부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

생체모사환경에서 DLC 필름의 부식마모 특성에 미치는 Si 함량의 영향에 관한 연구

김호건,김우중,김정구,박세준,이광렬 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.3

In a method to improve resistance to wear, corrosion and mechanical properties of protective coating, DLC coatings have been extensively studied over the past several years due to their unique combination of properties. Especially, Si-DLC coatings have been attracting increasing interest of researchers since they have a great potential for solving some of the major disadvantages of pure DLC coatings. Si-incorporated diamond-like carbon (Si-DLC) coatings ranging from 0 to 2 at.% were deposited on Ti alloy substrate by means of r.f. plasma-assisted chemical vapor deposition (r.f. PACVD) technique, using mixtures of benzene (C_(6)H_(6)) and silane (SiH_(4)) as the reaction gases. Corrosion and wear behavior of DLC coatings was investigated by electrochemical techniques (potentiodynamic polarization test and electrochemical impedance spectroscopy), tribological techchnique(wear test) and surface analyses (atomic force microscopy, scanning electron microscopy and Raman spectroscopy). It was found that DLC coatings with increasing Si content could acquire improved corrosion and wear resistance in the simulated body fluid environment (0.89 wt.% NaCl of pH 7.4 at 37℃). (Received December 6, 2004)

영양표시정착화사업(Ⅱ) : 식품참고량설정에 관한 연구 Study on the Establishement of the Reference Amount in Foods

김대병,장영미,김인복,이혜영,장재희,김보영,이정구,김창민,정해랑 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 영양표시에서 1회분량 및 영양소함량표시의 기준으로 사용되는 "식픔창고량"에 관한 연구를 수행하므로써 합리적이고 일관성있는 영양표시기준 개선을 위한 기초자료로 활용코자 하였다. 이를 위하여 미국 및 캐나다를 중심으로 제외국의 현황 및 식품참고량 설정방법을 조사 ·연구 하으며 제도도입 및 개선 방안을 강구하였파. 또한, 시판 제품의 영양료시현황 및 음료류 둥의 포장단위 등을 피악하여 식품참고량설정을 위한 기초자료로 활용코자 하였다. 앞으로 국민건강 ·영양조사자료의 체계적인 통계분석, 가공식품의 섭취량조사 등을 통하여 우리나라 국민의 1인 1회 섭취량자료의 축적이 선행되어야 할 것이다. The purpose of this ?roject is to study on the reference amounts customarily consumed per eating occasion to improve the nutrition labelling standards. We Performed to study on the methodology to establish the reference amounts on the basis of the review on the advanced counITy's status. And we investigated the packaged unit ofprocessed foods. Further study is needed to establlsh the customarily consumed amount per eating occasionthrough the statistical analysis of nationwide food consumption data. Our results will be helpful information to improve nutrition labelling system in Korea.

섬유송출 유압구동부 급제동시 발생하는 충격상승압 흡수장치에 관한 연구

이재구,김정현,김도태,김성동,정선환 한국공작기계학회 2003 한국생산제조학회지 Vol.12 No.1

The equipment of textiles let off is a part of inspection machine which inspects finished textiles and it checks up textiles through that. This study suggests a method to select the capacity and initial gas pressure of accumulator to control surge rising pressure occurring when suddenly braking action to a desired degree. An accumulator in hydraulic systems is hydraulic machinery which store kinetic energy of inertia body during braking. A series of computer simulations were done for the brake action. The results of the simulation work were compared with those of experiments.

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

장기적 트립토판 결여식이 생쥐의 유해감각예민도에 미치는 영향

서영대,박제민,김명정,전명호,양구범,장세헌,강철중,김정태,김용식 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

The depressive patients can be divided into two subgroups by presence and absence of pain symptoms. Those without pain symptoms have blunted pain sensitivity whereas those with pain have normal range of pain sensitivity, and are clinically characterized by anxiety and irritability. The aim of the study is to test if these clinical profiles of the depressives with pain symptoms are related with reduced level of brain serotonin(5-HT). Forty four mice were randomly divided into two groups : one group to be bred with tryptophan free diet and the other with normal control diet, each for 4 weeks. Before the beginning of the breeding period, measured were locomotor activity by open field test, anxiety by elevated plus maze and nociceptive sensitivity by tail flick test, before and after forced swimming(FS). During each FS, duration of immobilization was also measured. The sable sets of measurements were repeated at the end of the breeding period. The brain 5-HT and 5-hydroxyindoleacetic acid(5-HIAA) were measured by high performance liquid chromatography. The results were as follows 1.Four weeks of tryptophan free diet reduced significantly body weight, brain weight, and levels of 5-HT and 5-HIAA in the whole brain. 2.Tryptophan depletion did not influence basal nociceptive sensitivity as measured by tail flick latency before FS. The normal blunting of the pain sensitivity induced by forced swimming was preserved in the tryptophan depleted group. 3.Tryptophan depletion did not influence general locomotor activity in open field. 4.Tryptophan depletion increased significantly time spent on the open arms at the elevated plus maze test done before FS. This anxiolytic-like effect was reduced by FS. 5.Tryptophan depletion did not influence duration of immobilization during FS. From these results, it is suggested that the genesis of the depression with pain symptoms is not medicated by quantitative reduction of brain serotonin

기체크로마토그래피를 이용한 산양삼,백삼,홍삼중의 농약잔류 분석

맹주양;이용구;이숙재;정진아;김정미;김선화;김송아 순천향대학교 기초과학연구소 2010 순천향자연과학연구 논문집 Vol.16 No.2

Commercial Korean ginseng-Ginseng cultivated in mountains(GCM), White Ginseng (WG), and Red Ginseng (RG) - were used, respectively, to analyze the pesticide residues in them. The selected pesticides for the analysis of residue were procymidone and tolclofos-methyl. Procymidone residue was no detected in all of them and tolclofos-methy residue was shown as follows: RG(0.270ppm)>GCM(0.0541ppm)>WG(0.007ppm).

위의 유암종과 선종의 병발 1례

장재식,강혁주,이중현,서영범,윤병구,김용섭,이구,서정일,양창헌,이창우,김정란,윤환중 東國大學校醫學硏究所 2000 東國醫學 Vol.7 No.-

유암종은 전신에 퍼져 잇는 장크롬친화성 세포에서 기원하는데 위의 유암종은 비교적 드문 질환으로 모든 유암종의 1.9~2.2%에 해당하며 위에 발생하는 종양의 1% 미만에서 보고되고 있다. 유암종은 일반적으로 증상이 비특이적이고 면역조직화학검사에 의해서 진단되기 때문에 과거에는 드물게 발견되었으나 최근 내시경 기기 및 술기의 발전과 검사 빈도의 증가 및 면역조직화학검사의 발달로 진단율이 증가 추세에 있으며, 드물지만 유암종에서 선암과 공존하는 예들이 보고되고 있다. 저자들은 심와부 동통을 주소로 내원한 70세 남자 환자의 상부위장관내시경 검사에서 위체상부의 대만곡에서 0.4×0.4 cm 크기의 중간 함몰을 가진 Yamada 1형의 용종과 함께 전정부의 전벽에서 0.8×0.5 cm 크기의 융기된 점막 소견을 보여 조직학적으로 각각 위유암종 및 위선종임을 확진한 후 내시경적 용종 절제술로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Carcinoid tumors are arisen from enterochromaffin cells, which are scattered throughout the body. These tumors are composed of variable numbers of cells that contain endocrine granules in their cytoplasm, which can be identified by immunohistochemistry and electron microscopy. Gastric carcinoid tumors are relatively rare tumor, the reported incidence being 1.9~2.2% of all carcinoid tumors and less than 1% of all gastric tumors. Sometimes, composite carcinoid tumors and adenocarcinoma is reported. We experienced a case of the coincidence of carcinoid tumor and adenoma at the other site of the stomach in a 70 year old male patient. Gastrofiberscope showed 0.4×0.4 cm sized Yamada type I polyp with central depression on the greater curvature of the proximal body and 0.8×0.5 cm sized focal slightly elevated mucosa on the anterior wall of the antrum. The endoscopic biopsy specimens revealed carcinoid tumor and tubular adenoma with moderate atypism, respectively. The carcinoid tumor and adenoma were removed by endoscopic polypectomy. According to the follow-up gastrofiberoscopy after 7 month later, both lesions were nearly normal mucosa except whitish atrophic change after polypectomy.

장애인 수행능력향상을 위한 보조공학기기 제공과 인간공학적 접근의 필요성

정민예,김정란,민경철,구인순 한국장애인고용촉진공단 고용개발원 2006 장애와 고용 Vol.16 No.2

장애인의 기능을 향상시킬 수 있는 방법 중 하나는 보조공학기기의 제공이다. 보조공학기기의 제공은 감각, 지각, 인지, 운동능력 등을 전문적으로 평가할 수 있는 전문가에 의해 선택, 적용, 훈련되는 것이 중요하다. 또한 근골격계 질환을 예방하기 위한 인간공학적 접근에 대한 이해와 작업분석, 직무조정이 가능한 전문가에 의해 보조공학기기가 제공된다면 잔존기능의 향상 뿐 아니라 업무동안 바람직하지 못한 자세를 유지함으로써 발병할 수 있는 근골격계 질환 예방까지 기대할 수 있을 것이다. 본 연구에서는 보조공학기기의 이론적 배경과 인간공학적 접근의 이론적 배경을 소개하였고, 적절한 보조도구를 제공한 장애 근로자에 대해 근골격계 질환 위험요인을 측정하였으며, 이를 통한 자세보완이 장애 근로자의 작업 기능을 향상시킬 수 있음을 객관적으로 밝히는 평가결과를 제시하였다. 따라서 장애인의 직업능력을 향상시키려면 다양한 전문가들의 팀 어프로치가 필요하며 체계적인 서비스가 마련되어야 할 것이다. One of the methods to improve functions of the disabled person is to supply assistive devices. It is important for the disabled person that the devices should be supplied by an expert, who is capable of evaluating their sensory, perception, cognition and motor function. Moreover if the expert have knowledge about ergonomlcs, he or she will also prevent the musculo-skeletal disease which may be happen in work place. In this paper, we introduced the theoretical background of the assistive devices and ergonomic approach, and evaluate the risk factors of the musculo-skeletal disease of the disabled worker who was equipped a proper assistive device, and presented objective experimental results that posture intervention by using assistive device can be useful to improve work function of the disabled worker.

혈관과증식을 동반한 구개부 선방세포암의 치험례

김상중,심재환,박정훈,이원학,이정구 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.6

Vascular lesions of the oral and maxillofacial area is interesting to clinicians because it is difficult in management and has poor prognosis. There have been attempt to classify vascular lesion and recently new classification is introduced that have two basic entities, 1) hemangioma, 2) vascular malformation. It is useful that evaluation of lesion, treatment planning and predicting on prognosis. But vascular lesion is still difficult to clinicians about treatment. A case of acidic cell carcinoma combined with hypervascularity arising on the hard palate in a 28-year-old woman is reported. We mistook it for vascular lesion because of hypervascularity. The clinical and histologic feature are described. Literatures about neovascularization of tumor & acidic cell carcinoma are reviewd, too. And we attempt to solve the problem of hypervascularity.