제2형 당뇨병 환자의 치료에서 복약순응도가 혈당 조절에 미치는 영향

김경선,김민정,박소현,박영주,허정순,이은경,김선영,이수형,김상수,강양호,손석만,김인주,김용기 한국병원약사회 2009 병원약사회지 Vol.26 No.2

Abstract: As known in clinical trial like DCCT, UKPDS, tight glycemic control is essential to prevent complications from diabetes mellitus(DM). In type 2 diabetes taking multiple medication, nonadherence to medications is common problem. The aim of our study is to investigate adher-ence rate of patients with type 2 DM and to evaluate association between many factors including adherence rate and HbA_(1C). 441 patients with type 2 DM who visited Busan National University Hospital endocrine internal department from Aug 13 to Sep 2, 2008(3weeks) were enrolled. We conducted a man-to-man questionnaire survey about general knowledge about diabetes mellitus, medicine and adherence, and measured HbA_(1C). Among them, 305 patients taking oral hypo-glycemic agent(OHA) were analyzed to investigate correlation between adherence rate and glycemic control. We studied 305 patients(male 126, female 179, average age 61.2±9.8 years, DM duration 8.6±6.4 years, average adherence 88.8±16.2%, average HbA_(1C) 7.03± 1.18%). HbA_(1C) showed significant relation with DM duration(r=0.137, p=0.017), number of aHA in regimen (r=0.135, p=0.018), dosage frequency(r=0.132, p=0.026), Medication Refill Adherence(MRA)(r=-0.124, p=0.030) and adherence(r=-0.168, p=0.003). Adherence had significant relation with MRA(r=0.148, p=0.010) but didn't have statical corelationship with DM duration, number of aHA and dosage frequency. Patients that their adherence rate exceed 90% took fewer OHA(p=0.011) and went on a better dietary treatment(p=0.007). In patients controlling diabetes mellitus with aHA, when adherence rate and MRA was higher, HbA_(1C) was lower. As a result, to improve adher-ence rate, it is necessary to enhance patient education, do careful consideration about prescrip-tion medicine number and dosage frequency

해산어류와 두족류의 Anisakids Iarvae의 감염현황

손성원,이정훈,정영모,최용만 경남대학교 환경문제연구소 1994 환경연구 Vol.16 No.-

In this study, the infection status of the anisakids larvae was investigated. 8 species marine fishes and 2 species cephalopoda purchased from the near Southern sea in Korea, were examined to provide the importance of infection source of human body and the basic data for the prevention. The results obtained from this study were as follows. 1. The infection rate of anisakids larvae in marine fishes was 100% in Trichiurus lepturus, 100% in Scomber japonicus, 75.0% in Trachrus japonicus, 70.0% in Pseudosiciaena manchurica, 69.23% in Astroconger myriaster, 58.33% in Konosirus punctatus, 40.0% in Liparis tanakai, 20.0% in Seriola quinqureradiata, respectively. And, the infection rate of anisakids larvae in cephalopoda was 40.0% in Sepiella maindroni but Octopus rariabilis was not infected at all. 2. The total number of anisakids larvae collected from the parasitic organs was 2,199. The details were as follows: 1,032(46.93%) in the viscera, 868(39.47%) in the omentum. 191(8.69%) in the stomach, 82(3.73%) in the liver and 26(1.10%) in the muscle, respectively.

석면관련 폐질환의 진단에 있어서 흉부고해상도전산화단층촬영검사(HRCT)의 유용성

이현재,손지언,,홍영습,,이영일,예병진,유창훈,정갑열,김상훈,임형준,장은철,김정만,김준연 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 석면에 노출된 근로자에서 석면관련 폐질환의 양상을 분석하고 진단에 있어 HRCT의 유용성을 연구하여 석면에 대한 의학적 감시프로그램의 개발에 기여하고자 하였다. 방법: 석면에 직접 노출되는 작업자 68명과 간접 노출되는 작업자 94명 등 총 162명에 대해 OSHA 석면 표준, 의학적 감시 프로그램에 따라 단순 흉부방사선검사, 폐활량검사 및 우리나라 실정에 맞게 일부 수정한 의학적 설문지를 통해 면접조사의 방식으로 환자에 관한 정보를 수집하였으며, 자료의 신뢰성을 확보하기 위하여 면접조사는 1달 이상의 기간을 두고 2차례에 걸쳐 실시된 후 확인, 수정하였다. 또한, 석면관련 폐질환을 확진하기 위하여 HRCT를 추가적으로 실시하였다. 결과: HRCT결과 석면관련 폐질환의 유병율은 162명의 근로자중 17명으로 10.5%였는데, 직접 노출군에서 10명 (14.7%), 간접 노출군에서 7명 (7.4%)이었다. HRCT와 비교할 때 단순 흉부방사선검사의 민감도와 특이도는 각각 70.6%와 98.6%이었고, 양성 예측도와 음성 예측도는 각각 85.7%와 96.6%으로, HRCT는 단순흉부방사선검사에 비해 민감도가 높아 초기 석면관련 폐질환을 진단하는데 효과적이었다. 석면관련 폐질환의 진단에 있어 HRCT와 폐활량검사 사이에 유의한 관련성이 관찰되었다. HRCT 결과 석면관련 폐질환의 유무와 의학적 설문조사 결과의 빈도분석을 실시한 결과, 유의한 변수는 작업기간, 흡연량, 호흡기질환의 과거력, 기침, 호흡곤란이었다. 결론: HRCT는 석면관련 폐질환의 진단에 있어 단순 흉부방사선검사와 비교하여 민감도가 높아 초기 진단에 유용하므로 단순 흉부방사선선검사 결과 석면관련 폐질환소견을 보일 때뿐만 아니라, 정상소견을 보이더라도 폐활량 검사결과와 근무력, 흡연력, 호흡기질환의 과거력, 기침, 호흡곤란 등의 호흡기 증상을 참고하여 HRCT검사를 고려해야 한다. 또한, 본 연구에서 관련성이 없었던 요인들에 대해서도 향후 연관성을 규명하는 광범위한 전향적 연구가 필요하다. Objectives: This study was carried out to improve the medical surveillance program of workers exposed to asbestos by examining the usefulness of High Resolution Computed Tomography (HRCT) in the diagnosis of asbestos-related lung disease. Methods: The study subjects comprised 162 workers in a ship-repairing yard, 68 of whom had been directly exposed to asbestos and 94 indirectly exposed. The 'Occupational Safety & Health Administration (OSHA) asbestos standard, medical surveilance program' and HRCT were conducted to analyze the aspects of the asbestos-related lung disease. The OSHA asbestos standard, medical surveilance program consists of simple chest x-ray, spirometry and medical questionnarie. Results: Seventeen (10.5%) of the 162 subjects, 10 (14.7%) directly exposed and 7 (7.4%) indirectly exposed, revealed asbestos-related lung disease on HRCT. The sensitivity and specificity of simple chest x-ray for asbestos-related lung disease were 70.6% and 98.6%, and the positive and negative predictive values were 85.7% and 96.6% respectively, as compared with HRCT, HRCT was an effective diagnostic tool especially to detect early asbestos-related lung disease. The study results indicated a relative significant association between the results of spirometry and HRCT. The variables significantly associated with asbestos-related lung disease on HRCT were work duration, smoking history (pack-years), past history of respiratory disease, cough and dyspnea. Conclusions: In the diagnosis of asbestos-related lung disease, HRCT should be considered not only for workers with positive findings on simple chest x-ray, but also workers with specific findings on spirometry, occupational history, smoking history, and past history of respiratory disease, or with respiratory symptoms such as cough and dyspnea.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

장중첩증으로 발현된 원발성 림프종 1예

정태연,손석만,이창화,이원재,백승덕,최우혁,정희철,정소연,김남일,서정일,양창헌,이창우,정기훈,김정란 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.2

위장관은 악성 림프종이 가장 흔히 침범하는 림프절 외 장기이지만, 원발성 소장 악성림프종이 비교적 드물게 발생한다. 장중첩증은 장 림프종의 드문 징후이며, 다양한 영상 검사에 의하여 진단된다. 저자들은 회장 장중첩증에 의해 우연히 발견된 림프종의 예를 보고하는 바이다. 조직학적 소견은 미만성 대 B 세포의 악성 림프종이였고, 중증도의 미만성 대비분열성세포이였다. 환자는 수술적인 절제술과 항암요법을 시행하였고 15개월간 재발이 없는 상태로 추적 관찰 중이다. Although the gastrointestinal tract is one of the most frequent sites of extranodal malignant lymphoma, the occurrence of primary small intestinal lymphoma is relatively uncommon. The intussusception is a rare presenting sign of intestinal lymphoma, and diagnosed by various imaging studies. We report on a case of the lymphoma on ileum manifested by ileo-ileal intussusception. Pathologic type was malignant lymphoma with diffuse large B cell (REAL classification), intermediate grade, diffuse large noncleaved cell (Working formulation). The patient received surgical resection and combined chemotherapy and doing well for 15 months.

A study on the novel trench gate IGBT for high performance

Jung-Man Son,Jae-Hyun Lee,Seung-Bum Yuk,Mi-Jung Park,Yong-Seo Koo 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7

In this study, three types of new structural Trech type IGBT(Insulated Gate Bipolar Transistor) were proposed and electrical characteristics of these IGBTs were analyzed. The process and device simulation results show improved on-state, breakdown and switching characteristics in each structure. The first one was presented lower on state voltage drop(2.1V) than that of conventional one(2.4V). Also, second structure has higer breakdown voltage(1220V) and faster turn off time(9ns) than that of conventional structure. Finally, the last one of the proposed structure has combined the two structure (the first one and second one). This structure has superior electric characteristics than conventional structure about forward voltage drop and blocking capability, turnoff characteristics.

Poster Session : Effects of Sports Climbing Club Activity on Physical Fitness and Falling Injury-related Variables in Middle-aged Men

( Jung Jun Son ),( Chang Kyun Kang ),( Won Sang Jung ),( Man Gyoon Lee ) 한국체육학회 2013 In Pursuit of Evidence-Based Sport and Exercise Sc Vol.0 No.-

폐암 359 예에 대한 임상적 고찰

정만홍 ( Man Hong Jung ),손영배 ( Young Bae Son ),한병훈 ( Byung Hoon Han ),유재화 ( Jae Hwa Ryu ),정의룡 ( Eay Ryong Jung ),박병채 ( Byung Chai Park ) 대한내과학회 1985 대한내과학회지 Vol.29 No.6

스포츠 클라이밍 동호회 활동 경력이 중년 남성의 체력과 낙상관련 변인에 미치는 영향

손정준(Son, Jung-Jun),강창균(Kang, Chang-Kyun),정원상(Jung, Won-Sang),이만균(Lee, Man-Gyoon) 한국체육과학회 2013 한국체육과학회지 Vol.22 No.5

This study was designed to compare physical fitness and falling injury-related variables (isokinetic function of ankle and balance) among three groups, i.e., middle-aged men who have career longer than 5 yrs (5 yr group; n=15), who have career of 2-3 yrs (2-3 yr group; n=15), and who have career less than 1 yr (1 yr group; n=14), which were composed according to career of sports climbing club activity. Main results were as follows: 1) There were significant differences among three groups in first finger joint-grip strength in both sides, chin up, push up, 1-RM of lat pull down, modified grip-chin up, and ROM of hip joint during inversion in both sides. Vo₂max and 1-RM of leg press were significantly higher in 5 yr group and 2-3 yr group than 1 yr group. 2) Peak torques per body weight during dorsiflexion of right ankle at 30˚ ·sec<SUP>-1</SUP> and plantar flexion of right ankle at 120˚ ·sec<SUP>-1</SUP> were significantly lower in 1 yr group than the other two groups. 3) Sway for right dynamic balance was significantly lower in 5 yr group than the other two groups. 4) There was no significant difference in daily energy expenditure among three groups. It was concluded that physical fitness was getting more improved as career of sports climbing club activity is getting longer. All these positive differences were accomplished by sport climbing club activity per se regardless of physical activity level. Sports climbing would be beneficial for enhancing physical fitness and for preventing falling injury.

친환경 세라믹 고분자 수지 모르타르의 주차장 표면 마감의 재료적 특성에 관한 실험적 연구

손종만 ( Son Jung Man ),최은규 ( Choi Jun Kyu ),이신춘 ( Lee Sin Chun ),곽규성 ( Kwak Kyu Sung ),오상근 ( Oh Sang-keun ) 한국구조물진단유지관리공학회 2008 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.12 No.2

Recently, the parking lot supplied and enlarged. Even though the social problem on the lack of parking lot space increased gradually, the factor of environment, construction and structure which is connected directly to safety for finishing materials of parking lot. Therefore, new concept for finishing materials of parking lot to solve these problem very need. On investigation as yet, I could find the effect by environment and safety factor through the study on the Performance of a high molecular ceramic resin mortar finishing materials for parking lot. And the performance is satisfied with KS as proper method to keep long term safety. In summary, I consider that specification and quality control for the finishing materials of parking lot need to use in the job site.