Suppressive effects of three diketopiperzines from marine-derived bacteria on TGFBIp-mediated septic responese in human endothelial cells and mice

( Byeongjin Jung ),( Sae Kwang Ku ),( Ming Gao ),( Kyung Min Kim ),( Min Su Han ),( Hyukjae Choi ),( Jong Sup Bae ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

Diketopiperazine is a naturally occurring cyclic dipeptide found from diverse living organisma. The com-pounds in this structure class have been known with a broad spectrum of bioactivities including anti-inflamma-tory activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGB- β. TGFBIp is released by human umbilical vein endothelica cells and functions as a mediator of experi-mental sepsis. Here, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria and we hypothesized that 1-3 could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of 1-3 effectively inhibited lipopolysac-charide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, 1-3 sup-pressed cecal ligation and puncture (CLP)-induced sepsis lethality and pulmonary injury. In conclusion, 1-3 sup-pressed TGFBIp-mediated and CLP-induced septic response. Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflamma-tory diseases inhibition of the TGFBIp signaling pathway.

Limnoperna fortunei 幼生의 成長 및 變態에 關한 硏究

崔信錫,金正燮 忠南大學校 環境問題硏究所 1984 環境硏究 Vol.2 No.2

The metamorphosis and the growth of larva in Limnoperna fortunei were studied from October, 1981 to December, 1983. 1. The larva of this species is observed in the three different stages in the form of D- shaped. The shell length of the larva in the early stage is 130.44㎛ to 143.60㎛ and in the middle stage 161.67㎛ to 184.11㎛. In the late stage the length size of the larva increases up to 194.55㎛ to 208.45 ㎛. The shell height is 103.19 ㎛ to 119.47 ㎛, 126.51 ㎛ to 157.63㎛ and 136.87㎛ to 176.35㎛ in the three stages respectively. Thus the growth ratio of shell length to shell height is 1 : 0.75. 2. The metamorphosing stage begins when the shell height becomes larger than 210㎛ and the shell length exceedes 260㎛.

錦江의 魚類群集 分類에 關한 硏究 : A Study on the Classification of fish Communities in the Geum River

崔信錫,金正燮,申鳳燮 忠南大學校 環境問題硏究所 1985 環境硏究 Vol.3 No.1

1. Fishes of 53 species and 13 families were collected at 16 station in the Geum River from May 1977 to August 1980. 2. Fish communities were divided with common fishes which had high relative abundance and constancy value, and then divided minutely with continuum theory at ordinated partial table which was made from characteristic species with 10∼60% constance value. 3. Fish communities in the Geum River were divided into four : describing fome upper river, Zacco- Zacco community, Gobiobotia- Zacco community which was connection community, Pseudobagrus- Opsariichthys community and Coilia- Carassius community. 4. The structure of fish communities in the Geum River was complicated with following orders: Zacco- Zacco community, Pseuobagrus- Opsariichthys community, Gobiobotia- Zacco communty and Coilia- Carassius community.

美國 主要穀物의 段收反應 分析

崔正燮 韓國農業政策學會 1991 농업경영정책연구 Vol.18 No.1

美國의 休耕 補償政策은 植付面積을 制限시키므로 政策參與 農家에서는 段收를 올리기 위해서 劣等地를 休耕시킨다고 알려져왔다. 반면에 休耕地는 休耕計劃에 관계없이 농장별로 경작하지 않는 農地가 결정되어 있으므로 休耕計劃이 段收入를 높이지 않는다는 주장도 있다. 또한 美國 主要穀物 段收의 價格 彈力値가 매우 대조적으로 높거나 낮게 계측된 결과가 보고되어 있다. 本 硏究는 이러한 硏究課題에 대한 해답을 구하기 위해 2段階 推定法을 사용하여 美國의 옥수수, 小麥, 大豆의 段收 價格彈力値를 추정하였다. 硏究結果 休耕補償政策은 政策品目의 段收에 有意的인 效果를 미치지 않으며, 段收의 價格彈力値는 낮게 나타났다.

BCR-ABL 융합유전자를 동반한 급성 골수구성 백혈병 1예

최정민,송성은,이규진,이규원,이호섭 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

BCR-ABL 융합 유전자를 동반한 급성골수구성백혈병은 그 빈도가 매우 낮고, 만성골수구성백혈병의 급성악화기와 임상적으로 유사한 특징을 가진다. 항암화학요법으로 관해유도가 되기 어렵거나, 관해유도 후 재발의 빈도가 높은 특징을 가지고 있어 예후가 나쁘다고 알려져있다. 저자들은 BCR-ABL 융합 유전자를 동반한 급성골 수구성백혈병1례를 경험하였기에 문헌고찰과 함께 보고 하는 바이다. BCR-ABL fusion gene is the hallmark of chronic myelogenous leukemia (CML), but it has been rarely reported in acute myeloid leukemia (AML). AML with BCR-ABL fusion gene has different features from blast crisis of CML. We experienced a rare case of AML with BCR-ABL fusion gene. Here we report this case with a brief review of literatures.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

體育系講習所의 實態와 改善策에 관한 調査硏究

申正泰,崔仁燮 인제대학교 1986 仁濟論叢 Vol.2 No.2

1.The Aim : The aim of this study is to know the actual state of the facilities, trainers, trainees, the contents of training, etc., In the physical training institutions which established privately, and to take the improving measures. 2.The Methods : (The Step) This study is a kind of investigation, and the subject of investigation is 98 private physical training institutions in Pusan. The questionaire made by the research worker himself was used. The data was collected through trained investigators visiting there and interviewing the staffs. 3.The Result : 1) Facilities : Most of them is small in size and very poor in management, and therefore the financial support is needed and the standard of establishing institutions must be adjusted. 2) Trainers : The average age is 33.4 years old, and more than 57% of them are graduates from training college. The institution management career is about 1--6 years, and most have over ten years' experience as players and have the certificate of 4--6 grader in each major field(of sports). As 79.6% of them have careers as players, their physical training skill is excellent. 86% of the respondents participated in the study and training workshop for the improvement in quality, which are mostly under the superintendence of the association. For the improvement in quality of the trainers, the related laws and regulations need to be strengthened and also the standards of qualification need to be graded according to their abilities. 3) Trainees : Most of them are men, and that mostly elementary and secondary school students. The number is increasing but irregular, and 81.6% of them take part in the athletic contests 1--3 times a year. 4) The contents of training : Facilities are opened 3--4 times a day, and each is about 90 minutes long. The training plans are not good enough, and so it is desirable that the association presents a prescribed form. The completion term is formally decided, but it is for the acquisition of upper class or grade, and in general it is a continuous course. 5) The rest : 40.8% of respondents have had 1--2 accidents per year and most of the hospital expenses are paid by the institutions. The management of the institutions is their main business for 88% of them, and they are satisfied with the job. The most difficult thing in management is the financial problem.

웨이트트레이닝이 여성의 신체조성에 미치는 영향

이정섭,최석립 대구보건대학 2001 대구보건대학 論文集 Vol.21 No.-

Transition analysis of b body composition and subcutaneous fat after weight training program is next. First, Weight, Fat, Fat rate, the abdominal fat, the thigh after training is reduced. Secondly, Among transition of subcutaneous fat, biceps and triceps is reduced after training. However, subscapular and suprailiac represent no difference after training.

Vecuronium에 의한 기관내 삽관시 안압 및 심맥관계에 미치는 영향

신용섭,이정은,최세진 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

The effects of muscle relaxants(vecuronium, pancuronium, d-tubocurarine, and succinylcholine) for endotracheal intubation on intraocular pressure, blood pressure, heart rate, and arrhythmia were studied in 60 patients undergoing general anesthesia, The patients were divided into 4 groups : vecuronium group (0. 1 mg/kg), pancuronium group (0.08 mg/kg), d-tubocurarine group(0.4 mg/kg), and succinylcholine group(1 mg/kg) according to be administrated. Before induction of anesthesia, initial measurement of intraocular pressure (control value) was taken with Schiotz tonometer after instilling of a 0. 5% pontocaine on conjunctival sac. Subsequent measurement were undertaken as soon as the lid reflex was lost after thiopental sodium injection and then at 75-100% depression of first twitch height of train-of-four after intravenous administration of muscle relaxants. It was measured at 1, 3, 5, 10 minutes after endotracheal intubation too. Blood pressure (systolic and diastolic), heart rate, and ECG abnormalities were observed in all cases. The results were as follows; 1. After thiopental sodium injection, intraocular pressure(IOP) decreased than the control value. 2. At 70-100% depression of first twitch height, IOP decreaeed significantly in vecuronium, pancuronium and d-tubocurarine group, but increased significantly in succinylcholine group than the control value. 3. After 1 minute of endotracheal intubation, IOP increased in all groups. There was no stastistical significance in vecuronium group compared with the control value. 4. After 3 minutes of endotracheal intubation, IOP decreased in all groups. 5. The changes of systolic and diastolic blood pressure and heart rate in vecuronium group were the smallest value among all groups. 6. There was no arrythmia in vecurouium group.

최근 10년간 마취에 관한 임상적 고찰

신용섭,임정혁,최세진 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

To evaluate the specificity and the historical trends of the anesthetic agents and anesthetic methods used in Chungnam National University Hospital, anesthetic experiences of 21, 595 in total performed at Chungnam National University Hospital from January 1977 to December 1986 were analyzed stastically and clinically according to age, sex, surgical department, physical status, elective and emergency surgery, premedicants, induction agents, anesthetic methods, main anesthetic agent, anesthetic technique and muscle relaxants. The results were as follows: 1. The number of cases has been steadily increased. Considerable increase in the cases has been noted since 1985, when Chungnam National University Hospital was enlarged. 2. The distribution of the number of patients according to the age were 15, 332 cases (70. 9%) in the group of 16-60 years. 3. There were 12, 109 male (56. 1%) and 9,486 female (43.9/'0) cases. 4. 6, 128 cases (28.4%) were in general surgery, 4, 276 cases (19. 8%) in orthopedic surgery, 3, 138 cases (14.5%) in OB-GY and 1, 888 cases (8.7%) in ENT in order of numbers. 5. According to the ASA classification of physical status, most of the cases were belonged to the class 1 (33. 9%) class 2 (26.6%), class 1E (14.2%) and class 2E (12.5%). Almost cases were relatively in good physical status. 6. The rate of elective to emergency was 66. 5% (14, 370 cases) to 33. 5% (7, 225 cases). 7. As premedicants, a group of atropine, diazepam and hydroxyzine (33.4%) was given most frequently. Recently, glycopyrrolate has been used increasingly. 8. Thiopental sodium has been mainly used for intravenous induction agent. 9. General anesthesia has been used as the main method of anesthesia. 10. Halothane was the most commonly used anesthetic agent. Since 1979, the use of enflurane has been increased yearly. 11. The semiclosed circle breathing system was mainly employed. 12. Succinylcholine was given to most cases. Pancuronium was the most commonly used nondepolarizing muscle relaxant. Vecuronium has been used since 1986.