에탄올에 의한 간독성과 영양적 조절

서정숙 동아시아식생활학회 1995 동아시아식생활학회지 Vol.5 No.3

Ethanol can affect a wide range of organ and organelle systems. Some of its effects are directly due to the action of either ethanol or its metabolites, whereas others are related to nutritional deficiencies associated with ethanol intake. Some of the liver damages occurring in alcohol abusers are mainly due to generation of free radical during the metabolism of ethanol and subsequent lipid peroxidation. Acetaldehyde the main product of ethanol oxidation, is able to stimulate lipid peroxidation, possibly through the formation of free radicals, or depletion of levels of antioxidant substances. When scavengers of oxygen-derived tree radicals are added to the ethanol metabolizing system, they can prevent generation of the activity. Several authors have reported the ethanol-related variation of antioxidants such as α-tocopherol, ascorbic acid, selenium and glutathione, which are important factors in the defence against oxidative injury. Ethanol also alters the degradation of key nutrients, thereby promoting deficiencies as well as toxic interactions with vitamin A and β-carotene. It has been appeared that ethanol-induced hepatotoxicity may be partially prevented by the administration of antioxidants.

임신중 산전 초음파로 진단된 자궁근종의 임상적 고찰

서정호,김윤숙,김대원,이동운,최규연,이정재,이임순 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Objectives: To study the clinical manifestations; time, mode of delivery, size of myomas and outcome of pregnancy in cases of myomas that were detected prior to pregnancy or during the antenatal care and after delivery. Methods: We statistically analyzed 76 patients with uterine myomas in pregnancy admitted to Soonchunhyang Seoul Hospital during the period of Jan. 1999 and Dec. 2001. Results: The results are as follows. 1. The mean age of patients in the detected group and undetected group were 32.9 years and 32.3 years, respectively. There was no difference in the proportion of primarity between the detected group(98.2%) and the undetected group(79.6%) 2. The most common type of uterine myoma in both groups was intramural myoma (detected group 94.1% vs undetected group 81.3%). The uterine myomas were most commonly located in the anterior portion and fundus(detected group 52.9% and 23.5% respectively vs undetected group 47.4% and 23.7% respectively) and the proportion was not significantly different between the two groups. Uterine myomas with a diameter of 3cm or more in the detected group were detected by clinical examination and ultrasonogram. Rate of uterine myomas with a diameter of 3cm or more in the detected group is 76.5% and less than 3cm is 54.2% which detected incidentally at delivery. 3. The proportion of term infants were detected group 88.2% vs undetected group 91.5%. 4. The most common indications for cesarean section in both groups were cephalopelvic disproportion and repeated cesarean section (detected group 41.2% and 45.8% respectively vs undetected group 11.8% and 18.6% respectively) and there was no significant difference between the two groups. 5. Secondary pathologic changes in the all myomectomy specimens were degeneration in both groups but there was no necrosis or sarcomatous change. 6. Antenatal complications were preterm labor, premature repture of membranes, spontaneous abortion, malpresentation, and placenta previa. Intrauterine growth retardation and placental abruption were not seen in both groups. Conclusion: Myoma detected by ultrasonogram before or during pregnancy is not a significant implication of pregnancy outcome.

부모의 양육태도와 자녀의 갈등

이정숙,서병숙 漢陽大學校 韓國生活科學硏究所 1992 韓國 生活 科學 硏究 Vol.- No.10

Child-rearing attitudes of parents in home teaching are the first examples for the children to establish their personal relations and to prompt their socialization, and have also a profound influence on the formation of character and behavior, and on the development of human intelligence. The purpose of this study is the find how the parents' child-rearing attitudes influnence of the parents' child-rearing attitude and the latent factors of conflict of children through reference to literature and real demonstration and to search for the way to improve the relations between parents and their children through a interview. Eleven junior-college students in Seoul who are interested in a drama volunteered to take part in the interview. Their ages range between 21 and 35-all not married. the period was for six months from June 5 to December 5. Interview shows that parents' rejective, over-protective and indifferent attitudes toward their children bring about the problem behaviors and conflicts between the unconsciousness. Parents' negative attitudes and the conflicts between unconsciousness in childhood are the factors of the conflicts of the children in adolescence. this study is summarized into the following ; Parents' negative attitude toward their children in childhood can be the cause of the conflicts of their children in adolescence. The result of interview shows that parents negative attitude toward the children causes them to have conflict.

중등교사의 주의력 결핍·과잉 행동장애에 대한 지식, 대처 및 교육적 중재

이정옥,서지민,김정순,전성숙 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2

Purpose : This study investigated the prevalence of middle school students with ADHD and the level of middle school teacher's knowledge, coping strategies, and educational intervention for ADHD. Methods : There were 185 teachers and 6,381 middle school students at the 6 middle schools in Pusan. The data was collected from December 20, 2003 to January 10, 2004. Results : 195 middle school students had ADHD (3.1%). The male students with ADHD made up 4.4% of the total students and the female students with ADHD totaled 1.3%. The mean score of middle school teacher's knowledge about ADHD was 21.86 of the score total 32. The teachers used a negative coping style less than an active and passive coping style. Of the educational interventions, the environmental intervention in the classroom was used more than the educational intervention activity. 61.1% of the teachers responded that they did not know very much about ADHD. 93.5% of the teachers had no educational experience with ADHD. 94.1% felt that they needed an education program about ADHD and over half of them intended to participate in an ADHD education program. Conclusion : Based on the results of this study, we concluded that the middle school teachers felt that they had insufficient knowledge about ADHD. They wanted the opportunity to increase their knowledge of ADHD. Therefore, it is necessary for educational programs about ADHD for teachers to be developed and made available to them.

비타민 A 섭취가 에탄올을 급여한 흰쥐의 지질함량과 항산화 영양소 상태에 미치는 영향

양경미,서정숙 경산대학교 생명자원개발연구소 2002 생명자원과 산업 Vol.6 No.-

본 연구는 에탄올의 공급과 함께 비타민 A 활성물질을 식이 중에 보충하여 흰쥐에게 공급한 후 체내 지질 함량과 항산화영양소의 변화를 관찰하고자 시도되었다. 각 실험군은 에탄올을 rq여하고 동시에 비타민 A를 결핍시킨 실험군(FE), 에탄올과 함께 β-carotene 급여군(BE), 에탄올과 retinyl acetate 급여군(RE), 13-cis-retinoic acid 급여군(RAE) 그리고 에탄올 대신에 동일한 열량을 설탕으로 공급시킨 각각의 pair-fed 군(FP, BP, RP, RAP)으로 구분하여 각각 8마리씩 임의배치하여 7주간 액체식이 형태로 사육하였다. 혈장 내 총 지질 함량은 비타민 결핍군에서 가장 높았으며 에탄올 급여군 중 pair-fed 군에 비해서는 RAE군 만이 유의적인 증가를 보였다. 중성지질 함량은 RAE와 RAP군에서 가장 높았으며 에탄올 급여군 중 pair-fed 군에 비해 RE군만이 유의적인 증가를 보였고 인지질은 에탄올과 비타민 A 급여에 의한 영향은 없었다. 총 콜레스테롤 함량은 에탄올 급여군 중 pair-fed 군에 비해 RE군 만이 유의적인 증가를 보였다. HDL-콜레스테롤은 에탄올 급여나 비타민 A의 섭취형태에 의한 차이가 크게 나타나지 않았으며, HDL-콜레스테롤/총 콜레스테롤은 에탄올 급여군 중 BE군 만이 pair-fed 군에 비해 유의적으로 낮았다. 이와같이 혈장과 비타민 A 결핍에 의해서 가장 많은 영향을 받았으며, 이 영향은 비타민 A의 보충에 의해서도 조절될 수 없었다. 혈장내 α-tocopherol 함량은 에탄올 급여로 감소되었으나 간 조직내에서는 β-carotene 섭취군만이 낮은 함량을 보였다. 그러나 간 조직내 tocopheryl acetate 함량은 pair-fed 군에 비해서 에탄올 급여로 현저히 저하되었다. 혈장과 간 조직내에서 에탄올 급여에 의한 비타민 E 함량 감소는 tetinyl acetate 공급으로 그 감소 정도가 가장 저하되었다. 혈장내 총 비타민 C 함량은 에탄올 급여와 동시에 β-carotene이나 retinyl acetate 섭취군이 pair-fed 군에 비해 낮았으며 환원형과 산화형 비타민 C 함량비는 에탄올 급여로 낮았으나 β-carotene을 섭취시킨 군만이 높게 나타났다. 간 조직내 총 비타민 C 함량은 13-cis-retinoic acid 섭취군을 제외한 전군에서 에탄올 급여로 증가되었으며 환원형과 산화형 비타민 C비는 에탄올 급여군 중 β-carotene을 섭취시켰을 때 가장 높았다. 이러한 결과들로 보아 에탄올은 체내 항산화 영양소 상태의 변화를 초래하며 비타민 A의 공급여부 뿐만 아니라 형태별 섭취에 의해서 항산화 영양소 상태가 변화될 수 있는 것으로 나타났다. 그러나 생체내 항산화 영양소들은 서로 상쇄, 상승 혹은 길항작용을 통해서 상호영향을 미치므로 각각의 항산화 영양소 상태 변화에 대한 정확한 기전규명을 위해서는 다각적인 연구가 요구된다고 볼 수 있다. 그러나 지질과산화물의 함량과 체내 항산화 영양소 상태는 상호관련성이 있었으며 본 실험에서 에탄올 공급에 의한 항산화 영양소 함량의 감소는 대체로 비타민 A를 retinyl acetate 형태로 섭취시켰을 때 다소 경감되는 것으로 나타났다. The present study was conducted to investigate the effect of dietary vitamin A on the status of lipid content and antioxidants in ethanol-treated rats. Weaning rats were fed a basal diet until they reached about 160-180g body weight. Thereafter, four experimental groups were fed a liquid diet containing 36% ethanol of tatal calorie and four pair-fed groups were fed isocaloric sucrose instead of ethanol. Additionally, the liquid diet contained adequate amount of β-carotene, retinyl acetate, or 13-cis-retinoic acid except vitamin A deficient diet. The rats were sacrificed after 7 weeks of feeding periods. Plasma contents of total lipid triglyceride were increased in vitamin A-deficient and 13-cis-retinoic acid groups. Plasma concentration of total cholesterol in retinyl acetate group was higher than that of pair-fed controls. HDL-cholesterol/total cholesterol was increased in β-carotene group. The hepatic levels of total lipid and triglyceride in β-carotene. The hepatic levels of total lipid and triglyceride in β-carotene and retinyl acetate groups were significantly increased compaired with the pair-fed control groups. Total cholesterol content was significantly increased in vitamin A-deficient group with ethanol. In the changes of antioxidants status, significant decrease in hepatic vitamin E content was found in rats treated with chronic ethanol. However, dietary supplementation of retinyl acetate modified the change to some extent. Total vitamin C content of liver increased in vitamin A-deficient or β-carotene groups with ethanol feeding.

가족성 아밀로이드성 말초신경병증 1예

양우석,서민정,권유석,유현정,노숙영,백소아 대한근전도전기진단의학회 2003 대한근전도 전기진단의학회지 Vol.5 No.2

여고생의 의복착용과 구매행동

권수애,이진희,서정은,차윤숙,김은영 충북대학교 교육생활연구소 2001 생활과학연구논총 Vol.4 No.-

The purpose of this study was to investigate the wearing and purchase behavior of clothing among girls' high school students. The subjects of this study were 393 girls' high school students in Chongju. The data were collected by questionnaires and analyzed by frequencies and χ2 -test. The results were as follows: 1)Most of girls' high school students wore plain clothes 2-4 days per a week when they went out after school, and the seventy percents of them tended to exchange their clothing each other and to modify their school uniform. 2)In a purchase behavior, they use the display in stores to seek for information regarding clothing products and they were supported by their parents for buying their clothes. Also, most of them purchased their clothes once or twice a season. About thirty five percents of them, purchased their clothes in famous brand stores. 3)The frequency of purchasing clothing products was related with the variables of allowance. self-perceived economic state, the frequency of wearing plain clothes, and the exchange of clothes.

병리검사 처방오류 개선 시스템 구축

이현임,최영진,구숙희,양승주,김병로,김묘정,신일근,신미옥,서임선 한국의료QA학회 2006 한국의료질향상학회지 Vol.13 No.2

문제: 조직병리검사의 처방이 복잡하고 전문화됨에 따라 오류처방이 빈번하게 발생되고 이를 해결하기위한 프로세스가 복잡하여 부서간의 갈등과 업무의 가중, 또한 병원 수입 감소가 초래되었다. 목적: 발생된 오류처방의 유형과 발생율, 오류처방을 해결하기 위한 프로세스를 파악하여 이에 대한 문제점을 개선하여 업무의 효율성과 관련부서간의 부가업무 감소와 갈등해소, 더불어 병원수익을 향상시키는 것에 목표를 두고 활동하였다. 의료기관: 서울시에 소재한 종합병원 질 향상 활동: 조직병리검사 처방의 오류처방 발생 원인과 유형, 발생율을 조사하여 원인을 파악하고 개선을 위한 프로세스를 구축하여 질 향상을 도모하였다. 개선효과: 수술실에서 의뢰한 외과 입원환자의 일반조직병리검사 오류율은 개선 전 7.8%에서 개선 후 3.5%, 동결절편조직검사 오류율은 개선 전 28.6%에서 개선 후 0%로 이전보다 모두 개선되었다. 또한 수술실 간호사의 업무 만족도는 일반조직병리검사의 처방시 95%, 동결절편조직검사 처방시 90%로 높은 만족도를 보였다. 단 병리과의 경우 업무가 증가됨에 따라 초과근무시간이 증가하였다.

면접조사를 통한 초등학생의 영양교육 실태 및 실천도 조사

오유진,이영미,김정현,안홍석,김정원,박혜련,서정숙,김경원,권오란,박혜경,이은주,성현이 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4

This study investigated the experience and practice of elementary school students on nutrition education. The data were collected from 217 male and female students attending 5-6th grade elementary schools in Seoul and Kyunggi-Do from March to June 2007, interviewing face to face by a nutrition teacher and 3 interns of a nutrition teacher. The results were as follows: 86.5% of the subjects learned about ‘Table etiquette’, ‘Reasons for eating fruits and vegetables’ (78.7%), ‘Food waste and environment’ (72.3%), ‘Healthy snacks’ (55.7%), ‘Food sanitation’ (52.3%), ‘Food culture of foreign countries’ (48.1%). Nutrition education experience was significantly different by gender. A total of 43.5% boys responded that they never learned about ‘basic food preperation’ (p < 0.01). They had learned ‘Nutrients for body’ and ‘Food waste and environment’ in school, ‘Healthy weight loss’, ‘Food culture of foreign countries’, ‘Food circulation’ on television, Most content (‘Table etiquette’, ‘Simple cooking’, ‘Food sanitati n’, ‘Eating behaviors for health’, ‘Reasons for eating fruits and vegetables’, ‘Healthy snacks’) was learned from parents. The practice after nutrition education was higher in ‘Table etiquette’ (2.14), ‘Eating fruits and vegetables’ (2.07) than others compared with education experience. The most reason of non-practice on nutrition information was ‘Troublesome’. In ‘Nutrients for body’, a boy answered ‘Difficult for practice’ 20.0%, a girl answered ‘Difficult to understand’ 32.6%, showing a significant difference between the gender groups (p < 0.001). They remembered the ‘Nutrients for body’ (49.6%), ‘Food sanitation’ (44.5%) because of ‘important content’,‘Basic food preparation’ (40.6%), ‘Food culture of foreign countries’ (36.3%) because of ‘interesting content’, ‘Healthy weight loss’ (52.0%), ‘Eating behavior for health’ (44.5%) and ‘Healthy snacks’ (33.7%) because of ‘need for my health’.

Neuroprotective Effects of Quercetin 3-O-Methyl Ether, Quercetin and (±)-Dihydroquercetin in a Rat Model of Transient Focal Cerebral Ischemia

Jung, Seo-Yun,Kim, Hyoung-Ja,Lee, Ji-Yong,Cho, Jung-Sook,Lee, Yong-Sup,Jin, Chang-Bae Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.7