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Lee, Bom-Bi,Sur, Bong-Jun,Cho, Se-Hyung,Yeom, Mi-Jung,Shim, In-Sop,Lee, Hye-Jung,Hahm, Dae-Hyun The Korean Society for Integrative Biology 2012 Animal cells and systems Vol.16 No.4
The purpose of this study was to examine whether Phellodendri Cortex extract (PCE) could improve learning and memory impairments caused by lipopolysaccharide (LPS)-induced inflammation in the rat brain. The effect of PCE on modulating pro-inflammatory mediators in the hippocampus and its underlying mechanism were investigated. Injection of LPS into the lateral ventricle caused acute regional inflammation and subsequent deficits in spatial learning ability in the rats. Daily administration of PCE (50, 100, and 200 mg/kg, i.p.) for 21 days markedly improved the LPS-induced learning and memory disabilities in the Morris water maze and passive avoidance test. PCE administration significantly decreased the expression of pro-inflammatory mediators such as tumor necrosis factor-${\alpha}$, interleukin-$1{\beta}$, and cyclooxygenase-2 mRNA in the hippocampus, as assessed by RT-PCR analysis and immunohistochemistry. Together, these findings suggest that PCE significantly attenuated LPS-induced spatial cognitive impairment through inhibiting the expression of pro-inflammatory mediators in the rat brain. These results suggested that PCE may be effective in preventing or slowing the development of neurological disorders, including Alzheimer's disease, by improving cognitive and memory function because of its anti-inflammation activity in the brain.
Bang, Jun Soo,Oh, Da Hee,Choi, Hyun Mi,Sur, Bong-Jun,Lim, Sung-Jig,Kim, Jung Yeon,Yang, Hyung-In,Yoo, Myung Chul,Hahm, Dae-Hyun,Kim, Kyoung Soo BioMed Central 2009 Arthritis research & therapy Vol.11 No.2
<P><B>Introduction</B></P><P>The objective of this study was to determine the anti-inflammatory, nociceptive, and antiarthritic effects of piperine, the active phenolic component in black pepper extract.</P><P><B>Methods</B></P><P>The <I>in vitro </I>anti-inflammatory activity of piperine was tested on interleukin 1β (IL1β)-stimulated fibroblast-like synoviocytes derived form patients with rheumatoid arthritis. The levels of IL6, matrix metalloproteinase (MMPs), cyclo-oxygenase 2 (COX-2), and prostaglandin E2 (PGE<SUB>2</SUB>) were investigated by ELISA and RT-PCR analysis. The analgesic and antiarthritic activities of piperine were investigated on rat models of carrageenan-induced acute paw pain and arthritis. The former were evaluated with a paw pressure test, and the latter by measuring the squeaking score, paw volume, and weight distribution ratio. Piperine was administrated orally to rats at 20 and 100 mg/kg/day for 8 days.</P><P><B>Results</B></P><P>Piperine inhibited the expression of IL6 and MMP13 and reduced the production of PGE<SUB>2 </SUB>in a dose dependant manner at concentrations of 10 to 100 μg/ml. In particular, the production of PGE<SUB>2 </SUB>was significantly inhibited even at 10 μg/ml of piperine. Piperine inhibited the migration of activator protein 1 (AP-1), but not nuclear factor (NF)κB, into the nucleus in IL1β-treated synoviocytes. In rats, piperine significantly reduced nociceptive and arthritic symptoms at days 8 and 4, respectively. Histological staining showed that piperine significantly reduced the inflammatory area in the ankle joints.</P><P><B>Conclusions</B></P><P>These results suggest that piperine has anti-inflammatory, antinociceptive, and antiarthritic effects in an arthritis animal model. Thus, piperine should be further studied with regard to use either as a pharmaceutical or as a dietary supplement for the treatment of arthritis.</P>
Mo¨ssbauer Study of the Ferrimagnetic Spinel Co_0.1Fe_0.9Cr_2S_4
Kim, Chul Sung,Shim, In Bo,Ha, Min Yong,Choi, Hyung,Sur, Jung Chul 圓光大學校 基礎自然科學硏究所 1990 基礎科學硏究誌 Vol.9 No.3
The ferrimagnetic normal spinel Co_0.1Fe_0.9Cr_2S_4 has been studied using the Mo¨ssbauer effect. Spectra have been collected over the temperature range 12-300 K. The absence of quadrupole splitting above the Ne'el temperature T_N indicates that iron ions occupy only the tetrahedral (A) sites. The isomer shift indicates that the charge stale of a Fe ion is ferrous in character. It is notable that, as the temperature decreases below T_N=178 K, both quadruple splitting and asymmetrical line broadening appear and increase with decreasing temperature, suggesting the appearence of a dynamic Jahn-Teller distortion. The magnetic hyperfine field and quadrupole splitting at 12 K are found lo be 181 kOe and 1.10 ㎜/s, respectively. The Debye temperature is found to be 231 K.