 서비스를 대상으로 한 다양한 DDoS 공격이 진행 중일 때 패킷들의 TCP 헤더 내에 SYN, ACK 혹은 RST 등 다양한 플래그 값들이 설정된 패킷의 수와 총 패킷수와의 비율을 조사 분석하였다. 그 결과, 특정 플래그가 설정된 패킷 수의 비율이 각각의 DDoS 공격 유형에 따라서 매우 독특한 특성을 가짐을 발견하였다. 본 연구의 결과로 얻어진 이 특징들은 DDoS 공격을 조기에 탐지하는 기법과 시스템을 DDoS 공격으로부터 보호하는 기법 연구에 많은 도움을 줄 것으로 예상된다. This paper presents the analytic model of Distributed Denial-of-Service (DDoS) attacks in two settings: the normal Web server without any attack and the Web server with DDoS attacks. In these settings, we measure TCP flag rate, which is expressed in terms of the ratio of the number of TCP flags, i.e., SYN, ACK, RST, etc., packets over the total number of TCP packets, and Protocol rate, which is defined by the ratio of the number of TCP (UDP or ICMP) packets over the total number of W packets. The experimental results show a distinctive and predictive pattern of DDoS attacks. We wish our approach can be used to detect and prevent DDoS attacks.