급성 관동맥증후군 환자의 신기능 이상과 주요 심장사건과의 관계

이상재,윤경호,최준호,송미진,김연경,박은미,김현정,이은미,유남진,김남호,오석규,정진원 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

Systematic Review of Heavy Metal Concentrations in Fish and Shellfish in Korea

Shinhee Ye,Jiyoung Shin,Jueun Lee,Eun Mi Jung,Jeongsook Lee,Eunsun Yun,Yeosook Kim,Younghee Oh,Eun-Hee Ha 이화여자대학교 의과학연구소 2018 EMJ (Ewha medical journal) Vol.41 No.1

Objectives: Heavy metals ingested through the consumption of aquatic products can accumulate in the human body over the long-term and cause various health problems. This study aims to present comprehensive data on the amount of heavy metals found in fish and shellfish in Korea using a systematic review of studies that report on that issue. Methods: The study used the following databases: PubMed, Korean Studies Information Service System, and Research Information Sharing Service. The search terms for PubMed included fish OR shellfish OR seafood AND mercury OR cadmium OR lead OR heavy metal AND Korea. The search terms for Korean Studies Information Service System and Research Information Sharing Service included eoryu sueun, eoryu kadeumyum, eoryu nab, eoryu jung-geumsog, paeryu sueun, paeryu kadeumyum, paeryu nab, paeryu jung-geumsog, eopaeryu sueun, eopaeryu kadeumyum, eopaeryu nab, and eopaeryu jung-geumsog. Results: A total of 32 articles were selected for review. The total mercury, lead, and cadmium concentrations in fish and shellfish reported in each of the articles are summarized, as are the species of fish and shellfish with relatively high concentrations of heavy metals. Total mercury concentrations tended to be higher in predatory fish species, such as sharks, billfishes, and tuna, while lead and cadmium concentrations tended to be higher in shellfish. Conclusion: This paper is the first to report a comprehensive summary of the concentrations of heavy metals in fish and shellfish. This data could be used as evidence to protect Koreans from exposure to heavy metals due to the consumption of highly polluted aquatic products.

급성 신우신염이 선행된 Escherichia coli 농흉 1예

차치운,조준형,김미진,오윤정,연재우,이성규,오미정,채지영,김수연 대한감염학회 2009 감염과 화학요법 Vol.41 No.5

We experienced a case of acute pyelonephritis which progressed to Escherichia coli bacteremia and later complicated by empyema in a 65-year-old female. She was successfully treated with intravenous antibiotic therapy and percutaneous drainage of empyema.

Benzodiazepinone과 1,5-Benzodiazepine 유도체의 합성 연구

정대일,이용균,박유미,최태원,정일수,김인식,김윤영 東亞大學校 1997 東亞論叢 Vol.34 No.-

The reaction of o-phenylenediamine 5 with acrylic acid 11 in the presencce of P₂O5+H₃PO₄afforded benzodiazepinone 13 and pyridobenzodiazepinono 17. The reactions of o-phenylenediamine 5 with acrylic acid 11 in the presence of PPA or SiO₂afforded only benzodiazepinone 13. But the reaction of O-phenylenediamine 5 with acrylic acid 11 in the presence of acetonedicarboxylic acid 18 or acetonedicarboxylic acid 18 and PPA or acetonedicarboxylic acid 18 and SiO₂was respectively synthesized 2,4,4,-trimethyI-3H-5-hydro-1.5-benzodi-azepine 23 as new cyclic imine compound. We propose that formation of 2-(2`-imine)propyI-N-isopropylidene aniline proceed though 2-amino, N-isopropylidene aniline intermediate C and 2-(N-a-methylethyI) amino, N-isopropylidene aniline intermediate G. The reaction of o-phenylenediamine 5 with acetonedicarboxylic acid 18 in the presence of PPA or SiO₂or HCI gave 2,4,4-trimethyI-3H-5-hydro-1,5-benzodiazepine 23. Using acetone 19 instead of acetonedicarboxylic acid 18, the reaction of o-phenylenediamine 5 in the presence of PPA or SiO₂or acrylic acid 11 was synthesized 2,4,4-trimethyI-3H-5-hydro-1,5-benzodiazepine 23 as same product. And also the reaction of o-phenylenediamine 5 with acetone 19 and acrylic 11 in the presence of PPA or SiO₂was obtained 2,4,4-trimethyI-3H-5-hydro-1,5-benzodiazepine 23. In case of acetophenone 21 in stead of acceton 19, the reaction of o-phenylenediamine 5 in presence of PPA or SiO₂at 40~45℃ were obtained 2,4-diphenyI-4methyI-3H-5-hydro-1,5-benzodiazepine 24. The reaction of o-phenylenediamine 5 with crotonic acid 25 in the presence of PPA or P₂O5+H₃PO₄or SiO₂at 100~110℃ afforded respectively 4-methybenzodiazepinone 26 as 1:1 cycloadduct.

Nortropinone 유도체로부터 Nortropane Spirohydantoin 유도체의 합성

정대일,박유미,박종훈,김윤영,정두희,김인식 東亞大學校 1998 東亞論叢 Vol.35 No.-

The nortropinones 11 (tropinone lla, N-isopropylnortropinone 11b, N-Carbethoxynortropinone 11c, N-furfurylnortropinone 11d, N-(p-methoxyphenyl)nortropinone 11e) were respectively synthesized by the treatment of acetonedicarboxylic acid 8 with, 2, 5-dimethoxytetrahydrofurane 9 in various amines 10 (methylamine 10a, N-isopropylamine 10b, ethylcarbamate 10c, furfurylamine 10d, p-anisidine 10e). The nortropane spirohydantoins 14 (tropane spirohydanttoin 14a, N-isopropylnortropane spirohydantoin 14b, N-Carbethoxynortropane spirohydantoin 14c, N-furfurylnortropane spirohydantion 14d, n_(p-methoxyphenyl) nortropane spirohydantoin 14e) were respectively synthesized by the treatment of synthesized nortropinones 11 (tropinone 11a 54%, N-isopropylnortropinone 11b 50%, N-Carbethoxynortropinone 11c 58%, N-furfurylnortropinone 11d 31%, N-(p-methoxyphenyl) nortropinone 11e, 70%) with potassium cyanide 12, ammonium carbonate 13.

마우스에서 조합시험법에 의한 고려홍삼의 생식발생독성 평가

김미라, 박동선, 장자영, 신선희, 이예은, 백인정, 연정민, 이세라 , 남상섭, 황방연, 노재섭, 김순선, 조대현, 남상윤, 이범준, 김윤배, 윤영원 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

연무에 있어서 대규모 대기 확산현상의 수치해석

윤경미,배명환,김정민 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-

The spectral finite difference method with a highly spatial resolution and a fast computation speed is applied to simulate the numerical analysis of large-scale atmospheric diffusion phenomenon in smog. A two-dimensional domain as an analytic object is selected, and an analytic fluid is assumed to be laminar, incompressible and viscous. Heat flux and smog inflow are taken in a fixed section on an abscissa as a fire phenomenon. Two-dimensional Navier-Stokes equations with a buoyancy under Boussinesq assumption, continuity equation, energy equation and diffusion equation as governing equations are used. Using a conformal boundary-fitted coordinate system, numerical analyses are performed on various conditions. Dimensionless values of concentration, temperature and stream function increase with the Grashof number. Only dimensionless concentration increases with dimensionless diffusion coefficient, but dimensionless values of temperature and stream function are not changed with dimensionless diffusion coefficient. Except dimensionless values of stream function, concentration and temperature decrease with increasing the Reynolds number.

변연골 흡수가 내측연결 임플란트 매식체의 응력분포에 미치는 영향

윤미정,윤민철,엄태관,허중보,정창모 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.2

Purpose: The change of the marginal bone around dental implants have significance not only for the functional maintenance but also for the esthetic success of the implant. The purpose of this study was to investigate the load transfer of internal conical joint type implant according to marginal bone resorption by using the three-dimensional finite element analysis model. Materials and methods: The internal conical joint type system was selected as an experimental model. Finite element models of bone/implant/prosthesis complex were constructed. A load of 300 N was applied vertically beside 3 mm of implant axis. Results: The pattern of stress distribution according to marginal bone resorption was similar. The maximum equivalent stress of implant was increase according to marginal bone resorption and the largest maximum equivalent stress was shown at model of 1 mm marginal bone resorption. Although marginal bone loss more than 1mm was occurred increasing of stress, the width of the stress increase was decreasing. Conclusion: According to these results, the exposure of thin neck portion of internal conical joint type implant is most important factor in stress increasing. 연구 목적: 지금까지 성공적인 임플란트 치료를 위해 많은 연구가 진행되어 왔으며, 임플란트 주변 골 흡수 현상에 대한 연구는 매우 관심이 높은 분야 중 하나이다. 이에 본 연구에서는 삼차원 유한요소응력분석을 이용하여 변연골 흡수가 내측연결 임플란트 매식체의 기계적 안정성에 미치는 영향을 간접적으로 확인하고자 하였다. 연구 재료 및 방법: 악골에 식립된 내측연결 형태의 임플란트 매식체에 티타늄 소재의 임플란트 지대주를 지대주 나사로 연결하고 상부에 금합금관을 장착하는 삼차원 유한요소모형을 설계하였다. 0, 1, 2, 3 mm의 변연골 흡수 상태를 적용하고, 교합면 중심에서부터 3 mm 편측에 300 N의 수직 하중을 가하여 임플란트 매식체에 발생하는 최대 주응력을 계산하였다. 결과: 유한요소분석결과 변연골 흡수에 따른 임플란트 매식체의 최대 주응력 분포는 유사한 양상을 보였으며, 임플란트 매식체 상단에서 가장 높은 응력 집중이 나타났다. 최대 주응력은 처음 1 mm 변연골 흡수를 가정하였을 때 가장 크게 증가하였고, 이후 변연골 흡수가 증가할수록 응력은 증가하였지만 응력 증가의 폭은 감소하는 경향을 보였다. 결론: 이러한 결과로부터 내측연결 임플란트에서 매식체 두께가 얇은 경부의 노출은 변연골 흡수로 인한 응력 증가에 가장 큰 원인임을 알 수 있었으며, 매식체의 변형, 균열 및 파절 등의 기계적 실패를 감소시키기 위해서는 이에 대한 외과적, 보철적 고려가 필요할 것으로 생각된다.

치매예방을 위한 건강증진행위에 영향을 미치는 요인

윤미정,손애리 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

As an income level and health conditions enhance. the average span of human lire has been elongated and the older population has expanded in a result. This has caused many problems and dementia is one of them. This study eras performed to provide basic prevention measurement or dementia by examining how people conceive or the disease. The target population was 301 adults of 40 years old and above residing in Daejeon city, Korea. The duration of the survey was from Dec. 1, 2003 to Dec. 8, 2003. The reliability of tools used in this study is between 0.65 and 0.83 or Cronbach's alpha. The level of acknowledgement of Dementia has a positive relationship with perceived severity, perceived benefits. health promotion behavior. and social support. Positive perceptions and beliefs tend to lead a higher possibility of Dementia prevention. Therefore programs that enable proper education or Dementia prevention, and early detection are necessary as well as specialized processionals and facilities that can manage and accommodate the programs. This study may be utilized in preparation and donning for dementia prevention programs and policies of older people. Also it can be useful for developing and enhancing various health programs and policies when applied appropriately.

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.1

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18. It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PK15 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.